JP2018515106A5 - - Google Patents
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- JP2018515106A5 JP2018515106A5 JP2017559428A JP2017559428A JP2018515106A5 JP 2018515106 A5 JP2018515106 A5 JP 2018515106A5 JP 2017559428 A JP2017559428 A JP 2017559428A JP 2017559428 A JP2017559428 A JP 2017559428A JP 2018515106 A5 JP2018515106 A5 JP 2018515106A5
- Authority
- JP
- Japan
- Prior art keywords
- gene encoding
- promoter
- genetically engineered
- gene
- pal
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2021027597A JP7245271B2 (ja) | 2015-05-13 | 2021-02-24 | 高フェニルアラニン血症を低減させるように操作された細菌 |
| JP2023037515A JP7592777B2 (ja) | 2015-05-13 | 2023-03-10 | 高フェニルアラニン血症を低減させるように操作された細菌 |
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562161137P | 2015-05-13 | 2015-05-13 | |
| US62/161,137 | 2015-05-13 | ||
| US201562256052P | 2015-11-16 | 2015-11-16 | |
| US62/256,052 | 2015-11-16 | ||
| PCT/US2016/032562 WO2016183531A1 (en) | 2015-05-13 | 2016-05-13 | Bacteria engineered to reduce hyperphenylalaninemia |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021027597A Division JP7245271B2 (ja) | 2015-05-13 | 2021-02-24 | 高フェニルアラニン血症を低減させるように操作された細菌 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2018515106A JP2018515106A (ja) | 2018-06-14 |
| JP2018515106A5 true JP2018515106A5 (https=) | 2019-06-13 |
| JP6843768B2 JP6843768B2 (ja) | 2021-03-17 |
Family
ID=56117975
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017559428A Active JP6843768B2 (ja) | 2015-05-13 | 2016-05-13 | 高フェニルアラニン血症を低減させるように操作された細菌 |
| JP2021027597A Active JP7245271B2 (ja) | 2015-05-13 | 2021-02-24 | 高フェニルアラニン血症を低減させるように操作された細菌 |
| JP2023037515A Active JP7592777B2 (ja) | 2015-05-13 | 2023-03-10 | 高フェニルアラニン血症を低減させるように操作された細菌 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021027597A Active JP7245271B2 (ja) | 2015-05-13 | 2021-02-24 | 高フェニルアラニン血症を低減させるように操作された細菌 |
| JP2023037515A Active JP7592777B2 (ja) | 2015-05-13 | 2023-03-10 | 高フェニルアラニン血症を低減させるように操作された細菌 |
Country Status (12)
| Country | Link |
|---|---|
| US (6) | US10610546B2 (https=) |
| EP (2) | EP3882259B1 (https=) |
| JP (3) | JP6843768B2 (https=) |
| AU (3) | AU2016262569B9 (https=) |
| BR (1) | BR112017024384A2 (https=) |
| CA (1) | CA2985819A1 (https=) |
| ES (1) | ES2881384T3 (https=) |
| IL (2) | IL296538A (https=) |
| PL (1) | PL3294760T3 (https=) |
| SG (1) | SG10202003100XA (https=) |
| WO (1) | WO2016183531A1 (https=) |
| ZA (1) | ZA201707678B (https=) |
Families Citing this family (49)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2865825T3 (es) | 2014-04-01 | 2021-10-18 | Rubius Therapeutics Inc | Procedimientos y composiciones para inmunomodulación |
| US9688967B2 (en) | 2014-12-05 | 2017-06-27 | Synlogic, Inc. | Bacteria engineered to treat diseases associated with hyperammonemia |
| US10610546B2 (en) | 2015-05-13 | 2020-04-07 | Synlogic Operating Company Inc. | Bacteria engineered to reduce hyperphenylalaninemia |
| US20160206666A1 (en) | 2014-12-22 | 2016-07-21 | Synlogic, Inc. | Bacteria engineered to treat diseases that benefit from reduced gut inflammation and/or tighten gut mucosal barrier |
