JP2018515106A5 - - Google Patents
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- JP2018515106A5 JP2018515106A5 JP2017559428A JP2017559428A JP2018515106A5 JP 2018515106 A5 JP2018515106 A5 JP 2018515106A5 JP 2017559428 A JP2017559428 A JP 2017559428A JP 2017559428 A JP2017559428 A JP 2017559428A JP 2018515106 A5 JP2018515106 A5 JP 2018515106A5
- Authority
- JP
- Japan
- Prior art keywords
- gene encoding
- promoter
- genetically engineered
- gene
- pal
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2021027597A JP7245271B2 (ja) | 2015-05-13 | 2021-02-24 | 高フェニルアラニン血症を低減させるように操作された細菌 |
| JP2023037515A JP7592777B2 (ja) | 2015-05-13 | 2023-03-10 | 高フェニルアラニン血症を低減させるように操作された細菌 |
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562161137P | 2015-05-13 | 2015-05-13 | |
| US62/161,137 | 2015-05-13 | ||
| US201562256052P | 2015-11-16 | 2015-11-16 | |
| US62/256,052 | 2015-11-16 | ||
| PCT/US2016/032562 WO2016183531A1 (en) | 2015-05-13 | 2016-05-13 | Bacteria engineered to reduce hyperphenylalaninemia |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021027597A Division JP7245271B2 (ja) | 2015-05-13 | 2021-02-24 | 高フェニルアラニン血症を低減させるように操作された細菌 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2018515106A JP2018515106A (ja) | 2018-06-14 |
| JP2018515106A5 true JP2018515106A5 (https=) | 2019-06-13 |
| JP6843768B2 JP6843768B2 (ja) | 2021-03-17 |
Family
ID=56117975
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017559428A Active JP6843768B2 (ja) | 2015-05-13 | 2016-05-13 | 高フェニルアラニン血症を低減させるように操作された細菌 |
| JP2021027597A Active JP7245271B2 (ja) | 2015-05-13 | 2021-02-24 | 高フェニルアラニン血症を低減させるように操作された細菌 |
| JP2023037515A Active JP7592777B2 (ja) | 2015-05-13 | 2023-03-10 | 高フェニルアラニン血症を低減させるように操作された細菌 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021027597A Active JP7245271B2 (ja) | 2015-05-13 | 2021-02-24 | 高フェニルアラニン血症を低減させるように操作された細菌 |
| JP2023037515A Active JP7592777B2 (ja) | 2015-05-13 | 2023-03-10 | 高フェニルアラニン血症を低減させるように操作された細菌 |
Country Status (12)
| Country | Link |
|---|---|
| US (6) | US10610546B2 (https=) |
| EP (2) | EP3882259B1 (https=) |
| JP (3) | JP6843768B2 (https=) |
| AU (3) | AU2016262569B9 (https=) |
| BR (1) | BR112017024384A2 (https=) |
| CA (1) | CA2985819A1 (https=) |
| ES (1) | ES2881384T3 (https=) |
| IL (2) | IL296538A (https=) |
| PL (1) | PL3294760T3 (https=) |
| SG (1) | SG10202003100XA (https=) |
| WO (1) | WO2016183531A1 (https=) |
| ZA (1) | ZA201707678B (https=) |
Families Citing this family (49)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MA39819A (fr) | 2014-04-01 | 2017-02-08 | Rubius Therapeutics Inc | Méthodes et compositions d'immunomodulation |
| WO2016183532A1 (en) * | 2015-05-13 | 2016-11-17 | Synlogic, Inc. | Bacteria engineered to treat a disease or disorder |
| US9688967B2 (en) | 2014-12-05 | 2017-06-27 | Synlogic, Inc. | Bacteria engineered to treat diseases associated with hyperammonemia |
| US20160206666A1 (en) | 2014-12-22 | 2016-07-21 | Synlogic, Inc. | Bacteria engineered to treat diseases that benefit from reduced gut inflammation and/or tighten gut mucosal barrier |
