JP2018517415A - がんを処置するための改変ｎｋ−９２細胞 - Google Patents

がんを処置するための改変ｎｋ−９２細胞 Download PDF

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JP2018517415A
JP2018517415A JP2017564059A JP2017564059A JP2018517415A JP 2018517415 A JP2018517415 A JP 2018517415A JP 2017564059 A JP2017564059 A JP 2017564059A JP 2017564059 A JP2017564059 A JP 2017564059A JP 2018517415 A JP2018517415 A JP 2018517415A
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cells
cell
monoclonal antibody
seq
car
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JP2018517415A5 (https=
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ティエン リー
ティエン リー
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ナントクエスト インコーポレイテッド
ナントクエスト インコーポレイテッド
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Publication of JP2018517415A5 publication Critical patent/JP2018517415A5/ja
Priority to JP2021036808A priority Critical patent/JP7275178B2/ja
Priority to JP2023025723A priority patent/JP7836780B2/ja
Priority to JP2025048124A priority patent/JP2025089426A/ja
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JP2017564059A 2015-06-10 2016-06-10 がんを処置するための改変ｎｋ−９２細胞 Pending JP2018517415A (ja)

Priority Applications (3)

Application Number Priority Date Filing Date Title
JP2021036808A JP7275178B2 (ja) 2015-06-10 2021-03-09 がんを処置するための改変ｎｋ－９２細胞
JP2023025723A JP7836780B2 (ja) 2015-06-10 2023-02-22 がんを処置するための改変ｎｋ－９２細胞
JP2025048124A JP2025089426A (ja) 2015-06-10 2025-03-24 がんを処置するための改変ｎｋ－９２細胞

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201562173701P 2015-06-10 2015-06-10
US62/173,701 2015-06-10
US201662337044P 2016-05-16 2016-05-16
US62/337,044 2016-05-16
PCT/US2016/036991 WO2016201304A1 (en) 2015-06-10 2016-06-10 Modified nk-92 cells for treating cancer

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JP2021036808A Division JP7275178B2 (ja) 2015-06-10 2021-03-09 がんを処置するための改変ｎｋ－９２細胞

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JP2018517415A true JP2018517415A (ja) 2018-07-05
JP2018517415A5 JP2018517415A5 (https=) 2019-06-27

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JP2017564059A Pending JP2018517415A (ja) 2015-06-10 2016-06-10 がんを処置するための改変ｎｋ−９２細胞
JP2021036808A Active JP7275178B2 (ja) 2015-06-10 2021-03-09 がんを処置するための改変ｎｋ－９２細胞
JP2023025723A Active JP7836780B2 (ja) 2015-06-10 2023-02-22 がんを処置するための改変ｎｋ－９２細胞
JP2025048124A Pending JP2025089426A (ja) 2015-06-10 2025-03-24 がんを処置するための改変ｎｋ－９２細胞

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JP2021036808A Active JP7275178B2 (ja) 2015-06-10 2021-03-09 がんを処置するための改変ｎｋ－９２細胞
JP2023025723A Active JP7836780B2 (ja) 2015-06-10 2023-02-22 がんを処置するための改変ｎｋ－９２細胞
JP2025048124A Pending JP2025089426A (ja) 2015-06-10 2025-03-24 がんを処置するための改変ｎｋ－９２細胞

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US (3) US10738279B2 (https=)
EP (3) EP4424326A3 (https=)
JP (4) JP2018517415A (https=)
KR (4) KR20250027585A (https=)
CN (2) CN113502270B (https=)
AU (1) AU2016275030B2 (https=)
CA (1) CA2987290C (https=)
ES (1) ES2958720T3 (https=)
IL (2) IL255884B2 (https=)
WO (1) WO2016201304A1 (https=)

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2022542368A (ja) * 2019-07-26 2022-10-03 ナントクウェスト，インコーポレーテッド 腫瘍溶解のための有効な治療用製剤としての、抗体を予め負荷したｃｄ１６＋ｎｋ－９２細胞
JP2023519908A (ja) * 2020-03-28 2023-05-15 ボード オブ リージェンツ，ザ ユニバーシティ オブ テキサス システム 癌の治療のための細胞免疫療法
US11788059B2 (en) 2015-06-10 2023-10-17 Immunity Bio, Inc. Modified NK-92 cells for treating cancer
JP7524070B2 (ja) 2018-10-31 2024-07-29 イミュニティーバイオ、インコーポレイテッド Ｃｄ１９－ｃａｒを発現するｎｋ細胞によるｃｄ１９陽性リンパ悪性腫瘍の排除
JP2025024042A (ja) * 2018-08-01 2025-02-19 イミュニティーバイオ、インコーポレイテッド 細胞免疫療法の安定した遺伝子改変のための、ホーミング受容体又はサイトカインとキメラ抗原受容体とを含むクアドリシストロニックシステム
JP2025087816A (ja) * 2018-10-31 2025-06-10 イミュニティーバイオ、インコーポレイテッド Ｐｄ－ｌ１キメラ抗原受容体を発現するｎｋ細胞によるｐｄ－ｌ１陽性悪性腫瘍の排除

