JP2018516889A5 - - Google Patents
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- Publication number
- JP2018516889A5 JP2018516889A5 JP2017558678A JP2017558678A JP2018516889A5 JP 2018516889 A5 JP2018516889 A5 JP 2018516889A5 JP 2017558678 A JP2017558678 A JP 2017558678A JP 2017558678 A JP2017558678 A JP 2017558678A JP 2018516889 A5 JP2018516889 A5 JP 2018516889A5
- Authority
- JP
- Japan
- Prior art keywords
- drug
- core
- iud
- implant
- segment
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000003814 drug Substances 0.000 claims description 31
- 229940079593 drug Drugs 0.000 claims description 31
- 229920000642 polymer Polymers 0.000 claims description 12
- -1 polysiloxane Polymers 0.000 claims description 12
- 239000000463 material Substances 0.000 claims description 8
- 239000011159 matrix material Substances 0.000 claims description 5
- 239000000203 mixture Substances 0.000 claims description 5
- 229920000233 poly(alkylene oxides) Polymers 0.000 claims description 5
- 229920000435 poly(dimethylsiloxane) Polymers 0.000 claims description 5
- 229920001296 polysiloxane Polymers 0.000 claims description 5
- XUIMIQQOPSSXEZ-UHFFFAOYSA-N Silicon Chemical compound [Si] XUIMIQQOPSSXEZ-UHFFFAOYSA-N 0.000 claims description 4
- 239000004205 dimethyl polysiloxane Substances 0.000 claims description 3
- 229920003171 Poly (ethylene oxide) Polymers 0.000 claims description 2
- 229920002379 silicone rubber Polymers 0.000 claims description 2
- 238000000034 method Methods 0.000 claims 13
- 239000007943 implant Substances 0.000 claims 8
- 239000000262 estrogen Substances 0.000 claims 5
- 229940011871 estrogen Drugs 0.000 claims 5
- 239000000583 progesterone congener Substances 0.000 claims 5
- RJKFOVLPORLFTN-LEKSSAKUSA-N Progesterone Chemical class C1CC2=CC(=O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H](C(=O)C)[C@@]1(C)CC2 RJKFOVLPORLFTN-LEKSSAKUSA-N 0.000 claims 4
- 229910052710 silicon Inorganic materials 0.000 claims 3
- 239000010703 silicon Substances 0.000 claims 3
- WWYNJERNGUHSAO-XUDSTZEESA-N (+)-Norgestrel Chemical compound O=C1CC[C@@H]2[C@H]3CC[C@](CC)([C@](CC4)(O)C#C)[C@@H]4[C@@H]3CCC2=C1 WWYNJERNGUHSAO-XUDSTZEESA-N 0.000 claims 2
- BFPYWIDHMRZLRN-UHFFFAOYSA-N 17alpha-ethynyl estradiol Natural products OC1=CC=C2C3CCC(C)(C(CC4)(O)C#C)C4C3CCC2=C1 BFPYWIDHMRZLRN-UHFFFAOYSA-N 0.000 claims 2
- BFPYWIDHMRZLRN-SLHNCBLASA-N Ethinyl estradiol Chemical compound OC1=CC=C2[C@H]3CC[C@](C)([C@](CC4)(O)C#C)[C@@H]4[C@@H]3CCC2=C1 BFPYWIDHMRZLRN-SLHNCBLASA-N 0.000 claims 2
- 229960002568 ethinylestradiol Drugs 0.000 claims 2
- 229960004400 levonorgestrel Drugs 0.000 claims 2
- 235000013870 dimethyl polysiloxane Nutrition 0.000 claims 1
- CXQXSVUQTKDNFP-UHFFFAOYSA-N octamethyltrisiloxane Chemical compound C[Si](C)(C)O[Si](C)(C)O[Si](C)(C)C CXQXSVUQTKDNFP-UHFFFAOYSA-N 0.000 claims 1
- 238000004987 plasma desorption mass spectroscopy Methods 0.000 claims 1
- 125000000217 alkyl group Chemical group 0.000 description 3
- 239000012528 membrane Substances 0.000 description 3
- KPUWHANPEXNPJT-UHFFFAOYSA-N disiloxane Chemical class [SiH3]O[SiH3] KPUWHANPEXNPJT-UHFFFAOYSA-N 0.000 description 2
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 description 2
- 125000004432 carbon atom Chemical group C* 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 125000001153 fluoro group Chemical group F* 0.000 description 1
- 125000000524 functional group Chemical group 0.000 description 1
- 125000001424 substituent group Chemical group 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP15167521.2 | 2015-05-13 | ||
| EP15167521 | 2015-05-13 | ||
| PCT/EP2016/060298 WO2016180764A1 (en) | 2015-05-13 | 2016-05-09 | A long acting drug delivery device and its use in contraception |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2018516889A JP2018516889A (ja) | 2018-06-28 |
| JP2018516889A5 true JP2018516889A5 (https=) | 2020-07-02 |
| JP6898856B2 JP6898856B2 (ja) | 2021-07-07 |
Family
ID=53174913
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017558678A Active JP6898856B2 (ja) | 2015-05-13 | 2016-05-09 | 長時間作用型薬物送達装置および避妊におけるその使用 |
Country Status (8)
| Country | Link |
|---|---|
| US (3) | US11096888B2 (https=) |
| EP (1) | EP3294300B1 (https=) |
| JP (1) | JP6898856B2 (https=) |
| CN (1) | CN108135910B (https=) |
| CA (1) | CA2985717A1 (https=) |
| ES (1) | ES3009909T3 (https=) |
| FI (1) | FI3294300T3 (https=) |
