JP2018508469A5 - - Google Patents
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- JP2018508469A5 JP2018508469A5 JP2017533956A JP2017533956A JP2018508469A5 JP 2018508469 A5 JP2018508469 A5 JP 2018508469A5 JP 2017533956 A JP2017533956 A JP 2017533956A JP 2017533956 A JP2017533956 A JP 2017533956A JP 2018508469 A5 JP2018508469 A5 JP 2018508469A5
- Authority
- JP
- Japan
- Prior art keywords
- antagonist
- patient
- expression level
- egfr
- fgfr3
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 238000000034 method Methods 0.000 claims 36
- 230000014509 gene expression Effects 0.000 claims 28
- 108090000623 proteins and genes Proteins 0.000 claims 24
- 239000005557 antagonist Substances 0.000 claims 22
- 239000000523 sample Substances 0.000 claims 19
- 102100027842 Fibroblast growth factor receptor 3 Human genes 0.000 claims 18
- 101710182396 Fibroblast growth factor receptor 3 Proteins 0.000 claims 18
- 102100025064 Cellular tumor antigen p53 Human genes 0.000 claims 17
- 108010078814 Tumor Suppressor Protein p53 Proteins 0.000 claims 17
- 239000003814 drug Substances 0.000 claims 15
- 206010005003 Bladder cancer Diseases 0.000 claims 13
- 229940122558 EGFR antagonist Drugs 0.000 claims 13
- 239000002246 antineoplastic agent Substances 0.000 claims 11
- 239000003795 chemical substances by application Substances 0.000 claims 10
- 208000007097 Urinary Bladder Neoplasms Diseases 0.000 claims 9
- 201000005112 urinary bladder cancer Diseases 0.000 claims 9
- 239000012634 fragment Substances 0.000 claims 8
- 238000011319 anticancer therapy Methods 0.000 claims 7
- 102000052116 epidermal growth factor receptor activity proteins Human genes 0.000 claims 7
- 108700015053 epidermal growth factor receptor activity proteins Proteins 0.000 claims 7
- YOHYSYJDKVYCJI-UHFFFAOYSA-N n-[3-[[6-[3-(trifluoromethyl)anilino]pyrimidin-4-yl]amino]phenyl]cyclopropanecarboxamide Chemical compound FC(F)(F)C1=CC=CC(NC=2N=CN=C(NC=3C=C(NC(=O)C4CC4)C=CC=3)C=2)=C1 YOHYSYJDKVYCJI-UHFFFAOYSA-N 0.000 claims 7
- -1 BCL2B Proteins 0.000 claims 5
- 238000004393 prognosis Methods 0.000 claims 5
- 230000004083 survival effect Effects 0.000 claims 5
- 229940124597 therapeutic agent Drugs 0.000 claims 5
- 239000005551 L01XE03 - Erlotinib Substances 0.000 claims 4
- 229940127089 cytotoxic agent Drugs 0.000 claims 4
- AAKJLRGGTJKAMG-UHFFFAOYSA-N erlotinib Chemical compound C=12C=C(OCCOC)C(OCCOC)=CC2=NC=NC=1NC1=CC=CC(C#C)=C1 AAKJLRGGTJKAMG-UHFFFAOYSA-N 0.000 claims 4
- 206010028980 Neoplasm Diseases 0.000 claims 3
- 230000003387 muscular Effects 0.000 claims 3
- 150000003384 small molecules Chemical class 0.000 claims 3
- 238000011282 treatment Methods 0.000 claims 3
- WSFSSNUMVMOOMR-UHFFFAOYSA-N Formaldehyde Chemical compound O=C WSFSSNUMVMOOMR-UHFFFAOYSA-N 0.000 claims 2
- 241001467552 Mycobacterium bovis BCG Species 0.000 claims 2
- 229940034982 antineoplastic agent Drugs 0.000 claims 2
- 238000003556 assay Methods 0.000 claims 2
- 229960000190 bacillus calmette–guérin vaccine Drugs 0.000 claims 2
- 239000002254 cytotoxic agent Substances 0.000 claims 2
