JP2017516501A5 - - Google Patents
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- JP2017516501A5 JP2017516501A5 JP2017515878A JP2017515878A JP2017516501A5 JP 2017516501 A5 JP2017516501 A5 JP 2017516501A5 JP 2017515878 A JP2017515878 A JP 2017515878A JP 2017515878 A JP2017515878 A JP 2017515878A JP 2017516501 A5 JP2017516501 A5 JP 2017516501A5
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- JP
- Japan
- Prior art keywords
- hybridization
- classifier biomarkers
- biomarkers
- classifier
- sample
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 239000000090 biomarker Substances 0.000 claims description 94
- 238000009396 hybridization Methods 0.000 claims description 33
- 239000000523 sample Substances 0.000 claims description 33
- 206010058467 Lung neoplasm malignant Diseases 0.000 claims description 12
- 201000005202 lung cancer Diseases 0.000 claims description 12
- 208000020816 lung neoplasm Diseases 0.000 claims description 12
- 108091034117 Oligonucleotide Proteins 0.000 claims description 9
- JLCPHMBAVCMARE-UHFFFAOYSA-N [3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-hydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methyl [5-(6-aminopurin-9-yl)-2-(hydroxymethyl)oxolan-3-yl] hydrogen phosphate Polymers Cc1cn(C2CC(OP(O)(=O)OCC3OC(CC3OP(O)(=O)OCC3OC(CC3O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c3nc(N)[nH]c4=O)C(COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3CO)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cc(C)c(=O)[nH]c3=O)n3cc(C)c(=O)[nH]c3=O)n3ccc(N)nc3=O)n3cc(C)c(=O)[nH]c3=O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)O2)c(=O)[nH]c1=O JLCPHMBAVCMARE-UHFFFAOYSA-N 0.000 claims description 9
- 208000009956 adenocarcinoma Diseases 0.000 claims description 9
- 206010041823 squamous cell carcinoma Diseases 0.000 claims description 9
- 108020004707 nucleic acids Proteins 0.000 claims description 8
- 150000007523 nucleic acids Chemical class 0.000 claims description 8
- 102000039446 nucleic acids Human genes 0.000 claims description 8
- 208000002458 carcinoid tumor Diseases 0.000 claims description 7
- 210000004072 lung Anatomy 0.000 claims description 7
- 208000000649 small cell carcinoma Diseases 0.000 claims description 7
- 230000000955 neuroendocrine Effects 0.000 claims description 6
- WSFSSNUMVMOOMR-UHFFFAOYSA-N Formaldehyde Chemical group O=C WSFSSNUMVMOOMR-UHFFFAOYSA-N 0.000 claims description 4
- 230000000295 complement effect Effects 0.000 claims description 3
- 239000012188 paraffin wax Substances 0.000 claims description 3
- 238000003556 assay Methods 0.000 claims 3
- 239000003814 drug Substances 0.000 claims 3
- 239000013074 reference sample Substances 0.000 claims 3
- 229940124597 therapeutic agent Drugs 0.000 claims 3
- 230000003321 amplification Effects 0.000 claims 2
- 239000003153 chemical reaction reagent Substances 0.000 claims 2
- 238000003199 nucleic acid amplification method Methods 0.000 claims 2
- VEEGZPWAAPPXRB-BJMVGYQFSA-N (3e)-3-(1h-imidazol-5-ylmethylidene)-1h-indol-2-one Chemical compound O=C1NC2=CC=CC=C2\C1=C/C1=CN=CN1 VEEGZPWAAPPXRB-BJMVGYQFSA-N 0.000 claims 1
- 239000003155 DNA primer Substances 0.000 claims 1
- 108020004711 Nucleic Acid Probes Proteins 0.000 claims 1
- 238000011529 RT qPCR Methods 0.000 claims 1
- 239000004037 angiogenesis inhibitor Substances 0.000 claims 1
