JP2018509438A5 - - Google Patents
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- JP2018509438A5 JP2018509438A5 JP2017549483A JP2017549483A JP2018509438A5 JP 2018509438 A5 JP2018509438 A5 JP 2018509438A5 JP 2017549483 A JP2017549483 A JP 2017549483A JP 2017549483 A JP2017549483 A JP 2017549483A JP 2018509438 A5 JP2018509438 A5 JP 2018509438A5
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- Prior art keywords
- alkyl
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- pharmaceutical composition
- substituted
- Prior art date
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- 125000000217 alkyl group Chemical group 0.000 claims 63
- 239000008194 pharmaceutical composition Substances 0.000 claims 19
- 229910052739 hydrogen Inorganic materials 0.000 claims 15
- 125000000623 heterocyclic group Chemical group 0.000 claims 13
- 239000003862 glucocorticoid Substances 0.000 claims 10
- 125000003545 alkoxy group Chemical group 0.000 claims 9
- 239000001257 hydrogen Substances 0.000 claims 9
- 125000003342 alkenyl group Chemical group 0.000 claims 8
- 229910052736 halogen Inorganic materials 0.000 claims 8
- 150000002367 halogens Chemical class 0.000 claims 8
- 125000004093 cyano group Chemical group *C#N 0.000 claims 7
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 7
- 239000003112 inhibitor Substances 0.000 claims 7
- 230000002401 inhibitory effect Effects 0.000 claims 7
- 125000003118 aryl group Chemical group 0.000 claims 6
- 125000000753 cycloalkyl group Chemical group 0.000 claims 6
- 150000002431 hydrogen Chemical class 0.000 claims 6
- 229910052799 carbon Inorganic materials 0.000 claims 5
- 229910052731 fluorine Inorganic materials 0.000 claims 5
- 125000001072 heteroaryl group Chemical group 0.000 claims 5
- 229910052757 nitrogen Inorganic materials 0.000 claims 5
- 229910052760 oxygen Inorganic materials 0.000 claims 5
- 229940065521 Glucocorticoid inhalants for obstructive airway disease Drugs 0.000 claims 4
- 229940037128 Systemic Glucocorticoids Drugs 0.000 claims 4
- 125000000304 alkynyl group Chemical group 0.000 claims 4
- 229910052794 bromium Inorganic materials 0.000 claims 4
- 125000004452 carbocyclyl group Chemical group 0.000 claims 4
- 229910052801 chlorine Inorganic materials 0.000 claims 4
- 150000001875 compounds Chemical class 0.000 claims 4
- 125000005842 heteroatoms Chemical group 0.000 claims 4
- -1 polymorph Substances 0.000 claims 4
- 239000000651 prodrug Substances 0.000 claims 4
- 229940002612 prodrugs Drugs 0.000 claims 4
- 150000003839 salts Chemical class 0.000 claims 4
- 239000011780 sodium chloride Substances 0.000 claims 4
- 206010038683 Respiratory disease Diseases 0.000 claims 3
- 125000005418 aryl aryl group Chemical group 0.000 claims 3
- 125000004432 carbon atoms Chemical group C* 0.000 claims 3
- 125000006297 carbonyl amino group Chemical group [H]N([*:2])C([*:1])=O 0.000 claims 3
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims 3
- 239000000969 carrier Substances 0.000 claims 3
- 239000003085 diluting agent Substances 0.000 claims 3
- 125000005843 halogen group Chemical group 0.000 claims 3
- UFHFLCQGNIYNRP-UHFFFAOYSA-N hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 3
- 125000004433 nitrogen atoms Chemical group N* 0.000 claims 3
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 3
- 239000012453 solvate Substances 0.000 claims 3
- 229910052717 sulfur Inorganic materials 0.000 claims 3
- 125000006552 (C3-C8) cycloalkyl group Chemical group 0.000 claims 2
- 229960004436 Budesonide Drugs 0.000 claims 2
- VOVIALXJUBGFJZ-VXKMTNQYSA-N Budesonide Chemical compound C1CC2=CC(=O)C=C[C@]2(C)[C@@H]2[C@@H]1[C@@H]1C[C@H]3O[C@@H](CCC)O[C@@]3(C(=O)CO)[C@@]1(C)C[C@@H]2O VOVIALXJUBGFJZ-VXKMTNQYSA-N 0.000 claims 2