| EP3711488A1 (en) | 2015-05-06 | 2020-09-23 | Snipr Technologies Limited | Altering microbial populations & modifying microbiota |
| US11883439B2 (en) | 2015-05-13 | 2024-01-30 | Synlogic Operating Company, Inc. | Bacteria engineered to treat a disease or disorder |
| ES2881384T3 (es) | 2015-05-13 | 2021-11-29 | Synlogic Operating Co Inc | Bacterias manipuladas para reducir la hiperfenilalaninemia |
| US11685925B2 (en) | 2015-10-30 | 2023-06-27 | Synlogic Operating Company, Inc. | Bacteria engineered to treat diseases that benefit from reduced gut inflammation and/or tightened gut mucosal barrier |
| ES2925049T3 (es) * | 2015-11-16 | 2022-10-13 | Synlogic Operating Co Inc | Bacterias manipuladas para reducir la hiperfenilalaninemia |
| US9988624B2 (en) | 2015-12-07 | 2018-06-05 | Zymergen Inc. | Microbial strain improvement by a HTP genomic engineering platform |
| US11208649B2 (en) | 2015-12-07 | 2021-12-28 | Zymergen Inc. | HTP genomic engineering platform |
| US11566238B2 (en) | 2016-12-15 | 2023-01-31 | The Board Of Trustees Of The Leland Stanford Junior University | Compositions and methods for modulating growth of a genetically modified gut bacterial cell |
| US11384358B2 (en) | 2017-03-29 | 2022-07-12 | President And Fellows Of Harvard College | Method of regulating gene expression in a cell |
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| US12331320B2 (en) | 2018-10-10 | 2025-06-17 | The Research Foundation For The State University Of New York | Genome edited cancer cell vaccines |
| US12421518B2 (en) | 2018-12-10 | 2025-09-23 | Tenza, Inc. | Methods and compositions for treating hyperoxaluria |
| WO2020132017A1 (en) * | 2018-12-20 | 2020-06-25 | University Of South Carolina | Pharmabiotic treatments for metabolic disorders |
| KR20220003030A (ko) | 2019-04-29 | 2022-01-07 | 신로직 오퍼레이팅 컴퍼니, 인코포레이티드 | 살아 있는 세포 계수 기술에 의한 유전적으로 조작된 미생물의 계수 |
| CA3142608A1 (en) | 2019-06-04 | 2020-12-10 | Cocoon Biotech Inc. | Silk-based products, formulations, and methods of use |
| JP2022537214A (ja) * | 2019-06-21 | 2022-08-24 | ギンゴー バイオワークス， インコーポレイテッド | メープルシロップ尿症（ｍｓｕｄ）の処置のおける使用のための酵素の生合成 |
| CN110257291B (zh) * | 2019-06-25 | 2021-07-23 | 北京大学 | 一株耐受镍离子毒性的无色杆菌及其应用 |
| CA3156035A1 (en) | 2019-09-27 | 2021-04-01 | Intrexon Actobiotics Nv D/B/A Precigen Actobio | Treatment of celiac disease |
| JP2023501539A (ja) | 2019-11-12 | 2023-01-18 | アクティム・セラピューティクス・インコーポレイテッド | 免疫刺激細菌デリバリープラットフォーム、および治療用産物のデリバリーのためのその使用 |
| EP4090773A2 (en) | 2020-01-17 | 2022-11-23 | Université catholique de Louvain | Genetically modified bacterium with altered envelop integrity and uses thereof |
| US20230105474A1 (en) * | 2020-02-25 | 2023-04-06 | Synlogic Operating Company, Inc. | Recombinant bacteria engineered to treat diseases associated with uric acid and methods of use thereof |
| BR112022018571A2 (pt) * | 2020-03-20 | 2022-11-01 | Synlogic Operating Co Inc | Microrganismos manipulados para reduzir a hiperfenilalaninemia |
| WO2021207647A1 (en) * | 2020-04-09 | 2021-10-14 | Computational International LLC | Small molecule drugs as targeted therapeutics |