| CN107667173A (zh) | 2015-05-06 | 2018-02-06 | 斯尼普技术有限公司 | 改变微生物种群和改善微生物群 |
| US11883439B2 (en) | 2015-05-13 | 2024-01-30 | Synlogic Operating Company, Inc. | Bacteria engineered to treat a disease or disorder |
| EP3294757B1 (en) * | 2015-05-13 | 2023-12-27 | Synlogic Operating Company, Inc. | Bacteria engineered to treat a disease or disorder |
| US11685925B2 (en) | 2015-10-30 | 2023-06-27 | Synlogic Operating Company, Inc. | Bacteria engineered to treat diseases that benefit from reduced gut inflammation and/or tightened gut mucosal barrier |
| WO2017087580A1 (en) * | 2015-11-16 | 2017-05-26 | Synlogic, Inc. | Bacteria engineered to reduce hyperphenylalaninemia |
| US11208649B2 (en) | 2015-12-07 | 2021-12-28 | Zymergen Inc. | HTP genomic engineering platform |
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| WO2018183685A1 (en) * | 2017-03-29 | 2018-10-04 | President And Fellows Of Harvard College | Methods of regulating gene expression in a cell |
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| CN107904222B (zh) * | 2017-11-30 | 2019-10-08 | 江南大学 | 一种热稳定性提高的l-氨基酸脱氨酶突变体及其构建方法 |
| JP7460531B2 (ja) | 2017-12-05 | 2024-04-02 | バイオピーエルエックス，インコーポレイティド | 微生物感染を防ぐための方法および組成物 |
| US12331320B2 (en) | 2018-10-10 | 2025-06-17 | The Research Foundation For The State University Of New York | Genome edited cancer cell vaccines |
| JP2022512380A (ja) | 2018-12-10 | 2022-02-03 | ノヴォム バイオテクノロジーズ，インコーポレイテッド | 高シュウ酸尿症を治療するための方法及び組成物 |
| WO2020132017A1 (en) * | 2018-12-20 | 2020-06-25 | University Of South Carolina | Pharmabiotic treatments for metabolic disorders |
| WO2020223345A1 (en) | 2019-04-29 | 2020-11-05 | Antipov Eugene | Enumeration of genetically engineered microorganisms by live cell counting techniques |
| AU2020288624B2 (en) | 2019-06-04 | 2025-09-25 | Cocoon Biotech Inc. | Silk-based products, formulations, and methods of use |
| CN114450403A (zh) * | 2019-06-21 | 2022-05-06 | 银杏生物制品公司 | 用于在枫糖尿症(msud)的治疗中使用的酶的生物合成 |
| CN110257291B (zh) * | 2019-06-25 | 2021-07-23 | 北京大学 | 一株耐受镍离子毒性的无色杆菌及其应用 |
| CA3156035A1 (en) | 2019-09-27 | 2021-04-01 | Intrexon Actobiotics Nv D/B/A Precigen Actobio | Treatment of celiac disease |
| CA3161450A1 (en) | 2019-11-12 | 2021-05-20 | Actym Therapeutics, Inc. | Immunostimulatory bacteria delivery platforms and their use for delivery of therapeutic products |
| AU2021208600A1 (en) | 2020-01-17 | 2022-07-28 | Université Catholique de Louvain | Genetically modified bacterium with altered envelop integrity and uses thereof |
| US20230105474A1 (en) * | 2020-02-25 | 2023-04-06 | Synlogic Operating Company, Inc. | Recombinant bacteria engineered to treat diseases associated with uric acid and methods of use thereof |
| CN115298308A (zh) * | 2020-03-20 | 2022-11-04 | 同生运营公司 | 经工程化以减轻高苯丙氨酸血症的微生物 |
| WO2021207647A1 (en) * | 2020-04-09 | 2021-10-14 | Computational International LLC | Small molecule drugs as targeted therapeutics |
| CA3188581A1 (en) * | 2020-07-02 | 2022-01-06 | The Regents Of The University Of California | Persistent memory t-cell responses to cancer and infectious-disease antigens by manipulation of amino acid-catabolism pathways |