- 231100000599 cytotoxic agent Toxicity 0.000 claims 2
- 229960001433 erlotinib Drugs 0.000 claims 2
- 238000003364 immunohistochemistry Methods 0.000 claims 2
- 230000002401 inhibitory effect Effects 0.000 claims 2
- 108020004999 messenger RNA Proteins 0.000 claims 2
- 239000013610 patient sample Substances 0.000 claims 2
- 238000003752 polymerase chain reaction Methods 0.000 claims 2
- 102000004169 proteins and genes Human genes 0.000 claims 2
- 230000003439 radiotherapeutic effect Effects 0.000 claims 2
- 229940120982 tarceva Drugs 0.000 claims 2
- 239000005483 tyrosine kinase inhibitor Substances 0.000 claims 2
- 229940121358 tyrosine kinase inhibitor Drugs 0.000 claims 2
- 150000004917 tyrosine kinase inhibitor derivatives Chemical group 0.000 claims 2
- 102100026802 72 kDa type IV collagenase Human genes 0.000 claims 1
- 102000006311 Cyclin D1 Human genes 0.000 claims 1
- 108010058546 Cyclin D1 Proteins 0.000 claims 1
- 108010016788 Cyclin-Dependent Kinase Inhibitor p21 Proteins 0.000 claims 1
- 102100033270 Cyclin-dependent kinase inhibitor 1 Human genes 0.000 claims 1
- 108050002772 E3 ubiquitin-protein ligase Mdm2 Proteins 0.000 claims 1
- 102000012199 E3 ubiquitin-protein ligase Mdm2 Human genes 0.000 claims 1
- 102000003971 Fibroblast Growth Factor 1 Human genes 0.000 claims 1
- 108090000386 Fibroblast Growth Factor 1 Proteins 0.000 claims 1
- 102000003974 Fibroblast growth factor 2 Human genes 0.000 claims 1
- 108090000379 Fibroblast growth factor 2 Proteins 0.000 claims 1
- 102100037665 Fibroblast growth factor 9 Human genes 0.000 claims 1
- 102100021066 Fibroblast growth factor receptor substrate 2 Human genes 0.000 claims 1
- 102100021064 Fibroblast growth factor receptor substrate 3 Human genes 0.000 claims 1
- 102100031561 Hamartin Human genes 0.000 claims 1
- 101000627872 Homo sapiens 72 kDa type IV collagenase Proteins 0.000 claims 1
- 101001027380 Homo sapiens Fibroblast growth factor 9 Proteins 0.000 claims 1
- 101000818410 Homo sapiens Fibroblast growth factor receptor substrate 2 Proteins 0.000 claims 1
- 101000818396 Homo sapiens Fibroblast growth factor receptor substrate 3 Proteins 0.000 claims 1
- 101000795643 Homo sapiens Hamartin Proteins 0.000 claims 1
- 101001120056 Homo sapiens Phosphatidylinositol 3-kinase regulatory subunit alpha Proteins 0.000 claims 1
- 101000605639 Homo sapiens Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform Proteins 0.000 claims 1
- 101000595741 Homo sapiens Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform Proteins 0.000 claims 1
- 101000779418 Homo sapiens RAC-alpha serine/threonine-protein kinase Proteins 0.000 claims 1
- 101001012157 Homo sapiens Receptor tyrosine-protein kinase erbB-2 Proteins 0.000 claims 1
- 101000807561 Homo sapiens Tyrosine-protein kinase receptor UFO Proteins 0.000 claims 1
- 101000785626 Homo sapiens Zinc finger E-box-binding homeobox 1 Proteins 0.000 claims 1
- 101000723833 Homo sapiens Zinc finger E-box-binding homeobox 2 Proteins 0.000 claims 1
- 101000702691 Homo sapiens Zinc finger protein SNAI1 Proteins 0.000 claims 1
