JP2018512397A - 癌治療の有効性を高めるための組成物及び方法 - Google Patents
癌治療の有効性を高めるための組成物及び方法 Download PDFInfo
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- JP2018512397A JP2018512397A JP2017547001A JP2017547001A JP2018512397A JP 2018512397 A JP2018512397 A JP 2018512397A JP 2017547001 A JP2017547001 A JP 2017547001A JP 2017547001 A JP2017547001 A JP 2017547001A JP 2018512397 A JP2018512397 A JP 2018512397A
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- tumor
- antibody
- chemotherapy
- ctla4
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/39558—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against tumor tissues, cells, antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
- A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
- A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
- A61K31/7068—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/10—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70578—NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
- C07K16/244—Interleukins [IL]
- C07K16/247—IL-4
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
- C07K16/2818—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against CD28 or CD152
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2878—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
- A61K2039/507—Comprising a combination of two or more separate antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/545—Medicinal preparations containing antigens or antibodies characterised by the dose, timing or administration schedule
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/10—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy
- A61N2005/1092—Details
- A61N2005/1098—Enhancing the effect of the particle by an injected agent or implanted device
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/52—Constant or Fc region; Isotype
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/54—F(ab')2
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/55—Fab or Fab'
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/567—Framework region [FR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/75—Agonist effect on antigen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/12—Pulmonary diseases
- G01N2800/125—Adult respiratory distress syndrome
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Immunology (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Genetics & Genomics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Zoology (AREA)
- Toxicology (AREA)
- Gastroenterology & Hepatology (AREA)
- Cell Biology (AREA)
- Oncology (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Pathology (AREA)
- Radiology & Medical Imaging (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562131562P | 2015-03-11 | 2015-03-11 | |
| US62/131,562 | 2015-03-11 | ||
| PCT/US2016/021486 WO2016145030A1 (en) | 2015-03-11 | 2016-03-09 | Compositions and methods for enhancing the efficacy of cancer therapy |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2018512397A true JP2018512397A (ja) | 2018-05-17 |
| JP2018512397A5 JP2018512397A5 (enExample) | 2019-04-18 |
Family
ID=56880519
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017547001A Pending JP2018512397A (ja) | 2015-03-11 | 2016-03-09 | 癌治療の有効性を高めるための組成物及び方法 |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US20180044428A1 (enExample) |
| EP (1) | EP3268387A4 (enExample) |
| JP (1) | JP2018512397A (enExample) |
| KR (1) | KR20180002597A (enExample) |
| CN (1) | CN107531773A (enExample) |
| AU (1) | AU2016229810A1 (enExample) |
| CA (1) | CA2978318A1 (enExample) |
| HK (1) | HK1247630A1 (enExample) |
| IL (1) | IL254103A0 (enExample) |
| RU (1) | RU2017134104A (enExample) |
| SG (1) | SG11201706958SA (enExample) |
| WO (1) | WO2016145030A1 (enExample) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2022511096A (ja) * | 2018-12-08 | 2022-01-28 | ボード オブ リージェンツ,ザ ユニバーシティ オブ テキサス システム | がんおよび他の疾患の診断および処置のための腫瘍促進がん関連線維芽細胞の同定および標的化 |
