JP2018505890A5 - - Google Patents
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- JP2018505890A5 JP2018505890A5 JP2017541665A JP2017541665A JP2018505890A5 JP 2018505890 A5 JP2018505890 A5 JP 2018505890A5 JP 2017541665 A JP2017541665 A JP 2017541665A JP 2017541665 A JP2017541665 A JP 2017541665A JP 2018505890 A5 JP2018505890 A5 JP 2018505890A5
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- 210000003491 skin Anatomy 0.000 claims description 50
- 108090000765 processed proteins & peptides Proteins 0.000 claims description 31
- 239000000203 mixture Substances 0.000 claims description 30
- MIJYXULNPSFWEK-GTOFXWBISA-N 3beta-hydroxyolean-12-en-28-oic acid Chemical compound C1C[C@H](O)C(C)(C)[C@@H]2CC[C@@]3(C)[C@]4(C)CC[C@@]5(C(O)=O)CCC(C)(C)C[C@H]5C4=CC[C@@H]3[C@]21C MIJYXULNPSFWEK-GTOFXWBISA-N 0.000 claims description 24
- JKLISIRFYWXLQG-UHFFFAOYSA-N Epioleonolsaeure Natural products C1CC(O)C(C)(C)C2CCC3(C)C4(C)CCC5(C(O)=O)CCC(C)(C)CC5C4CCC3C21C JKLISIRFYWXLQG-UHFFFAOYSA-N 0.000 claims description 24
- YBRJHZPWOMJYKQ-UHFFFAOYSA-N Oleanolic acid Natural products CC1(C)CC2C3=CCC4C5(C)CCC(O)C(C)(C)C5CCC4(C)C3(C)CCC2(C1)C(=O)O YBRJHZPWOMJYKQ-UHFFFAOYSA-N 0.000 claims description 24
- MIJYXULNPSFWEK-UHFFFAOYSA-N Oleanolinsaeure Natural products C1CC(O)C(C)(C)C2CCC3(C)C4(C)CCC5(C(O)=O)CCC(C)(C)CC5C4=CCC3C21C MIJYXULNPSFWEK-UHFFFAOYSA-N 0.000 claims description 24
- 229940100243 oleanolic acid Drugs 0.000 claims description 24
- HZLWUYJLOIAQFC-UHFFFAOYSA-N prosapogenin PS-A Natural products C12CC(C)(C)CCC2(C(O)=O)CCC(C2(CCC3C4(C)C)C)(C)C1=CCC2C3(C)CCC4OC1OCC(O)C(O)C1O HZLWUYJLOIAQFC-UHFFFAOYSA-N 0.000 claims description 24
- 108090000623 proteins and genes Proteins 0.000 claims description 14
- 230000000694 effects Effects 0.000 claims description 9
- 102100031784 Loricrin Human genes 0.000 claims description 8
- 210000002950 fibroblast Anatomy 0.000 claims description 8
- 108010079309 loricrin Proteins 0.000 claims description 8
- 108010035532 Collagen Proteins 0.000 claims description 5
- 102000008186 Collagen Human genes 0.000 claims description 5
- 229920001436 collagen Polymers 0.000 claims description 5
- 108090000976 Aquaporin 5 Proteins 0.000 claims description 4
- 102000008143 Bone Morphogenetic Protein 2 Human genes 0.000 claims description 4
- 108010049931 Bone Morphogenetic Protein 2 Proteins 0.000 claims description 4
- 102100036419 Calmodulin-like protein 5 Human genes 0.000 claims description 4
- 102000018156 Claudin-7 Human genes 0.000 claims description 4
- 108050007296 Claudin-7 Proteins 0.000 claims description 4
- 108010037362 Extracellular Matrix Proteins Proteins 0.000 claims description 4
- 102000010834 Extracellular Matrix Proteins Human genes 0.000 claims description 4
- 102100028314 Filaggrin Human genes 0.000 claims description 4
- 101710088660 Filaggrin Proteins 0.000 claims description 4
- 101000714353 Homo sapiens Calmodulin-like protein 5 Proteins 0.000 claims description 4
- 101000987003 Homo sapiens Tumor protein 63 Proteins 0.000 claims description 4
- 102000012334 Integrin beta4 Human genes 0.000 claims description 4
- 108010022238 Integrin beta4 Proteins 0.000 claims description 4