Families Citing this family (56)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2945320A1 (en) 2014-04-10 2015-10-15 Seattle Children's Hospital (dba Seattle Children's Research Institute) Drug regulated transgene expression
AU2015259877B2 (en) 2014-05-15 2021-02-25 National University Of Singapore Modified natural killer cells and uses thereof
WO2017027291A1 (en) 2015-08-07 2017-02-16 Seattle Children's Hospital (dba Seattle Children's Research Institute) Bispecific car t-cells for solid tumor targeting
SG11201810640RA (en) * 2016-06-08 2018-12-28 Intrexon Corp Cd33 specific chimeric antigen receptors
KR102528384B1 (ko) * 2017-01-06 2023-05-02 이뮤너티바이오, 인크. 감소된 cd96/tigit 발현을 갖는 유전자 변형된 nk-92 세포
KR20190102259A (ko) * 2017-01-10 2019-09-03 인트렉손 코포레이션 신규의 유전자 스위치 발현 시스템을 통한 폴리펩티드의 발현 조절
CA3051866A1 (en) * 2017-02-01 2018-08-09 Nant Holdings Ip, Llc Calreticulin-mediated cancer treatment
CA3054078A1 (en) * 2017-02-20 2018-08-23 Dragonfly Therapeutics, Inc. Proteins binding cd33, nkg2d and cd16
KR102769529B1 (ko) 2017-03-08 2025-02-19 이뮤너티바이오, 인크. 임상용 변형된 NK-92 haNK003 세포
BR112019018915A2 (pt) 2017-03-15 2020-04-14 Pandion Therapeutics Inc imunotolerância direcionada
KR102660336B1 (ko) 2017-03-27 2024-04-26 내셔널 유니버시티 오브 싱가포르 절단된 nkg2d 키메라 수용체 및 자연 살해 세포 면역요법에서의 그의 용도
MX2019011570A (es) 2017-03-27 2019-11-18 Nat Univ Singapore Lineas celulares estimuladoras para expansion y activacion ex vivo de celulas asesinas naturales.
EP3601538A4 (en) * 2017-03-27 2021-03-10 Nantcell, Inc. ANK AND IL-12 COMPOSITIONS AND METHODS
BR112019020909A2 (pt) * 2017-04-05 2020-05-12 Korea Research Institute Of Bioscience And Biotechnology Proteína de fusão ativadora de célula nk, célula nk e composição farmacêutica incluindo a mesma
EP4317422A3 (en) * 2017-04-13 2024-05-01 Senti Biosciences, Inc. Combinatorial cancer immunotherapy
JP2020521452A (ja) 2017-05-24 2020-07-27 パンディオン・セラピューティクス・インコーポレイテッド 標的化免疫寛容
TWI676483B (zh) * 2017-08-06 2019-11-11 強普生技股份有限公司 醫藥套組及其用途
EP3697438A4 (en) 2017-10-18 2021-08-18 Intrexon Corporation POLYPEPTIDE COMPOSITIONS WITH SPACERS
US12053490B2 (en) 2017-10-26 2024-08-06 St. Jude Children's Research Hospital, Inc. Methods and compositions for treating CD33+ cancers and improving in vivo persistence of chimeric antigen receptor T cells
WO2019089813A1 (en) * 2017-11-01 2019-05-09 Nantkwest, Inc. Nk-92 cells to stimulate anti-cancer vaccine
CN111788301A (zh) * 2017-11-24 2020-10-16 昂克治疗有限公司 靶向肿瘤细胞的经修饰的自然杀伤细胞和自然杀伤细胞系
US10946068B2 (en) 2017-12-06 2021-03-16 Pandion Operations, Inc. IL-2 muteins and uses thereof
US10174091B1 (en) 2017-12-06 2019-01-08 Pandion Therapeutics, Inc. IL-2 muteins
USRE50550E1 (en) 2017-12-06 2025-08-26 Pandion Operations, Inc. IL-2 muteins and uses thereof
WO2019127215A1 (en) * 2017-12-28 2019-07-04 Nanjing Legend Biotech Co., Ltd. Multispecific chimeric receptors comprising an nkg2d domain and methods of use thereof
CN110028589B (zh) * 2018-02-07 2023-07-21 阿思科力(苏州)生物科技有限公司 嵌合抗原受体、表达该嵌合抗原受体的nkg2d car-nk细胞及其制备方法和应用
AU2019219454A1 (en) 2018-02-09 2020-08-27 National University Of Singapore Activating chimeric receptors and uses thereof in natural killer cell immunotherapy
CN112004829A (zh) 2018-03-12 2020-11-27 南克维斯特公司 Cd33car修饰的高亲和力nk细胞(t-hank)用于降低髓系衍生的抑制细胞的抑制活性(或降低对nk细胞活性的负面影响)的用途