| JP2023525140A (ja) * | 2020-05-13 | 2023-06-14 | アンセルム(アンスティチュート・ナシオナル・ドゥ・ラ・サンテ・エ・ドゥ・ラ・ルシェルシュ・メディカル) | Ox40活性化特性を有する組換えタンパク質 |
| US12473598B2 (en) | 2018-03-28 | 2025-11-18 | Board Of Regents, The University Of Texas System | Identification of epigenetic alterations in DNA isolated from exosomes |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MY189692A (en) | 2015-05-07 | 2022-02-26 | Memorial Sloan Kettering Cancer Center | Anti-ox40 antibodies and methods of use thereof |
| US20160347848A1 (en) * | 2015-05-28 | 2016-12-01 | Medimmune Limited | Therapeutic combinations and methods for treating neoplasia |
| WO2017021913A1 (en) * | 2015-08-04 | 2017-02-09 | Glaxosmithkline Intellectual Property Development Limited | Combination treatments and uses and methods thereof |
| IL299072A (en) | 2015-12-02 | 2023-02-01 | Memorial Sloan Kettering Cancer Center | Antibodies and methods of use thereof |
| CA3041340A1 (en) | 2016-11-09 | 2018-05-17 | Agenus Inc. | Anti-ox40 antibodies, anti-gitr antibodies, and methods of use thereof |
| EP3582855A1 (en) * | 2017-02-15 | 2019-12-25 | GlaxoSmithKline Intellectual Property Development Limited | Combination treatment for cancer |
| CN112007149A (zh) * | 2019-05-29 | 2020-12-01 | 思格(苏州)生物科技有限公司 | 一种新型复合免疫佐剂及其应用 |
| WO2021062332A1 (en) * | 2019-09-27 | 2021-04-01 | Icahn School Of Medicine At Mount Sinai | Combination of inhibitors of il4 signaling and immune checkpoints for treating cancer |
| WO2021098851A1 (en) * | 2019-11-20 | 2021-05-27 | Eucure (Beijing) Biopharma Co., Ltd | Anti-ctla4/ox40 bispecific antibodies and uses thereof |
| US20230002499A1 (en) * | 2019-11-21 | 2023-01-05 | Beigene (Beijing) Co., Ltd. | Methods of cancer treatment with anti-ox40 antibody in combination with chemotherapeutic agents |
| CN113045655A (zh) * | 2019-12-27 | 2021-06-29 | 高诚生物医药(香港)有限公司 | 抗ox40抗体及其用途 |
| EP4448111A1 (en) * | 2021-12-15 | 2024-10-23 | Board of Regents, The University of Texas System | Methods and compositions for altering a tumor microbiome |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2012533619A (ja) * | 2009-07-20 | 2012-12-27 | ブリストル−マイヤーズ スクイブ カンパニー | 増殖性疾患の相乗的処置のための抗ctla4抗体と多様な治療レジメンとの組み合わせ |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2007107349A1 (en) * | 2006-03-22 | 2007-09-27 | Apogenix Gmbh | Antibody specific for human il-4 for the treament of cancer |
| EP2007423A2 (en) * | 2006-04-05 | 2008-12-31 | Pfizer Products Incorporated | Ctla4 antibody combination therapy |
| MX2009009194A (es) * | 2007-02-27 | 2009-10-08 | Genentech Inc | Anticuerpos ox40 antagonistas y su uso en el tratamiento de enfermedades inflamatorias y autoinmunes. |
| WO2010014784A2 (en) * | 2008-08-01 | 2010-02-04 | Bristol-Myers Squibb Company | Combination of anti-ctla4 antibody with diverse therapeutic regimens for the synergistic treatment of proliferative diseases |
| WO2011146382A1 (en) * | 2010-05-17 | 2011-11-24 | Bristol-Myers Squibb Company | Improved immunotherapeutic dosing regimens and combinations thereof |
| GB201116092D0 (en) * | 2011-09-16 | 2011-11-02 | Bioceros B V | Antibodies and uses thereof |
| WO2013114367A2 (en) * | 2012-02-01 | 2013-08-08 | Compugen Ltd. | C10rf32 antibodies, and uses thereof for treatment of cancer |
| WO2017134292A1 (en) * | 2016-02-04 | 2017-08-10 | Glenmark Pharmaceuticals S.A. | Anti-ox40 antagonistic antibodies for the treatment of atopic dermatitis |
-
2016
- 2016-03-09 WO PCT/US2016/021486 patent/WO2016145030A1/en not_active Ceased
- 2016-03-09 CA CA2978318A patent/CA2978318A1/en not_active Abandoned
- 2016-03-09 EP EP16762392.5A patent/EP3268387A4/en not_active Withdrawn
- 2016-03-09 AU AU2016229810A patent/AU2016229810A1/en not_active Abandoned
- 2016-03-09 SG SG11201706958SA patent/SG11201706958SA/en unknown
- 2016-03-09 HK HK18107203.8A patent/HK1247630A1/zh unknown
- 2016-03-09 JP JP2017547001A patent/JP2018512397A/ja active Pending
- 2016-03-09 US US15/556,864 patent/US20180044428A1/en not_active Abandoned
- 2016-03-09 CN CN201680014559.7A patent/CN107531773A/zh active Pending
