JP2018508567A5 - - Google Patents
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- JP2018508567A5 JP2018508567A5 JP2017555423A JP2017555423A JP2018508567A5 JP 2018508567 A5 JP2018508567 A5 JP 2018508567A5 JP 2017555423 A JP2017555423 A JP 2017555423A JP 2017555423 A JP2017555423 A JP 2017555423A JP 2018508567 A5 JP2018508567 A5 JP 2018508567A5
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- antigen
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- nucleotide sequence
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- 239000000427 antigen Substances 0.000 claims 39
- 102000036639 antigens Human genes 0.000 claims 39
- 108091007433 antigens Proteins 0.000 claims 39
- 239000002773 nucleotide Substances 0.000 claims 19
- 125000003729 nucleotide group Chemical group 0.000 claims 19
- 239000013603 viral vector Substances 0.000 claims 16
- 102100022019 Pregnancy-specific beta-1-glycoprotein 2 Human genes 0.000 claims 13
- 101001133056 Homo sapiens Mucin-1 Proteins 0.000 claims 10
- 102100034256 Mucin-1 Human genes 0.000 claims 10
- 239000012634 fragment Substances 0.000 claims 7
- 125000003275 alpha amino acid group Chemical group 0.000 claims 4
- 230000008088 immune pathway Effects 0.000 claims 4
- 230000028993 immune response Effects 0.000 claims 3
- 239000002245 particle Substances 0.000 claims 3
- 230000003612 virological effect Effects 0.000 claims 3
- 102100038078 CD276 antigen Human genes 0.000 claims 2
- -1 CD86 Proteins 0.000 claims 2
- 102100034458 Hepatitis A virus cellular receptor 2 Human genes 0.000 claims 2
- 101000834898 Homo sapiens Alpha-synuclein Proteins 0.000 claims 2
- 101000611936 Homo sapiens Programmed cell death protein 1 Proteins 0.000 claims 2
- 101000652359 Homo sapiens Spermatogenesis-associated protein 2 Proteins 0.000 claims 2
- 102100037850 Interferon gamma Human genes 0.000 claims 2
- 108010074328 Interferon-gamma Proteins 0.000 claims 2
- 102000000588 Interleukin-2 Human genes 0.000 claims 2
- 108010002350 Interleukin-2 Proteins 0.000 claims 2
- 102100033627 Killer cell immunoglobulin-like receptor 3DL1 Human genes 0.000 claims 2
- 102100040678 Programmed cell death protein 1 Human genes 0.000 claims 2
- 230000024932 T cell mediated immunity Effects 0.000 claims 2
- 102100038929 V-set domain-containing T-cell activation inhibitor 1 Human genes 0.000 claims 2
- 230000002163 immunogen Effects 0.000 claims 2
- 108090000623 proteins and genes Proteins 0.000 claims 2
- 230000028327 secretion Effects 0.000 claims 2
- 102100029822 B- and T-lymphocyte attenuator Human genes 0.000 claims 1
- 206010005003 Bladder cancer Diseases 0.000 claims 1
- 206010006187 Breast cancer Diseases 0.000 claims 1
- 208000026310 Breast neoplasm Diseases 0.000 claims 1
- 102100027207 CD27 antigen Human genes 0.000 claims 1
- 101710185679 CD276 antigen Proteins 0.000 claims 1
- 108010029697 CD40 Ligand Proteins 0.000 claims 1
- 101150013553 CD40 gene Proteins 0.000 claims 1
- 102100032937 CD40 ligand Human genes 0.000 claims 1
- 102100025221 CD70 antigen Human genes 0.000 claims 1
- 101710098119 Chaperonin GroEL 2 Proteins 0.000 claims 1
- 206010009944 Colon cancer Diseases 0.000 claims 1
- 208000001333 Colorectal Neoplasms Diseases 0.000 claims 1
- 206010052360 Colorectal adenocarcinoma Diseases 0.000 claims 1
- 206010052358 Colorectal cancer metastatic Diseases 0.000 claims 1
- 102000004127 Cytokines Human genes 0.000 claims 1
- 108090000695 Cytokines Proteins 0.000 claims 1
- 102100039498 Cytotoxic T-lymphocyte protein 4 Human genes 0.000 claims 1
