JP2018513174A5 - - Google Patents
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- Publication number
- JP2018513174A5 JP2018513174A5 JP2017555210A JP2017555210A JP2018513174A5 JP 2018513174 A5 JP2018513174 A5 JP 2018513174A5 JP 2017555210 A JP2017555210 A JP 2017555210A JP 2017555210 A JP2017555210 A JP 2017555210A JP 2018513174 A5 JP2018513174 A5 JP 2018513174A5
- Authority
- JP
- Japan
- Prior art keywords
- compound
- solvate
- ester
- salt
- pharmaceutical composition
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 150000001875 compounds Chemical class 0.000 claims description 43
- 150000002148 esters Chemical class 0.000 claims description 22
- 150000003839 salts Chemical class 0.000 claims description 22
- 239000012453 solvate Substances 0.000 claims description 22
- 239000008194 pharmaceutical composition Substances 0.000 claims description 16
- 239000002552 dosage form Substances 0.000 claims description 10
- 239000000203 mixture Substances 0.000 claims description 8
- 125000000217 alkyl group Chemical group 0.000 claims description 6
- 150000002596 lactones Chemical group 0.000 claims description 6
- 206010017943 Gastrointestinal conditions Diseases 0.000 claims description 4
- 239000000546 pharmaceutical excipient Substances 0.000 claims description 4
- 206010012735 Diarrhoea Diseases 0.000 claims description 2
- 208000005577 Gastroenteritis Diseases 0.000 claims description 2
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims description 2
- 208000022559 Inflammatory bowel disease Diseases 0.000 claims description 2
- 206010049416 Short-bowel syndrome Diseases 0.000 claims description 2
- 210000001035 gastrointestinal tract Anatomy 0.000 claims description 2
- 229910052739 hydrogen Inorganic materials 0.000 claims description 2
- 239000001257 hydrogen Substances 0.000 claims description 2
- 238000013268 sustained release Methods 0.000 claims description 2
- 239000012730 sustained-release form Substances 0.000 claims description 2
- 230000000699 topical effect Effects 0.000 claims description 2
- 230000001823 pruritic effect Effects 0.000 claims 1
- 238000000034 method Methods 0.000 description 7
- 208000003251 Pruritus Diseases 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562151618P | 2015-04-23 | 2015-04-23 | |
| US62/151,618 | 2015-04-23 | ||
| PCT/US2016/029024 WO2016172613A1 (en) | 2015-04-23 | 2016-04-22 | Compounds for treating pruritic conditions |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2018513174A JP2018513174A (ja) | 2018-05-24 |
| JP2018513174A5 true JP2018513174A5 (enExample) | 2019-05-30 |
| JP6744327B2 JP6744327B2 (ja) | 2020-08-19 |
Family
ID=57144302
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017555210A Active JP6744327B2 (ja) | 2015-04-23 | 2016-04-22 | そう痒状態治療用化合物 |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US9624233B2 (enExample) |
| EP (1) | EP3286198B1 (enExample) |
| JP (1) | JP6744327B2 (enExample) |
| AU (1) | AU2016252892B2 (enExample) |
| CA (1) | CA2981625C (enExample) |
| CY (1) | CY1124163T1 (enExample) |
| DK (1) | DK3286198T3 (enExample) |
| ES (1) | ES2867799T3 (enExample) |
| HR (1) | HRP20210606T1 (enExample) |
| HU (1) | HUE054399T2 (enExample) |
| LT (1) | LT3286198T (enExample) |
| PL (1) | PL3286198T3 (enExample) |
| PT (1) | PT3286198T (enExample) |
| SI (1) | SI3286198T1 (enExample) |
| WO (1) | WO2016172613A1 (enExample) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111116597A (zh) * | 2018-10-31 | 2020-05-08 | 扬子江药业集团江苏紫龙药业有限公司 | 一种纳布啡游离碱的制备方法 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4477456A (en) | 1981-07-02 | 1984-10-16 | E. I. Du Pont De Nemours And Company | Octahydro-4A,7-ethano- and -etheno-benzofuro[3,2-e]isoquinoline derivatives having analgesic, narcotic antagonist and anorexigenic properties |
| US7195882B2 (en) * | 2003-06-03 | 2007-03-27 | Roche Diagnostics Operations, Inc. | Monoclonal antibodies specific for buprenorphine and metabolites thereof |
| CA2682125C (en) * | 2007-03-29 | 2015-06-16 | Progenics Pharmaceuticals, Inc. | Peripheral opioid receptor antagonists and uses thereof |
| EP2935278B1 (en) * | 2012-12-19 | 2017-03-15 | Novartis AG | Tricyclic compounds for inhibiting the cftr channel |
-
2016
- 2016-04-22 CA CA2981625A patent/CA2981625C/en active Active
- 2016-04-22 EP EP16784019.8A patent/EP3286198B1/en active Active
- 2016-04-22 WO PCT/US2016/029024 patent/WO2016172613A1/en not_active Ceased
- 2016-04-22 PL PL16784019T patent/PL3286198T3/pl unknown
- 2016-04-22 ES ES16784019T patent/ES2867799T3/es active Active
- 2016-04-22 SI SI201631169T patent/SI3286198T1/sl unknown
- 2016-04-22 DK DK16784019.8T patent/DK3286198T3/da active
- 2016-04-22 LT LTEP16784019.8T patent/LT3286198T/lt unknown
- 2016-04-22 HU HUE16784019A patent/HUE054399T2/hu unknown
- 2016-04-22 PT PT167840198T patent/PT3286198T/pt unknown
- 2016-04-22 AU AU2016252892A patent/AU2016252892B2/en active Active
- 2016-04-22 JP JP2017555210A patent/JP6744327B2/ja active Active
- 2016-04-22 HR HRP20210606TT patent/HRP20210606T1/hr unknown
- 2016-04-22 US US15/136,742 patent/US9624233B2/en active Active
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2021
- 2021-05-18 CY CY20211100427T patent/CY1124163T1/el unknown