WO2019182425A1 (ko) * 2018-03-23 2019-09-26 주식회사 에스엘바이젠 신규 키메라 항원 수용체 암호화 유전자가 형질도입된 유전자 변형 nk 세포주 및 그의 용도
CN112055717B (zh) 2018-04-02 2024-04-26 新加坡国立大学 用在免疫细胞中表达的膜结合抗细胞因子非信号传导粘合剂中和人细胞因子
IL321548A (en) 2018-05-22 2025-08-01 Immunitybio Inc Recombinant NK cells expressing a chimeric antigen receptor (CAR) for epsilon-FC and uses thereof
US12498363B2 (en) 2018-08-01 2025-12-16 Immunitybio, Inc. Combined invasion and cytotoxicity assay using chemokine secreting target cells
EP3844186A4 (en) 2018-08-29 2022-08-17 National University of Singapore METHOD OF SPECIFIC STIMULATION OF SURVIVAL AND EXPANSION OF GENETICALLY MODIFIED IMMUNE CELLS
IL316887A (en) * 2018-11-06 2025-01-01 Immunitybio Inc NK-92 cells with chimeric antigen receptor modification
US12109238B2 (en) 2018-11-06 2024-10-08 Immunitybio, Inc. Chimeric antigen receptor-modified NK-92 cells
US12590148B2 (en) 2018-11-26 2026-03-31 Nkarta, Inc. Methods for the simultaneous expansion of multiple immune cell types, related compositions and uses of same in cancer immunotherapy
CN121518401A (zh) * 2018-11-26 2026-02-13 免疫生物公司 具有稳定的Fc受体表达的IL-2依赖性NK-92细胞
AU2020232691B2 (en) 2019-03-05 2023-06-29 Nkarta, Inc. CD19-directed chimeric antigen receptors and uses thereof in immunotherapy
WO2020205100A1 (en) 2019-03-15 2020-10-08 Nantcell, Inc. Recombinant eril-15 nk cells
WO2020236875A1 (en) 2019-05-20 2020-11-26 Pandion Therapeutics, Inc. Madcam targeted immunotolerance
CN113574169A (zh) * 2019-08-01 2021-10-29 南克维斯特公司 抗b7-h4嵌合抗原受体修饰的nk-92细胞
KR20210033436A (ko) * 2019-09-18 2021-03-26 주식회사 에스엘바이젠 신규 키메라 항원 수용체 암호화 유전자가 형질도입된 유전자 변형 nk 세포주 및 그의 용도
US20210106619A1 (en) * 2019-10-10 2021-04-15 Nantkwest, Inc. NK-92 Bone and Brain targeting
EP4061385A4 (en) * 2019-11-19 2024-08-14 Acibadem Mehmet Ali Aydinlar Üniversitesi METHOD FOR REDESIGNING AND EXPANDING NK92 CELLS FOR USE IN IMMUNOTHERAPY
AU2020387167B2 (en) * 2019-11-20 2024-10-24 Immunitybio, Inc. Cell-mediated transient delivery of immune-enhancing molecules into the tumor microenvironment
CN113646435A (zh) * 2019-12-09 2021-11-12 南克维斯特公司 通过非抗生素依赖性阳性选择筛选表达多基因转基因的细胞克隆
EP4097219A4 (en) * 2020-01-28 2023-10-11 ImmunityBio, Inc. Chimeric antigen receptor-modified nk-92 cells targeting egfr super-family receptors
US11230699B2 (en) 2020-01-28 2022-01-25 Immunitybio, Inc. Chimeric antigen receptor-modified NK-92 cells targeting EGFR super-family receptors
CN115397973A (zh) * 2020-01-30 2022-11-25 免疫生物公司 表达car的nk细胞消除bcma阳性恶性肿瘤
US11981715B2 (en) 2020-02-21 2024-05-14 Pandion Operations, Inc. Tissue targeted immunotolerance with a CD39 effector
CA3184940A1 (en) 2020-07-07 2022-01-13 Jennifer Donglan WU Mic antibodies and binding agents and methods of using the same
IL302335A (en) * 2020-10-26 2023-06-01 Res Inst Nationwide Childrens Hospital NK cells with chimeric antigen receptor (CAR) and uses thereof
US11591381B2 (en) 2020-11-30 2023-02-28 Crispr Therapeutics Ag Gene-edited natural killer cells
WO2022144632A1 (en) 2020-12-30 2022-07-07 Crispr Therapeutics Ag Compositions and methods for differentiating stem cells into nk cells
WO2024236557A1 (en) 2023-05-12 2024-11-21 Gilboa Therapeutics LTD Compositions comprising an fc domain for the treatment of medical conditions
WO2025158400A1 (en) * 2024-01-24 2025-07-31 Yale University Compositions and methods of natural killer cell hyperboosts for enhancement of nk cell therapy

