JP2018518498A5 - - Google Patents
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- Publication number
- JP2018518498A5 JP2018518498A5 JP2017566151A JP2017566151A JP2018518498A5 JP 2018518498 A5 JP2018518498 A5 JP 2018518498A5 JP 2017566151 A JP2017566151 A JP 2017566151A JP 2017566151 A JP2017566151 A JP 2017566151A JP 2018518498 A5 JP2018518498 A5 JP 2018518498A5
- Authority
- JP
- Japan
- Prior art keywords
- delivery device
- transdermal delivery
- ketamine
- plasma concentration
- immediate release
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 230000037317 transdermal delivery Effects 0.000 claims 21
- YQEZLKZALYSWHR-UHFFFAOYSA-N Ketamine Chemical compound C=1C=CC=C(Cl)C=1C1(NC)CCCCC1=O YQEZLKZALYSWHR-UHFFFAOYSA-N 0.000 claims 13
- 229960003299 ketamine Drugs 0.000 claims 13
- 230000036470 plasma concentration Effects 0.000 claims 8
- 239000012729 immediate-release (IR) formulation Substances 0.000 claims 5
- 239000003795 chemical substances by application Substances 0.000 claims 3
- 238000009472 formulation Methods 0.000 claims 3
- 239000000203 mixture Substances 0.000 claims 3
- 239000004820 Pressure-sensitive adhesive Substances 0.000 claims 2
- 239000000853 adhesive Substances 0.000 claims 2
- 230000001070 adhesive effect Effects 0.000 claims 2
- 230000002411 adverse Effects 0.000 claims 2
- YKPUWZUDDOIDPM-SOFGYWHQSA-N capsaicin Chemical group COC1=CC(CNC(=O)CCCC\C=C\C(C)C)=CC=C1O YKPUWZUDDOIDPM-SOFGYWHQSA-N 0.000 claims 2
- 238000002425 crystallisation Methods 0.000 claims 2
- 229940079593 drug Drugs 0.000 claims 2
- 239000003814 drug Substances 0.000 claims 2
- 230000000694 effects Effects 0.000 claims 2
- 208000024714 major depressive disease Diseases 0.000 claims 2
- DBMJMQXJHONAFJ-UHFFFAOYSA-M Sodium laurylsulphate Chemical compound [Na+].CCCCCCCCCCCCOS([O-])(=O)=O DBMJMQXJHONAFJ-UHFFFAOYSA-M 0.000 claims 1
- VMWNQDUVQKEIOC-CYBMUJFWSA-N apomorphine Chemical compound C([C@H]1N(C)CC2)C3=CC=C(O)C(O)=C3C3=C1C2=CC=C3 VMWNQDUVQKEIOC-CYBMUJFWSA-N 0.000 claims 1
- 229960004046 apomorphine Drugs 0.000 claims 1
- 229960002504 capsaicin Drugs 0.000 claims 1
- 235000017663 capsaicin Nutrition 0.000 claims 1
- 230000008025 crystallization Effects 0.000 claims 1
- VWTINHYPRWEBQY-UHFFFAOYSA-N denatonium Chemical compound [O-]C(=O)C1=CC=CC=C1.C=1C=CC=CC=1C[N+](CC)(CC)CC(=O)NC1=C(C)C=CC=C1C VWTINHYPRWEBQY-UHFFFAOYSA-N 0.000 claims 1
- 229940006275 denatonium Drugs 0.000 claims 1
- 239000003623 enhancer Substances 0.000 claims 1
- 239000003112 inhibitor Substances 0.000 claims 1
- 230000035515 penetration Effects 0.000 claims 1
- 239000003961 penetration enhancing agent Substances 0.000 claims 1
- 235000019333 sodium laurylsulphate Nutrition 0.000 claims 1
- 229940100640 transdermal system Drugs 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562185573P | 2015-06-27 | 2015-06-27 | |
| US62/185,573 | 2015-06-27 | ||
| PCT/US2016/039601 WO2017003935A1 (en) | 2015-06-27 | 2016-06-27 | Ketamine transdermal delivery system |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2018518498A JP2018518498A (ja) | 2018-07-12 |
