JP2018510884A5 - - Google Patents
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- JP2018510884A5 JP2018510884A5 JP2017552153A JP2017552153A JP2018510884A5 JP 2018510884 A5 JP2018510884 A5 JP 2018510884A5 JP 2017552153 A JP2017552153 A JP 2017552153A JP 2017552153 A JP2017552153 A JP 2017552153A JP 2018510884 A5 JP2018510884 A5 JP 2018510884A5
- Authority
- JP
- Japan
- Prior art keywords
- substituted
- arylalkyl
- composition
- heteroarylalkyl
- unsubstituted
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- PRAAPINBUWJLGA-UHFFFAOYSA-N O=C(Cc1ncccc1)Nc1nnc(CCCCc2ccc(NC(Cc3cc(OC(F)(F)F)ccc3)=O)nn2)[s]1 Chemical compound O=C(Cc1ncccc1)Nc1nnc(CCCCc2ccc(NC(Cc3cc(OC(F)(F)F)ccc3)=O)nn2)[s]1 PRAAPINBUWJLGA-UHFFFAOYSA-N 0.000 description 1
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2021069815A JP2021102662A (ja) | 2015-04-06 | 2021-04-16 | グルタミナーゼの阻害剤を用いる肺がんの処置 |
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562143494P | 2015-04-06 | 2015-04-06 | |
| US62/143,494 | 2015-04-06 | ||
| US201562149489P | 2015-04-17 | 2015-04-17 | |
| US62/149,489 | 2015-04-17 | ||
| PCT/US2016/026127 WO2016164401A1 (en) | 2015-04-06 | 2016-04-06 | Treatment of lung cancer with inhibitors of glutaminase |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021069815A Division JP2021102662A (ja) | 2015-04-06 | 2021-04-16 | グルタミナーゼの阻害剤を用いる肺がんの処置 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2018510884A JP2018510884A (ja) | 2018-04-19 |
| JP2018510884A5 true JP2018510884A5 (https=) | 2019-05-16 |
| JP6944377B2 JP6944377B2 (ja) | 2021-10-06 |
Family
ID=57015711
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017552153A Expired - Fee Related JP6944377B2 (ja) | 2015-04-06 | 2016-04-06 | グルタミナーゼの阻害剤を用いる肺がんの処置 |
| JP2021069815A Withdrawn JP2021102662A (ja) | 2015-04-06 | 2021-04-16 | グルタミナーゼの阻害剤を用いる肺がんの処置 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021069815A Withdrawn JP2021102662A (ja) | 2015-04-06 | 2021-04-16 | グルタミナーゼの阻害剤を用いる肺がんの処置 |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US10441587B2 (https=) |
| EP (1) | EP3280415A4 (https=) |
| JP (2) | JP6944377B2 (https=) |
| KR (1) | KR20170132333A (https=) |
| CN (1) | CN107949387B (https=) |
| AU (1) | AU2016246521B2 (https=) |
| BR (1) | BR112017021312A2 (https=) |
| CA (1) | CA2981762A1 (https=) |
| EA (1) | EA035354B1 (https=) |
| IL (1) | IL254876A0 (https=) |
| MX (1) | MX383034B (https=) |
| SG (1) | SG11201708153XA (https=) |
| WO (1) | WO2016164401A1 (https=) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8604016B2 (en) | 2011-11-21 | 2013-12-10 | Calithera Biosciences Inc. | Heterocyclic inhibitors of glutaminase |
| BR112015010955A2 (pt) | 2012-11-16 | 2017-07-11 | Calithera Biosciences Inc | inibidores de glutaminase heterocíclica |
| EP3556757A1 (en) | 2014-04-30 | 2019-10-23 | Pfizer Inc | Cycloalkyl-linked diheterocycle derivatives |
| CA2957225A1 (en) | 2014-08-07 | 2016-02-11 | Calithera Biosciences, Inc. | Crystal forms of glutaminase inhibitors |
| CN108601767A (zh) | 2015-10-05 | 2018-09-28 | 卡利泰拉生物科技公司 | 用谷氨酰胺酶抑制剂和免疫肿瘤学药剂的组合疗法 |
| WO2018039441A1 (en) * | 2016-08-25 | 2018-03-01 | Calithera Biosciences, Inc. | Combination therapy with glutaminase inhibitors |
