JP2018520648A - 初代細胞におけるエンドヌクレアーゼに基づいた遺伝子編集の向上 - Google Patents
初代細胞におけるエンドヌクレアーゼに基づいた遺伝子編集の向上 Download PDFInfo
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- JP2018520648A JP2018520648A JP2017559075A JP2017559075A JP2018520648A JP 2018520648 A JP2018520648 A JP 2018520648A JP 2017559075 A JP2017559075 A JP 2017559075A JP 2017559075 A JP2017559075 A JP 2017559075A JP 2018520648 A JP2018520648 A JP 2018520648A
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- C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
- C12N15/90—Stable introduction of foreign DNA into chromosome
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- A61K48/005—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'active' part of the composition delivered, i.e. the nucleic acid delivered
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- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
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- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
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- C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
- C12N7/04—Inactivation or attenuation; Producing viral sub-units
- C12N7/045—Pseudoviral particles; Non infectious pseudovirions, e.g. genetically engineered
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- C12N2310/00—Structure or type of the nucleic acid
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- C12N2310/20—Type of nucleic acid involving clustered regularly interspaced short palindromic repeats [CRISPR]
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- C12N2750/00011—Details
- C12N2750/14011—Parvoviridae
- C12N2750/14111—Dependovirus, e.g. adenoassociated viruses
- C12N2750/14141—Use of virus, viral particle or viral elements as a vector
- C12N2750/14143—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
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- C12N2800/00—Nucleic acids vectors
- C12N2800/80—Vectors containing sites for inducing double-stranded breaks, e.g. meganuclease restriction sites
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- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
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- Cell Biology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Enzymes And Modification Thereof (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562161104P | 2015-05-13 | 2015-05-13 | |
| US62/161,104 | 2015-05-13 | ||
| PCT/US2016/032153 WO2016183345A1 (en) | 2015-05-13 | 2016-05-12 | Enhancing endonuclease based gene editing in primary cells |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2018520648A true JP2018520648A (ja) | 2018-08-02 |
| JP2018520648A5 JP2018520648A5 (OSRAM) | 2019-06-13 |
Family
ID=57248271
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017559075A Ceased JP2018520648A (ja) | 2015-05-13 | 2016-05-12 | 初代細胞におけるエンドヌクレアーゼに基づいた遺伝子編集の向上 |
Country Status (8)
| Country | Link |
|---|---|
| US (3) | US10563226B2 (OSRAM) |
| EP (1) | EP3294343A4 (OSRAM) |
| JP (1) | JP2018520648A (OSRAM) |
| CN (1) | CN108136047B (OSRAM) |
| AU (1) | AU2016262093B2 (OSRAM) |
| CA (1) | CA2985650A1 (OSRAM) |
| HK (1) | HK1252144A1 (OSRAM) |
| WO (1) | WO2016183345A1 (OSRAM) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2024503249A (ja) * | 2020-12-21 | 2024-01-25 | 2セブンティ バイオ インコーポレイテッド | 部位特異的変異導入のための組成物及び方法 |
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| US9950282B2 (en) | 2012-03-15 | 2018-04-24 | Flodesign Sonics, Inc. | Electronic configuration and control for acoustic standing wave generation |
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| US20150044192A1 (en) | 2013-08-09 | 2015-02-12 | President And Fellows Of Harvard College | Methods for identifying a target site of a cas9 nuclease |
