JP2018514592A5 - - Google Patents
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- JP2018514592A5 JP2018514592A5 JP2018508628A JP2018508628A JP2018514592A5 JP 2018514592 A5 JP2018514592 A5 JP 2018514592A5 JP 2018508628 A JP2018508628 A JP 2018508628A JP 2018508628 A JP2018508628 A JP 2018508628A JP 2018514592 A5 JP2018514592 A5 JP 2018514592A5
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- JP
- Japan
- Prior art keywords
- xaa
- ser
- ala
- composition
- composition according
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 239000000203 mixture Substances 0.000 claims 28
- 150000001875 compounds Chemical class 0.000 claims 15
- 102000011690 Adiponectin Human genes 0.000 claims 10
- 108010076365 Adiponectin Proteins 0.000 claims 10
- 239000000816 peptidomimetic Substances 0.000 claims 10
- 150000003839 salts Chemical class 0.000 claims 9
- 150000001413 amino acids Chemical class 0.000 claims 8
- MTCFGRXMJLQNBG-UWTATZPHSA-N D-Serine Chemical compound OC[C@@H](N)C(O)=O MTCFGRXMJLQNBG-UWTATZPHSA-N 0.000 claims 5
- SNDPXSYFESPGGJ-UHFFFAOYSA-N L-norVal-OH Natural products CCCC(N)C(O)=O SNDPXSYFESPGGJ-UHFFFAOYSA-N 0.000 claims 4
- 108090000765 processed proteins & peptides Proteins 0.000 claims 4
- 125000001433 C-terminal amino-acid group Chemical group 0.000 claims 3
- 208000003556 Dry Eye Syndromes Diseases 0.000 claims 3
- 206010013774 Dry eye Diseases 0.000 claims 3
- 239000003937 drug carrier Substances 0.000 claims 3
- 238000002347 injection Methods 0.000 claims 3
- 239000007924 injection Substances 0.000 claims 3
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 2
- DCXYFEDJOCDNAF-UWTATZPHSA-N D-Asparagine Chemical compound OC(=O)[C@H](N)CC(N)=O DCXYFEDJOCDNAF-UWTATZPHSA-N 0.000 claims 2
- QNAYBMKLOCPYGJ-UHFFFAOYSA-N D-alpha-Ala Natural products CC([NH3+])C([O-])=O QNAYBMKLOCPYGJ-UHFFFAOYSA-N 0.000 claims 2
- UCMIRNVEIXFBKS-UHFFFAOYSA-N beta-alanine Chemical compound NCCC(O)=O UCMIRNVEIXFBKS-UHFFFAOYSA-N 0.000 claims 2
- 238000009472 formulation Methods 0.000 claims 2
- 125000005647 linker group Chemical group 0.000 claims 2
- 150000002634 lipophilic molecules Chemical class 0.000 claims 2
- 229920000642 polymer Polymers 0.000 claims 2
- 239000000725 suspension Substances 0.000 claims 2
- 230000026683 transduction Effects 0.000 claims 2
- 238000010361 transduction Methods 0.000 claims 2
- 206010051625 Conjunctival hyperaemia Diseases 0.000 claims 1
- PMATZTZNYRCHOR-CGLBZJNRSA-N Cyclosporin A Chemical compound CC[C@@H]1NC(=O)[C@H]([C@H](O)[C@H](C)C\C=C\C)N(C)C(=O)[C@H](C(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](C(C)C)NC(=O)[C@H](CC(C)C)N(C)C(=O)CN(C)C1=O PMATZTZNYRCHOR-CGLBZJNRSA-N 0.000 claims 1
- 229930105110 Cyclosporin A Natural products 0.000 claims 1
- 108010036949 Cyclosporine Proteins 0.000 claims 1
- 206010061218 Inflammation Diseases 0.000 claims 1
- SNDPXSYFESPGGJ-BYPYZUCNSA-N L-2-aminopentanoic acid Chemical compound CCC[C@H](N)C(O)=O SNDPXSYFESPGGJ-BYPYZUCNSA-N 0.000 claims 1
