EA201590051A1 - Новое соединение, обладающее способностью ингибировать фермент 11бета-hsd1, или его фармацевтически приемлемая соль, способ его получения и фармацевтическая композиция, содержащая такое соединение в качестве активного ингредиента - Google Patents

Новое соединение, обладающее способностью ингибировать фермент 11бета-hsd1, или его фармацевтически приемлемая соль, способ его получения и фармацевтическая композиция, содержащая такое соединение в качестве активного ингредиента

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EA201590051A1
EA201590051A1 EA201590051A EA201590051A EA201590051A1 EA 201590051 A1 EA201590051 A1 EA 201590051A1 EA 201590051 A EA201590051 A EA 201590051A EA 201590051 A EA201590051 A EA 201590051A EA 201590051 A1 EA201590051 A1 EA 201590051A1
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pharmaceutical composition
compound
composition
pharmaceutically acceptable
applicatorials
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EA201590051A
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English (en)
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EA026005B1 (ru
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Чеол Киу Хан
Дзин Аух
Нам Сонг Чои
Чанг Киун Хан
Тае-Дзеонг Ким
Камса Пае
Йоунг Дзуне Син
Донг-Ох Хан
Сун Кил Ахн
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Бамикем Ко., Лтд.
Ахн-Гоок Фармасьютикал Ко., Лтд.
Инчхон Юниверсити Индастри Академик Кооперейшн Фаундейшн
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Publication of EA201590051A1 publication Critical patent/EA201590051A1/ru
Publication of EA026005B1 publication Critical patent/EA026005B1/ru

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    • C07C311/01—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms
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Abstract

Изобретение относится к новому соединению или его фармацевтически приемлемой соли, ингибирующим активность фермента 11β-HSD1, к способу получения такого соединения и к фармацевтической композиции, включающей такое соединение в качестве активного ингредиента. Поскольку соединение по настоящему изобретению селективно ингибирует активность 11β-HSD1 (11β-гидроксистероиддегидрогеназа типа 1), соединение по настоящему изобретению можно эффективно использовать в качестве терапевтического средства для лечения заболеваний, вызванных чрезмерной активацией 11β-HSD1, таких как инсулиннезависимый диабет II типа, инсулинорезистентность, ожирение, липидное расстройство, метаболический синдром и другие заболевания или состояния, опосредованные чрезмерной активностью глюкокортикоида.
EA201590051A 2012-06-20 2013-06-04 НОВОЕ СОЕДИНЕНИЕ, ОБЛАДАЮЩЕЕ СПОСОБНОСТЬЮ ИНГИБИРОВАТЬ ФЕРМЕНТ 11β-HSD1, ИЛИ ЕГО ФАРМАЦЕВТИЧЕСКИ ПРИЕМЛЕМАЯ СОЛЬ, СПОСОБ ЕГО ПОЛУЧЕНИЯ И ФАРМАЦЕВТИЧЕСКАЯ КОМПОЗИЦИЯ, СОДЕРЖАЩАЯ ТАКОЕ СОЕДИНЕНИЕ В КАЧЕСТВЕ АКТИВНОГО ИНГРЕДИЕНТА EA026005B1 (ru)

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KR20120066333A KR20130142801A (ko) 2012-06-20 2012-06-20 １１β－ＨＳＤ１ 효소의 억제활성을 갖는 신규한 화합물 또는 이의 약학적으로 허용가능한 염, 이의 제조방법 및 이를 유효성분으로 함유하는 약학적 조성물
PCT/KR2013/004913 WO2013191396A1 (ko) 2012-06-20 2013-06-04 11β-HSD1 효소의 억제활성을 갖는 신규한 화합물 또는 이의 약학적으로 허용가능한 염, 이의 제조방법 및 이를 유효성분으로 함유하는 약학적 조성물

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