| US9359599B2 (en) | 2013-08-22 | 2016-06-07 | President And Fellows Of Harvard College | Engineered transcription activator-like effector (TALE) domains and uses thereof |
| US9322037B2 (en) | 2013-09-06 | 2016-04-26 | President And Fellows Of Harvard College | Cas9-FokI fusion proteins and uses thereof |
| US9737604B2 (en) | 2013-09-06 | 2017-08-22 | President And Fellows Of Harvard College | Use of cationic lipids to deliver CAS9 |
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| WO2017023803A1 (en) | 2015-07-31 | 2017-02-09 | Regents Of The University Of Minnesota | Modified cells and methods of therapy |
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Citations (5)
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| JP2004505633A (ja) * | 2000-08-03 | 2004-02-26 | オニックス ファーマシューティカルズ,インコーポレイティド | アデノウイルスe1b−55k単一アミノ酸変異体および使用方法 |
| WO2008153421A1 (en) * | 2007-06-15 | 2008-12-18 | Otago Innovation Limited | Anticancer therapies |
| WO2014165349A1 (en) * | 2013-04-04 | 2014-10-09 | Trustees Of Dartmouth College | Compositions and methods for in vivo excision of hiv-1 proviral dna |
| US8999641B2 (en) * | 2012-12-12 | 2015-04-07 | The Broad Institute Inc. | Engineering and optimization of systems, methods and compositions for sequence manipulation with functional domains |
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| EP1591521A1 (en) | 2004-04-30 | 2005-11-02 | Cellectis | I-Dmo I derivatives with enhanced activity at 37 degrees C and use thereof |
| EP2412806B1 (en) | 2010-07-28 | 2014-01-08 | Institut Pasteur | Use of terminal deoxynucleotidyl transferase for mutagenic DNA repair to generate variability, at a determined position in DNA |
| US20130337454A1 (en) | 2010-10-27 | 2013-12-19 | Philippe Duchateau | Method for increasing the efficiency of double-strand break-induced mutagenesis |
| US9044492B2 (en) | 2011-02-04 | 2015-06-02 | Cellectis Sa | Method for modulating the efficiency of double-strand break-induced mutagenesis |
| WO2013009525A1 (en) | 2011-07-08 | 2013-01-17 | Cellectis S.A. | Method for increasing the efficiency of double-strand break-induced mutagenssis |
| US20130129668A1 (en) * | 2011-09-01 | 2013-05-23 | The Regents Of The University Of California | Diagnosis and treatment of arthritis using epigenetics |
| US9234213B2 (en) * | 2013-03-15 | 2016-01-12 | System Biosciences, Llc | Compositions and methods directed to CRISPR/Cas genomic engineering systems |
| CN106102781A (zh) * | 2013-08-29 | 2016-11-09 | 英联邦高等教育系统天普大学 | 用于hiv感染的rna指导的治疗的方法和组合物 |
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| DK3441468T3 (da) * | 2013-10-17 | 2021-07-26 | Sangamo Therapeutics Inc | Afgivelsesfremgangsmåder og sammensætninger til nukleasemedieret genom-manipulation |
| US10584321B2 (en) | 2015-02-13 | 2020-03-10 | University Of Massachusetts | Compositions and methods for transient delivery of nucleases |
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| WO2008153421A1 (en) * | 2007-06-15 | 2008-12-18 | Otago Innovation Limited | Anticancer therapies |
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| JP2024503249A (ja) * | 2020-12-21 | 2024-01-25 | 2セブンティ バイオ インコーポレイテッド | 部位特異的変異導入のための組成物及び方法 |
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| EP3294343A4 (en) | 2018-09-26 |
| AU2016262093A1 (en) | 2017-11-30 |
| CN108136047B (zh) | 2022-12-13 |
| EP3294343A1 (en) | 2018-03-21 |
| AU2016262093B2 (en) | 2022-08-18 |
| CN108136047A (zh) | 2018-06-08 |
| US10563226B2 (en) | 2020-02-18 |
| CA2985650A1 (en) | 2016-11-17 |
| AU2016262093A8 (en) | 2017-12-07 |
| US20160333377A1 (en) | 2016-11-17 |
| HK1252144A1 (zh) | 2019-05-17 |
| US20180119174A1 (en) | 2018-05-03 |
| WO2016183345A1 (en) | 2016-11-17 |
| US20200377911A1 (en) | 2020-12-03 |
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