JP2018516978A5 - - Google Patents
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- JP2018516978A5 JP2018516978A5 JP2018511592A JP2018511592A JP2018516978A5 JP 2018516978 A5 JP2018516978 A5 JP 2018516978A5 JP 2018511592 A JP2018511592 A JP 2018511592A JP 2018511592 A JP2018511592 A JP 2018511592A JP 2018516978 A5 JP2018516978 A5 JP 2018516978A5
- Authority
- JP
- Japan
- Prior art keywords
- guide rna
- cas
- cas protein
- mutation
- promoter
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2021189812A JP2022031769A (ja) | 2015-05-16 | 2021-11-24 | 深部イントロン突然変異の遺伝子編集 |
| JP2024038537A JP2024073536A (ja) | 2015-05-16 | 2024-03-13 | 深部イントロン突然変異の遺伝子編集 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562162720P | 2015-05-16 | 2015-05-16 | |
| US62/162,720 | 2015-05-16 | ||
| PCT/US2016/027987 WO2016186772A2 (en) | 2015-05-16 | 2016-04-15 | Gene editing of deep intronic mutations |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021189812A Division JP2022031769A (ja) | 2015-05-16 | 2021-11-24 | 深部イントロン突然変異の遺伝子編集 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2018516978A JP2018516978A (ja) | 2018-06-28 |
| JP2018516978A5 true JP2018516978A5 (cg-RX-API-DMAC7.html) | 2019-05-23 |
| JP6985250B2 JP6985250B2 (ja) | 2021-12-22 |
Family
ID=55809259
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018511592A Active JP6985250B2 (ja) | 2015-05-16 | 2016-04-15 | 深部イントロン突然変異の遺伝子編集 |
| JP2021189812A Pending JP2022031769A (ja) | 2015-05-16 | 2021-11-24 | 深部イントロン突然変異の遺伝子編集 |
| JP2024038537A Pending JP2024073536A (ja) | 2015-05-16 | 2024-03-13 | 深部イントロン突然変異の遺伝子編集 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021189812A Pending JP2022031769A (ja) | 2015-05-16 | 2021-11-24 | 深部イントロン突然変異の遺伝子編集 |
| JP2024038537A Pending JP2024073536A (ja) | 2015-05-16 | 2024-03-13 | 深部イントロン突然変異の遺伝子編集 |
Country Status (16)
Families Citing this family (76)
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| US9228207B2 (en) | 2013-09-06 | 2016-01-05 | President And Fellows Of Harvard College | Switchable gRNAs comprising aptamers |
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| WO2018039438A1 (en) | 2016-08-24 | 2018-03-01 | President And Fellows Of Harvard College | Incorporation of unnatural amino acids into proteins using base editing |
| IT201600102542A1 (it) * | 2016-10-12 | 2018-04-12 | Univ Degli Studi Di Trento | Plasmide e sistema lentivirale contenente un circuito autolimitante della Cas9 che ne incrementa la sicurezza. |
| WO2018071868A1 (en) | 2016-10-14 | 2018-04-19 | President And Fellows Of Harvard College | Aav delivery of nucleobase editors |
| JP7272952B2 (ja) | 2016-12-05 | 2023-05-12 | エディタス・メディシン、インコーポレイテッド | 内因性および起源ＤＮＡのワンショットガイドＲＮＡ（ｏｇＲＮＡ）標的化のためのシステムおよび方法 |
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| KR102103103B1 (ko) | 2018-08-16 | 2020-04-21 | (주)라트바이오 | 인위적 뉴클레아제를 생산하는 형질전환 동물 및 형질전환 배아 |
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| SG11202105326WA (en) * | 2018-11-21 | 2021-06-29 | Stridebio Inc | Recombinant viral vectors and nucleic acids for producing the same |
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| BR112021019180A2 (pt) * | 2019-03-27 | 2022-03-03 | Res Inst Nationwide Childrens Hospital | Geração de células nk primárias de receptor de antígeno quimérico (car) para imunoterapia de câncer usando uma combinação de vírus cas9/rnp e aav |
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| CN114072497B (zh) * | 2019-04-15 | 2025-11-18 | 宾夕法尼亚州大学信托人 | 用于调控酶表达和使酶表达自失活的组合物以及用于调节酶的脱靶活性的方法 |
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| CN111370055B (zh) * | 2020-03-05 | 2023-05-23 | 中南大学 | 内含子保留预测模型建立方法及其预测方法 |
| CN115667531A (zh) * | 2020-03-24 | 2023-01-31 | 世代生物公司 | 非病毒DNA载体和其用于表达戈谢（Gaucher）治疗剂的用途 |
| DE112021002672T5 (de) | 2020-05-08 | 2023-04-13 | President And Fellows Of Harvard College | Vefahren und zusammensetzungen zum gleichzeitigen editieren beider stränge einer doppelsträngigen nukleotid-zielsequenz |
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| US20220325298A1 (en) * | 2021-04-12 | 2022-10-13 | University Of Pittsburgh - Of The Commonwealth System Of Higher Education | Crispr epigenetic therapeutics for pain management |
| JP7780172B2 (ja) * | 2021-07-30 | 2025-12-04 | 国立研究開発法人理化学研究所 | 筋萎縮性側索硬化症におけるｃｅｐ２９０遺伝子の変異 |
| CN114306277B (zh) * | 2021-11-02 | 2023-08-04 | 中国人民解放军空军军医大学 | 一种靶向psma的巨噬细胞膜包裹的仿生纳米药物载体及应用 |
| EP4223877A1 (en) | 2022-02-08 | 2023-08-09 | Eberhard Karls Universität Tübingen Medizinische Fakultät | System and method for editing genomic dna to modulate splicing |
| WO2025135916A1 (ko) * | 2023-12-22 | 2025-06-26 | 주식회사 툴젠 | 낮은 면역원성을 가지는 cas9 단백질 변이체 |
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-
2016
- 2016-04-15 KR KR1020177036029A patent/KR102584873B1/ko active Active
- 2016-04-15 US US15/574,420 patent/US11896651B2/en active Active
- 2016-04-15 IL IL296365A patent/IL296365A/en unknown
- 2016-04-15 MX MX2017014665A patent/MX2017014665A/es unknown
- 2016-04-15 ES ES16718840T patent/ES2952598T3/es active Active
- 2016-04-15 SG SG10201910750WA patent/SG10201910750WA/en unknown
- 2016-04-15 KR KR1020237033136A patent/KR20230142649A/ko active Pending
- 2016-04-15 CA CA2986021A patent/CA2986021A1/en active Pending
- 2016-04-15 CN CN201680041691.7A patent/CN107849547B/zh active Active
- 2016-04-15 SG SG10201912907PA patent/SG10201912907PA/en unknown
- 2016-04-15 EP EP16718840.8A patent/EP3298134B8/en active Active
- 2016-04-15 RU RU2021132397A patent/RU2021132397A/ru unknown
- 2016-04-15 WO PCT/US2016/027987 patent/WO2016186772A2/en not_active Ceased
- 2016-04-15 JP JP2018511592A patent/JP6985250B2/ja active Active
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