HK1247941A1 - 抗替代性轻链抗体 - Google Patents

抗替代性轻链抗体 Download PDF

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Publication number
HK1247941A1
HK1247941A1 HK18107353.6A HK18107353A HK1247941A1 HK 1247941 A1 HK1247941 A1 HK 1247941A1 HK 18107353 A HK18107353 A HK 18107353A HK 1247941 A1 HK1247941 A1 HK 1247941A1
Authority
HK
Hong Kong
Prior art keywords
light chain
chain antibodies
surrogate light
antibodies
present
Prior art date
Application number
HK18107353.6A
Other languages
English (en)
Chinese (zh)
Inventor
Lawrence Horowitz
Original Assignee
Children’s Health Care d/b/a Children’s Minnesota
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Children’s Health Care d/b/a Children’s Minnesota filed Critical Children’s Health Care d/b/a Children’s Minnesota
Publication of HK1247941A1 publication Critical patent/HK1247941A1/zh

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/42—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against immunoglobulins
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/564—Immunoassay; Biospecific binding assay; Materials therefor for pre-existing immune complex or autoimmune disease, i.e. systemic lupus erythematosus, rheumatoid arthritis, multiple sclerosis, rheumatoid factors or complement components C1-C9
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/575—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/57505—Immunoassay; Biospecific binding assay; Materials therefor for cancer of the blood, e.g. leukaemia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/10—Musculoskeletal or connective tissue disorders
    • G01N2800/101—Diffuse connective tissue disease, e.g. Sjögren, Wegener's granulomatosis
    • G01N2800/102—Arthritis; Rheumatoid arthritis, i.e. inflammation of peripheral joints

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Food Science & Technology (AREA)
  • Analytical Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Cell Biology (AREA)
  • Biotechnology (AREA)
  • Rheumatology (AREA)
  • Rehabilitation Therapy (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
HK18107353.6A 2015-02-02 2016-01-27 抗替代性轻链抗体 HK1247941A1 (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201562111018P 2015-02-02 2015-02-02
US201562111018 2015-02-02
PCT/US2016/015166 WO2016126488A1 (en) 2015-02-02 2016-01-27 Anti-surrogate light chain antibodies

Publications (1)

Publication Number Publication Date
HK1247941A1 true HK1247941A1 (zh) 2018-10-05

Family

ID=56564528

Family Applications (1)

Application Number Title Priority Date Filing Date
HK18107353.6A HK1247941A1 (zh) 2015-02-02 2016-01-27 抗替代性轻链抗体

Country Status (10)

Country Link
US (1) US10858448B2 (https=)
EP (2) EP3253793A4 (https=)
JP (1) JP2018507254A (https=)
KR (1) KR102590740B1 (https=)
CN (1) CN107849123A (https=)
AU (1) AU2016215676B2 (https=)
CA (2) CA3185253A1 (https=)
HK (1) HK1247941A1 (https=)
IL (1) IL253579A0 (https=)
WO (1) WO2016126488A1 (https=)

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3253793A4 (en) 2015-02-02 2018-11-14 i2 Pharmaceuticals, Inc. Anti-surrogate light chain antibodies
CN107635578A (zh) 2015-02-05 2018-01-26 Stc.Unm 公司 抗前‑bcr拮抗剂和方法
EP3548055A4 (en) 2016-12-02 2020-08-19 University of Southern California SYNTHETIC IMMUNE RECEPTORS AND THEIR PROCESSES FOR USE
SG11202108398YA (en) * 2019-02-01 2021-08-30 Novarock Biotherapeutics Ltd Anti-claudin 18 antibodies and methods of use thereof
CA3138550A1 (en) * 2019-04-30 2020-11-05 Target Discovery Merger Sub II, LLC Cancer associated antibody compositions and methods of use
CN112300282A (zh) * 2020-11-03 2021-02-02 南京北恒生物科技有限公司 靶向cd7的人源化抗体及其用途
EP4294837A1 (en) * 2021-02-16 2023-12-27 Children's Health Care d/b/a Children's Minnesota Methods for treating b-all by administering a pre-bcr complex antagonist
CN120344653A (zh) * 2022-10-04 2025-07-18 明克治疗公司 成纤维细胞活化蛋白(fap)car-恒定型自然杀伤t细胞及其用途
WO2025212740A1 (en) * 2024-04-03 2025-10-09 Mink Therapeutics, Inc. Composition and methods for treating colorectal cancer liver metastasis (crc liver mets)

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CN107635578A (zh) * 2015-02-05 2018-01-26 Stc.Unm 公司 抗前‑bcr拮抗剂和方法

Also Published As

Publication number Publication date
EP3253793A4 (en) 2018-11-14
WO2016126488A1 (en) 2016-08-11
US20180265594A1 (en) 2018-09-20
CA2975346A1 (en) 2016-08-11
US10858448B2 (en) 2020-12-08
AU2016215676A1 (en) 2017-08-10
EP3253793A1 (en) 2017-12-13
KR102590740B1 (ko) 2023-10-18
CA3185253A1 (en) 2016-08-11
IL253579A0 (en) 2017-09-28
CN107849123A (zh) 2018-03-27
KR20170120120A (ko) 2017-10-30
EP4177267A1 (en) 2023-05-10
AU2016215676B2 (en) 2021-12-02
JP2018507254A (ja) 2018-03-15

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