JP2018520205A5 - - Google Patents
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- Publication number
- JP2018520205A5 JP2018520205A5 JP2018511323A JP2018511323A JP2018520205A5 JP 2018520205 A5 JP2018520205 A5 JP 2018520205A5 JP 2018511323 A JP2018511323 A JP 2018511323A JP 2018511323 A JP2018511323 A JP 2018511323A JP 2018520205 A5 JP2018520205 A5 JP 2018520205A5
- Authority
- JP
- Japan
- Prior art keywords
- formula
- compound represented
- crystalline form
- mesylate salt
- powder
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- AFVFQIVMOAPDHO-UHFFFAOYSA-N Methanesulfonic acid Chemical class CS(O)(=O)=O AFVFQIVMOAPDHO-UHFFFAOYSA-N 0.000 claims 14
- 150000001875 compounds Chemical class 0.000 claims 12
- 239000002904 solvent Substances 0.000 claims 7
- 238000000634 powder X-ray diffraction Methods 0.000 claims 6
- 238000005033 Fourier transform infrared spectroscopy Methods 0.000 claims 4
- 150000002825 nitriles Chemical class 0.000 claims 4
- WEVYAHXRMPXWCK-UHFFFAOYSA-N Acetonitrile Chemical group CC#N WEVYAHXRMPXWCK-UHFFFAOYSA-N 0.000 claims 3
- 238000002425 crystallisation Methods 0.000 claims 3
- 230000008025 crystallization Effects 0.000 claims 3
- 238000004519 manufacturing process Methods 0.000 claims 3
- 238000010521 absorption reaction Methods 0.000 claims 2
- 239000013078 crystal Substances 0.000 claims 2
- 238000000034 method Methods 0.000 claims 2
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims 1
- 208000024770 Thyroid neoplasm Diseases 0.000 claims 1
- 150000001338 aliphatic hydrocarbons Chemical class 0.000 claims 1
- 239000003560 cancer drug Substances 0.000 claims 1
- 239000012830 cancer therapeutic Substances 0.000 claims 1
- 150000001793 charged compounds Chemical class 0.000 claims 1
- 150000004292 cyclic ethers Chemical class 0.000 claims 1
- 150000002576 ketones Chemical class 0.000 claims 1
- 229940098779 methanesulfonic acid Drugs 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 238000002360 preparation method Methods 0.000 claims 1
- 238000003756 stirring Methods 0.000 claims 1
- 201000002510 thyroid cancer Diseases 0.000 claims 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510263300 | 2015-05-21 | ||
| CN201510263300.3 | 2015-05-21 | ||
| PCT/CN2016/085360 WO2016184436A1 (zh) | 2015-05-21 | 2016-06-08 | 乐伐替尼甲磺酸盐的新晶型及其制备方法 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2018520205A JP2018520205A (ja) | 2018-07-26 |
| JP2018520205A5 true JP2018520205A5 (cg-RX-API-DMAC7.html) | 2018-09-06 |
Family
ID=57319484
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018511323A Pending JP2018520205A (ja) | 2015-05-21 | 2016-06-08 | レンバチニブメシル酸塩の新規結晶形及びその製造方法 |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US10246418B2 (cg-RX-API-DMAC7.html) |
| EP (1) | EP3287444A4 (cg-RX-API-DMAC7.html) |
| JP (1) | JP2018520205A (cg-RX-API-DMAC7.html) |
| CN (2) | CN113527203B (cg-RX-API-DMAC7.html) |
| IL (1) | IL255738A (cg-RX-API-DMAC7.html) |
| MX (1) | MX2017014799A (cg-RX-API-DMAC7.html) |
| WO (1) | WO2016184436A1 (cg-RX-API-DMAC7.html) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107075051B (zh) | 2014-09-30 | 2019-09-03 | 株式会社Lg化学 | 嵌段共聚物 |
| US10562855B2 (en) * | 2016-06-08 | 2020-02-18 | Crystal Pharmatech Co., Ltd. | Crystalline form of lenvantinib mesylate and process of preparation thereof |