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2008505071A (ja) * 2004-07-02 2008-02-21 アヴァリス・アクチエボラーグ 細胞を遺伝学的に活性化する方法、および、該細胞の使用
US20080247990A1 (en) * 2004-07-10 2008-10-09 Fox Chase Cancer Center Genetically modified human natural killer cell lines
EP2161339A1 (en) * 2008-08-29 2010-03-10 F. Hoffmann-La Roche Ag ADCC with modified NK92 cells
WO2015066054A1 (en) * 2013-11-01 2015-05-07 Conkwest, Inc. Tumoricidal and antimicrobial compositions and methods
WO2015075469A1 (en) * 2013-11-21 2015-05-28 Ucl Business Plc Cell

Family Cites Families (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8034332B2 (en) 1997-04-30 2011-10-11 Conkwest, Inc. Interleukin-secreting natural killer cell lines and methods of use
AU7267398A (en) 1997-04-30 1998-11-24 Hans Klingemann Natural killer cell lines and methods of use
WO1999024566A1 (en) 1997-11-06 1999-05-20 Roche Diagnostics Gmbh Tumor-specific antigens, methods for their production and their use for immunization and diagnosis
WO2000020460A1 (en) 1998-10-05 2000-04-13 Ludwig Institute For Cancer Research Methods for producing human tumor antigen specific antibodies
US7098008B2 (en) 2000-04-25 2006-08-29 Ic&G Do. Ltd. Selected primers for detection of MAGE or GAGE genes for diagnosis of cancer and methods of use
SE526227C2 (sv) * 2002-05-15 2005-08-02 North China Pharmaceutical Group Metod för rening av rekombinant humant serumalbumin
DE60334453D1 (de) 2002-05-30 2010-11-18 Macrogenics Inc Cd16a bindungsproteine und verwendung zur behandlung von immunkrankheiten
US8946385B2 (en) * 2007-01-30 2015-02-03 Chugai Seiyaku Kabushiki Kaisha Chimeric Fcγ receptor and method for determination of ADCC activity by using the receptor
WO2011163401A2 (en) 2010-06-22 2011-12-29 Neogenix Oncology, Inc. Colon and pancreas cancer specific antigens and antibodies
ES2754394T3 (es) 2010-09-08 2020-04-17 Chemotherapeutisches Forschungsinstitut Georg Speyer Haus Receptores de antígenos quiméricos con una región bisagra optimizada
PH12013501201A1 (en) 2010-12-09 2013-07-29 Univ Pennsylvania Use of chimeric antigen receptor-modified t cells to treat cancer
WO2013051718A1 (ja) 2011-10-07 2013-04-11 国立大学法人三重大学 キメラ抗原受容体
WO2013059593A1 (en) 2011-10-20 2013-04-25 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Anti-cd22 chimeric antigen receptors
CN103483452B (zh) * 2012-06-12 2021-08-13 上海细胞治疗集团有限公司 双信号独立的嵌合抗原受体及其用途
CN104769103B (zh) 2012-09-04 2018-06-08 塞勒克提斯公司 多链嵌合抗原受体和其用途
AU2013327136A1 (en) * 2012-10-02 2015-04-16 Memorial Sloan-Kettering Cancer Center Compositions and methods for immunotherapy
WO2014099671A1 (en) 2012-12-20 2014-06-26 Bluebird Bio, Inc. Chimeric antigen receptors and immune cells targeting b cell malignancies
EP3447072A3 (en) * 2013-03-05 2019-05-22 Baylor College of Medicine Engager cells comprising cd3 scfv and an antigen recognition domain that binds a tumor antigen for immunotherapy
EP2970426B1 (en) * 2013-03-15 2019-08-28 Michael C. Milone Targeting cytotoxic cells with chimeric receptors for adoptive immunotherapy
CN115028735A (zh) * 2013-05-03 2022-09-09 俄亥俄州创新基金会 Cs1-特异性嵌合抗原受体工程化的免疫效应细胞
CN104561069A (zh) * 2013-10-23 2015-04-29 深圳先进技术研究院 含重组嵌合抗原受体基因表达盒的微环dna重组母质粒、含该表达盒的微环dna及应用
EP4424326A3 (en) 2015-06-10 2024-11-13 ImmunityBio, Inc. Modified nk-92 cells for treating cancer
KR102665280B1 (ko) * 2018-10-31 2024-05-10 난트퀘스트, 인크. Cd19-car 발현 nk 세포에 의한 cd19-양성 림프성 악성종양의 제거