- 102000003728 Peroxisome Proliferator-Activated Receptors Human genes 0.000 claims description 4
- 108090000029 Peroxisome Proliferator-Activated Receptors Proteins 0.000 claims description 4
- 102000004669 Protein-Lysine 6-Oxidase Human genes 0.000 claims description 4
- 108010003894 Protein-Lysine 6-Oxidase Proteins 0.000 claims description 4
- 102000046299 Transforming Growth Factor beta1 Human genes 0.000 claims description 4
- 101800002279 Transforming growth factor beta-1 Proteins 0.000 claims description 4
- 102100027881 Tumor protein 63 Human genes 0.000 claims description 4
- 238000007634 remodeling Methods 0.000 claims description 4
- 229940099456 transforming growth factor beta 1 Drugs 0.000 claims description 4
- 230000015572 biosynthetic process Effects 0.000 claims description 3
- 238000003786 synthesis reaction Methods 0.000 claims description 3
- 101150095412 47 gene Proteins 0.000 claims description 2
- 102000004392 Aquaporin 5 Human genes 0.000 claims description 2
- 102000029816 Collagenase Human genes 0.000 claims description 2
- 108060005980 Collagenase Proteins 0.000 claims description 2
- 102000018233 Fibroblast Growth Factor Human genes 0.000 claims description 2
- 108050007372 Fibroblast Growth Factor Proteins 0.000 claims description 2
- 101150097459 HSP90 gene Proteins 0.000 claims description 2
- 101100181431 Homo sapiens LCE3D gene Proteins 0.000 claims description 2
- 101000945496 Homo sapiens Proliferation marker protein Ki-67 Proteins 0.000 claims description 2
- 102100024572 Late cornified envelope protein 3D Human genes 0.000 claims description 2
- 102000002274 Matrix Metalloproteinases Human genes 0.000 claims description 2
- 108010000684 Matrix Metalloproteinases Proteins 0.000 claims description 2
- 102000016387 Pancreatic elastase Human genes 0.000 claims description 2
- 108010067372 Pancreatic elastase Proteins 0.000 claims description 2
- 102100034836 Proliferation marker protein Ki-67 Human genes 0.000 claims description 2
- 102000004887 Transforming Growth Factor beta Human genes 0.000 claims description 2
- 108090001012 Transforming Growth Factor beta Proteins 0.000 claims description 2
- 239000000427 antigen Substances 0.000 claims description 2
- 108091007433 antigens Proteins 0.000 claims description 2
- 102000036639 antigens Human genes 0.000 claims description 2
- 230000022131 cell cycle Effects 0.000 claims description 2
- 230000004663 cell proliferation Effects 0.000 claims description 2
- 229960002424 collagenase Drugs 0.000 claims description 2
- 230000004069 differentiation Effects 0.000 claims description 2
- 210000002744 extracellular matrix Anatomy 0.000 claims description 2
- 229940126864 fibroblast growth factor Drugs 0.000 claims description 2
- 230000001939 inductive effect Effects 0.000 claims description 2
- 239000003112 inhibitor Substances 0.000 claims description 2
- 230000005764 inhibitory process Effects 0.000 claims description 2
- 210000002510 keratinocyte Anatomy 0.000 claims description 2
- 239000011159 matrix material Substances 0.000 claims description 2
- 230000003061 melanogenesis Effects 0.000 claims description 2
