JP2018517398A5 - - Google Patents
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- JP2018517398A5 JP2018517398A5 JP2017552146A JP2017552146A JP2018517398A5 JP 2018517398 A5 JP2018517398 A5 JP 2018517398A5 JP 2017552146 A JP2017552146 A JP 2017552146A JP 2017552146 A JP2017552146 A JP 2017552146A JP 2018517398 A5 JP2018517398 A5 JP 2018517398A5
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- 108090000765 processed proteins & peptides Proteins 0.000 claims description 165
- 229920001184 polypeptide Polymers 0.000 claims description 164
- 102000004196 processed proteins & peptides Human genes 0.000 claims description 164
- 238000000034 method Methods 0.000 claims description 152
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- 108090000623 proteins and genes Proteins 0.000 claims description 41
- 235000018102 proteins Nutrition 0.000 claims description 37
- 102000004169 proteins and genes Human genes 0.000 claims description 37
- 150000007523 nucleic acids Chemical group 0.000 claims description 36
- 241000588724 Escherichia coli Species 0.000 claims description 34
- 108091028043 Nucleic acid sequence Proteins 0.000 claims description 33
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- 235000001014 amino acid Nutrition 0.000 claims description 11
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- 206010009900 Colitis ulcerative Diseases 0.000 claims description 3
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- 239000004599 antimicrobial Substances 0.000 claims description 3
- 230000005907 cancer growth Effects 0.000 claims description 3
- 210000000981 epithelium Anatomy 0.000 claims description 3
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- MTCFGRXMJLQNBG-REOHCLBHSA-N (2S)-2-Amino-3-hydroxypropansäure Chemical compound OC[C@H](N)C(O)=O MTCFGRXMJLQNBG-REOHCLBHSA-N 0.000 claims description 2
- 206010009944 Colon cancer Diseases 0.000 claims description 2
- 239000004471 Glycine Substances 0.000 claims description 2
- QNAYBMKLOCPYGJ-REOHCLBHSA-N L-alanine Chemical compound C[C@H](N)C(O)=O QNAYBMKLOCPYGJ-REOHCLBHSA-N 0.000 claims description 2
- ROHFNLRQFUQHCH-YFKPBYRVSA-N L-leucine Chemical compound CC(C)C[C@H](N)C(O)=O ROHFNLRQFUQHCH-YFKPBYRVSA-N 0.000 claims description 2
- ROHFNLRQFUQHCH-UHFFFAOYSA-N Leucine Natural products CC(C)CC(N)C(O)=O ROHFNLRQFUQHCH-UHFFFAOYSA-N 0.000 claims description 2
- 206010028980 Neoplasm Diseases 0.000 claims description 2
- MTCFGRXMJLQNBG-UHFFFAOYSA-N Serine Natural products OCC(N)C(O)=O MTCFGRXMJLQNBG-UHFFFAOYSA-N 0.000 claims description 2
- 235000004279 alanine Nutrition 0.000 claims description 2
- 208000029742 colonic neoplasm Diseases 0.000 claims description 2
- 238000012217 deletion Methods 0.000 claims description 2
- 230000037430 deletion Effects 0.000 claims description 2
- 230000002496 gastric effect Effects 0.000 claims description 2
- 230000002209 hydrophobic effect Effects 0.000 claims description 2
- 208000015181 infectious disease Diseases 0.000 claims description 2
- 210000004347 intestinal mucosa Anatomy 0.000 claims description 2
- 238000004519 manufacturing process Methods 0.000 claims description 2
- 239000002207 metabolite Substances 0.000 claims description 2
- 108020004707 nucleic acids Proteins 0.000 claims description 2
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- 238000003776 cleavage reaction Methods 0.000 description 34