| WO2022006424A2 (en) * | 2020-07-02 | 2022-01-06 | The Regents Of The University Of Californa | Persistent memory t-cell responses to cancer and infectious-disease antigens by manipulation of amino acid-catabolism pathways |
| WO2022006748A1 (en) | 2020-07-07 | 2022-01-13 | New Portal Limited | Genetically engineered live bacteria and methods of constructing the same |
| IL300447A (en) | 2020-08-12 | 2023-04-01 | Actym Therapeutics Inc | Bacteria-based ingredients that stimulate the immune system, treatments and platforms for delivering RNA |
| US20230332164A1 (en) * | 2020-09-30 | 2023-10-19 | Synlogic Operating Company, Inc. | Bacteria engineered to secrete active proteins |
| IL302604A (en) * | 2020-11-10 | 2023-07-01 | Palena Therapeutics Inc | Epitope-Encapsulated Random Peptide (EERP) Preparations for the Treatment of Immune-Mediated Conditions and Methods of Use |
| EP4256039A2 (en) | 2020-12-02 | 2023-10-11 | Synlogic Operating Company, Inc. | Engineered microorganisms |
| CN112501098B (zh) * | 2020-12-11 | 2023-01-03 | 上海陶宇晟生物技术有限责任公司 | 具有降解苯丙氨酸能力的工程益生菌 |
| CN116847860A (zh) | 2020-12-31 | 2023-10-03 | 同生运营公司 | 经工程化以减轻高苯丙氨酸血症的微生物 |
| CN112662606A (zh) * | 2021-01-06 | 2021-04-16 | 中国科学院分子植物科学卓越创新中心 | 用于治疗苯丙酮尿症的工程益生菌 |
| CN112662607A (zh) * | 2021-01-07 | 2021-04-16 | 上海陶宇晟生物技术有限责任公司 | 具备表面展示苯丙氨酸解氨酶的工程益生菌 |
| JP2024526149A (ja) * | 2021-06-24 | 2024-07-17 | ロンザ・グリーンウッド・エルエルシー | 消化管への活性物質の投与を制御する方法 |
| WO2023086796A2 (en) | 2021-11-09 | 2023-05-19 | Actym Therapeutics, Inc. | Immunostimulatory bacteria for converting macrophages into a phenotype amenable to treatment, and companion diagnostic for identifying subjects for treatment |
| CN116836899A (zh) * | 2022-03-02 | 2023-10-03 | 和度生物技术(上海)有限公司 | 一种用于治疗高苯丙氨酸血症的工程微生物及其用途 |
| CN114717172B (zh) * | 2022-03-21 | 2022-09-23 | 江南大学 | 合成l-缬氨酸的大肠杆菌及其构建方法与应用 |
| GB202209518D0 (en) | 2022-06-29 | 2022-08-10 | Snipr Biome Aps | Treating & preventing E coli infections |
| CN116463362B (zh) * | 2023-06-15 | 2023-09-19 | 中国中医科学院中药研究所 | 一种细胞分裂抑制剂的制备方法 |
| WO2025170927A1 (en) * | 2024-02-06 | 2025-08-14 | The Cleveland Clinic Foundation | Kynurenine responsive bacteria and cancer therapies |
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| GB9107305D0 (en) | 1991-04-08 | 1991-05-22 | Unilever Plc | Probiotic |
| CN1154845A (zh) | 1996-09-09 | 1997-07-23 | 首都医学院附属北京红十字朝阳医院 | 能表达活性苯丙氨酸脱氨酶的基因工程菌口服制剂 |
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| EP2886658A1 (en) | 2005-03-10 | 2015-06-24 | BASF Enzymes LLC | Lyase enzymes, nucleic acids encoding them and methods for making and using them |
| WO2008118176A2 (en) | 2006-06-02 | 2008-10-02 | Verenium Corporation | Lase enzymes, nucleic acids encoding them and methods for making and using them |
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| US9688967B2 (en) | 2014-12-05 | 2017-06-27 | Synlogic, Inc. | Bacteria engineered to treat diseases associated with hyperammonemia |
| SG11201704543XA (en) * | 2014-12-05 | 2017-07-28 | Synlogic Inc | Bacteria engineered to treat diseases associated with hyperammonemia |
| WO2016183532A1 (en) | 2015-05-13 | 2016-11-17 | Synlogic, Inc. | Bacteria engineered to treat a disease or disorder |