| JP2018518498A5 true JP2018518498A5 (enExample) | 2019-08-08 |
| JP6845162B2 JP6845162B2 (ja) | 2021-03-17 |
Family
ID=57609546
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017566151A Active JP6845162B2 (ja) | 2015-06-27 | 2016-06-27 | ケタミン経皮送達システム |
Country Status (9)
| Country | Link |
|---|---|
| US (2) | US11191734B2 (enExample) |
| EP (1) | EP3297620A4 (enExample) |
| JP (1) | JP6845162B2 (enExample) |
| KR (1) | KR102299359B1 (enExample) |
| CN (1) | CN107847469A (enExample) |
| AU (1) | AU2016288188B2 (enExample) |
| CA (1) | CA2987909C (enExample) |
| HK (1) | HK1248578A1 (enExample) |
| WO (1) | WO2017003935A1 (enExample) |
Families Citing this family (31)
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|---|---|---|---|---|
| US20140274981A1 (en) | 2013-03-15 | 2014-09-18 | Janssen Pharmaceutica Nv | Pharmaceutical composition of s-ketamine hydrochloride |
| EP3193853A1 (en) | 2014-09-15 | 2017-07-26 | Janssen Pharmaceutica NV | VAL66MET (SNP rs6265) GENOTYPE SPECIFIC DOSING REGIMENS AND METHODS FOR THE TREATMENT OF DEPRESSION |
| WO2018091473A1 (en) | 2016-11-15 | 2018-05-24 | Klaria Pharma Holding Ab | Pharmaceutical formulation |
| WO2018195318A1 (en) * | 2017-04-20 | 2018-10-25 | Guangzhou Dazhou Biomedicine Ltd. | Transdermal drug delivery system for ketamine |
| TW201946617A (zh) * | 2017-04-28 | 2019-12-16 | 日商日東電工股份有限公司 | 經皮吸收製劑 |
| GB201709141D0 (en) | 2017-06-08 | 2017-07-26 | Klaria Pharma Holding Ab | Pharmaceutical formulation |
| US20200009081A1 (en) | 2017-09-13 | 2020-01-09 | Janssen Pharmaceutica N.V. | Delivery Of Esketamine For The Treatment Of Depression |
| WO2019094596A1 (en) | 2017-11-09 | 2019-05-16 | The Trustees Of Columbia University In The City Of New York | Biomarkers for efficacy of prophylactic treatments against stress-induced affective disorders |
| WO2019094757A1 (en) | 2017-11-09 | 2019-05-16 | The Trustees Of Columbia University In The City Of New York | Pharmacological prophylactics against stress-induced affective disorders in females |
| CN107823195A (zh) * | 2017-11-24 | 2018-03-23 | 无锡市精神卫生中心 | R‑氯胺酮在抑郁症急性期治疗中的应用 |
| IL319020A (en) | 2017-12-22 | 2025-04-01 | Janssen Pharmaceuticals Inc | Esketamine for the treatment of depression |
| ES2907692T3 (es) | 2017-12-29 | 2022-04-26 | Celon Pharma Sa | Composición de ketamina de polvo seco para su administración por vía pulmonar en la depresión resistente al tratamiento |
| CN111936127A (zh) | 2018-02-15 | 2020-11-13 | 国立大学法人千叶大学 | 炎症性疾病或骨病的预防或治疗剂及医药组合物 |
| MX2020011269A (es) | 2018-04-25 | 2020-12-11 | Shinkei Therapeutics Llc | Dispositivo de administración transdérmica de tetrabenazina. |
| CN118121577A (zh) | 2018-05-04 | 2024-06-04 | 感知神经科学公司 | 治疗物质滥用的方法 |
| GB201808462D0 (en) | 2018-05-23 | 2018-07-11 | Klaria Pharma Holding Ab | Pharmaceutical formulation |
| US20210308040A1 (en) * | 2018-10-26 | 2021-10-07 | Guangzhou Dazhou Biomedicine Ltd. | Ketamine oral transmucosal delivery system |
| CN111346073B (zh) * | 2018-12-21 | 2022-06-10 | 宜昌人福药业有限责任公司 | 一种透皮给药的药物组合物及其制备方法和应用 |
