JP2018518498A5 - - Google Patents
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- Publication number
- JP2018518498A5 JP2018518498A5 JP2017566151A JP2017566151A JP2018518498A5 JP 2018518498 A5 JP2018518498 A5 JP 2018518498A5 JP 2017566151 A JP2017566151 A JP 2017566151A JP 2017566151 A JP2017566151 A JP 2017566151A JP 2018518498 A5 JP2018518498 A5 JP 2018518498A5
- Authority
- JP
- Japan
- Prior art keywords
- delivery device
- transdermal delivery
- ketamine
- plasma concentration
- immediate release
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 230000037317 transdermal delivery Effects 0.000 claims 21
- YQEZLKZALYSWHR-UHFFFAOYSA-N Ketamine Chemical compound C=1C=CC=C(Cl)C=1C1(NC)CCCCC1=O YQEZLKZALYSWHR-UHFFFAOYSA-N 0.000 claims 13
- 229960003299 ketamine Drugs 0.000 claims 13
- 230000036470 plasma concentration Effects 0.000 claims 8
- 239000012729 immediate-release (IR) formulation Substances 0.000 claims 5
- 239000003795 chemical substances by application Substances 0.000 claims 3
- 238000009472 formulation Methods 0.000 claims 3
- 239000000203 mixture Substances 0.000 claims 3
- 239000004820 Pressure-sensitive adhesive Substances 0.000 claims 2
- 239000000853 adhesive Substances 0.000 claims 2
- 230000001070 adhesive effect Effects 0.000 claims 2
- 230000002411 adverse Effects 0.000 claims 2
- YKPUWZUDDOIDPM-SOFGYWHQSA-N capsaicin Chemical group COC1=CC(CNC(=O)CCCC\C=C\C(C)C)=CC=C1O YKPUWZUDDOIDPM-SOFGYWHQSA-N 0.000 claims 2
- 238000002425 crystallisation Methods 0.000 claims 2
- 229940079593 drug Drugs 0.000 claims 2
- 239000003814 drug Substances 0.000 claims 2
- 230000000694 effects Effects 0.000 claims 2
- 208000024714 major depressive disease Diseases 0.000 claims 2
- DBMJMQXJHONAFJ-UHFFFAOYSA-M Sodium laurylsulphate Chemical compound [Na+].CCCCCCCCCCCCOS([O-])(=O)=O DBMJMQXJHONAFJ-UHFFFAOYSA-M 0.000 claims 1
- VMWNQDUVQKEIOC-CYBMUJFWSA-N apomorphine Chemical compound C([C@H]1N(C)CC2)C3=CC=C(O)C(O)=C3C3=C1C2=CC=C3 VMWNQDUVQKEIOC-CYBMUJFWSA-N 0.000 claims 1
- 229960004046 apomorphine Drugs 0.000 claims 1
- 229960002504 capsaicin Drugs 0.000 claims 1
- 235000017663 capsaicin Nutrition 0.000 claims 1
- 230000008025 crystallization Effects 0.000 claims 1
- VWTINHYPRWEBQY-UHFFFAOYSA-N denatonium Chemical compound [O-]C(=O)C1=CC=CC=C1.C=1C=CC=CC=1C[N+](CC)(CC)CC(=O)NC1=C(C)C=CC=C1C VWTINHYPRWEBQY-UHFFFAOYSA-N 0.000 claims 1
- 229940006275 denatonium Drugs 0.000 claims 1
- 239000003623 enhancer Substances 0.000 claims 1
- 239000003112 inhibitor Substances 0.000 claims 1
- 230000035515 penetration Effects 0.000 claims 1
- 239000003961 penetration enhancing agent Substances 0.000 claims 1
- 235000019333 sodium laurylsulphate Nutrition 0.000 claims 1
- 229940100640 transdermal system Drugs 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562185573P | 2015-06-27 | 2015-06-27 | |
| US62/185,573 | 2015-06-27 | ||
| PCT/US2016/039601 WO2017003935A1 (en) | 2015-06-27 | 2016-06-27 | Ketamine transdermal delivery system |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2018518498A JP2018518498A (ja) | 2018-07-12 |
| JP2018518498A5 true JP2018518498A5 (enExample) | 2019-08-08 |
| JP6845162B2 JP6845162B2 (ja) | 2021-03-17 |
Family
ID=57609546
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017566151A Active JP6845162B2 (ja) | 2015-06-27 | 2016-06-27 | ケタミン経皮送達システム |
Country Status (9)
| Country | Link |
|---|---|
| US (2) | US11191734B2 (enExample) |
| EP (1) | EP3297620A4 (enExample) |
| JP (1) | JP6845162B2 (enExample) |
| KR (1) | KR102299359B1 (enExample) |
| CN (1) | CN107847469A (enExample) |
| AU (1) | AU2016288188B2 (enExample) |
| CA (1) | CA2987909C (enExample) |