- 230000037333 procollagen synthesis Effects 0.000 claims description 2
- 231100000241 scar Toxicity 0.000 claims description 2
- ZRKFYGHZFMAOKI-QMGMOQQFSA-N tgfbeta Chemical compound C([C@H](NC(=O)[C@H](C(C)C)NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](N)CCSC)C(C)C)[C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](C)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N1[C@@H](CCC1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(O)=O)C1=CC=C(O)C=C1 ZRKFYGHZFMAOKI-QMGMOQQFSA-N 0.000 claims description 2
- 210000001519 tissue Anatomy 0.000 claims description 2
- 239000008194 pharmaceutical composition Substances 0.000 claims 24
- 230000036571 hydration Effects 0.000 claims 1
- 238000006703 hydration reaction Methods 0.000 claims 1
- 102000004196 processed proteins & peptides Human genes 0.000 claims 1
- 230000008591 skin barrier function Effects 0.000 claims 1
- 238000000034 method Methods 0.000 description 14
- 230000004888 barrier function Effects 0.000 description 1
- 230000000673 metalloproteinaselike Effects 0.000 description 1
- 230000037067 skin hydration Effects 0.000 description 1
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US12/979,667 US8987212B2 (en) | 2007-08-07 | 2010-12-28 | Oleanoyl peptide composition and method of treating skin aging |
| US14/614,538 US20150148297A1 (en) | 2007-08-07 | 2015-02-05 | Oleanoyl peptide composition and collagen enhancement |
| US14/614,538 | 2015-02-05 | ||
| PCT/US2015/067277 WO2016126343A1 (en) | 2015-02-05 | 2015-12-22 | Oleanoyl peptide composition and collagen enhancement |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2018505890A JP2018505890A (ja) | 2018-03-01 |
| JP2018505890A5 true JP2018505890A5 (enExample) | 2018-12-13 |
Family
ID=45464381
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011290738A Active JP6176893B2 (ja) | 2010-12-28 | 2011-12-28 | オレアノイルペプチド組成物および皮膚の加齢を治療する方法 |
| JP2017541665A Pending JP2018505890A (ja) | 2010-12-28 | 2015-12-22 | オレアノイルペプチド組成物およびコラーゲンの増強 |
| JP2017087118A Pending JP2017206503A (ja) | 2010-12-28 | 2017-04-26 | オレアノイルペプチド組成物および皮膚の加齢を治療する方法 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011290738A Active JP6176893B2 (ja) | 2010-12-28 | 2011-12-28 | オレアノイルペプチド組成物および皮膚の加齢を治療する方法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017087118A Pending JP2017206503A (ja) | 2010-12-28 | 2017-04-26 | オレアノイルペプチド組成物および皮膚の加齢を治療する方法 |
Country Status (10)
| Country | Link |
|---|---|
| US (3) | US8987212B2 (enExample) |
| EP (1) | EP2510919A3 (enExample) |
| JP (3) | JP6176893B2 (enExample) |
| KR (1) | KR20170101946A (enExample) |
| AU (2) | AU2011265587B2 (enExample) |
| BR (1) | BRPI1105822A2 (enExample) |
| CA (1) | CA2975170C (enExample) |
| EA (1) | EA035128B9 (enExample) |
| MY (1) | MY188723A (enExample) |
| WO (1) | WO2012091743A1 (enExample) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8987212B2 (en) * | 2007-08-07 | 2015-03-24 | Muhammed Majeed | Oleanoyl peptide composition and method of treating skin aging |
| PH12017501070B1 (en) | 2014-12-23 | 2022-04-29 | Avon Prod Inc | Peptides and their use in the treatment of skin |
| PH12017501234B1 (en) * | 2015-02-05 | 2023-10-18 | Muhammed Majeed | Oleanoyl peptide composition and collagen enhancement |