| MA55218A (fr) | 2019-03-05 | 2022-01-12 | Janssen Pharmaceuticals Inc | Eskétamine pour le traitement de la dépression |
| US11752114B2 (en) | 2019-04-17 | 2023-09-12 | Lts Lohmann Therapie-Systeme Ag | Transdermal therapeutic system |
| EP3725306A1 (en) | 2019-04-17 | 2020-10-21 | LTS Lohmann Therapie-Systeme AG | Transdermal therapeutic system |
| AU2020257564B2 (en) * | 2019-04-17 | 2023-03-02 | Lts Lohmann Therapie-Systeme Ag | Transdermal therapeutic system |
| CN109966272A (zh) * | 2019-04-30 | 2019-07-05 | 深圳市泛谷药业股份有限公司 | 一种氯胺酮透皮贴剂及其制备方法 |
| GB201912505D0 (en) * | 2019-08-30 | 2019-10-16 | Klaria Pharma Holding Ab | Pharmaceutical formulation |
| TWI862759B (zh) | 2019-12-20 | 2024-11-21 | 昱展新藥生技股份有限公司 | 氯胺酮雙羥萘酸鹽的長效注射劑型 |
| US11559497B2 (en) | 2020-06-19 | 2023-01-24 | Guangzhou Dazhou Biomedicine Ltd. | Transdermal drug delivery system for ketamine |
| EP3949956A1 (en) * | 2020-08-06 | 2022-02-09 | LTS Lohmann Therapie-Systeme AG | Esketamine-suspension-tts |
| CN117797130A (zh) * | 2022-09-30 | 2024-04-02 | 宜昌人福药业有限责任公司 | S-氯胺酮经皮组合物及其制备方法和应用 |
| WO2024067729A1 (zh) * | 2022-09-30 | 2024-04-04 | 宜昌人福药业有限责任公司 | S-氯胺酮经皮组合物及其制备方法和应用 |
| US12005035B1 (en) * | 2023-08-14 | 2024-06-11 | Daniel C. Javitt | Compositions and methods for treatment of chronic pain and depression |
| WO2025037252A1 (en) * | 2023-08-14 | 2025-02-20 | Javitt Daniel C | Compositions and methods for treatment of chronic pain and depression |
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| US5635204A (en) * | 1994-03-04 | 1997-06-03 | Montefiore Medical Center | Method for transdermal induction of anesthesia, analgesia or sedation |
| WO1997007750A1 (en) * | 1995-08-30 | 1997-03-06 | Weg Stuart L | Administration of ketamine to manage pain and to reduce drug dependency |
| US6248789B1 (en) | 1996-08-29 | 2001-06-19 | Stuart L. Weg | Administration of ketamine to manage pain and to reduce drug dependency |
| US6017961A (en) | 1999-07-08 | 2000-01-25 | Flores; John Anthony | Ketamine and n-butyl-p-aminobezoate in PLO |
| PT2266558T (pt) | 2001-06-07 | 2017-07-21 | Analgesic Neuropharmaceuticals Llc | Tratamento da dor neuropática com o antagonista dos recetores de n-metil-d-aspartato (nmda) dextrometorfano |
| US20030082225A1 (en) * | 2001-10-19 | 2003-05-01 | Mason Paul Arthur | Sterile, breathable patch for treating wound pain |
| US6855735B2 (en) | 2002-03-20 | 2005-02-15 | Temple University Of The Commonwealth System Of Higher Education | Ketamine treatment of restless legs syndrome |
| US20050148673A1 (en) | 2002-07-11 | 2005-07-07 | Harbut Ronald E. | Prolonged administration of NMDA antagonist and safener drug to alter neuropathic pain condition |
| AU2003268026A1 (en) | 2002-07-30 | 2004-02-16 | Peter Migaly | Combination therapy for depression, prevention of suicide, and varous medical and psychiatric conditions |
| US7273889B2 (en) | 2002-09-25 | 2007-09-25 | Innovative Drug Delivery Systems, Inc. | NMDA receptor antagonist formulation with reduced neurotoxicity |