| KR20190040302A (ko) | 2016-08-25 | 2019-04-17 | 칼리테라 바이오사이언시즈, 인코포레이티드 | 글루타미나제 억제제와의 병용 요법 |
| WO2018165516A1 (en) * | 2017-03-10 | 2018-09-13 | Calithera Biosciences, Inc. | Combination therapy with glutaminase inhibitors |
| JP7156856B2 (ja) * | 2018-08-21 | 2022-10-19 | 国立大学法人富山大学 | 抗肥満剤 |
| JP7188936B2 (ja) * | 2018-08-21 | 2022-12-13 | 国立大学法人富山大学 | 抗炎症剤 |
| WO2021076814A1 (en) * | 2019-10-15 | 2021-04-22 | Cornell University | Methods of inhibiting liver-type glutaminase, gls2 |
| US20240082158A1 (en) * | 2020-05-21 | 2024-03-14 | University Of Pittsburgh-Of The Commonwealth System Of Higher Education | Compositions and methods for administering a yap1/wwrt1 inhibiting composition and a gls1 inhibiting composition |
| CN111514460B (zh) * | 2020-05-22 | 2021-12-14 | 西安交通大学 | 大气压冷等离子体在抑制谷氨酰胺酶活性方面的用途及酶抑制剂 |
| CN113956233B (zh) * | 2021-10-22 | 2023-06-06 | 南方医科大学 | 一种酰胺类化合物或其药学上可接受的盐及其制备方法和应用 |
| US20250288577A1 (en) * | 2022-04-29 | 2025-09-18 | Cornell University | Methods of treating a virus infection and methods of inhibiting viral replication |
Family Cites Families (32)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US1019519A (en) | 1911-07-11 | 1912-03-05 | Oscar Martin Polin | Apparatus for making backing for teeth. |
| US6451828B1 (en) | 2000-08-10 | 2002-09-17 | Elan Pharmaceuticals, Inc. | Selective inhibition of glutaminase by bis-thiadiazoles |
| AU2002305926A1 (en) | 2001-02-05 | 2002-10-08 | Exegenics Inc. | Cysteine protease inhibitors |
| CA2578680C (en) | 2004-04-15 | 2011-06-14 | University Of Florida Research Foundation, Inc. | Proteolytic markers as diagnostic biomarkers for cancer, organ injury and muscle rehabilitation/exercise overtraining |
| KR101325374B1 (ko) | 2008-02-19 | 2013-11-08 | 가부시키가이샤 오츠까 세이야꾸 고죠 | 신체 기능의 회복에 유용한 경구 또는 경장 조성물 |
| US20130109643A1 (en) | 2010-05-10 | 2013-05-02 | The Johns Hopkins University | Metabolic inhibitor against tumors having an idh mutation |
| WO2012006506A1 (en) | 2010-07-09 | 2012-01-12 | Massachusetts Institute Of Technology | Metabolic gene, enzyme, and flux targets for cancer therapy |
| US20120302605A1 (en) | 2010-11-18 | 2012-11-29 | Deuteria Pharmaceuticals, Llc | 3-deutero-pomalidomide |
| CN103030597B (zh) * | 2011-09-30 | 2014-10-01 | 南昌滨西科技有限公司 | 肾脏型谷氨酰胺酶抑制剂及其制备方法和用途 |
| US8604016B2 (en) | 2011-11-21 | 2013-12-10 | Calithera Biosciences Inc. | Heterocyclic inhibitors of glutaminase |
| ES2761866T3 (es) * | 2011-11-21 | 2020-05-21 | Calithera Biosciences Inc | Inhibidores heterocíclicos de glutaminasa |
| EP2855698A4 (en) * | 2012-05-24 | 2016-03-30 | Dana Farber Cancer Inst Inc | OBTAINING TO THE GLUTAMINE-TO-PYRUVAT SIGNAL PATH FOR THE TREATMENT OF CANCER ASSOCIATED WITH THE KRAS ONKOGEN |
| MX2015003114A (es) | 2012-09-10 | 2015-07-06 | Celgene Corp | Metodos para el tratamiento de cancer de mama localmente avanzado. |
| WO2014043633A1 (en) | 2012-09-17 | 2014-03-20 | Agios Pharmaceuticals, Inc. | Use of e-cadherin and vimentin for selection of treatment responsive patients |
| BR112015010955A2 (pt) | 2012-11-16 | 2017-07-11 | Calithera Biosciences Inc | inibidores de glutaminase heterocíclica |
| SG11201504022RA (en) | 2012-11-21 | 2015-06-29 | Agios Pharmaceuticals Inc | Glutamase inhibitors and method of use |