| BR112019013581A2 (pt) * | 2016-12-29 | 2020-01-07 | Dr. Reddy’S Laboratories Limited | Formas no estado sólido de mesilato de lenvatinibe |
| CN110494423B (zh) * | 2017-04-25 | 2022-04-26 | 苏州科睿思制药有限公司 | 乐伐替尼甲磺酸盐的新晶型及其制备方法 |
| WO2019111283A1 (en) * | 2017-12-09 | 2019-06-13 | Msn Laboratories Private Limited, R&D Center | Novel polymorphs of 4-[3-chloro-4-(n'-cyclopropyl ureido)phenoxy]-7-methoxyquinoline-6-carboxamide, its salts and process for the preparation thereof |
| CN109988112A (zh) * | 2017-12-29 | 2019-07-09 | 四川科伦药物研究院有限公司 | 仑伐替尼甲磺酸盐的晶型及其制备方法 |
| WO2019228485A1 (zh) * | 2018-06-01 | 2019-12-05 | 成都苑东生物制药股份有限公司 | 一种甲磺酸乐伐替尼新晶型及其制备方法 |
| CN110818634B (zh) * | 2018-08-13 | 2021-11-30 | 上海新礼泰药业有限公司 | 甲磺酸乐伐替尼的精制方法 |
| EP3620453A1 (en) | 2018-09-07 | 2020-03-11 | Indena S.p.A. | New crystal form of lenvatinib |
| CN111574359A (zh) * | 2019-02-19 | 2020-08-25 | 愈磐生物科技（苏州）有限公司 | 乐伐替尼-没食子酸共晶晶型及其应用 |
| CN111689897B (zh) * | 2019-03-13 | 2024-02-06 | 齐鲁制药有限公司 | 一种高纯度甲磺酸乐伐替尼晶型c的制备方法 |
| CN109867626A (zh) * | 2019-04-18 | 2019-06-11 | 安礼特（上海）医药科技有限公司 | 一种甲磺酸仑伐替尼多晶型物及其制备方法 |
| CN110229103A (zh) * | 2019-06-27 | 2019-09-13 | 尚科生物医药（上海）有限公司 | 一种乐伐替尼甲磺酸盐晶型b的制备方法 |
| CN112174886A (zh) * | 2019-07-02 | 2021-01-05 | 成都苑东生物制药股份有限公司 | 一种甲磺酸乐伐替尼晶型x的制备方法 |
| WO2021007189A1 (en) * | 2019-07-08 | 2021-01-14 | Rezolute, Inc. | Crystalline forms of plasma kallikrein inhibitors |
| CN110563644A (zh) * | 2019-10-30 | 2019-12-13 | 北京赛思源生物医药技术有限公司 | 一种仑伐替尼甲磺酸盐的新晶型 |
| US11059787B2 (en) | 2019-11-12 | 2021-07-13 | Shenzhen Bolan Pharmaceutical Co., Ltd | Crystalline form of lenvatinib mesylate and methods thereof |
| CN117945999B (zh) * | 2020-01-19 | 2025-08-22 | 重庆医药工业研究院有限责任公司 | 一种氟伐替尼或甲磺酸盐的晶型及其制备方法 |
| WO2021213453A1 (zh) * | 2020-04-24 | 2021-10-28 | 成都苑东生物制药股份有限公司 | 一种甲磺酸仑伐替尼晶型xi及其制备方法 |
| CN112939859B (zh) * | 2021-02-03 | 2022-03-11 | 南京方生和医药科技有限公司 | 甲磺酸仑伐替尼m晶型的制备方法 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6627646B2 (en) * | 2001-07-17 | 2003-09-30 | Sepracor Inc. | Norastemizole polymorphs |
| SI1698623T1 (sl) | 2003-12-25 | 2015-07-31 | Eisai R&D Management Co., Ltd. | Kristal soli 4-(3-kloro -4-(ciklopropilaminokarbonil)amino-fenoksi)-7- metoksi-6-kinolinkarboksamida ali njihov solvat in postopek njune proizvodnje |
| JP4834553B2 (ja) * | 2004-09-17 | 2011-12-14 | エーザイ・アール・アンド・ディー・マネジメント株式会社 | 医薬組成物 |
| CA2606719C (en) * | 2005-06-23 | 2010-08-10 | Eisai R & D Management Co., Ltd. | Amorphous salt of 4-(3-chloro-4-(cyclopropylaminocarbonyl)aminophenoxy)-7-methoxy-6-quinolinecarboxamide and process for producing the same |
| ME02359B (me) * | 2009-08-19 | 2016-06-20 | Eisai R&D Man Co Ltd | Farmaceutska kompozicija koja sadrži derivate hinolina |
-
2016
- 2016-06-08 EP EP16795923.8A patent/EP3287444A4/en not_active Withdrawn
- 2016-06-08 JP JP2018511323A patent/JP2018520205A/ja active Pending
- 2016-06-08 CN CN202110477564.4A patent/CN113527203B/zh active Active
- 2016-06-08 WO PCT/CN2016/085360 patent/WO2016184436A1/zh not_active Ceased
- 2016-06-08 CN CN201680036277.7A patent/CN107848979A/zh active Pending
- 2016-06-08 US US15/575,352 patent/US10246418B2/en active Active
- 2016-06-08 MX MX2017014799A patent/MX2017014799A/es unknown
-
2017
- 2017-11-19 IL IL255738A patent/IL255738A/en unknown
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