| WO (1) | WO2016180764A1 (https=) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP7242648B2 (ja) * | 2017-09-27 | 2023-03-20 | バイエル・オサケユキテュア | エラストマーマトリックスからの治療活性剤の放出を変更するための方法 |
| US11690806B2 (en) | 2018-05-24 | 2023-07-04 | Celanese Eva Performance Polymers Llc | Implantable device for sustained release of a macromolecular drug compound |
| KR20260007295A (ko) | 2018-05-24 | 2026-01-13 | 셀라니즈 이브이에이 퍼포먼스 폴리머스 엘엘씨 | 거대 분자 약물 화합물의 지속적인 방출을 위한 이식가능 장치 |
| US11689849B2 (en) | 2018-05-24 | 2023-06-27 | Nureva, Inc. | Method, apparatus and computer-readable media to manage semi-constant (persistent) sound sources in microphone pickup/focus zones |
| US20230404911A1 (en) * | 2018-12-11 | 2023-12-21 | Lupin Inc. | Drug delivery system for ultra-low dose estrogen combinations and methods and uses thereof |
| CN113365634A (zh) * | 2018-12-11 | 2021-09-07 | 卢品公司 | 超低剂量雌激素组合的药物递送系统及其方法和用途 |
| CN112315898B (zh) * | 2020-11-04 | 2021-08-13 | 国家卫生健康委科学技术研究所 | 含有芳香化酶抑制剂的阴道缓控释给药系统及其制备方法 |
| BR112023022439A2 (pt) | 2021-04-26 | 2023-12-26 | Celanese Eva Performance Polymers Llc | Dispositivo implantável para liberação sustentada de um composto de fármaco macromolecular |
Family Cites Families (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3920805A (en) | 1971-12-09 | 1975-11-18 | Upjohn Co | Pharmaceutical devices and method |
| US4215691A (en) | 1978-10-11 | 1980-08-05 | Alza Corporation | Vaginal contraceptive system made from block copolymer |
| US4292965A (en) | 1978-12-29 | 1981-10-06 | The Population Council, Inc. | Intravaginal ring |
| DE3040978A1 (de) | 1980-10-28 | 1982-05-27 | Schering Ag, 1000 Berlin Und 4619 Bergkamen | Vaginalring |
| FR2618329B1 (fr) | 1987-07-22 | 1997-03-28 | Dow Corning Sa | Procede de fabrication d'un anneau capable d'assurer la liberation d'un agent therapeutique, et anneau fabrique par ce procede |
| PH30867A (en) | 1992-07-31 | 1997-12-09 | Leiras Oy | Method and equipment for installing a medicine capsule on a support. |
| FI90627C (fi) | 1992-07-31 | 1994-03-10 | Leiras Oy | Laitteisto lääkeainesauvan varustamiseksi vaipalla |
| WO1997002015A1 (en) | 1995-07-04 | 1997-01-23 | Akzo Nobel N.V. | Ring-shaped devices |
| IL123813A0 (en) * | 1997-04-11 | 1998-10-30 | Akzo Nobel Nv | Drug delivery system for two or more active substances |
| FI107339B (fi) | 1998-06-30 | 2001-07-13 | Leiras Oy | Lääkeaineiden läpäisynopeutta säätävä kalvo tai matriisi |
| US6056976A (en) | 1998-11-12 | 2000-05-02 | Leiras Oy | Elastomer, its preparation and use |
| US6063395A (en) * | 1998-11-12 | 2000-05-16 | Leiras Oy | Drug delivery device especially for the delivery of progestins and estrogens |
| US6476079B1 (en) * | 1999-12-23 | 2002-11-05 | Leiras Oy | Devices for the delivery of drugs having antiprogestinic properties |
| HUP0401438A3 (en) | 2001-08-31 | 2008-04-28 | Schering Oy | Drug delivery system |
| AU2004233997C1 (en) * | 2003-04-29 | 2014-01-30 | Massachusetts Institiute Of Technology | Methods and devices for the sustained release of multiple drugs |
| EP2062568A1 (en) | 2007-11-22 | 2009-05-27 | Bayer Schering Pharma Oy | Vaginal delivery system |
| TW200927141A (en) * | 2007-11-22 | 2009-07-01 | Bayer Schering Pharma Oy | Vaginal delivery system |
| EP2140860A1 (en) | 2008-07-03 | 2010-01-06 | Bayer Schering Pharma Oy | An improved method of contraception |
| FI121000B (fi) | 2008-11-19 | 2010-06-15 | Bayer Schering Pharma Oy | Intravaginaalinen antojärjestelmä ja menetelmä sen valmistamiseksi |
| WO2013013172A1 (en) * | 2011-07-20 | 2013-01-24 | The University Of Utah Research Foundation | Intravaginal devices for drug delivery |
| WO2014122563A1 (en) * | 2013-02-08 | 2014-08-14 | Qpharma Ab | An intra vaginal device, and a method of reducing the rate of diffusion of active ingredients in said intra vaginal device |
-
2016
- 2016-05-09 CN CN201680041265.3A patent/CN108135910B/zh active Active
- 2016-05-09 US US15/573,187 patent/US11096888B2/en active Active
- 2016-05-09 CA CA2985717A patent/CA2985717A1/en active Pending
- 2016-05-09 WO PCT/EP2016/060298 patent/WO2016180764A1/en not_active Ceased
- 2016-05-09 FI FIEP16720866.9T patent/FI3294300T3/fi active
- 2016-05-09 JP JP2017558678A patent/JP6898856B2/ja active Active
- 2016-05-09 EP EP16720866.9A patent/EP3294300B1/en active Active
- 2016-05-09 ES ES16720866T patent/ES3009909T3/es active Active
-
2021
- 2021-06-30 US US17/364,199 patent/US12357563B2/en active Active
-
2025
- 2025-06-18 US US19/242,221 patent/US20260053736A1/en active Pending
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