- 239000000443 aerosol Substances 0.000 claims 1
- 229940121363 anti-inflammatory agent Drugs 0.000 claims 1
- 239000002260 anti-inflammatory agent Substances 0.000 claims 1
- 239000000607 artificial tear Substances 0.000 claims 1
- 108010044259 asparaginyl-isoleucyl-prolyl-norvalyl-leucyl-tyrosyl-seryl-phenylalanyl-alanyl-serinamide Proteins 0.000 claims 1
- 229960001265 ciclosporin Drugs 0.000 claims 1
- 239000003246 corticosteroid Substances 0.000 claims 1
- 229960001334 corticosteroids Drugs 0.000 claims 1
- 229930182912 cyclosporin Natural products 0.000 claims 1
- 239000003405 delayed action preparation Substances 0.000 claims 1
- 239000000839 emulsion Substances 0.000 claims 1
- 208000030533 eye disease Diseases 0.000 claims 1
- 239000000499 gel Substances 0.000 claims 1
- 239000000017 hydrogel Substances 0.000 claims 1
- 230000004054 inflammatory process Effects 0.000 claims 1
- 238000010255 intramuscular injection Methods 0.000 claims 1
- 239000007927 intramuscular injection Substances 0.000 claims 1
- 238000010253 intravenous injection Methods 0.000 claims 1
- 239000002502 liposome Substances 0.000 claims 1
- 239000007788 liquid Substances 0.000 claims 1
- 239000011859 microparticle Substances 0.000 claims 1
- 239000003595 mist Substances 0.000 claims 1
- 230000035772 mutation Effects 0.000 claims 1
- 239000002105 nanoparticle Substances 0.000 claims 1
- 239000000243 solution Substances 0.000 claims 1
- 238000010254 subcutaneous injection Methods 0.000 claims 1
- 239000007929 subcutaneous injection Substances 0.000 claims 1
- 208000024891 symptom Diseases 0.000 claims 1
- 239000006188 syrup Substances 0.000 claims 1
- 235000020357 syrup Nutrition 0.000 claims 1
- 238000002054 transplantation Methods 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562156127P | 2015-05-01 | 2015-05-01 | |
| US62/156,127 | 2015-05-01 | ||
| PCT/US2016/030142 WO2016179007A1 (en) | 2015-05-01 | 2016-04-29 | Adiponectin peptidomimetics for treating ocular disorders |
Publications (4)
| Publication Number | Publication Date |
|---|---|
| JP2018514592A JP2018514592A (ja) | 2018-06-07 |
| JP2018514592A5 true JP2018514592A5 (enExample) | 2019-06-13 |
| JPWO2016179007A5 JPWO2016179007A5 (enExample) | 2022-10-27 |
| JP7245649B2 JP7245649B2 (ja) | 2023-03-24 |
Family
ID=57218292
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018508628A Active JP7245649B2 (ja) | 2015-05-01 | 2016-04-29 | 眼疾患を治療するためのアディポネクチンペプチド模倣薬（関連出願の相互参照） |
Country Status (12)
| Country | Link |
|---|---|
| US (6) | US10987401B2 (enExample) |
| EP (3) | EP3288577B1 (enExample) |
| JP (1) | JP7245649B2 (enExample) |
| KR (2) | KR20170141692A (enExample) |
| CN (3) | CN107530396B (enExample) |
| AU (3) | AU2016257724B2 (enExample) |
| CA (3) | CA2981822C (enExample) |
| DK (1) | DK3288577T3 (enExample) |
| ES (1) | ES2903448T3 (enExample) |
| IL (1) | IL272449A (enExample) |
| SG (1) | SG11202001140UA (enExample) |