| US9597274B2 (en) | 2015-06-17 | 2017-03-21 | Avon Products, Inc. | Peptides and their use in the treatment of skin |
| US10493020B2 (en) | 2016-04-14 | 2019-12-03 | The Procter & Gamble Company | Method of improving the appearance of periorbital dyschromia |
| KR102007078B1 (ko) | 2017-03-24 | 2019-08-05 | (주)셀아이콘랩 | 콜라겐 생성을 촉진시키는 신규한 헵타펩타이드 단량체 및 이량체를 포함하는 피부 노화 방지를 위한 화장품 조성물 |
| CA3075729A1 (en) | 2017-09-14 | 2019-03-21 | Phoenix Biotechnology, Inc. | Use of oleandrin to treatn viral infection |
| JP7370966B2 (ja) | 2017-09-14 | 2023-10-30 | フェニックス・バイオテクノロジー・インコーポレイテッド | 神経学的状態を治療するための方法および改善された神経保護組成物 |
| RU2733372C1 (ru) * | 2017-09-21 | 2020-10-01 | Сами Лабс Лимитед | Способ получения трипептида, содержащего олеаноловую кислоту, и его терапевтические применения |
| EP3773932A4 (en) * | 2018-04-03 | 2022-04-27 | Sami Labs Limited | SKIN CARE COMPOSITIONS AND THEIR APPLICATIONS |
| CN110143994B (zh) * | 2019-03-22 | 2020-08-04 | 中国医学科学院药用植物研究所 | 辽东楤木单体皂苷衍生物及其制备方法和用途 |
| CN110117307B (zh) * | 2019-03-22 | 2020-08-04 | 中国医学科学院药用植物研究所 | 楤木皂苷衍生物及其制备方法和用途 |
| JP7153083B2 (ja) | 2020-03-31 | 2022-10-13 | フェニックス・バイオテクノロジー・インコーポレイテッド | コロナウイルス感染を治療するための方法および組成物 |
| EP4009981B1 (en) | 2020-03-31 | 2023-08-16 | Phoenix Biotechnology, Inc. | Method and compositions for treating coronavirus infection |
| CZ2020207A3 (cs) * | 2020-04-09 | 2021-06-02 | Contipro A.S. | Pentapeptid odvozený od kaseinu a kompozice, která jej zahrnuje a jejich topické použití |
Family Cites Families (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5055298A (en) | 1987-12-01 | 1991-10-08 | Chemisches Laboratorium Dr. Kurt Richter Gmbh | Cosmetic composition comprising an extracellular connective tissue matrix |
| US5198465A (en) | 1991-06-19 | 1993-03-30 | Dioguardi Francesco S | Compositions based on amino acids for preventing and treating precursor deficiencies in the synthesis of collagen |
| EP1005333B1 (en) | 1997-02-25 | 2005-01-12 | The Regents Of The University Of Michigan | Methods and compositions for preventing and treating chronological aging in human skin |
| US6809075B1 (en) | 2000-05-30 | 2004-10-26 | Connective Tissue Imagineering Llc | Elastin peptide analogs and uses of same incombination with skin enhancing agents |
| FR2777183B1 (fr) * | 1998-04-10 | 2001-03-02 | Oreal | Utilisation d'au moins un hydroxystilbene dans une composition destinee a favoriser la desquamation de la peau et composition le comprenant |
| FR2783169B1 (fr) * | 1998-09-15 | 2001-11-02 | Sederma Sa | Utilisation cosmetique ou dermopharmaceutique de peptides pour la cicatrisation et pour l'amelioration de l'aspect cutane lors du vieillissement naturel ou accelere (heliodermie, pollution) |
| US6777389B1 (en) | 1998-11-19 | 2004-08-17 | Connective Tissue Imagineering Llc | Cosmetic or dermatological use of 7-hydroxylated steroids in combination with elastin derived peptides |
| US6492326B1 (en) | 1999-04-19 | 2002-12-10 | The Procter & Gamble Company | Skin care compositions containing combination of skin care actives |
| MXPA01013218A (es) * | 1999-06-30 | 2002-06-04 | Unilever Nv | Composiciones cosmeticas para el cuidado de la piel conteniendo alcohol cumico. |