| HK (1) | HK1248578A1 (enExample) |
| WO (1) | WO2017003935A1 (enExample) |
Families Citing this family (32)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20140275278A1 (en) | 2013-03-15 | 2014-09-18 | Janssen Pharmaceutica Nv | Pharmaceutical composition of s-ketamine hydrochloride |
| HRP20211629T1 (hr) | 2013-09-13 | 2022-02-04 | National University Corporation Chiba University | Primjena r-ketamina i njegove soli kao lijekova |
| CA2961208A1 (en) | 2014-09-15 | 2016-03-24 | Janssen Pharmaceutica Nv | Val66met (snp rs6265) genotype specific dosing regimens and methods for the treatment of depression |
| WO2018091473A1 (en) | 2016-11-15 | 2018-05-24 | Klaria Pharma Holding Ab | Pharmaceutical formulation |
| US20200030251A1 (en) * | 2017-04-20 | 2020-01-30 | Guangzhou Dazhou Biomedicine Ltd. | Transdermal drug delivery system for ketamine |
| US11179469B2 (en) | 2017-04-28 | 2021-11-23 | Nitto Denko Corporation | Transdermal absorption preparation |
| GB201709141D0 (en) | 2017-06-08 | 2017-07-26 | Klaria Pharma Holding Ab | Pharmaceutical formulation |
| US20200009081A1 (en) | 2017-09-13 | 2020-01-09 | Janssen Pharmaceutica N.V. | Delivery Of Esketamine For The Treatment Of Depression |
| US11491120B2 (en) | 2017-11-09 | 2022-11-08 | The Trustees Of Columbia University In The City Of New York | Pharmacological prophylactics against stress-induced affective disorders in females |
| WO2019094596A1 (en) | 2017-11-09 | 2019-05-16 | The Trustees Of Columbia University In The City Of New York | Biomarkers for efficacy of prophylactic treatments against stress-induced affective disorders |
| CN107823195A (zh) * | 2017-11-24 | 2018-03-23 | 无锡市精神卫生中心 | R‑氯胺酮在抑郁症急性期治疗中的应用 |
| MX2020006650A (es) | 2017-12-22 | 2020-11-06 | Janssen Pharmaceuticals Inc | Esketamina para el tratamiento de la depresión. |
| PL3505157T3 (pl) | 2017-12-29 | 2022-04-11 | Celon Pharma S.A. | Kompozycja ketaminy w postaci suchego proszku do podawania dopłucnego w leczeniu depresji opornej na leczenie |
| CN118453559A (zh) | 2018-02-15 | 2024-08-09 | 国立大学法人千叶大学 | 炎症性疾病或骨病的预防或治疗剂及医药组合物 |
| DK3784237T3 (da) * | 2018-04-25 | 2024-01-08 | Shinkei Therapeutics Inc | Indretning til transdermal levering af tetrabenazin |
| CA3099293A1 (en) | 2018-05-04 | 2019-11-07 | Perception Neuroscience, Inc. | Methods of treating substance abuse |
| GB201808462D0 (en) | 2018-05-23 | 2018-07-11 | Klaria Pharma Holding Ab | Pharmaceutical formulation |
| US20210308040A1 (en) * | 2018-10-26 | 2021-10-07 | Guangzhou Dazhou Biomedicine Ltd. | Ketamine oral transmucosal delivery system |
| CN111346073B (zh) * | 2018-12-21 | 2022-06-10 | 宜昌人福药业有限责任公司 | 一种透皮给药的药物组合物及其制备方法和应用 |
| WO2020178653A1 (en) | 2019-03-05 | 2020-09-10 | Janssen Pharmaceuticals, Inc. | Esketamine for the treatment of depression |
| BR112021019190A2 (pt) * | 2019-04-17 | 2021-11-30 | Lts Lohmann Therapie Systeme Ag | Sistema terapêutico transdérmico |
| EP3725306A1 (en) | 2019-04-17 | 2020-10-21 | LTS Lohmann Therapie-Systeme AG | Transdermal therapeutic system |
| US11752114B2 (en) | 2019-04-17 | 2023-09-12 | Lts Lohmann Therapie-Systeme Ag | Transdermal therapeutic system |
| CN109966272A (zh) * | 2019-04-30 | 2019-07-05 | 深圳市泛谷药业股份有限公司 | 一种氯胺酮透皮贴剂及其制备方法 |
| GB201912505D0 (en) * | 2019-08-30 | 2019-10-16 | Klaria Pharma Holding Ab | Pharmaceutical formulation |
| WO2021121366A1 (en) | 2019-12-20 | 2021-06-24 | Alar Pharmaceuticals Inc. | Long-acting injectable formulations of ketamine pamoate salts |
| WO2021255522A1 (en) * | 2020-06-19 | 2021-12-23 | Guangzhou Dazhou Biomedicine Ltd. | Transdermal drug delivery system for ketamine |