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- 101000632178 Homo sapiens Homeobox protein Nkx-2.1 Proteins 0.000 description 5
- 101000845269 Homo sapiens Transcription termination factor 1 Proteins 0.000 description 5
- 101000845264 Homo sapiens Transcription termination factor 2 Proteins 0.000 description 5
- 102100031079 Transcription termination factor 1 Human genes 0.000 description 5
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- 108091005804 Peptidases Proteins 0.000 description 4
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- POIUWJQBRNEFGX-XAMSXPGMSA-N cathelicidin Chemical compound C([C@@H](C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H]([C@@H](C)CC)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CO)C(O)=O)NC(=O)[C@H](CC=1C=CC=CC=1)NC(=O)[C@H](CC(O)=O)NC(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@@H](N)CC(C)C)C1=CC=CC=C1 POIUWJQBRNEFGX-XAMSXPGMSA-N 0.000 description 4
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- 239000003124 biologic agent Substances 0.000 description 2
- 102000014509 cathelicidin Human genes 0.000 description 2
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- SWISGLLTKITYOP-UHFFFAOYSA-N thuricin cd Chemical compound N1C(=O)CNC(=O)C(C(C)CC)NC(=O)CNC(=O)C(CCC(O)=O)NC(=O)C(CO)NC(=O)C(C(C)CC)NC(=O)C(C(C)C)NC(=O)C(NC(=O)C(CO)NC(=O)CNC(=O)C(C(C)CC)NC2=O)CSC1(CO)C(=O)NC(CC(C)C)C(=O)NC(C(C)C)C(=O)NCC(=O)NC(C(NC(C)C(=O)N1)=O)(C(C)O)SCC2NC(=O)CNC(=O)C(C(C)CC)NC(=O)C(C(C)C)NC(=O)C(NC(=O)C(C)NC(=O)C(C)NC(=O)C(CC(N)=O)NC(=O)CN)CSC(C(=O)NC(CC(C)C)C(=O)NCC(O)=O)(C(C)O)NC(=O)C1CC1=CC=CC=C1 SWISGLLTKITYOP-UHFFFAOYSA-N 0.000 description 2
- 108010062877 Bacteriocins Proteins 0.000 description 1
- 230000000844 anti-bacterial effect Effects 0.000 description 1
- LAWKVNVCUPIOMG-HWWYPGLISA-N gardimycin Chemical compound C1=CC=C2C(C[C@H](C(=O)NCC(=O)N[C@H](CO)C(=O)N[C@H](C)C(=O)NCC(=O)N[C@H](CC)C(=O)N[C@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@H](C)C(=O)N[C@@H](C)C(=O)N[C@H](C)C(O)=O)C(C)C)NC(=O)[C@@H](NC(=O)[C@@H](C)NC(=O)[C@@H](CC)NC(=O)[C@@H](CCC(O)=O)NC(=O)[C@@H](NC(=O)[C@@H](CC)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](C)N)[C@@H](C)CC)C(C)C)=CNC2=C1 LAWKVNVCUPIOMG-HWWYPGLISA-N 0.000 description 1
- 108010070411 gardimycin Proteins 0.000 description 1
- 230000012743 protein tagging Effects 0.000 description 1
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2021030187A JP7156726B2 (ja) | 2015-04-06 | 2021-02-26 | 機能的タンパク質配列をディスプレイする生合成アミロイドに基づく材料 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562143560P | 2015-04-06 | 2015-04-06 | |
| US62/143,560 | 2015-04-06 | ||
| PCT/US2016/026161 WO2016164422A2 (en) | 2015-04-06 | 2016-04-06 | Biosynthetic amyloid-based materials displaying functional protein sequences |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021030187A Division JP7156726B2 (ja) | 2015-04-06 | 2021-02-26 | 機能的タンパク質配列をディスプレイする生合成アミロイドに基づく材料 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2018517398A JP2018517398A (ja) | 2018-07-05 |
| JP2018517398A5 true JP2018517398A5 (cg-RX-API-DMAC7.html) | 2019-05-16 |
| JP6916524B2 JP6916524B2 (ja) | 2021-08-11 |
Family
ID=57072695
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017552146A Active JP6916524B2 (ja) | 2015-04-06 | 2016-04-06 | 機能的タンパク質配列をディスプレイする生合成アミロイドに基づく材料 |