- 101000633054 Homo sapiens Zinc finger protein SNAI2 Proteins 0.000 claims 1
- 238000002944 PCR assay Methods 0.000 claims 1
- 108010011536 PTEN Phosphohydrolase Proteins 0.000 claims 1
- 102000014160 PTEN Phosphohydrolase Human genes 0.000 claims 1
- 102100026169 Phosphatidylinositol 3-kinase regulatory subunit alpha Human genes 0.000 claims 1
- 102100038332 Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform Human genes 0.000 claims 1
- 102100036061 Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform Human genes 0.000 claims 1
- 102100033810 RAC-alpha serine/threonine-protein kinase Human genes 0.000 claims 1
- 102100030086 Receptor tyrosine-protein kinase erbB-2 Human genes 0.000 claims 1
- 102100029986 Receptor tyrosine-protein kinase erbB-3 Human genes 0.000 claims 1
- 101710100969 Receptor tyrosine-protein kinase erbB-3 Proteins 0.000 claims 1
- 102100027881 Tumor protein 63 Human genes 0.000 claims 1
- 101710140697 Tumor protein 63 Proteins 0.000 claims 1
- 102100037236 Tyrosine-protein kinase receptor UFO Human genes 0.000 claims 1
- 102100026457 Zinc finger E-box-binding homeobox 1 Human genes 0.000 claims 1
- 102100028458 Zinc finger E-box-binding homeobox 2 Human genes 0.000 claims 1
- 102100030917 Zinc finger protein SNAI1 Human genes 0.000 claims 1
- 102100029570 Zinc finger protein SNAI2 Human genes 0.000 claims 1
- 229940124650 anti-cancer therapies Drugs 0.000 claims 1
- 201000010099 disease Diseases 0.000 claims 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 1
- 230000001394 metastastic effect Effects 0.000 claims 1
- 206010061289 metastatic neoplasm Diseases 0.000 claims 1
- 239000012188 paraffin wax Substances 0.000 claims 1
- 238000010837 poor prognosis Methods 0.000 claims 1
- 238000003753 real-time PCR Methods 0.000 claims 1
- 230000000306 recurrent effect Effects 0.000 claims 1
- 230000001225 therapeutic effect Effects 0.000 claims 1
- 229960005486 vaccine Drugs 0.000 claims 1
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2021099307A JP2021169451A (ja) | 2014-12-24 | 2021-06-15 | 膀胱癌の治療、診断、及び予後判定方法 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201462096741P | 2014-12-24 | 2014-12-24 | |
| US62/096,741 | 2014-12-24 | ||
| PCT/US2015/000237 WO2016105503A1 (en) | 2014-12-24 | 2015-12-23 | Therapeutic, diagnostic and prognostic methods for cancer of the bladder |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021099307A Division JP2021169451A (ja) | 2014-12-24 | 2021-06-15 | 膀胱癌の治療、診断、及び予後判定方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2018508469A JP2018508469A (ja) | 2018-03-29 |
| JP2018508469A5 true JP2018508469A5 (enExample) | 2019-01-31 |
| JP6900314B2 JP6900314B2 (ja) | 2021-07-07 |
Family
ID=55275150
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017533956A Active JP6900314B2 (ja) | 2014-12-24 | 2015-12-23 | 膀胱癌の治療、診断、及び予後判定方法 |
| JP2021099307A Pending JP2021169451A (ja) | 2014-12-24 | 2021-06-15 | 膀胱癌の治療、診断、及び予後判定方法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021099307A Pending JP2021169451A (ja) | 2014-12-24 | 2021-06-15 | 膀胱癌の治療、診断、及び予後判定方法 |
