JP2018508193A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2018508193A5 JP2018508193A5 JP2017538576A JP2017538576A JP2018508193A5 JP 2018508193 A5 JP2018508193 A5 JP 2018508193A5 JP 2017538576 A JP2017538576 A JP 2017538576A JP 2017538576 A JP2017538576 A JP 2017538576A JP 2018508193 A5 JP2018508193 A5 JP 2018508193A5
- Authority
- JP
- Japan
- Prior art keywords
- occupied
- antibody
- seq
- chain variable
- variable region
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 125000003275 alpha amino acid group Chemical group 0.000 claims 18
- 150000007523 nucleic acids Chemical class 0.000 claims 5
- 102000039446 nucleic acids Human genes 0.000 claims 5
- 108020004707 nucleic acids Proteins 0.000 claims 5
- 201000010099 disease Diseases 0.000 claims 3
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 3
- 239000008194 pharmaceutical composition Substances 0.000 claims 3
- NFGXHKASABOEEW-UHFFFAOYSA-N 1-methylethyl 11-methoxy-3,7,11-trimethyl-2,4-dodecadienoate Chemical compound COC(C)(C)CCCC(C)CC=CC(C)=CC(=O)OC(C)C NFGXHKASABOEEW-UHFFFAOYSA-N 0.000 claims 2
- 150000001413 amino acids Chemical class 0.000 claims 2
- 230000000295 complement effect Effects 0.000 claims 2
- 239000013604 expression vector Substances 0.000 claims 2
- 239000012634 fragment Substances 0.000 claims 2
- 238000000034 method Methods 0.000 claims 2
- 238000003259 recombinant expression Methods 0.000 claims 2
- 208000024827 Alzheimer disease Diseases 0.000 claims 1
- 102000009490 IgG Receptors Human genes 0.000 claims 1
- 108010073807 IgG Receptors Proteins 0.000 claims 1
- 102000008394 Immunoglobulin Fragments Human genes 0.000 claims 1
- 108010021625 Immunoglobulin Fragments Proteins 0.000 claims 1
- 102100039648 Lactadherin Human genes 0.000 claims 1
- 101710191666 Lactadherin Proteins 0.000 claims 1
- 208000001826 Marfan syndrome Diseases 0.000 claims 1
- 241001529936 Murinae Species 0.000 claims 1
- 208000008589 Obesity Diseases 0.000 claims 1
- 206010033645 Pancreatitis Diseases 0.000 claims 1
- 230000004913 activation Effects 0.000 claims 1
- 230000002776 aggregation Effects 0.000 claims 1
- 238000004220 aggregation Methods 0.000 claims 1
- 125000000539 amino acid group Chemical group 0.000 claims 1
- 208000007474 aortic aneurysm Diseases 0.000 claims 1
- 230000008021 deposition Effects 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 208000019622 heart disease Diseases 0.000 claims 1
- 208000027866 inflammatory disease Diseases 0.000 claims 1
- 206010025135 lupus erythematosus Diseases 0.000 claims 1
- 230000035772 mutation Effects 0.000 claims 1
- 235000020824 obesity Nutrition 0.000 claims 1
- 230000002265 prevention Effects 0.000 claims 1
- 230000000717 retained effect Effects 0.000 claims 1
- 230000002194 synthesizing effect Effects 0.000 claims 1
- 230000002792 vascular Effects 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562106690P | 2015-01-22 | 2015-01-22 | |
| US62/106,690 | 2015-01-22 | ||
| PCT/US2016/014633 WO2016118930A1 (en) | 2015-01-22 | 2016-01-22 | Antibodies recognizing medin |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2018508193A JP2018508193A (ja) | 2018-03-29 |
| JP2018508193A5 true JP2018508193A5 (enExample) | 2019-02-28 |
Family
ID=55305090
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017538576A Pending JP2018508193A (ja) | 2015-01-22 | 2016-01-22 | メディンを認識する抗体 |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US20160251417A1 (enExample) |
| EP (1) | EP3247392A1 (enExample) |
| JP (1) | JP2018508193A (enExample) |
| CA (1) | CA2974511A1 (enExample) |
| HK (1) | HK1247132A1 (enExample) |
| WO (1) | WO2016118930A1 (enExample) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US10442855B2 (en) | 2015-01-22 | 2019-10-15 | Prothena Biosciences Limited | Antibodies recognizing medin |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2000061637A1 (en) * | 1999-04-14 | 2000-10-19 | Smithkline Beecham Corporation | Erythropoietin receptor antibodies |
| AU2007226696C1 (en) * | 2006-03-10 | 2016-02-04 | Wyeth Llc | Anti-5T4 antibodies and uses thereof |
| JP5558834B2 (ja) * | 2007-02-23 | 2014-07-23 | ヤンセン アルツハイマー イミュノセラピー | シヌクレイノパチーおよびアミロイド形成疾患（ａｍｙｌｏｉｄｏｇｅｎｉｃｄｉｓｅａｓｅ）の予防および処置 |
| EP2125894B1 (en) * | 2007-03-22 | 2018-12-19 | Biogen MA Inc. | Binding proteins, including antibodies, antibody derivatives and antibody fragments, that specifically bind cd154 and uses thereof |
| JP5564049B2 (ja) * | 2008-09-29 | 2014-07-30 | ヤンセン バイオテツク，インコーポレーテツド | 抗ｃｄ１４７抗体、方法及び使用 |
| JP6014596B2 (ja) * | 2010-11-09 | 2016-10-25 | メディミューン，エルエルシー | 均一コンジュゲーションのための抗体足場 |
-
2016
- 2016-01-22 EP EP16703215.0A patent/EP3247392A1/en not_active Withdrawn
- 2016-01-22 CA CA2974511A patent/CA2974511A1/en not_active Abandoned
- 2016-01-22 HK HK18106911.3A patent/HK1247132A1/zh unknown
- 2016-01-22 US US15/004,854 patent/US20160251417A1/en not_active Abandoned
- 2016-01-22 WO PCT/US2016/014633 patent/WO2016118930A1/en not_active Ceased
- 2016-01-22 JP JP2017538576A patent/JP2018508193A/ja active Pending
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2018506277A5 (enExample) | ||
| Safdari et al. | Antibody humanization methods–a review and update | |
| US11041022B2 (en) | Humanized antibodies against c-Kit | |
| JP6588534B2 (ja) | 抗ｐｄ−１のモノクローナル抗体およびその獲得方法 | |
| CN110156892B (zh) | 抗pd-l1抗体及其作为治疗剂及诊断剂的用途 | |
| JP2018510617A5 (enExample) | ||
| JP2016512551A5 (enExample) | ||
| JP2012530496A5 (enExample) | ||
| JP2018509889A5 (enExample) | ||
| JP2018183173A5 (enExample) | ||
| RU2017102514A (ru) | Гуманизированные анти-тау-антитела | |
| JP2020508655A5 (enExample) | ||
| JP2020536532A5 (enExample) | ||
| JP2017526370A5 (enExample) | ||
| Ahmadzadeh et al. | Antibody humanization methods for development of therapeutic applications | |
| JP2019520797A5 (enExample) | ||
| JP2019532619A5 (enExample) | ||
| JP2014519317A5 (enExample) | ||
| JP2013545455A5 (enExample) | ||
| JP2018503380A5 (enExample) | ||
| WO2013064701A2 (en) | Bispecific antibodies and methods for isolating same | |
| JP2012526558A5 (enExample) | ||
| JP2019525728A5 (enExample) | ||
| JP2008516970A5 (enExample) | ||
| JP2015533853A5 (enExample) |