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2008505071A (ja) * 2004-07-02 2008-02-21 アヴァリス・アクチエボラーグ 細胞を遺伝学的に活性化する方法、および、該細胞の使用
US20080247990A1 (en) * 2004-07-10 2008-10-09 Fox Chase Cancer Center Genetically modified human natural killer cell lines
EP2161339A1 (en) * 2008-08-29 2010-03-10 F. Hoffmann-La Roche Ag ADCC with modified NK92 cells
WO2015066054A1 (en) * 2013-11-01 2015-05-07 Conkwest, Inc. Tumoricidal and antimicrobial compositions and methods
WO2015075469A1 (en) * 2013-11-21 2015-05-28 Ucl Business Plc Cell

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
CANCER GENE THERAPY, 2012, VOL.19, PP.84-100, JPN6020012607, ISSN: 0004245630 *
CLINICAL CANCER RESEARCH, 2014, VOL.20, PP.962-971, JPN6020012600, ISSN: 0004384627 *
EXPERIMENTAL HEMATOLOGY, 2005, VOL.33, PP.159-164, JPN6020012601, ISSN: 0004384628 *
FRONTIERS IN IMMUNOLOGY, 2015, VOL.6, ARTICLE 195 (PP.1-6), JPN6020012598, ISSN: 0004384626 *
ONCOIMMUNOLOGY, 2013, VOL.2, E26527 (PP.1-8), JPN6020012604, ISSN: 0004245629 *

Cited By (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11788059B2 (en) 2015-06-10 2023-10-17 Immunity Bio, Inc. Modified NK-92 cells for treating cancer
JP2025024042A (ja) * 2018-08-01 2025-02-19 イミュニティーバイオ、インコーポレイテッド 細胞免疫療法の安定した遺伝子改変のための、ホーミング受容体又はサイトカインとキメラ抗原受容体とを含むクアドリシストロニックシステム
US12584138B2 (en) 2018-08-01 2026-03-24 Immunitybio, Inc. Quadricistronic system comprising a homing receptor and chimeric antigen receptor for stable genetic modification of cellular immunotherapies
JP7524070B2 (ja) 2018-10-31 2024-07-29 イミュニティーバイオ、インコーポレイテッド Ｃｄ１９－ｃａｒを発現するｎｋ細胞によるｃｄ１９陽性リンパ悪性腫瘍の排除
JP2025087816A (ja) * 2018-10-31 2025-06-10 イミュニティーバイオ、インコーポレイテッド Ｐｄ－ｌ１キメラ抗原受容体を発現するｎｋ細胞によるｐｄ－ｌ１陽性悪性腫瘍の排除
JP2022542368A (ja) * 2019-07-26 2022-10-03 ナントクウェスト，インコーポレーテッド 腫瘍溶解のための有効な治療用製剤としての、抗体を予め負荷したｃｄ１６＋ｎｋ－９２細胞
JP7555392B2 (ja) 2019-07-26 2024-09-24 ナントクウェスト，インコーポレーテッド 腫瘍溶解のための有効な治療用製剤としての、抗体を予め負荷したｃｄ１６＋ｎｋ－９２細胞
JP2024170601A (ja) * 2019-07-26 2024-12-10 ナントクウェスト，インコーポレーテッド 腫瘍溶解のための有効な治療用製剤としての、抗体を予め負荷したｃｄ１６＋ｎｋ－９２細胞
JP2023519908A (ja) * 2020-03-28 2023-05-15 ボード オブ リージェンツ，ザ ユニバーシティ オブ テキサス システム 癌の治療のための細胞免疫療法
JP7773789B2 (ja) 2020-03-28 2025-11-20 ボード オブ リージェンツ，ザ ユニバーシティ オブ テキサス システム 癌の治療のための細胞免疫療法

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