- 101150029662 E1 gene Proteins 0.000 claims 1
- 101150005585 E3 gene Proteins 0.000 claims 1
- 101150066038 E4 gene Proteins 0.000 claims 1
- 238000011510 Elispot assay Methods 0.000 claims 1
- 102100031351 Galectin-9 Human genes 0.000 claims 1
- 101100229077 Gallus gallus GAL9 gene Proteins 0.000 claims 1
- 108010007707 Hepatitis A Virus Cellular Receptor 2 Proteins 0.000 claims 1
- 101000864344 Homo sapiens B- and T-lymphocyte attenuator Proteins 0.000 claims 1
- 101000914511 Homo sapiens CD27 antigen Proteins 0.000 claims 1
- 101000884279 Homo sapiens CD276 antigen Proteins 0.000 claims 1
- 101000934356 Homo sapiens CD70 antigen Proteins 0.000 claims 1
- 101000889276 Homo sapiens Cytotoxic T-lymphocyte protein 4 Proteins 0.000 claims 1
- 101001068133 Homo sapiens Hepatitis A virus cellular receptor 2 Proteins 0.000 claims 1
- 101001019455 Homo sapiens ICOS ligand Proteins 0.000 claims 1
- 101001037256 Homo sapiens Indoleamine 2,3-dioxygenase 1 Proteins 0.000 claims 1
- 101000945351 Homo sapiens Killer cell immunoglobulin-like receptor 3DL1 Proteins 0.000 claims 1
- 101001137987 Homo sapiens Lymphocyte activation gene 3 protein Proteins 0.000 claims 1
- 101000884270 Homo sapiens Natural killer cell receptor 2B4 Proteins 0.000 claims 1
- 101001117317 Homo sapiens Programmed cell death 1 ligand 1 Proteins 0.000 claims 1
- 101001117312 Homo sapiens Programmed cell death 1 ligand 2 Proteins 0.000 claims 1
- 101000914514 Homo sapiens T-cell-specific surface glycoprotein CD28 Proteins 0.000 claims 1
- 101000914484 Homo sapiens T-lymphocyte activation antigen CD80 Proteins 0.000 claims 1
- 101000638251 Homo sapiens Tumor necrosis factor ligand superfamily member 9 Proteins 0.000 claims 1
- 101000955999 Homo sapiens V-set domain-containing T-cell activation inhibitor 1 Proteins 0.000 claims 1
- 101000666896 Homo sapiens V-type immunoglobulin domain-containing suppressor of T-cell activation Proteins 0.000 claims 1
- 241001135569 Human adenovirus 5 Species 0.000 claims 1
- 102100034980 ICOS ligand Human genes 0.000 claims 1
- 102100040061 Indoleamine 2,3-dioxygenase 1 Human genes 0.000 claims 1
- 108090000174 Interleukin-10 Proteins 0.000 claims 1
- 102000013462 Interleukin-12 Human genes 0.000 claims 1
- 108010065805 Interleukin-12 Proteins 0.000 claims 1
- 108090000176 Interleukin-13 Proteins 0.000 claims 1
- 102000003810 Interleukin-18 Human genes 0.000 claims 1
- 108090000171 Interleukin-18 Proteins 0.000 claims 1
- 108010002386 Interleukin-3 Proteins 0.000 claims 1
- 108090000978 Interleukin-4 Proteins 0.000 claims 1
- 108010002616 Interleukin-5 Proteins 0.000 claims 1
- 108090001005 Interleukin-6 Proteins 0.000 claims 1
- 108090001007 Interleukin-8 Proteins 0.000 claims 1
- 102000004890 Interleukin-8 Human genes 0.000 claims 1
- 108010002335 Interleukin-9 Proteins 0.000 claims 1
- 108010043610 KIR Receptors Proteins 0.000 claims 1
- 102000017578 LAG3 Human genes 0.000 claims 1
- 206010058467 Lung neoplasm malignant Diseases 0.000 claims 1
- 108010061593 Member 14 Tumor Necrosis Factor Receptors Proteins 0.000 claims 1
- 102100038082 Natural killer cell receptor 2B4 Human genes 0.000 claims 1
- 206010028980 Neoplasm Diseases 0.000 claims 1
- 102000004473 OX40 Ligand Human genes 0.000 claims 1
- 108010042215 OX40 Ligand Proteins 0.000 claims 1
- 206010061902 Pancreatic neoplasm Diseases 0.000 claims 1
- 102100024216 Programmed cell death 1 ligand 1 Human genes 0.000 claims 1
- 102100024213 Programmed cell death 1 ligand 2 Human genes 0.000 claims 1