| US6794362B1 (en) | 2000-05-30 | 2004-09-21 | Connective Tissue Imagineering Llc | Asparagine containing elastin peptide analogs |
| FR2813018B1 (fr) * | 2000-08-21 | 2004-02-06 | Boots Co Plc | Compositions cosmetiques renfermant au moins un compose stimulant la neosynthese des laminines, et/ou de l'integrine alpha-2 beta-1 et/ou du collagene iv de la jonction dermo- epidermique |
| DE10121069A1 (de) * | 2001-04-26 | 2002-10-31 | Beiersdorf Ag | Verwendung von Tetrahydrocurcuminoiden oder deren Derivaten als Wirkstoffe zur Herstellung von kosmetischen und dermatologischen Zubereitungen zum Schutz und zur Behandlung der trockenen bzw. alterstrockenen Haut |
| FR2826266B1 (fr) | 2001-06-26 | 2005-02-25 | Oreal | Composition cosmetique ou dermatologique comprenant une association entre un compose de la famille des n-acylaminoamides et au moins un inhibiteur de metalloproteinases matricielles |
| US6906036B2 (en) | 2001-08-16 | 2005-06-14 | Kimberly-Clark Worldwide, Inc. | Anti-aging and wound healing compounds |
| US20030124205A1 (en) * | 2001-12-28 | 2003-07-03 | Avon Products, Inc. | Topical cosmetic composition having a natural plant active ingredient and method of using same |
| KR100753472B1 (ko) * | 2002-03-15 | 2007-08-31 | 주식회사 엘지생활건강 | 사람 콜라겐 ⅰ형의 ｃ-말단에서 유래된 펩타이드에ｔａｔ 펩타이드가 결합된 융합 펩타이드, 이의 제조방법,및 이를 포함하는 피부주름개선 화장료 조성물 |
| US8691247B2 (en) * | 2006-12-26 | 2014-04-08 | Ad Lunam Labs Inc. | Skin rejuvenation cream |
| US20090169651A1 (en) * | 2007-06-28 | 2009-07-02 | Muhammed Majeed | Anti-skin damage compositions with complimentary dual mode of action |
| US8383594B2 (en) * | 2007-08-07 | 2013-02-26 | Sami Labs Limited | Peptides modified with triterpenoids and small organic molecules: synthesis and use in cosmeceuticals |
| US8987212B2 (en) * | 2007-08-07 | 2015-03-24 | Muhammed Majeed | Oleanoyl peptide composition and method of treating skin aging |
| WO2010093848A1 (en) * | 2009-02-13 | 2010-08-19 | Invitrx, Inc. | Skin cream |
-
2010
- 2010-12-28 US US12/979,667 patent/US8987212B2/en active Active
-
2011
- 2011-02-27 WO PCT/US2011/026395 patent/WO2012091743A1/en not_active Ceased
- 2011-12-28 BR BRPI1105822A patent/BRPI1105822A2/pt not_active IP Right Cessation
- 2011-12-28 JP JP2011290738A patent/JP6176893B2/ja active Active
- 2011-12-28 EP EP11195892.2A patent/EP2510919A3/en not_active Withdrawn
- 2011-12-30 AU AU2011265587A patent/AU2011265587B2/en not_active Ceased
-
2015
- 2015-02-05 US US14/614,538 patent/US20150148297A1/en not_active Abandoned
- 2015-12-22 MY MYPI2017702419A patent/MY188723A/en unknown
- 2015-12-22 AU AU2015381703A patent/AU2015381703B2/en not_active Ceased
- 2015-12-22 EA EA201791761A patent/EA035128B9/ru not_active IP Right Cessation
- 2015-12-22 KR KR1020177020364A patent/KR20170101946A/ko not_active Ceased
- 2015-12-22 CA CA2975170A patent/CA2975170C/en active Active
- 2015-12-22 JP JP2017541665A patent/JP2018505890A/ja active Pending
- 2015-12-30 US US14/983,874 patent/US10071043B2/en active Active
-
2017
- 2017-04-26 JP JP2017087118A patent/JP2017206503A/ja active Pending
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