JP2018507254A - 抗代替軽鎖抗体 - Google Patents

抗代替軽鎖抗体 Download PDF

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Publication number
JP2018507254A
JP2018507254A JP2017558627A JP2017558627A JP2018507254A JP 2018507254 A JP2018507254 A JP 2018507254A JP 2017558627 A JP2017558627 A JP 2017558627A JP 2017558627 A JP2017558627 A JP 2017558627A JP 2018507254 A JP2018507254 A JP 2018507254A
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JP
Japan
Prior art keywords
antibody
sequence
seq
human
antigen
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Pending
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JP2017558627A
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English (en)
Japanese (ja)
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JP2018507254A5 (https=
Inventor
ローレンス ホロヴィッツ，
ローレンス ホロヴィッツ，
Original Assignee
アイツー ファーマシューティカルズ， インコーポレーテッド
アイツー ファーマシューティカルズ， インコーポレーテッド
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Application filed by アイツー ファーマシューティカルズ， インコーポレーテッド, アイツー ファーマシューティカルズ， インコーポレーテッド filed Critical アイツー ファーマシューティカルズ， インコーポレーテッド
Publication of JP2018507254A publication Critical patent/JP2018507254A/ja
Publication of JP2018507254A5 publication Critical patent/JP2018507254A5/ja
Pending legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/42—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against immunoglobulins
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/564—Immunoassay; Biospecific binding assay; Materials therefor for pre-existing immune complex or autoimmune disease, i.e. systemic lupus erythematosus, rheumatoid arthritis, multiple sclerosis, rheumatoid factors or complement components C1-C9
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/575—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/57505—Immunoassay; Biospecific binding assay; Materials therefor for cancer of the blood, e.g. leukaemia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/10—Musculoskeletal or connective tissue disorders
    • G01N2800/101—Diffuse connective tissue disease, e.g. Sjögren, Wegener's granulomatosis
    • G01N2800/102—Arthritis; Rheumatoid arthritis, i.e. inflammation of peripheral joints

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Food Science & Technology (AREA)
  • Analytical Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Cell Biology (AREA)
  • Biotechnology (AREA)
  • Rheumatology (AREA)
  • Rehabilitation Therapy (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
JP2017558627A 2015-02-02 2016-01-27 抗代替軽鎖抗体 Pending JP2018507254A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201562111018P 2015-02-02 2015-02-02
US62/111,018 2015-02-02
PCT/US2016/015166 WO2016126488A1 (en) 2015-02-02 2016-01-27 Anti-surrogate light chain antibodies

Publications (2)

Publication Number Publication Date
JP2018507254A true JP2018507254A (ja) 2018-03-15
JP2018507254A5 JP2018507254A5 (https=) 2019-02-28

Family

ID=56564528

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2017558627A Pending JP2018507254A (ja) 2015-02-02 2016-01-27 抗代替軽鎖抗体

Country Status (10)

Country Link
US (1) US10858448B2 (https=)
EP (2) EP3253793A4 (https=)
JP (1) JP2018507254A (https=)
KR (1) KR102590740B1 (https=)
CN (1) CN107849123A (https=)
AU (1) AU2016215676B2 (https=)
CA (2) CA3185253A1 (https=)
HK (1) HK1247941A1 (https=)
IL (1) IL253579A0 (https=)
WO (1) WO2016126488A1 (https=)

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EP3253793A4 (en) 2015-02-02 2018-11-14 i2 Pharmaceuticals, Inc. Anti-surrogate light chain antibodies
CN107635578A (zh) 2015-02-05 2018-01-26 Stc.Unm 公司 抗前‑bcr拮抗剂和方法
EP3548055A4 (en) 2016-12-02 2020-08-19 University of Southern California SYNTHETIC IMMUNE RECEPTORS AND THEIR PROCESSES FOR USE
SG11202108398YA (en) * 2019-02-01 2021-08-30 Novarock Biotherapeutics Ltd Anti-claudin 18 antibodies and methods of use thereof
CA3138550A1 (en) * 2019-04-30 2020-11-05 Target Discovery Merger Sub II, LLC Cancer associated antibody compositions and methods of use
CN112300282A (zh) * 2020-11-03 2021-02-02 南京北恒生物科技有限公司 靶向cd7的人源化抗体及其用途
EP4294837A1 (en) * 2021-02-16 2023-12-27 Children's Health Care d/b/a Children's Minnesota Methods for treating b-all by administering a pre-bcr complex antagonist
CN120344653A (zh) * 2022-10-04 2025-07-18 明克治疗公司 成纤维细胞活化蛋白(fap)car-恒定型自然杀伤t细胞及其用途
WO2025212740A1 (en) * 2024-04-03 2025-10-09 Mink Therapeutics, Inc. Composition and methods for treating colorectal cancer liver metastasis (crc liver mets)

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Also Published As

Publication number Publication date
EP3253793A4 (en) 2018-11-14
WO2016126488A1 (en) 2016-08-11
US20180265594A1 (en) 2018-09-20
CA2975346A1 (en) 2016-08-11
US10858448B2 (en) 2020-12-08
HK1247941A1 (zh) 2018-10-05
AU2016215676A1 (en) 2017-08-10
EP3253793A1 (en) 2017-12-13
KR102590740B1 (ko) 2023-10-18
CA3185253A1 (en) 2016-08-11
IL253579A0 (en) 2017-09-28
CN107849123A (zh) 2018-03-27
KR20170120120A (ko) 2017-10-30
EP4177267A1 (en) 2023-05-10
AU2016215676B2 (en) 2021-12-02

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