JP2018512160A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2018512160A5 JP2018512160A5 JP2017553970A JP2017553970A JP2018512160A5 JP 2018512160 A5 JP2018512160 A5 JP 2018512160A5 JP 2017553970 A JP2017553970 A JP 2017553970A JP 2017553970 A JP2017553970 A JP 2017553970A JP 2018512160 A5 JP2018512160 A5 JP 2018512160A5
- Authority
- JP
- Japan
- Prior art keywords
- sample
- biomarkers
- classifier biomarkers
- item
- subtype
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000000090 biomarker Substances 0.000 claims description 194
- 238000000034 method Methods 0.000 claims description 102
- 230000014509 gene expression Effects 0.000 claims description 51
- 238000009396 hybridization Methods 0.000 claims description 43
- 208000009956 adenocarcinoma Diseases 0.000 claims description 17
- 210000004072 lung Anatomy 0.000 claims description 13
- 206010058467 Lung neoplasm malignant Diseases 0.000 claims description 12
- 238000010240 RT-PCR analysis Methods 0.000 claims description 12
- 201000005202 lung cancer Diseases 0.000 claims description 12
- 208000020816 lung neoplasm Diseases 0.000 claims description 12
- 201000002120 neuroendocrine carcinoma Diseases 0.000 claims description 12
- 206010041823 squamous cell carcinoma Diseases 0.000 claims description 12
- 108020004707 nucleic acids Proteins 0.000 claims description 11
- 150000007523 nucleic acids Chemical class 0.000 claims description 11
- 102000039446 nucleic acids Human genes 0.000 claims description 11
- 108091034117 Oligonucleotide Proteins 0.000 claims description 10
- JLCPHMBAVCMARE-UHFFFAOYSA-N [3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-hydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methyl [5-(6-aminopurin-9-yl)-2-(hydroxymethyl)oxolan-3-yl] hydrogen phosphate Polymers Cc1cn(C2CC(OP(O)(=O)OCC3OC(CC3OP(O)(=O)OCC3OC(CC3O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c3nc(N)[nH]c4=O)C(COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3CO)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cc(C)c(=O)[nH]c3=O)n3cc(C)c(=O)[nH]c3=O)n3ccc(N)nc3=O)n3cc(C)c(=O)[nH]c3=O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)O2)c(=O)[nH]c1=O JLCPHMBAVCMARE-UHFFFAOYSA-N 0.000 claims description 10
- 238000004458 analytical method Methods 0.000 claims description 10
- 230000000295 complement effect Effects 0.000 claims description 9
- WSFSSNUMVMOOMR-UHFFFAOYSA-N Formaldehyde Chemical compound O=C WSFSSNUMVMOOMR-UHFFFAOYSA-N 0.000 claims description 8
- 201000010099 disease Diseases 0.000 claims description 8
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 8
- 238000012896 Statistical algorithm Methods 0.000 claims description 6
- 238000010195 expression analysis Methods 0.000 claims description 5
- 239000012188 paraffin wax Substances 0.000 claims description 5
- 230000000877 morphologic effect Effects 0.000 claims description 4
- 238000003559 RNA-seq method Methods 0.000 claims description 3
- 201000009030 Carcinoma Diseases 0.000 claims description 2
- 208000002458 carcinoid tumor Diseases 0.000 claims description 2
- 208000000649 small cell carcinoma Diseases 0.000 claims description 2
- 230000004083 survival effect Effects 0.000 claims description 2
- 238000004519 manufacturing process Methods 0.000 claims 1
- 230000000955 neuroendocrine Effects 0.000 claims 1
- 239000000523 sample Substances 0.000 description 58
- 230000002757 inflammatory effect Effects 0.000 description 7
- 230000002062 proliferating effect Effects 0.000 description 7
- 230000000241 respiratory effect Effects 0.000 description 7
- 239000002299 complementary DNA Substances 0.000 description 5
- 108020004999 messenger RNA Proteins 0.000 description 2
- 238000003556 assay Methods 0.000 description 1
- 239000012520 frozen sample Substances 0.000 description 1
- 210000005265 lung cell Anatomy 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562147547P | 2015-04-14 | 2015-04-14 | |
| US62/147,547 | 2015-04-14 | ||
| PCT/US2016/027503 WO2016168446A1 (en) | 2015-04-14 | 2016-04-14 | Methods for typing of lung cancer |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2018512160A JP2018512160A (ja) | 2018-05-17 |
| JP2018512160A5 true JP2018512160A5 (enExample) | 2019-05-23 |
Family
ID=57126370
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017553970A Pending JP2018512160A (ja) | 2015-04-14 | 2016-04-14 | 肺がんのタイピングのための方法 |
Country Status (6)
| Country | Link |
|---|---|
