CN107849613A - 用于肺癌分型的方法 - Google Patents

用于肺癌分型的方法 Download PDF

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Publication number
CN107849613A
CN107849613A CN201680034117.9A CN201680034117A CN107849613A CN 107849613 A CN107849613 A CN 107849613A CN 201680034117 A CN201680034117 A CN 201680034117A CN 107849613 A CN107849613 A CN 107849613A
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CN
China
Prior art keywords
biomarkers
classifier
classifier biomarkers
sample
hybridization
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN201680034117.9A
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English (en)
Chinese (zh)
Inventor
H·法鲁基
M·莱戈德曼
G·梅休
C·佩罗
D·N·海耶斯
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Gene Center Therapeutics Inc
University of North Carolina at Chapel Hill
Original Assignee
Gene Center Therapeutics Inc
University of North Carolina at Chapel Hill
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Application filed by Gene Center Therapeutics Inc, University of North Carolina at Chapel Hill filed Critical Gene Center Therapeutics Inc
Publication of CN107849613A publication Critical patent/CN107849613A/zh
Pending legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/112—Disease subtyping, staging or classification
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/118—Prognosis of disease development
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/158—Expression markers

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  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Analytical Chemistry (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Physics & Mathematics (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Hospice & Palliative Care (AREA)
  • Biophysics (AREA)
  • Oncology (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
CN201680034117.9A 2015-04-14 2016-04-14 用于肺癌分型的方法 Pending CN107849613A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201562147547P 2015-04-14 2015-04-14
US62/147,547 2015-04-14
PCT/US2016/027503 WO2016168446A1 (en) 2015-04-14 2016-04-14 Methods for typing of lung cancer

Publications (1)

Publication Number Publication Date
CN107849613A true CN107849613A (zh) 2018-03-27

Family

ID=57126370

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201680034117.9A Pending CN107849613A (zh) 2015-04-14 2016-04-14 用于肺癌分型的方法

Country Status (6)

Country Link
US (4) US20190203296A1 (enExample)
EP (1) EP3283654A4 (enExample)
JP (1) JP2018512160A (enExample)
CN (1) CN107849613A (enExample)
CA (1) CA2982775A1 (enExample)
WO (1) WO2016168446A1 (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN116403648A (zh) * 2023-06-06 2023-07-07 中国医学科学院肿瘤医院 一种基于多维分析建立的小细胞肺癌免疫新分型方法

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3149209B1 (en) * 2014-05-30 2021-02-17 Genecentric Therapeutics, Inc. Methods for typing of lung cancer
US11514289B1 (en) * 2016-03-09 2022-11-29 Freenome Holdings, Inc. Generating machine learning models using genetic data
CA3024744A1 (en) 2016-05-17 2017-11-23 Genecentric Therapeutics, Inc. Methods for subtyping of lung squamous cell carcinoma
EP3458612B1 (en) 2016-05-17 2023-11-15 Genecentric Therapeutics, Inc. Methods for subtyping of lung adenocarcinoma
CN109182526A (zh) * 2018-10-10 2019-01-11 杭州翱锐生物科技有限公司 用于早期肝癌辅助诊断的试剂盒及其检测方法
WO2023009173A1 (en) * 2021-07-30 2023-02-02 Oregon Health & Science University Methods for selecting melanoma patients for therapy and methods of reducing or preventing melanoma metastasis

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101509035A (zh) * 2008-09-05 2009-08-19 中国人民解放军总医院 肺癌分型的基因序列及其应用
US20100233695A1 (en) * 2007-06-01 2010-09-16 University Of North Carolina At Chapel Hill Molecular diagnosis and typing of lung cancer variants

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1444361A4 (en) * 2001-09-28 2006-12-27 Whitehead Biomedical Inst CLASSIFICATION OF PULMONARY CARCINOMAS BY ANALYSIS OF GENE EXPRESSION
TW200413725A (en) * 2002-09-30 2004-08-01 Oncotherapy Science Inc Method for diagnosing non-small cell lung cancers
US20060024692A1 (en) * 2002-09-30 2006-02-02 Oncotherapy Science, Inc. Method for diagnosing non-small cell lung cancers
EP3149209B1 (en) * 2014-05-30 2021-02-17 Genecentric Therapeutics, Inc. Methods for typing of lung cancer

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20100233695A1 (en) * 2007-06-01 2010-09-16 University Of North Carolina At Chapel Hill Molecular diagnosis and typing of lung cancer variants
CN101509035A (zh) * 2008-09-05 2009-08-19 中国人民解放军总医院 肺癌分型的基因序列及其应用

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
EUNG-SIRK LEE等: "Prediction of recurrence-free survival in postoperative non-small cell lung cancer patients by using an integrated model of clinical information and gene expression", 《CLIN CANCER RES》 *
MATTHEW D. WILKERSON等: "Prediction of Lung Cancer Histological Types by RT-qPCR Gene Expression in FFPE Specimens", 《THE JOURNAL OF MOLECULAR DIAGNOSTICS》 *

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN116403648A (zh) * 2023-06-06 2023-07-07 中国医学科学院肿瘤医院 一种基于多维分析建立的小细胞肺癌免疫新分型方法
CN116403648B (zh) * 2023-06-06 2023-08-01 中国医学科学院肿瘤医院 一种基于多维分析建立的小细胞肺癌免疫新分型方法

Also Published As

Publication number Publication date
US20220002820A1 (en) 2022-01-06
US20220243283A1 (en) 2022-08-04
EP3283654A4 (en) 2018-12-12
CA2982775A1 (en) 2016-10-20
US20190203296A1 (en) 2019-07-04
EP3283654A1 (en) 2018-02-21
WO2016168446A1 (en) 2016-10-20
JP2018512160A (ja) 2018-05-17
US20210147948A1 (en) 2021-05-20

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Application publication date: 20180327