| WO (2) | WO2016179007A1 (enExample) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US10987401B2 (en) | 2015-05-01 | 2021-04-27 | Allysta Pharmaceuticals, Inc. | Adiponectin peptidomimetics for treating ocular disorders |
| CN110381920A (zh) * | 2017-03-09 | 2019-10-25 | 雅利斯塔制药公司 | 用于干眼病的肽 |
| CN107149676A (zh) * | 2017-05-05 | 2017-09-12 | 杨硕 | 脂联素和脂联素/胰岛素混合液在改善及治疗眼表角膜上皮及神经损伤中的应用 |
| WO2019061491A1 (en) * | 2017-09-30 | 2019-04-04 | Pro Sunfun Biotech Research And Development Co., Ltd. | PEPTIDE FOR OCULAR CARE, COMPOSITION AND METHOD OF USE THEREOF |
| CN109912685B (zh) * | 2017-12-13 | 2022-05-06 | 三凡生技研发股份有限公司 | 眼睛保护胜肽及其组合物及使用该胜肽的用途 |
| EP3768296B1 (en) * | 2018-03-23 | 2023-09-06 | Arch Biosurgery, Inc. | Sap and peptidomimetics for treatment of eye disease |
| EP3870204A4 (en) * | 2018-10-24 | 2022-12-21 | Allysta Pharmaceuticals, Inc. | Adiponectin peptidomimetics formulations |
| JP7699426B2 (ja) * | 2018-11-30 | 2025-06-27 | ロート製薬株式会社 | 光線による障害からの細胞保護用眼科組成物 |
| KR20220034199A (ko) | 2019-09-18 | 2022-03-17 | 알콘 인코포레이티드 | 습식-패킹 소프트 하이드로겔 안구 삽입물 |
| US11229549B2 (en) * | 2019-09-18 | 2022-01-25 | Vance M. Thompson | Tear transplantation and multi-part contact lens with absorbent portion |
| US11213551B1 (en) | 2021-04-05 | 2022-01-04 | Korb Research, Llc. | Ocular treatment compositions and methods of use thereof |
| KR20240108412A (ko) * | 2021-10-20 | 2024-07-09 | 스텔스 바이오테라퓨틱스 인코포레이티드 | 안과 병태를 치료하거나, 예방하거나, 억제하거나, 경감하거나 발병을 지연시키기 위한 방법 및 펩타이드 모방체를 포함하는 조성물 |
| WO2023069255A1 (en) * | 2021-10-20 | 2023-04-27 | Stealth Biotherapeutics Inc. | Methods and compositions comprising peptidomimitics for treating, preventing, inhibiting, ameliorating or delaying the onset of ophthalmic conditions |
| WO2023107796A1 (en) * | 2021-12-11 | 2023-06-15 | The Regents Of The University Of California | Ophthalmic formulations for macular degeneration |
| WO2024180472A1 (en) | 2023-02-28 | 2024-09-06 | Alcon Inc. | Ocular inserts |
| KR102609115B1 (ko) * | 2023-06-08 | 2023-12-05 | 주식회사 엔큐라젠 | 펩타이드를 포함하는 안구 질환의 치료용 조성물 |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5108921A (en) | 1989-04-03 | 1992-04-28 | Purdue Research Foundation | Method for enhanced transmembrane transport of exogenous molecules |
| US5643575A (en) | 1993-10-27 | 1997-07-01 | Enzon, Inc. | Non-antigenic branched polymer conjugates |
| US5824784A (en) | 1994-10-12 | 1998-10-20 | Amgen Inc. | N-terminally chemically modified protein compositions and methods |
| DE4437604A1 (de) | 1994-10-21 | 1996-04-25 | Basf Ag | Konjugate aus einem Poly- oder Oligopeptid und einer niedermolekularen lipophilen Verbindung |
| US5932462A (en) | 1995-01-10 | 1999-08-03 | Shearwater Polymers, Inc. | Multiarmed, monofunctional, polymer for coupling to molecules and surfaces |
| NZ507456A (en) | 1998-04-28 | 2003-10-31 | Applied Research Systems | Process and conjugated forms of PEGylated interferon- beta with polyethylene glycol (PEG) wherein the thiol reactive polyol agent is mono-methoxylated |