| ES2881384T3 (es) | 2015-05-13 | 2021-11-29 | Synlogic Operating Co Inc | Bacterias manipuladas para reducir la hiperfenilalaninemia |
| JP6799010B2 (ja) | 2015-05-28 | 2020-12-09 | エヴォルヴァ エスアー．Ｅｖｏｌｖａ Ｓａ． | フェニルプロパノイドおよびフェニルプロパノイド誘導体の生合成 |
| AU2016276973B2 (en) * | 2015-06-10 | 2022-09-01 | Synlogic Operating Company, Inc. | Bacteria engineered to treat disorders involving the catabolism of a branched chain amino acid |
| WO2016210373A2 (en) | 2015-06-24 | 2016-12-29 | Synlogic, Inc. | Recombinant bacteria engineered for biosafety, pharmaceutical compositions, and methods of use thereof |
| US20170216370A1 (en) | 2015-07-31 | 2017-08-03 | Synlogic, Inc. | Bacteria engineered to treat disorders involving propionate catabolism |
| ES2925049T3 (es) | 2015-11-16 | 2022-10-13 | Synlogic Operating Co Inc | Bacterias manipuladas para reducir la hiperfenilalaninemia |
| WO2017216704A1 (en) | 2016-06-13 | 2017-12-21 | Benson Hill Biosystems, Inc. | Increasing plant growth and yield by using a phenylalanine ammonia lyase sequence |
| CN111655841A (zh) | 2017-06-21 | 2020-09-11 | 同生运营公司 | 用于治疗紊乱的细菌 |
| JP2021531749A (ja) | 2018-07-12 | 2021-11-25 | コデクシス， インコーポレイテッド | 操作されたフェニルアラニンアンモニアリアーゼポリペプチド |
| BR112022018571A2 (pt) | 2020-03-20 | 2022-11-01 | Synlogic Operating Co Inc | Microrganismos manipulados para reduzir a hiperfenilalaninemia |
| CN116847860A (zh) | 2020-12-31 | 2023-10-03 | 同生运营公司 | 经工程化以减轻高苯丙氨酸血症的微生物 |
| WO2023044479A1 (en) | 2021-09-17 | 2023-03-23 | Synlogic Operating Company, Inc. | Methods for reducing hyperphenylalaninemia |
-
2016
- 2016-05-13 ES ES16728448T patent/ES2881384T3/es active Active
- 2016-05-13 IL IL296538A patent/IL296538A/en unknown
- 2016-05-13 EP EP21156322.6A patent/EP3882259B1/en active Active
- 2016-05-13 SG SG10202003100XA patent/SG10202003100XA/en unknown
- 2016-05-13 EP EP16728448.8A patent/EP3294760B1/en active Active
- 2016-05-13 CA CA2985819A patent/CA2985819A1/en active Pending
- 2016-05-13 WO PCT/US2016/032562 patent/WO2016183531A1/en not_active Ceased
- 2016-05-13 US US15/154,934 patent/US10610546B2/en active Active
- 2016-05-13 US US15/301,324 patent/US10195234B2/en active Active
- 2016-05-13 BR BR112017024384A patent/BR112017024384A2/pt not_active Application Discontinuation
- 2016-05-13 US US15/319,564 patent/US9889164B2/en active Active
- 2016-05-13 JP JP2017559428A patent/JP6843768B2/ja active Active
- 2016-05-13 AU AU2016262569A patent/AU2016262569B9/en active Active
- 2016-05-13 PL PL16728448T patent/PL3294760T3/pl unknown
- 2016-09-08 US US15/260,211 patent/US9943555B2/en active Active
-
2017
- 2017-11-12 IL IL255616A patent/IL255616B2/en unknown
- 2017-11-13 ZA ZA2017/07678A patent/ZA201707678B/en unknown
- 2017-12-22 US US15/852,762 patent/US10933102B2/en active Active
-
2020
- 2020-02-12 US US16/788,458 patent/US12409195B2/en active Active
-
2021
- 2021-02-24 JP JP2021027597A patent/JP7245271B2/ja active Active
- 2021-08-06 AU AU2021212141A patent/AU2021212141B2/en active Active
-
2023
- 2023-03-10 JP JP2023037515A patent/JP7592777B2/ja active Active
-
2024
- 2024-12-18 AU AU2024278562A patent/AU2024278562A1/en active Pending
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