Country Status (14)
| Country | Link |
|---|---|
| US (3) | US20170306418A1 (enExample) |
| EP (2) | EP3699290A1 (enExample) |
| JP (2) | JP6900314B2 (enExample) |
| KR (1) | KR20170095893A (enExample) |
| CN (1) | CN107223163A (enExample) |
| AU (1) | AU2015371312B2 (enExample) |
| CA (1) | CA2969830A1 (enExample) |
| HK (1) | HK1244847A1 (enExample) |
| IL (1) | IL252796B (enExample) |
| MX (1) | MX394474B (enExample) |
| MY (1) | MY188938A (enExample) |
| RU (1) | RU2739942C2 (enExample) |
| SG (1) | SG11201704852SA (enExample) |
| WO (1) | WO2016105503A1 (enExample) |
Families Citing this family (41)
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| KR101623985B1 (ko) | 2007-03-28 | 2016-05-25 | 프레지던트 앤드 펠로우즈 오브 하바드 칼리지 | 스티칭된 폴리펩티드 |
| TWI807362B (zh) | 2010-11-30 | 2023-07-01 | 日商中外製藥股份有限公司 | 細胞傷害誘導治療劑 |
| CN108929375A (zh) | 2011-10-18 | 2018-12-04 | 爱勒让治疗公司 | 拟肽大环化合物 |
| EP2819688A4 (en) | 2012-02-15 | 2015-10-28 | Aileron Therapeutics Inc | PEPTIDOMIMETIC MACROCYCLES CROSS-LINKED WITH TRIAZOLE AND THIOETHER |
| KR20150082307A (ko) | 2012-11-01 | 2015-07-15 | 에일러론 테라퓨틱스 인코포레이티드 | 이치환 아미노산 및 이의 제조 및 사용 방법 |
| SG10201902598VA (en) | 2014-09-24 | 2019-04-29 | Aileron Therapeutics Inc | Peptidomimetic macrocycles and formulations thereof |
| CN106999541A (zh) | 2014-09-24 | 2017-08-01 | 艾瑞朗医疗公司 | 拟肽大环化合物及其用途 |
| EP3229800A2 (en) * | 2014-12-11 | 2017-10-18 | Bayer Pharma Aktiengesellschaft | Use of pan fgfr inhibitors and method of identifying patients with cancer eligible for treatment with a pan fgfr inhibitor |
| MX2017011834A (es) | 2015-03-20 | 2018-04-11 | Aileron Therapeutics Inc | Macrociclos peptidomimeticos y usos de los mismos. |
| CA3002560A1 (en) | 2015-10-23 | 2017-04-27 | Array Biopharma, Inc. | 2-aryl- and 2-heteroaryl-substituted 2-pyridazin-3(2h)-one compounds as inhibitors of fgfr tyrosine kinases |
| US20180165599A1 (en) * | 2016-12-12 | 2018-06-14 | Business Objects Software Ltd. | Predictive model integration |
| US11255810B2 (en) | 2017-09-14 | 2022-02-22 | Siemens Healthcare Diagnostics Inc. | Adhesive-polymer containing membranes for in vitro diagnostic devices |
| CN110115758B (zh) * | 2018-02-05 | 2021-05-11 | 中山大学 | Pik3ip1蛋白在调节t细胞反应和制备抗肿瘤药物中的应用 |
| CN108676884A (zh) * | 2018-06-04 | 2018-10-19 | 海口市人民医院（中南大学湘雅医学院附属海口医院） | 一种用于预测膀胱癌的肿瘤标志物 |
| KR20210063330A (ko) * | 2018-09-19 | 2021-06-01 | 제넨테크, 인크. | 방광암에 대한 치료 및 진단 방법 |
| CN111289748A (zh) * | 2018-12-08 | 2020-06-16 | 惠州市中大惠亚医院 | ErbB3蛋白在制备膀胱癌无创诊断产品中的应用 |
| EP3898626A1 (en) | 2018-12-19 | 2021-10-27 | Array Biopharma, Inc. | Substituted pyrazolo[1,5-a]pyridine compounds as inhibitors of fgfr tyrosine kinases |
| WO2020131674A1 (en) | 2018-12-19 | 2020-06-25 | Array Biopharma Inc. | 7-((3,5-dimethoxyphenyl)amino)quinoxaline derivatives as fgfr inhibitors for treating cancer |
| JP7721449B2 (ja) * | 2019-04-12 | 2025-08-12 | ストラティファイヤー・モレキュラー・パソロジー・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング | Ｆｇｆｒの決定に基づいて試料を分類する方法 |
| CN110055331B (zh) * | 2019-05-10 | 2023-05-02 | 人和未来生物科技（长沙）有限公司 | 一种用于膀胱癌辅助诊断或筛查的试剂盒及其应用 |