| WO2014079011A1 (en) | 2012-11-22 | 2014-05-30 | Agios Pharmaceuticals, Inc. | Heterocyclic compounds for inhibiting glutaminase and their methods of use |
| US9029531B2 (en) | 2012-11-22 | 2015-05-12 | Agios Pharmaceuticals, Inc. | Compounds and their methods of use |
| BR112015012536A2 (pt) | 2012-12-03 | 2017-07-11 | Calithera Biosciences Inc | tratamento de câncer com inibidores heterocíclicos da glutaminase |
| WO2015061432A1 (en) | 2013-10-25 | 2015-04-30 | Calithera Biosciences, Inc. | Treatment of viral infections with inhibitors of glutaminase |
| EP3116872A4 (en) | 2014-03-14 | 2017-08-30 | Calithera Biosciences, Inc. | Combination therapy with glutaminase inhibitors |
| US10221459B2 (en) | 2014-05-13 | 2019-03-05 | Case Western Reserve University | Compositions and methods of treating cancer harboring PIKC3A mutations |
| KR20170012562A (ko) | 2014-06-13 | 2017-02-02 | 칼리테라 바이오사이언시즈 인코포레이티드 | 글루타미나제 억제제를 사용하는 병용 요법 |
| WO2016004418A1 (en) | 2014-07-03 | 2016-01-07 | Board Of Regents, University Of Texas System | Glutaminase inhibitor therapy |
| WO2016014890A1 (en) | 2014-07-24 | 2016-01-28 | Calithera Biosciences, Inc. | Treatment of multiple myeloma with heterocyclic inhibitors of glutaminase |
| CA2957225A1 (en) | 2014-08-07 | 2016-02-11 | Calithera Biosciences, Inc. | Crystal forms of glutaminase inhibitors |
| US10245254B2 (en) | 2014-10-03 | 2019-04-02 | University of Pittsburgh—of the Commonwealth System of Higher Education | Glutaminase inhibitors |
| WO2016077632A2 (en) | 2014-11-13 | 2016-05-19 | Buck Institute For Research On Aging | Inhibition of proline catabolism for the treatment of cancer and other therapeutic applications |
| CN107921031A (zh) * | 2015-03-30 | 2018-04-17 | 卡利泰拉生物科技公司 | 给予谷氨酰胺酶抑制剂的方法 |
| WO2018039442A1 (en) | 2016-08-25 | 2018-03-01 | Calithera Biosciences, Inc. | Treatment of cancer with inhibitors of glutaminase |
| KR20190040302A (ko) | 2016-08-25 | 2019-04-17 | 칼리테라 바이오사이언시즈, 인코포레이티드 | 글루타미나제 억제제와의 병용 요법 |
| WO2018039441A1 (en) | 2016-08-25 | 2018-03-01 | Calithera Biosciences, Inc. | Combination therapy with glutaminase inhibitors |
-
2016
- 2016-04-06 BR BR112017021312A patent/BR112017021312A2/pt not_active IP Right Cessation
- 2016-04-06 KR KR1020177032006A patent/KR20170132333A/ko not_active Ceased
- 2016-04-06 CA CA2981762A patent/CA2981762A1/en not_active Abandoned
- 2016-04-06 EA EA201792227A patent/EA035354B1/ru not_active IP Right Cessation
- 2016-04-06 WO PCT/US2016/026127 patent/WO2016164401A1/en not_active Ceased
- 2016-04-06 CN CN201680032522.7A patent/CN107949387B/zh not_active Expired - Fee Related
- 2016-04-06 MX MX2017012824A patent/MX383034B/es unknown
- 2016-04-06 SG SG11201708153XA patent/SG11201708153XA/en unknown
- 2016-04-06 JP JP2017552153A patent/JP6944377B2/ja not_active Expired - Fee Related
- 2016-04-06 AU AU2016246521A patent/AU2016246521B2/en not_active Ceased
- 2016-04-06 EP EP16777159.1A patent/EP3280415A4/en not_active Withdrawn
- 2016-04-06 US US15/091,816 patent/US10441587B2/en not_active Expired - Fee Related
-
2017
- 2017-10-03 IL IL254876A patent/IL254876A0/en unknown
-
2021
- 2021-04-16 JP JP2021069815A patent/JP2021102662A/ja not_active Withdrawn
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