- 229940121369 angiogenesis inhibitor Drugs 0.000 claims 1
- 239000002246 antineoplastic agent Substances 0.000 claims 1
- 229940127089 cytotoxic agent Drugs 0.000 claims 1
- 238000001514 detection method Methods 0.000 claims 1
- 239000002853 nucleic acid probe Substances 0.000 claims 1
- 239000013615 primer Substances 0.000 claims 1
- 238000012163 sequencing technique Methods 0.000 claims 1
- 238000000034 method Methods 0.000 description 32
- 239000002299 complementary DNA Substances 0.000 description 3
- 239000012520 frozen sample Substances 0.000 description 1
- 210000005265 lung cell Anatomy 0.000 description 1
- 108020004999 messenger RNA Proteins 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201462005229P | 2014-05-30 | 2014-05-30 | |
| US62/005,229 | 2014-05-30 | ||
| PCT/US2015/033611 WO2015184461A1 (en) | 2014-05-30 | 2015-06-01 | Methods for typing of lung cancer |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2017516501A JP2017516501A (ja) | 2017-06-22 |
| JP2017516501A5 true JP2017516501A5 (enExample) | 2018-07-12 |
Family
ID=54699976
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017515878A Pending JP2017516501A (ja) | 2014-05-30 | 2015-06-01 | 肺がんのタイピング法 |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US10829819B2 (enExample) |
| EP (1) | EP3149209B1 (enExample) |
| JP (1) | JP2017516501A (enExample) |
| CN (1) | CN107208131A (enExample) |
| CA (1) | CA2950623A1 (enExample) |
| WO (1) | WO2015184461A1 (enExample) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2016168446A1 (en) * | 2015-04-14 | 2016-10-20 | Genecentric Diagnostics, Inc. | Methods for typing of lung cancer |
| EP3458612B1 (en) | 2016-05-17 | 2023-11-15 | Genecentric Therapeutics, Inc. | Methods for subtyping of lung adenocarcinoma |
| CN109863251B (zh) | 2016-05-17 | 2022-11-18 | 基因中心治疗公司 | 对肺鳞状细胞癌亚型分型的方法 |
| WO2020076897A1 (en) * | 2018-10-09 | 2020-04-16 | Genecentric Therapeutics, Inc. | Detecting cancer cell of origin |
| CN112375826B (zh) * | 2020-12-03 | 2021-08-27 | 远见生物科技（上海）有限公司 | 一种鉴别非小细胞肺癌亚型的环状rna组合物标志物及其应用 |
| CN113186287B (zh) * | 2021-05-10 | 2023-03-24 | 深圳康华君泰生物科技有限公司 | 用于非小细胞肺癌分型的生物标志物及其应用 |
| CN115851927A (zh) * | 2022-08-09 | 2023-03-28 | 上海善准医疗科技有限公司 | 肺鳞癌分子分型及生存风险基因群及诊断产品和应用 |
Family Cites Families (29)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4843155A (en) | 1987-11-19 | 1989-06-27 | Piotr Chomczynski | Product and process for isolating RNA |
| US6040138A (en) | 1995-09-15 | 2000-03-21 | Affymetrix, Inc. | Expression monitoring by hybridization to high density oligonucleotide arrays |
| US5143854A (en) | 1989-06-07 | 1992-09-01 | Affymax Technologies N.V. | Large scale photolithographic solid phase synthesis of polypeptides and receptor binding screening thereof |
| US5800992A (en) | 1989-06-07 | 1998-09-01 | Fodor; Stephen P.A. | Method of detecting nucleic acids |
| US5744101A (en) | 1989-06-07 | 1998-04-28 | Affymax Technologies N.V. | Photolabile nucleoside protecting groups |
| AU669489B2 (en) | 1991-09-18 | 1996-06-13 | Affymax Technologies N.V. | Method of synthesizing diverse collections of oligomers |
| EP0916396B1 (en) | 1991-11-22 | 2005-04-13 | Affymetrix, Inc. (a Delaware Corporation) | Combinatorial strategies for polymer synthesis |
| US5384261A (en) | 1991-11-22 | 1995-01-24 | Affymax Technologies N.V. | Very large scale immobilized polymer synthesis using mechanically directed flow paths |