| EP3949956A1 (en) * | 2020-08-06 | 2022-02-09 | LTS Lohmann Therapie-Systeme AG | Esketamine-suspension-tts |
| CN117797131A (zh) * | 2022-09-30 | 2024-04-02 | 宜昌人福药业有限责任公司 | S-氯胺酮经皮组合物及其制备方法和应用 |
| CN117797130A (zh) * | 2022-09-30 | 2024-04-02 | 宜昌人福药业有限责任公司 | S-氯胺酮经皮组合物及其制备方法和应用 |
| US12005035B1 (en) * | 2023-08-14 | 2024-06-11 | Daniel C. Javitt | Compositions and methods for treatment of chronic pain and depression |
| WO2025037252A1 (en) * | 2023-08-14 | 2025-02-20 | Javitt Daniel C | Compositions and methods for treatment of chronic pain and depression |
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| WO1997007750A1 (en) * | 1995-08-30 | 1997-03-06 | Weg Stuart L | Administration of ketamine to manage pain and to reduce drug dependency |
| US6248789B1 (en) | 1996-08-29 | 2001-06-19 | Stuart L. Weg | Administration of ketamine to manage pain and to reduce drug dependency |
| US6017961A (en) | 1999-07-08 | 2000-01-25 | Flores; John Anthony | Ketamine and n-butyl-p-aminobezoate in PLO |
| ES2357808T3 (es) | 2001-06-07 | 2011-04-29 | Christine Dr. Sang | Tratamiento del dolor neuropático con antagonistas del receptor de n-metil-d-aspartato (nmda). |
| US20030082225A1 (en) * | 2001-10-19 | 2003-05-01 | Mason Paul Arthur | Sterile, breathable patch for treating wound pain |
| US6855735B2 (en) | 2002-03-20 | 2005-02-15 | Temple University Of The Commonwealth System Of Higher Education | Ketamine treatment of restless legs syndrome |
| US20050148673A1 (en) | 2002-07-11 | 2005-07-07 | Harbut Ronald E. | Prolonged administration of NMDA antagonist and safener drug to alter neuropathic pain condition |
| EP1551393A4 (en) | 2002-07-30 | 2010-06-16 | Peter Migaly | COMBINATION OF THERAPY FOR DEPRESSION, PREVENTION OF SUICIDE AND VARIOUS MEDICAL AND PSYCHIATRIC DISORDERS |
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| WO2014020155A1 (en) | 2012-08-02 | 2014-02-06 | Clinpharm Reform Gmbh | Oral transmucosal adminstration forms of s-ketamine |
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| FR2994844B1 (fr) | 2012-08-31 | 2015-01-02 | Assist Publ Hopitaux De Paris | Formulation gelifiante a base de ketamine |
| EA201590697A1 (ru) | 2012-10-08 | 2015-09-30 | Окленд Юнисервисиз Лимитед | Производные кетамина |
| US20140275278A1 (en) | 2013-03-15 | 2014-09-18 | Janssen Pharmaceutica Nv | Pharmaceutical composition of s-ketamine hydrochloride |
| AU2014250756B2 (en) | 2013-04-12 | 2019-03-07 | Icahn School Of Medicine At Mount Sinai | Method for treating post-traumatic stress disorder |
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| CN109475500A (zh) | 2016-05-25 | 2019-03-15 | 财团法人卫生研究院 | 用于减低氯胺酮致精神病状副作用及成瘾疾患的方法与组合物 |
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| US20200030251A1 (en) | 2017-04-20 | 2020-01-30 | Guangzhou Dazhou Biomedicine Ltd. | Transdermal drug delivery system for ketamine |
-
2016
- 2016-06-27 AU AU2016288188A patent/AU2016288188B2/en not_active Ceased
- 2016-06-27 KR KR1020187002315A patent/KR102299359B1/ko not_active Expired - Fee Related
- 2016-06-27 EP EP16818548.6A patent/EP3297620A4/en not_active Withdrawn
- 2016-06-27 HK HK18108421.2A patent/HK1248578A1/zh unknown
- 2016-06-27 CA CA2987909A patent/CA2987909C/en active Active
- 2016-06-27 WO PCT/US2016/039601 patent/WO2017003935A1/en not_active Ceased
- 2016-06-27 US US15/736,182 patent/US11191734B2/en active Active
- 2016-06-27 CN CN201680037543.8A patent/CN107847469A/zh active Pending
- 2016-06-27 JP JP2017566151A patent/JP6845162B2/ja active Active
-
2021
- 2021-12-02 US US17/540,695 patent/US20220193000A1/en not_active Abandoned
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