- 2016-03-09 KR KR1020177025629A patent/KR20180002597A/ko not_active Withdrawn
- 2016-03-09 RU RU2017134104A patent/RU2017134104A/ru not_active Application Discontinuation
-
2017
- 2017-08-22 IL IL254103A patent/IL254103A0/en unknown
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2012533619A (ja) * | 2009-07-20 | 2012-12-27 | ブリストル−マイヤーズ スクイブ カンパニー | 増殖性疾患の相乗的処置のための抗ctla4抗体と多様な治療レジメンとの組み合わせ |
Non-Patent Citations (11)
| Title |
|---|
| DEWAN MZ ET AL.: "Fractionated but not single-dose radiotherapy induces an immune-mediated abscopal effect when combin", CLINICAL CANCER RESEARCH, vol. 15, no. 17, JPN6020013296, 1 September 2009 (2009-09-01), pages 5379 - 5388, ISSN: 0004249595 * |
| FRIEDMAN DJ ET AL.: "Preparative immunotherapy with anti-OX40 and anti-CTLA4 improves the response to chemotherapy", JOURNAL FOR IMMUNOTHERAPY OF CANCER, vol. Vol.2, Suppl.3, JPN6020013291, 2014, pages 207, ISSN: 0004399463 * |
| GOUGH MJ ET AL.: "Adjuvant therapy with agonistic antibodies to CD134 (OX40) increases local control after surgical or", JOURNAL OF IMMUNOTHERAPY, vol. 33, no. 8, JPN6020013302, October 2010 (2010-10-01), pages 798 - 809, ISSN: 0004249598 * |
| HIRSCHHORN-CYMERMAN D ET AL.: "OX40 engagement and chemotherapy combination provides potent antitumor immunity with concomitant reg", THE JOURNAL OF EXPERIMENTAL MEDICINE, vol. 206, no. 5, JPN6020013299, 11 May 2009 (2009-05-11), pages 1103 - 1116, ISSN: 0004399466 * |
| JURE-KUNKEL M ET AL.: "Synergy between chemotherapeutic agents and CTLA-4 blockade in preclinical tumor models", CANCER IMMUNOLOGY, IMMUNOTHERAPY, vol. 62, no. 9, JPN6020013293, 2013, pages 1533 - 1545, ISSN: 0004399464 * |
| PICONESE S ET AL.: "OX40 triggering blocks suppression by regulatory T cells and facilitates tumor rejection", THE JOURNAL OF EXPERIMENTAL MEDICINE, vol. 205, no. 4, JPN6020013306, 14 April 2008 (2008-04-14), pages 825 - 839, ISSN: 0004249600 * |
| REDMOND WL ET AL.: "Combined targeting of costimulatory (OX40) and coinhibitory (CTLA-4) pathways elicits potent effecto", CANCER IMMUNOLOGY RESEARCH, vol. 2, no. 2, JPN6020013297, February 2014 (2014-02-01), pages 142 - 153, ISSN: 0004399465 * |
| SADUN RE ET AL.: "Fc-mOX40L fusion protein produces complete remission and enhanced survival in 2 murine tumor models", JOURNAL OF IMMUNOTHERAPY, vol. 31, no. 3, JPN6020013308, April 2008 (2008-04-01), pages 235 - 245, ISSN: 0004249601 * |
| YOKOUCHI H ET AL.: "Anti-OX40 monoclonal antibody therapy in combination with radiotherapy results in therapeutic antitu", CANCER SCIENCE, vol. 99, no. 2, JPN6020013304, February 2008 (2008-02-01), pages 361 - 367, ISSN: 0004249599 * |
| がんの冊子 各種がんシリーズ 大腸がん[ONLINE], vol. 第2版, JPN6020013311, March 2012 (2012-03-01), ISSN: 0004249602 * |
| 松島 綱治 ほか: "腫瘍会合性マクロファージ", 実験医学, vol. 第31巻,第12号, JPN6020013312, 2013, pages 1872 - 1876, ISSN: 0004249603 * |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US12473598B2 (en) | 2018-03-28 | 2025-11-18 | Board Of Regents, The University Of Texas System | Identification of epigenetic alterations in DNA isolated from exosomes |
| JP2022511096A (ja) * | 2018-12-08 | 2022-01-28 | ボード オブ リージェンツ,ザ ユニバーシティ オブ テキサス システム | がんおよび他の疾患の診断および処置のための腫瘍促進がん関連線維芽細胞の同定および標的化 |
| JP2023525140A (ja) * | 2020-05-13 | 2023-06-14 | アンセルム(アンスティチュート・ナシオナル・ドゥ・ラ・サンテ・エ・ドゥ・ラ・ルシェルシュ・メディカル) | Ox40活性化特性を有する組換えタンパク質 |
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| Publication number | Publication date |
|---|---|
| EP3268387A1 (en) | 2018-01-17 |
| KR20180002597A (ko) | 2018-01-08 |
| EP3268387A4 (en) | 2018-10-10 |
| CN107531773A (zh) | 2018-01-02 |
| US20180044428A1 (en) | 2018-02-15 |
| AU2016229810A1 (en) | 2017-09-14 |
| WO2016145030A1 (en) | 2016-09-15 |
| RU2017134104A (ru) | 2019-04-03 |
| RU2017134104A3 (enExample) | 2019-08-30 |
| HK1247630A1 (zh) | 2018-09-28 |
| CA2978318A1 (en) | 2016-09-15 |
| IL254103A0 (en) | 2017-10-31 |
| SG11201706958SA (en) | 2017-09-28 |
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