| JP2021030187A Active JP7156726B2 (ja) | 2015-04-06 | 2021-02-26 | 機能的タンパク質配列をディスプレイする生合成アミロイドに基づく材料 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021030187A Active JP7156726B2 (ja) | 2015-04-06 | 2021-02-26 | 機能的タンパク質配列をディスプレイする生合成アミロイドに基づく材料 |
Country Status (4)
| Country | Link |
|---|---|
| US (2) | US20180258435A1 (cg-RX-API-DMAC7.html) |
| EP (1) | EP3280397A4 (cg-RX-API-DMAC7.html) |
| JP (2) | JP6916524B2 (cg-RX-API-DMAC7.html) |
| WO (1) | WO2016164422A2 (cg-RX-API-DMAC7.html) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9815871B2 (en) | 2013-04-23 | 2017-11-14 | President And Fellows Of Harvard College | Genetic reprogramming of bacterial biofilms |
| EP3280397A4 (en) | 2015-04-06 | 2018-08-22 | President and Fellows of Harvard College | Biosynthetic amyloid-based materials displaying functional protein sequences |
| US11098133B2 (en) * | 2016-05-19 | 2021-08-24 | President And Fellows Of Harvard College | Methods of making gels and films using curli nanofibers |
| FR3099648B1 (fr) * | 2019-07-30 | 2023-01-13 | Centre Nat Rech Scient | Membrane échangeuse d’ions |
| CN110585482B (zh) * | 2019-08-02 | 2022-03-01 | 大连理工大学 | 一种具有抗菌性能的杂萘联苯聚芳醚腈及其表面改性方法 |
| CN112608876B (zh) * | 2020-12-30 | 2024-02-09 | 江苏大学 | 一种生物素化Curli蛋白的活细胞标记方法及其应用 |
| GB202216905D0 (en) * | 2022-11-11 | 2022-12-28 | Oxford Nanopore Tech Plc | Novel pore monomers and pores |
| KR102855274B1 (ko) * | 2022-12-06 | 2025-09-08 | 충남대학교산학협력단 | strep-tag 결합물질에 대한 결합능을 가지는 융합단백질을 암호화하는 유전자 구조물 및 이를 함유하는 발현벡터, 재조합 균주 및 항암 조성물 |
Family Cites Families (34)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5762620A (en) | 1992-04-02 | 1998-06-09 | Ndm Acquisition Corp. | Wound dressing containing a partially dehydrated hydrogel |
| US6864365B1 (en) * | 1999-04-05 | 2005-03-08 | Innovation And Development Corporation, University Of Victoria | Bacterial fimbrial system for presentation of heterologous peptide sequences |
| US6916789B2 (en) * | 2001-07-02 | 2005-07-12 | Merrion Research I Limited | Peyer's patch and/or M-cell targeting ligands |
| WO2003068934A2 (en) | 2002-02-14 | 2003-08-21 | Rutter William J | Chimeric molecules for cleavage in a treated host |
| DE602004026570D1 (de) | 2003-04-30 | 2010-05-27 | Univ Drexel | Thermogelierende polymermischungen für biomaterialanwendungen |
| WO2006096515A2 (en) | 2005-03-04 | 2006-09-14 | Biorexis Pharmaceutical Corporation | Modified transferrin fusion proteins |
| CN101605900B (zh) | 2007-01-12 | 2014-04-23 | 阿克图杰尼斯公司 | 乳球菌启动子和其用途 |
| JP2009073766A (ja) * | 2007-09-21 | 2009-04-09 | Otsuka Pharmaceut Co Ltd | 医薬 |
| WO2010111516A2 (en) | 2009-03-25 | 2010-09-30 | Whitehead Institute For Biomedical Research | Compositions and methods for inhibiting biofilms |
| US20110033389A1 (en) | 2009-04-29 | 2011-02-10 | Zhifeng Chen | Modified antibodies for passive immunotherapy |
| US20110108199A1 (en) | 2009-11-10 | 2011-05-12 | Tyco Healthcare Group Lp | Hemostatic Tapes and Dispensers Therefor |
| JP2013519699A (ja) * | 2010-02-16 | 2013-05-30 | ノヴォ ノルディスク アー／エス | 因子ｖｉｉｉ融合タンパク質 |
| US9526794B2 (en) | 2010-03-31 | 2016-12-27 | Wayne State University | Injectable dendrimer hydrogel nanoparticles |
| KR20110111594A (ko) | 2010-04-05 | 2011-10-12 | 서울대학교산학협력단 | 알파-시뉴클레인 유래 곱슬 아밀로이드 섬유의 제조방법, 이를 이용한 하이드로젤의 제조 방법 및 그 이용 방법 |