- 102000008122 Casein Kinase I Human genes 0.000 claims 2
- 108010049812 Casein Kinase I Proteins 0.000 claims 2
- 241000709661 Enterovirus Species 0.000 claims 2
- 241000725643 Respiratory syncytial virus Species 0.000 claims 2
- 230000002009 allergen Effects 0.000 claims 2
- 125000002950 monocyclic group Chemical group 0.000 claims 2
- 241000712461 unidentified influenza virus Species 0.000 claims 2
- 125000006555 (C3-C5) cycloalkyl group Chemical group 0.000 claims 1
- 125000002373 5 membered heterocyclic group Chemical group 0.000 claims 1
- 208000006673 Asthma Diseases 0.000 claims 1
- 125000000882 C2-C6 alkenyl group Chemical group 0.000 claims 1
- 125000003601 C2-C6 alkynyl group Chemical group 0.000 claims 1
- 125000001313 C5-C10 heteroaryl group Chemical group 0.000 claims 1
- 208000006545 Chronic Obstructive Pulmonary Disease Diseases 0.000 claims 1
- 229920000089 Cyclic olefin copolymer Polymers 0.000 claims 1
- 206010016654 Fibrosis Diseases 0.000 claims 1
- 210000004072 Lung Anatomy 0.000 claims 1
- 229960001664 Mometasone Drugs 0.000 claims 1
- 102000030951 Phosphotransferases Human genes 0.000 claims 1
- 108091000081 Phosphotransferases Proteins 0.000 claims 1
- 206010057190 Respiratory tract infection Diseases 0.000 claims 1
- 206010047461 Viral infection Diseases 0.000 claims 1
- 208000001756 Virus Disease Diseases 0.000 claims 1
- 229940093612 Zein Drugs 0.000 claims 1
- 229920002494 Zein Polymers 0.000 claims 1
- 108010055615 Zein Proteins 0.000 claims 1
- 125000005275 alkylenearyl group Chemical group 0.000 claims 1
- 125000002618 bicyclic heterocycle group Chemical group 0.000 claims 1
- 125000004122 cyclic group Chemical group 0.000 claims 1
- 239000000428 dust Substances 0.000 claims 1
- 230000004761 fibrosis Effects 0.000 claims 1
- 239000011737 fluorine Substances 0.000 claims 1
- YCKRFDGAMUMZLT-UHFFFAOYSA-N fluorine atom Chemical compound [F] YCKRFDGAMUMZLT-UHFFFAOYSA-N 0.000 claims 1
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 claims 1
- 239000000203 mixture Substances 0.000 claims 1
- QLIIKPVHVRXHRI-CXSFZGCWSA-N mometasone Chemical compound C1CC2=CC(=O)C=C[C@]2(C)[C@]2(Cl)[C@@H]1[C@@H]1C[C@@H](C)[C@@](C(=O)CCl)(O)[C@@]1(C)C[C@@H]2O QLIIKPVHVRXHRI-CXSFZGCWSA-N 0.000 claims 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 1
- 125000003367 polycyclic group Chemical group 0.000 claims 1
- 230000017613 viral reproduction Effects 0.000 claims 1
- 230000003612 virological Effects 0.000 claims 1
- 239000005019 zein Substances 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| AU2015901032 | 2015-03-23 | ||
| AU2015901032A AU2015901032A0 (en) | 2015-03-23 | Treatment of respiratory diseases | |
| PCT/AU2016/050209 WO2016149756A1 (en) | 2015-03-23 | 2016-03-23 | Treatment of respiratory diseases |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021007384A Division JP7169693B2 (ja) | 2015-03-23 | 2021-01-20 | 呼吸器疾患の治療 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2018509438A JP2018509438A (ja) | 2018-04-05 |
| JP2018509438A5 true JP2018509438A5 (US07846941-20101207-C00217.png) | 2019-05-09 |
| JP6827948B2 JP6827948B2 (ja) | 2021-02-10 |
Family
ID=56976881
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017549483A Active JP6827948B2 (ja) | 2015-03-23 | 2016-03-23 | 呼吸器疾患の治療 |
| JP2021007384A Active JP7169693B2 (ja) | 2015-03-23 | 2021-01-20 | 呼吸器疾患の治療 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021007384A Active JP7169693B2 (ja) | 2015-03-23 | 2021-01-20 | 呼吸器疾患の治療 |
Country Status (5)
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3273955A4 (en) | 2015-03-23 | 2019-05-01 | The University of Melbourne | TREATMENT OF RESPIRATORY DISEASES |