| WO2022006748A1 (en) | 2020-07-07 | 2022-01-13 | New Portal Limited | Genetically engineered live bacteria and methods of constructing the same |
| WO2022036159A2 (en) | 2020-08-12 | 2022-02-17 | Actym Therapeutics, Inc. | Immunostimulatory bacteria-based vaccines, therapeutics, and rna delivery platforms |
| US20230332164A1 (en) * | 2020-09-30 | 2023-10-19 | Synlogic Operating Company, Inc. | Bacteria engineered to secrete active proteins |
| US20230414732A1 (en) * | 2020-11-10 | 2023-12-28 | Palena Therapeutics, Inc. | Compositions of embedded epitope random peptides (eerp) for treatment of immune-mediated conditions, and methods of use |
| WO2022120028A2 (en) | 2020-12-02 | 2022-06-09 | Synlogic Operating Company, Inc. | Engineered microorganisms |
| CN112501098B (zh) * | 2020-12-11 | 2023-01-03 | 上海陶宇晟生物技术有限责任公司 | 具有降解苯丙氨酸能力的工程益生菌 |
| US20240316121A1 (en) | 2020-12-31 | 2024-09-26 | Synlogic Operating Company, Inc. | Microorganisms engineered to reduce hyperphenylalaninemia |
| CN112662606A (zh) * | 2021-01-06 | 2021-04-16 | 中国科学院分子植物科学卓越创新中心 | 用于治疗苯丙酮尿症的工程益生菌 |
| CN112662607A (zh) * | 2021-01-07 | 2021-04-16 | 上海陶宇晟生物技术有限责任公司 | 具备表面展示苯丙氨酸解氨酶的工程益生菌 |
| CN117479929A (zh) * | 2021-06-24 | 2024-01-30 | 龙沙格林伍德有限公司 | 控制活性物质向消化道施用的方法 |
| CA3235418A1 (en) | 2021-11-09 | 2023-05-19 | Actym Therapeutics, Inc. | Immunostimulatory bacteria for converting macrophages into a phenotype amenable to treatment, and companion diagnostic for identifying subjects for treatment |
| CN116836899A (zh) * | 2022-03-02 | 2023-10-03 | 和度生物技术(上海)有限公司 | 一种用于治疗高苯丙氨酸血症的工程微生物及其用途 |
| CN114717172B (zh) * | 2022-03-21 | 2022-09-23 | 江南大学 | 合成l-缬氨酸的大肠杆菌及其构建方法与应用 |
| GB202209518D0 (en) | 2022-06-29 | 2022-08-10 | Snipr Biome Aps | Treating & preventing E coli infections |
| CN116463362B (zh) * | 2023-06-15 | 2023-09-19 | 中国中医科学院中药研究所 | 一种细胞分裂抑制剂的制备方法 |
| WO2025170927A1 (en) * | 2024-02-06 | 2025-08-14 | The Cleveland Clinic Foundation | Kynurenine responsive bacteria and cancer therapies |
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| GB9107305D0 (en) | 1991-04-08 | 1991-05-22 | Unilever Plc | Probiotic |
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| EP1135461A4 (en) | 1998-12-02 | 2003-03-26 | Univ Boston | GEN NETWORKS FOR CONTROLLING GENE EXPRESSION |
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| US20150246085A1 (en) * | 2012-11-01 | 2015-09-03 | The Sydney Children's Hospital Network (Randwick & Westmead) | Genetically-Modified Probiotic for Treatment of Phenylketonuria |
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| KR102218930B1 (ko) | 2013-04-18 | 2021-02-23 | 코덱시스, 인코포레이티드 | 조작된 페닐알라닌 암모니아 리아제 폴리펩티드 |
| US10610546B2 (en) | 2015-05-13 | 2020-04-07 | Synlogic Operating Company Inc. | Bacteria engineered to reduce hyperphenylalaninemia |
| SG11201704543XA (en) * | 2014-12-05 | 2017-07-28 | Synlogic Inc | Bacteria engineered to treat diseases associated with hyperammonemia |
| US9688967B2 (en) | 2014-12-05 | 2017-06-27 | Synlogic, Inc. | Bacteria engineered to treat diseases associated with hyperammonemia |