- 108020004459 Small interfering RNA Proteins 0.000 claims 1
- 102100027213 T-cell-specific surface glycoprotein CD28 Human genes 0.000 claims 1
- 102100027222 T-lymphocyte activation antigen CD80 Human genes 0.000 claims 1
- 108060008682 Tumor Necrosis Factor Proteins 0.000 claims 1
- 102000000852 Tumor Necrosis Factor-alpha Human genes 0.000 claims 1
- 102100032101 Tumor necrosis factor ligand superfamily member 9 Human genes 0.000 claims 1
- 102100028785 Tumor necrosis factor receptor superfamily member 14 Human genes 0.000 claims 1
- 102100022153 Tumor necrosis factor receptor superfamily member 4 Human genes 0.000 claims 1
- 101710165473 Tumor necrosis factor receptor superfamily member 4 Proteins 0.000 claims 1
- 102100040245 Tumor necrosis factor receptor superfamily member 5 Human genes 0.000 claims 1
- 208000007097 Urinary Bladder Neoplasms Diseases 0.000 claims 1
- 108010079206 V-Set Domain-Containing T-Cell Activation Inhibitor 1 Proteins 0.000 claims 1
- 102100038282 V-type immunoglobulin domain-containing suppressor of T-cell activation Human genes 0.000 claims 1
- 230000000692 anti-sense effect Effects 0.000 claims 1
- 230000008350 antigen-specific antibody response Effects 0.000 claims 1
- FUHMZYWBSHTEDZ-UHFFFAOYSA-M bispyribac-sodium Chemical compound [Na+].COC1=CC(OC)=NC(OC=2C(=C(OC=3N=C(OC)C=C(OC)N=3)C=CC=2)C([O-])=O)=N1 FUHMZYWBSHTEDZ-UHFFFAOYSA-M 0.000 claims 1
- 201000011510 cancer Diseases 0.000 claims 1
- 230000037430 deletion Effects 0.000 claims 1
- 238000012217 deletion Methods 0.000 claims 1
- 238000003114 enzyme-linked immunosorbent spot assay Methods 0.000 claims 1
- IJJVMEJXYNJXOJ-UHFFFAOYSA-N fluquinconazole Chemical compound C=1C=C(Cl)C=C(Cl)C=1N1C(=O)C2=CC(F)=CC=C2N=C1N1C=NC=N1 IJJVMEJXYNJXOJ-UHFFFAOYSA-N 0.000 claims 1
- 239000003446 ligand Substances 0.000 claims 1
- 201000005202 lung cancer Diseases 0.000 claims 1
- 208000020816 lung neoplasm Diseases 0.000 claims 1
- 208000015486 malignant pancreatic neoplasm Diseases 0.000 claims 1
- 201000002528 pancreatic cancer Diseases 0.000 claims 1
- 208000008443 pancreatic carcinoma Diseases 0.000 claims 1
- 102000004169 proteins and genes Human genes 0.000 claims 1
- 108020003175 receptors Proteins 0.000 claims 1
- 102000005962 receptors Human genes 0.000 claims 1
- 150000003384 small molecules Chemical class 0.000 claims 1
- 238000007920 subcutaneous administration Methods 0.000 claims 1
- 201000005112 urinary bladder cancer Diseases 0.000 claims 1
- 239000013598 vector Substances 0.000 claims 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562101969P | 2015-01-09 | 2015-01-09 | |
| US62/101,969 | 2015-01-09 | ||
| US201562150236P | 2015-04-20 | 2015-04-20 | |
| US62/150,236 | 2015-04-20 | ||
| PCT/US2016/012496 WO2016112195A1 (en) | 2015-01-09 | 2016-01-07 | Methods and compositions for combination immunotherapy |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2018508567A JP2018508567A (ja) | 2018-03-29 |
| JP2018508567A5 true JP2018508567A5 (cg-RX-API-DMAC7.html) | 2019-02-14 |
| JP6647315B2 JP6647315B2 (ja) | 2020-02-14 |
Family
ID=56356431
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017555423A Active JP6647315B2 (ja) | 2015-01-09 | 2016-01-07 | 組み合わせ免疫療法のための方法および組成物 |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US11352642B2 (cg-RX-API-DMAC7.html) |
| EP (1) | EP3242940B1 (cg-RX-API-DMAC7.html) |
| JP (1) | JP6647315B2 (cg-RX-API-DMAC7.html) |
| KR (1) | KR102193635B1 (cg-RX-API-DMAC7.html) |
| CN (2) | CN107406857B (cg-RX-API-DMAC7.html) |