| JP2016193861A (ja) * | 2015-03-31 | 2016-11-17 | 国立大学法人山梨大学 | マスト細胞活性化を抑制するための医薬組成物 |
| TW201837027A (zh) * | 2017-02-01 | 2018-10-16 | 以色列商以色列耶路撒冷希伯來大學伊索研究發展有限公司 | 吡唑衍生物及其用途 |
| US20200079757A1 (en) * | 2017-05-03 | 2020-03-12 | The University Of Melbourne | Compounds for the treatment of respiratory diseases |
| WO2019090405A1 (pt) * | 2017-11-11 | 2019-05-16 | Carvalho Junior Mario Virgilio De | Medicamento de ciclesonida para cura e prevenção da gripe causada pelo vírus influenza |
| JP2022507118A (ja) * | 2018-11-07 | 2022-01-18 | ザ ユニヴァーシティー オブ メルボルン | 呼吸器疾患の処置のための化合物及び組成物 |
| KR102253324B1 (ko) * | 2019-11-27 | 2021-05-18 | 단디바이오사이언스 주식회사 | 호흡기 질환의 예방, 개선 또는 치료용 조성물 |
| WO2021167703A1 (en) | 2020-02-19 | 2021-08-26 | Nammi Therapeutics, Inc. | Formulated and/or co-formulated liposome compositions containing tgfb antagonist prodrugs useful in the treatment of cancer and methods thereof |
| AR122711A1 (es) * | 2020-06-25 | 2022-09-28 | Alchemedicine Inc | COMPUESTO HETEROCÍCLICO COMO INHIBIDOR DE CASEÍNA QUINASA 1d Y/O QUINASA 5 TIPO RECEPTOR DE ACTIVINA |
| MX2023009682A (es) | 2021-02-19 | 2023-10-30 | Sudo Biosciences Ltd | Inhibidores de tyk2 y sus usos. |
| WO2022175752A1 (en) | 2021-02-19 | 2022-08-25 | Sudo Biosciences Limited | Tyk2 inhibitors and uses thereof |
| EP4333853A1 (en) * | 2021-05-03 | 2024-03-13 | Thirona Bio, Inc. | Methods for treating a pulmonary disease with an alk-5 (tgf beta r1) inhibitor |
| CN115792229B (zh) * | 2022-01-28 | 2024-06-18 | 华中科技大学同济医学院附属同济医院 | 鼻分泌物中tPA在制备鼻息肉及其预后检测剂中的应用 |
| WO2024091485A1 (en) * | 2022-10-25 | 2024-05-02 | The Regents Of The University Of California | Compositions and methods for treating or preventing pulmonary fibrosis |
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| EP3273955A4 (en) | 2015-03-23 | 2019-05-01 | The University of Melbourne | TREATMENT OF RESPIRATORY DISEASES |
| JP2016193861A (ja) | 2015-03-31 | 2016-11-17 | 国立大学法人山梨大学 | マスト細胞活性化を抑制するための医薬組成物 |
| WO2017083971A1 (en) | 2015-11-16 | 2017-05-26 | University Of Manitoba | Compositions and methods for treatment of influenza |
| US11124841B2 (en) | 2016-10-28 | 2021-09-21 | University Of Utah Research Foundation | Methods and compositions for identifying and treating patients with small cell lung cancer |
| US20200079757A1 (en) | 2017-05-03 | 2020-03-12 | The University Of Melbourne | Compounds for the treatment of respiratory diseases |
| US10973820B2 (en) | 2017-12-13 | 2021-04-13 | Facio Intellectual Property B.V. | Compounds for treatment of diseases related to DUX4 expression |
| EP3846818A1 (en) | 2018-09-09 | 2021-07-14 | Qanatpharma AG | Use of casein kinase 1 inhibitors for treating vascular diseases |
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2016
- 2016-03-23 EP EP16767533.9A patent/EP3273955A4/en active Pending
- 2016-03-23 CN CN202110650935.4A patent/CN113350353A/zh active Pending
- 2016-03-23 US US15/559,360 patent/US10722513B2/en active Active
- 2016-03-23 CN CN202110636730.0A patent/CN113350352B/zh active Active
- 2016-03-23 JP JP2017549483A patent/JP6827948B2/ja active Active
- 2016-03-23 WO PCT/AU2016/050209 patent/WO2016149756A1/en active Application Filing
- 2016-03-23 CN CN201680026219.6A patent/CN107847480B/zh active Active
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2020
- 2020-06-30 US US16/917,581 patent/US11564925B2/en active Active
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2021
- 2021-01-20 JP JP2021007384A patent/JP7169693B2/ja active Active
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2022
- 2022-12-22 US US18/087,672 patent/US11975005B2/en active Active
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2024
- 2024-04-04 US US18/627,415 patent/US20240245690A1/en active Pending