| EP3294757B1 (en) | 2015-05-13 | 2023-12-27 | Synlogic Operating Company, Inc. | Bacteria engineered to treat a disease or disorder |
| CA2987508A1 (en) | 2015-05-28 | 2016-12-01 | Evolva Sa | Biosynthesis of phenylpropanoids and phenylpropanoid derivatives |
| IL256216B (en) * | 2015-06-10 | 2022-07-01 | Synlogic Operating Co Inc | Bacteria engineered to treat disorders involving the catabolism of a branched chain amino acid |
| WO2016210373A2 (en) | 2015-06-24 | 2016-12-29 | Synlogic, Inc. | Recombinant bacteria engineered for biosafety, pharmaceutical compositions, and methods of use thereof |
| US20170216370A1 (en) | 2015-07-31 | 2017-08-03 | Synlogic, Inc. | Bacteria engineered to treat disorders involving propionate catabolism |
| WO2017087580A1 (en) | 2015-11-16 | 2017-05-26 | Synlogic, Inc. | Bacteria engineered to reduce hyperphenylalaninemia |
| WO2017216704A1 (en) | 2016-06-13 | 2017-12-21 | Benson Hill Biosystems, Inc. | Increasing plant growth and yield by using a phenylalanine ammonia lyase sequence |
| CN111655841A (zh) | 2017-06-21 | 2020-09-11 | 同生运营公司 | 用于治疗紊乱的细菌 |
| JP2021531749A (ja) | 2018-07-12 | 2021-11-25 | コデクシス， インコーポレイテッド | 操作されたフェニルアラニンアンモニアリアーゼポリペプチド |
| CN115298308A (zh) | 2020-03-20 | 2022-11-04 | 同生运营公司 | 经工程化以减轻高苯丙氨酸血症的微生物 |
| US20240316121A1 (en) | 2020-12-31 | 2024-09-26 | Synlogic Operating Company, Inc. | Microorganisms engineered to reduce hyperphenylalaninemia |
| WO2023044479A1 (en) | 2021-09-17 | 2023-03-23 | Synlogic Operating Company, Inc. | Methods for reducing hyperphenylalaninemia |
-
2016
- 2016-05-13 US US15/154,934 patent/US10610546B2/en active Active
- 2016-05-13 AU AU2016262569A patent/AU2016262569B9/en active Active
- 2016-05-13 US US15/301,324 patent/US10195234B2/en active Active
- 2016-05-13 PL PL16728448T patent/PL3294760T3/pl unknown
- 2016-05-13 JP JP2017559428A patent/JP6843768B2/ja active Active
- 2016-05-13 IL IL296538A patent/IL296538A/en unknown
- 2016-05-13 BR BR112017024384A patent/BR112017024384A2/pt not_active Application Discontinuation
- 2016-05-13 CA CA2985819A patent/CA2985819A1/en active Pending
- 2016-05-13 ES ES16728448T patent/ES2881384T3/es active Active
- 2016-05-13 EP EP21156322.6A patent/EP3882259B1/en active Active
- 2016-05-13 US US15/319,564 patent/US9889164B2/en active Active
- 2016-05-13 EP EP16728448.8A patent/EP3294760B1/en active Active
- 2016-05-13 WO PCT/US2016/032562 patent/WO2016183531A1/en not_active Ceased
- 2016-05-13 SG SG10202003100XA patent/SG10202003100XA/en unknown
- 2016-09-08 US US15/260,211 patent/US9943555B2/en active Active
-
2017
- 2017-11-12 IL IL255616A patent/IL255616B2/en unknown
- 2017-11-13 ZA ZA2017/07678A patent/ZA201707678B/en unknown
- 2017-12-22 US US15/852,762 patent/US10933102B2/en active Active
-
2020
- 2020-02-12 US US16/788,458 patent/US12409195B2/en active Active
-
2021
- 2021-02-24 JP JP2021027597A patent/JP7245271B2/ja active Active
- 2021-08-06 AU AU2021212141A patent/AU2021212141B2/en active Active
-
2023
- 2023-03-10 JP JP2023037515A patent/JP7592777B2/ja active Active
-
2024
- 2024-12-18 AU AU2024278562A patent/AU2024278562A1/en active Pending
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