| AU (1) | AU2016205215B2 (cg-RX-API-DMAC7.html) |
| CA (1) | CA2974237C (cg-RX-API-DMAC7.html) |
| IL (1) | IL253341B (cg-RX-API-DMAC7.html) |
| WO (1) | WO2016112195A1 (cg-RX-API-DMAC7.html) |
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| WO2009006479A2 (en) | 2007-07-02 | 2009-01-08 | Etubics Corporation | Methods and compositions for producing an adenovirus vector for use with multiple vaccinations |
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| EP3242940B1 (en) | 2015-01-09 | 2023-03-29 | Etubics Corporation | Methods and compositions for combination immunotherapy |
| US10695417B2 (en) | 2015-01-09 | 2020-06-30 | Etubics Corporation | Human adenovirus serotype 5 vectors containing E1 and E2B deletions encoding the ebola virus glycoprotein |
| US11149087B2 (en) | 2015-04-20 | 2021-10-19 | Etubics Corporation | Methods and compositions for combination immunotherapy |
| AU2017272356A1 (en) * | 2016-06-03 | 2018-12-20 | Etubics Corporation | Compositions and methods for the treatment of human papillomavirus (HPV)-associated diseases |
| AU2017297608B2 (en) * | 2016-07-15 | 2020-03-19 | Etubics Corporation | Compositions and methods for flavivirus vaccination |
| CA3030451C (en) * | 2016-07-15 | 2023-09-05 | Etubics Corporation | Compositions and methods for alphavirus vaccination |
| US11422127B2 (en) | 2016-12-07 | 2022-08-23 | Albany Medical College | Ex vivo antigen and adjuvant pulsed peripheral blood mononuclear cells as a screening platform for candidate novel vaccines and candidate antigens |
| WO2018186924A1 (en) * | 2017-01-17 | 2018-10-11 | The University Of Chicago | Dysfunctional antigen-specific cd8+ t cells in the tumor microenvironment |
| EP3630168A4 (en) * | 2017-05-26 | 2020-07-01 | Etubics Corporation | COMBINED IMMUNOTHERAPIES USING IL-15 SUPERAGONISTS |
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| JP2021502114A (ja) * | 2017-11-10 | 2021-01-28 | キネオ メディカル テクノロジー カンパニー リミテッド | 改変された免疫細胞およびその使用 |
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| EP3897691A4 (en) * | 2018-12-21 | 2022-08-31 | The Regents of the University of California | IL-10 CONTAINING VACCINES AND THEIR USES |
| CN115066499A (zh) * | 2019-12-30 | 2022-09-16 | 格雷菲克斯公司 | 用于基因转移载体的高效产生的培养系统 |
| KR102371663B1 (ko) * | 2020-01-21 | 2022-03-04 | 코오롱생명과학 주식회사 | 아데노바이러스 벡터 |
| CN116059339B (zh) * | 2021-11-04 | 2023-09-22 | 元本(珠海横琴)生物科技有限公司 | 一种治疗和预防癌症的药物和应用 |
| CN117110607B (zh) * | 2023-09-16 | 2024-01-26 | 鲁东大学 | 一种检测副溶血性弧菌的组合物及其应用 |
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| EP4070818A3 (en) | 2014-01-06 | 2023-01-11 | The Trustees of the University of Pennsylvania | Pd1 and pdl1 antibodies and vaccine combinations and use of same for immunotherapy |
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- 2016-01-07 KR KR1020177022200A patent/KR102193635B1/ko active Active
- 2016-01-07 CN CN201680014846.8A patent/CN107406857B/zh active Active
- 2016-01-07 US US15/542,005 patent/US11352642B2/en active Active
- 2016-01-07 CN CN202110784166.7A patent/CN113456812B/zh active Active
- 2016-01-07 JP JP2017555423A patent/JP6647315B2/ja active Active
- 2016-01-07 CA CA2974237A patent/CA2974237C/en active Active
- 2016-01-07 AU AU2016205215A patent/AU2016205215B2/en active Active
- 2016-01-07 WO PCT/US2016/012496 patent/WO2016112195A1/en not_active Ceased
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2017
- 2017-07-05 IL IL253341A patent/IL253341B/en unknown
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