| US (4) | US20190203296A1 (enExample) |
| EP (1) | EP3283654A4 (enExample) |
| JP (1) | JP2018512160A (enExample) |
| CN (1) | CN107849613A (enExample) |
| CA (1) | CA2982775A1 (enExample) |
| WO (1) | WO2016168446A1 (enExample) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3149209B1 (en) * | 2014-05-30 | 2021-02-17 | Genecentric Therapeutics, Inc. | Methods for typing of lung cancer |
| US11514289B1 (en) * | 2016-03-09 | 2022-11-29 | Freenome Holdings, Inc. | Generating machine learning models using genetic data |
| CA3024744A1 (en) | 2016-05-17 | 2017-11-23 | Genecentric Therapeutics, Inc. | Methods for subtyping of lung squamous cell carcinoma |
| US10934595B2 (en) | 2016-05-17 | 2021-03-02 | Genecentric Therapeutics, Inc. | Methods for subtyping of lung adenocarcinoma |
| CN109182526A (zh) * | 2018-10-10 | 2019-01-11 | 杭州翱锐生物科技有限公司 | 用于早期肝癌辅助诊断的试剂盒及其检测方法 |
| US20240336972A1 (en) * | 2021-07-30 | 2024-10-10 | Oregon Health & Science University | Methods for selecting melanoma patients for therapy and methods of reducing or preventing melanoma metastasis |
| CN116403648B (zh) * | 2023-06-06 | 2023-08-01 | 中国医学科学院肿瘤医院 | 一种基于多维分析建立的小细胞肺癌免疫新分型方法 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2002343443A1 (en) * | 2001-09-28 | 2003-04-14 | Whitehead Institute For Biomedical Research | Classification of lung carcinomas using gene expression analysis |
| TW200413725A (en) * | 2002-09-30 | 2004-08-01 | Oncotherapy Science Inc | Method for diagnosing non-small cell lung cancers |
| US20060024692A1 (en) * | 2002-09-30 | 2006-02-02 | Oncotherapy Science, Inc. | Method for diagnosing non-small cell lung cancers |
| WO2008151110A2 (en) * | 2007-06-01 | 2008-12-11 | The University Of North Carolina At Chapel Hill | Molecular diagnosis and typing of lung cancer variants |
| CN101509035A (zh) * | 2008-09-05 | 2009-08-19 | 中国人民解放军总医院 | 肺癌分型的基因序列及其应用 |
| EP3149209B1 (en) * | 2014-05-30 | 2021-02-17 | Genecentric Therapeutics, Inc. | Methods for typing of lung cancer |
-
2016
- 2016-04-14 CN CN201680034117.9A patent/CN107849613A/zh active Pending
- 2016-04-14 EP EP16780736.1A patent/EP3283654A4/en not_active Withdrawn
- 2016-04-14 US US15/566,363 patent/US20190203296A1/en not_active Abandoned
- 2016-04-14 CA CA2982775A patent/CA2982775A1/en not_active Abandoned
- 2016-04-14 WO PCT/US2016/027503 patent/WO2016168446A1/en not_active Ceased
- 2016-04-14 JP JP2017553970A patent/JP2018512160A/ja active Pending
-
2021
- 2021-01-08 US US17/144,644 patent/US20210147948A1/en not_active Abandoned
- 2021-09-10 US US17/471,716 patent/US20220002820A1/en not_active Abandoned
-
2022
- 2022-04-21 US US17/725,936 patent/US20220243283A1/en not_active Abandoned
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2018512160A5 (enExample) | ||
| ES2741745T3 (es) | Método para usar la expresión génica para determinar el pronóstico de cáncer de próstata | |
| JP5486717B2 (ja) | 結腸直腸癌の予後のための遺伝子発現マーカー | |
| KR101579934B1 (ko) | 직장결장암용 예후 예측 | |
| US20140113978A1 (en) | Multifocal hepatocellular carcinoma microrna expression patterns and uses thereof | |
| KR20140105836A (ko) | 다유전자 바이오마커의 확인 | |
| JP2019527544A (ja) | 分子マーカー、参照遺伝子、及びその応用、検出キット、並びに検出モデルの構築方法 | |
| CN106148529B (zh) | 与胃癌相关的LncRNA标记物及其专用检测引物、检测方法、试剂盒与应用 | |
| WO2015073949A1 (en) | Method of subtyping high-grade bladder cancer and uses thereof | |
| JP2017516501A5 (enExample) | ||
| EP2982986B1 (en) | Method for manufacturing gastric cancer prognosis prediction model | |
| JP2017521051A (ja) | 甲状腺腫瘍の分類におけるmiRNA発現シグネチャー | |
| AU2016263590A1 (en) | Methods and compositions for diagnosing or detecting lung cancers | |
| WO2010101916A1 (en) | Methods for predicting cancer response to egfr inhibitors | |
| WO2010029440A1 (en) | Molecular classifier for evaluating the risk of metastasic relapse in breast cancer | |
| WO2020124350A1 (en) | Prediction of hcv-related hcc recurrence by exosomal lnc-dancr levels | |
| WO2014089055A1 (en) | Tivozanib response prediction | |
| JP7045527B2 (ja) | 肝機能障害の予測のためのマイクロrnaシグネチャ | |
| CN107299129B (zh) | 循环核酸作为乳腺癌生物标志物的应用 | |
| RU2012121874A (ru) | Диагностические способы для определения прогноза немелкоклеточного рака легкого | |
| JP2010523134A (ja) | Egfr/csf−1/caix発現に基づき非小細胞肺癌の化学療法計画および生存余命を決定する方法 | |
| TWI615472B (zh) | 預測乳癌復發之基因標記及方法 | |
| AU2019220440A1 (en) | Patient classification and prognostic method | |
| KR101504818B1 (ko) | 위암에 대한 예후 예측 시스템 | |
| CN114901836A (zh) | 肝移植的临床和分子预后标志物 |