| GB9814527D0 (en) | 1998-07-03 | 1998-09-02 | Cyclacel Ltd | Delivery system |
| JP2005535561A (ja) | 2002-01-18 | 2005-11-24 | プロテミックス コーポレイション リミティド | アディポネクチンのグリコアイソフォームとその使用 |
| EA200900786A1 (ru) * | 2005-04-29 | 2009-10-30 | Зе Риджентс Оф Зи Юнивесити Оф Кэлифонье | Пептид в качестве лекарственного средства и способ лечения патологий, связанных с воспалительными процессами, посредством пептида |
| WO2012142142A2 (en) * | 2011-04-12 | 2012-10-18 | Temple University - Of The Commonwealth System Higher Education | Adiponectin receptor agonists and methods of use |
| KR101438744B1 (ko) | 2012-08-02 | 2014-09-15 | 전남대학교산학협력단 | 아디포넥틴을 유효성분으로 포함하는 안구건조증 또는 염증성 안구표면 질환의 예방 또는 치료용 조성물 |
| CN104884006B (zh) * | 2012-10-26 | 2017-12-15 | 弗赛特影像5股份有限公司 | 用于持续释放药物到眼睛的眼科系统 |
| US10987401B2 (en) * | 2015-05-01 | 2021-04-27 | Allysta Pharmaceuticals, Inc. | Adiponectin peptidomimetics for treating ocular disorders |
-
2016
- 2016-04-29 US US15/571,039 patent/US10987401B2/en active Active
- 2016-04-29 DK DK16789840.2T patent/DK3288577T3/da active
- 2016-04-29 AU AU2016257724A patent/AU2016257724B2/en active Active
- 2016-04-29 EP EP16789840.2A patent/EP3288577B1/en active Active
- 2016-04-29 CN CN201680023972.XA patent/CN107530396B/zh active Active
- 2016-04-29 JP JP2018508628A patent/JP7245649B2/ja active Active
- 2016-04-29 KR KR1020177031104A patent/KR20170141692A/ko not_active Ceased
- 2016-04-29 CA CA2981822A patent/CA2981822C/en active Active
- 2016-04-29 CA CA3191203A patent/CA3191203A1/en active Pending
- 2016-04-29 ES ES16789840T patent/ES2903448T3/es active Active
- 2016-04-29 WO PCT/US2016/030142 patent/WO2016179007A1/en not_active Ceased
- 2016-04-29 EP EP21204663.5A patent/EP4014985A1/en not_active Withdrawn
- 2016-04-29 CN CN202210970186.8A patent/CN115919996A/zh active Pending
-
2017
- 2017-08-14 US US15/676,968 patent/US10537608B2/en active Active
-
2018
- 2018-08-07 KR KR1020207007015A patent/KR20200039749A/ko not_active Ceased
- 2018-08-07 CA CA3071670A patent/CA3071670A1/en active Pending
- 2018-08-07 AU AU2018318008A patent/AU2018318008A1/en not_active Abandoned
- 2018-08-07 EP EP18845611.5A patent/EP3668530A4/en not_active Withdrawn
- 2018-08-07 CN CN201880052451.6A patent/CN111032070A/zh active Pending
- 2018-08-07 SG SG11202001140UA patent/SG11202001140UA/en unknown
- 2018-08-07 WO PCT/US2018/045527 patent/WO2019036223A1/en not_active Ceased
-
2019
- 2019-11-24 US US16/693,355 patent/US11273197B2/en active Active
-
2020
- 2020-02-04 IL IL272449A patent/IL272449A/en unknown
-
2021
- 2021-01-11 US US17/146,397 patent/US11464825B2/en active Active
- 2021-05-20 AU AU2021203254A patent/AU2021203254A1/en not_active Abandoned
-
2022
- 2022-02-24 US US17/680,181 patent/US20220331393A1/en not_active Abandoned
- 2022-10-04 US US17/937,849 patent/US20230074446A1/en not_active Abandoned
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