| US20220267452A1 (en) * | 2019-07-12 | 2022-08-25 | Chugai Seiyaku Kabushiki Kaisha | Anti-mutation type fgfr3 antibody and use therefor |
| US20230115945A1 (en) | 2019-12-30 | 2023-04-13 | Tyra Biosciences, Inc. | Aminopyrimidine compounds |
| US12441707B2 (en) | 2019-12-30 | 2025-10-14 | Tyra Biosciences, Inc. | Indazole compounds |
| CN111269983A (zh) * | 2020-02-21 | 2020-06-12 | 深圳市众循精准医学研究院 | 一种膀胱癌基因扩增的fish检测方法、探针及试剂盒 |
| WO2021189082A1 (en) * | 2020-03-18 | 2021-09-23 | The Regents Of The University Of California | Risk-stratification of meningioma patients |
| CN111679076A (zh) * | 2020-06-15 | 2020-09-18 | 吉林医药学院 | 一种用于检测cyclinD1和BCL-2抗体的检测试剂盒 |
| WO2022006596A1 (en) * | 2020-06-30 | 2022-01-06 | Northwestern University | A single patient classifier for t1 high grade bladder cancer |
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| US12264149B2 (en) | 2020-12-30 | 2025-04-01 | Tyra Biosciences, Inc. | Indazole compounds as kinase inhibitors |
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| MX2023009954A (es) | 2021-02-26 | 2023-11-09 | Tyra Biosciences Inc | Compuestos de aminopirimidina y métodos de uso de estos. |
| JP2023023327A (ja) * | 2021-08-05 | 2023-02-16 | 国立大学法人大阪大学 | 腫瘍のサブタイプ決定方法及びその応用、並びにサブタイプ決定のための方法 |
| IT202200001817A1 (it) | 2022-02-02 | 2023-08-02 | Aizoon S R L | Procedimento per la prognosi di una malattia in seguito ad un trattamento terapeutico, relativo sistema e prodotto informatico |
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-
2015
- 2015-12-23 CA CA2969830A patent/CA2969830A1/en active Pending
- 2015-12-23 EP EP19212435.2A patent/EP3699290A1/en not_active Withdrawn
- 2015-12-23 RU RU2017125053A patent/RU2739942C2/ru active
- 2015-12-23 WO PCT/US2015/000237 patent/WO2016105503A1/en not_active Ceased
- 2015-12-23 MX MX2017008421A patent/MX394474B/es unknown
- 2015-12-23 JP JP2017533956A patent/JP6900314B2/ja active Active
- 2015-12-23 KR KR1020177017321A patent/KR20170095893A/ko not_active Ceased
- 2015-12-23 HK HK18104105.4A patent/HK1244847A1/zh unknown
- 2015-12-23 EP EP15831090.4A patent/EP3237638B1/en active Active
- 2015-12-23 SG SG11201704852SA patent/SG11201704852SA/en unknown
- 2015-12-23 CN CN201580075170.9A patent/CN107223163A/zh active Pending
- 2015-12-23 AU AU2015371312A patent/AU2015371312B2/en not_active Ceased
- 2015-12-23 MY MYPI2017000931A patent/MY188938A/en unknown
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2017
- 2017-06-08 IL IL252796A patent/IL252796B/en unknown
- 2017-06-21 US US15/628,775 patent/US20170306418A1/en not_active Abandoned
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2021
- 2021-06-15 JP JP2021099307A patent/JP2021169451A/ja active Pending
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2022
- 2022-05-12 US US17/743,230 patent/US20220267864A1/en not_active Abandoned
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2023
- 2023-01-20 US US18/157,597 patent/US20230220491A1/en not_active Abandoned
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