| US5556752A (en) | 1994-10-24 | 1996-09-17 | Affymetrix, Inc. | Surface-bound, unimolecular, double-stranded DNA |
| US5545531A (en) | 1995-06-07 | 1996-08-13 | Affymax Technologies N.V. | Methods for making a device for concurrently processing multiple biological chip assays |
| US5856174A (en) | 1995-06-29 | 1999-01-05 | Affymetrix, Inc. | Integrated nucleic acid diagnostic device |
| EP0880598A4 (en) | 1996-01-23 | 2005-02-23 | Affymetrix Inc | RAPID EVALUATION OF NUCLEIC ACID ABUNDANCE DIFFERENCE, WITH A HIGH-DENSITY OLIGONUCLEOTIDE SYSTEM |
| WO1999023254A1 (en) | 1997-10-31 | 1999-05-14 | Affymetrix, Inc. | Expression profiles in adult and fetal organs |
| US6020135A (en) | 1998-03-27 | 2000-02-01 | Affymetrix, Inc. | P53-regulated genes |
| WO2002040716A2 (en) * | 2000-11-16 | 2002-05-23 | Cemines, Llc | Profiling tumor specific markers for the diagnosis and treatment of neoplastic disease |
| US7473767B2 (en) | 2001-07-03 | 2009-01-06 | The Institute For Systems Biology | Methods for detection and quantification of analytes in complex mixtures |
| US20040009489A1 (en) * | 2001-09-28 | 2004-01-15 | Golub Todd R. | Classification of lung carcinomas using gene expression analysis |
| US7955800B2 (en) * | 2002-06-25 | 2011-06-07 | Advpharma Inc. | Metastasis-associated gene profiling for identification of tumor tissue, subtyping, and prediction of prognosis of patients |
| TW200413725A (en) | 2002-09-30 | 2004-08-01 | Oncotherapy Science Inc | Method for diagnosing non-small cell lung cancers |
| US20060024692A1 (en) | 2002-09-30 | 2006-02-02 | Oncotherapy Science, Inc. | Method for diagnosing non-small cell lung cancers |
| WO2008021115A2 (en) * | 2006-08-14 | 2008-02-21 | The Brigham And Women's Hospital, Inc. | Diagnostic tests using gene expression ratios |
| US8822153B2 (en) * | 2007-06-01 | 2014-09-02 | The University Of North Carolina At Chapel Hill | Molecular diagnosis and typing of lung cancer variants |
| CN101914542B (zh) * | 2009-04-28 | 2013-03-06 | 中国科学院化学研究所 | 用于不同亚型非小细胞肺癌分型的一种核酸适体及其筛选方法 |
| EP2691545B1 (en) * | 2011-03-28 | 2017-06-14 | Rosetta Genomics Ltd | Methods for lung cancer classification |
| WO2013172926A1 (en) | 2012-05-14 | 2013-11-21 | Yale University | Immune biomarkers and assays predictive of clinical response to immunotherapy for cancer |
| WO2013190090A1 (en) * | 2012-06-21 | 2013-12-27 | Philip Morris Products S.A. | Gene signatures for classifying and grading lung cancer |
| WO2016168446A1 (en) * | 2015-04-14 | 2016-10-20 | Genecentric Diagnostics, Inc. | Methods for typing of lung cancer |
| EP3458612B1 (en) | 2016-05-17 | 2023-11-15 | Genecentric Therapeutics, Inc. | Methods for subtyping of lung adenocarcinoma |
| CN109863251B (zh) | 2016-05-17 | 2022-11-18 | 基因中心治疗公司 | 对肺鳞状细胞癌亚型分型的方法 |
-
2015
- 2015-06-01 CN CN201580039130.9A patent/CN107208131A/zh active Pending
- 2015-06-01 JP JP2017515878A patent/JP2017516501A/ja active Pending
- 2015-06-01 WO PCT/US2015/033611 patent/WO2015184461A1/en not_active Ceased
- 2015-06-01 EP EP15800445.7A patent/EP3149209B1/en active Active
- 2015-06-01 CA CA2950623A patent/CA2950623A1/en not_active Abandoned
- 2015-06-01 US US15/314,773 patent/US10829819B2/en active Active
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