| WO2004045601A1 (en) | 2002-11-18 | 2004-06-03 | Yaupon Therapeutics, Inc. | Analgesic uses of norketamine and ketamine/norketamine prodrugs |
| US7687080B2 (en) * | 2002-11-25 | 2010-03-30 | Taraxos Inc. | Treatment of neuropathy |
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| EP1861104A4 (en) | 2005-03-04 | 2011-12-14 | Neurosystec Corp | IMPROVED GACYCLIDINE FORMULATIONS |
| JP2009530385A (ja) | 2006-03-22 | 2009-08-27 | マウント シナイ スクール オブ メディシン | うつ病の治療のためのケタミンの鼻内投与 |
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| CN104395283A (zh) | 2011-10-14 | 2015-03-04 | 美国政府健康及人类服务部 | (2r,6r)-羟基去甲氯胺酮、(s)-脱氢去甲氯胺酮以及(r,s)-氯胺酮的其他立体异构脱氢和羟基化代谢物在治疗忧郁症和神经性疼痛中的应用 |
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| PL2809307T3 (pl) * | 2012-01-31 | 2018-06-29 | Grünenthal GmbH | Plaster farmaceutyczny do podawania przezskórnego (1r,4r)-6'-fluoro-N,N-dimetylo-4-fenylo-4',9'-dihydro-3'H-spiro[cykloheksano-1,1'-pirano[3,4-b]indolo]-4-aminy |
| US20130209585A1 (en) | 2012-02-13 | 2013-08-15 | Stanley Kim | Topical NMDA Antagonist Formulations for the Treatment of Peripheral Neuropathy |
| PE20141906A1 (es) | 2012-03-12 | 2014-12-05 | Janssen Pharmaceutica Nv | Esketamina para el tratamiento de la depresion refractaria al tratamiento o resistente al tratamiento |
| WO2013149102A1 (en) | 2012-03-30 | 2013-10-03 | The General Hospital Corporation | Compositions comprising scopolamine and ketamine in the treatment of depression |
| WO2014020155A1 (en) | 2012-08-02 | 2014-02-06 | Clinpharm Reform Gmbh | Oral transmucosal adminstration forms of s-ketamine |
| KR20150096370A (ko) | 2012-08-23 | 2015-08-24 | 스튜어트 엘. 웨그 | 항불안제 조성물, 제형 및 사용방법 |
| FR2994844B1 (fr) | 2012-08-31 | 2015-01-02 | Assist Publ Hopitaux De Paris | Formulation gelifiante a base de ketamine |
| JP6309957B2 (ja) | 2012-10-08 | 2018-04-11 | オークランド ユニサービシーズ リミティド | ケタミン誘導体 |
| US20140274981A1 (en) | 2013-03-15 | 2014-09-18 | Janssen Pharmaceutica Nv | Pharmaceutical composition of s-ketamine hydrochloride |
| EP2983787B1 (en) | 2013-04-12 | 2019-10-02 | Icahn School of Medicine at Mount Sinai | Method for treating post-traumatic stress disorder |
| US9913803B2 (en) | 2013-08-26 | 2018-03-13 | Amorsa Therapeutics, Inc. | Single-layer oral dose of neuro-attenuating ketamine |
| EP3964203A1 (en) | 2013-09-13 | 2022-03-09 | National University Corporation Chiba University | Application of r-ketamine and salt thereof as pharmaceuticals |
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| US11207316B2 (en) | 2014-05-30 | 2021-12-28 | West Virginia University | Ketamine or dextromethorphan formulations and methods of use |
| WO2016025581A1 (en) | 2014-08-13 | 2016-02-18 | Janssen Pharmaceutica Nv | Method for the treatment of depression |
| RU2771275C2 (ru) | 2014-11-04 | 2022-04-29 | Аморса Терапьютикс, Инк. | Нейро-аттенуирующие кетаминовые и норкетаминовые соединения, их производные и способы их получения |
| US20180015054A1 (en) | 2014-12-31 | 2018-01-18 | Icahn School Of Medicine At Mount Sinai | Method of Maintaining the Anti-Depressant Effect of Ketamine With Lithium |