| US8741417B2 (en) | 2010-04-16 | 2014-06-03 | Korea University Research And Business Foundation | Films having switchable reflectivity |
| WO2012048289A1 (en) | 2010-10-08 | 2012-04-12 | Board Of Regents, The University Of Texas System | Anti-adhesive barrier membrane using alginate and hyaluronic acid for biomedical applications |
| US9265842B2 (en) * | 2010-10-15 | 2016-02-23 | Cornell University | Compositions and methods for treating endocrine, gastrointestinal or autoimmune disorders |
| KR20120060442A (ko) | 2010-12-02 | 2012-06-12 | 가톨릭대학교 산학협력단 | 위암 진단용 마커로서 ｔｆｆ2의 용도 |
| US9140698B2 (en) * | 2011-04-06 | 2015-09-22 | The Board Of Regents Of The University Of Texas System | Modulating bacterial MAM polypeptides in pathogenic disease |
| US9580480B2 (en) * | 2011-05-31 | 2017-02-28 | Massachusetts Institute Of Technology | Cell-directed synthesis of multifunctional nanopatterns and nanomaterials |
| WO2013009545A1 (en) | 2011-07-08 | 2013-01-17 | Amylin Pharmaceuticals, Inc. | Engineered polypeptides having enhanced duration of action with reduced immunogenicity |
| WO2013020074A2 (en) | 2011-08-03 | 2013-02-07 | Children's Medical Center Corporation | A broadly neutralizing human antibody that recognizes the receptor-binding pocket of influenza hemagglutinin |
| US9814756B2 (en) | 2012-06-15 | 2017-11-14 | Temple University—Of the Commonwealth System of Higher Education | Use of isolated bacterial amyloids for treatment of inflammatory disorders or diseases of the epithelium |
| CN104640561A (zh) * | 2012-07-23 | 2015-05-20 | 酵活有限公司 | 包含轻链和重链的选择性配对的免疫球蛋白构建体 |
| WO2014078489A1 (en) | 2012-11-16 | 2014-05-22 | President And Fellows Of Harvard College | Methods and compositions relating to amyloidogenic polypeptides |
| HRP20191865T1 (hr) * | 2013-01-14 | 2020-01-10 | Xencor, Inc. | Novi heterodimerni proteini |
| JP2014156428A (ja) * | 2013-02-15 | 2014-08-28 | Univ Of Tokyo | 抗体結合タンパク質 |
| WO2014139468A1 (en) * | 2013-03-15 | 2014-09-18 | Admark Healthcare, Llc | Fusion protein molecules and method of use |
| US9815871B2 (en) | 2013-04-23 | 2017-11-14 | President And Fellows Of Harvard College | Genetic reprogramming of bacterial biofilms |
| CN105960411A (zh) | 2013-11-30 | 2016-09-21 | 新加坡科技研究局 | 自组装肽、肽模拟物和肽缀合物作为构件用于生物制造和打印 |
| US20160326220A1 (en) | 2013-12-24 | 2016-11-10 | Vib Vzw | Secretion and functional display of chimeric polypeptides |
| US20150342893A1 (en) | 2014-05-29 | 2015-12-03 | Sigmoid Pharma Limited | Celecoxib formulations useful for treating colorectal cancer |
| EP3280397A4 (en) | 2015-04-06 | 2018-08-22 | President and Fellows of Harvard College | Biosynthetic amyloid-based materials displaying functional protein sequences |
| US11098133B2 (en) | 2016-05-19 | 2021-08-24 | President And Fellows Of Harvard College | Methods of making gels and films using curli nanofibers |
-
2016
- 2016-04-06 EP EP16777174.0A patent/EP3280397A4/en active Pending
- 2016-04-06 US US15/564,619 patent/US20180258435A1/en not_active Abandoned
- 2016-04-06 JP JP2017552146A patent/JP6916524B2/ja active Active
- 2016-04-06 WO PCT/US2016/026161 patent/WO2016164422A2/en not_active Ceased
-
2020
- 2020-02-10 US US16/785,874 patent/US11286491B2/en active Active
-
2021
- 2021-02-26 JP JP2021030187A patent/JP7156726B2/ja active Active
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