| WO2016172672A1 (en) | 2015-04-24 | 2016-10-27 | Icahn School Of Medicine At Mount Sinai | Method for treating suicidal ideation |
| US20160338977A1 (en) | 2015-05-20 | 2016-11-24 | Janssen Pharmaceutica Nv | Methods and kits for treating depression |
| WO2017041112A1 (en) | 2015-09-04 | 2017-03-09 | Cyprus Therapeutics, Inc. | Ketamine and cytochrome p 450 inhibitor combinations |
| WO2017087691A1 (en) | 2015-11-17 | 2017-05-26 | The Trustees Of Columbia University In The City Of New York | Pharmacological prophylactics against stress-induced affective disorders and their associated symptoms |
| WO2017139382A1 (en) | 2016-02-08 | 2017-08-17 | The Texas A&M University System | Combination of adjuvant drugs esketamine and brimonidine for medical treatments |
| EP3413903A4 (en) | 2016-02-12 | 2019-09-18 | Synergistic Therapeutics, LLC | ANTIDEPRESSIVE SUBLINGUAL AIRPLANE |
| US20170266319A1 (en) | 2016-03-21 | 2017-09-21 | Children's Hospital Medical Center | Methods and compositions for treating conditions associated with spinal cord injury |
| AU2017238859B2 (en) | 2016-03-25 | 2021-02-18 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Crystal forms and methods of synthesis of (2R, 6R)-hydroxynorketamine and (2S, 6S)-hydroxynorketamine |
| CN109475514A (zh) | 2016-03-25 | 2019-03-15 | 美国政府健康及人类服务部 | 使用(2r,6r)-羟基去甲氯胺酮和(2s,6s)-羟基去甲氯胺酮治疗抑郁、焦虑、快感缺乏、疲劳、自杀意念和创伤后应激障碍的方法 |
| GB2564990A (en) | 2016-04-01 | 2019-01-30 | Good Pharmaceutical Dev Company Llc | Topical compositions for neuropathic pain |
| AU2017250086A1 (en) | 2016-04-11 | 2018-09-20 | Clexio Biosciences Ltd. | Deuterated ketamine derivatives |
| US20170348252A1 (en) | 2016-04-21 | 2017-12-07 | Robert Kent | Preparation and Use of Ketamine Derivatives and Ketamine Modifiers in the Treatment of Pain |
| US11213495B2 (en) | 2016-05-25 | 2022-01-04 | National Health Research Institutes | Method and composition for decreasing the psychotomimetic side effect and addictive disorder of ketamine |
| EP3463323B1 (en) | 2016-06-03 | 2021-10-20 | Small Pharma Ltd | Solid oral dosage forms of 2r,6r-hydroxynorketamine or derivatives thereof |
| WO2018195318A1 (en) | 2017-04-20 | 2018-10-25 | Guangzhou Dazhou Biomedicine Ltd. | Transdermal drug delivery system for ketamine |
-
2016
- 2016-06-27 WO PCT/US2016/039601 patent/WO2017003935A1/en not_active Ceased
- 2016-06-27 CA CA2987909A patent/CA2987909C/en active Active
- 2016-06-27 AU AU2016288188A patent/AU2016288188B2/en not_active Ceased
- 2016-06-27 HK HK18108421.2A patent/HK1248578A1/zh unknown
- 2016-06-27 EP EP16818548.6A patent/EP3297620A4/en not_active Withdrawn
- 2016-06-27 US US15/736,182 patent/US11191734B2/en active Active
- 2016-06-27 JP JP2017566151A patent/JP6845162B2/ja active Active
- 2016-06-27 KR KR1020187002315A patent/KR102299359B1/ko not_active Expired - Fee Related
- 2016-06-27 CN CN201680037543.8A patent/CN107847469A/zh active Pending
-
2021
- 2021-12-02 US US17/540,695 patent/US20220193000A1/en not_active Abandoned
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