JP2018505861A5 - - Google Patents

Info

Publication number

JP2018505861A5

JP2018505861A5 JP2017533018A JP2017533018A JP2018505861A5 JP 2018505861 A5 JP2018505861 A5 JP 2018505861A5 JP 2017533018 A JP2017533018 A JP 2017533018A JP 2017533018 A JP2017533018 A JP 2017533018A JP 2018505861 A5 JP2018505861 A5 JP 2018505861A5

Authority

JP

Japan

Prior art keywords

amino acid

seq

terminal

terminal peptide

subject

Prior art date

2015-12-22

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Granted

Links

• Espacenet
• Global Dossier
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• 108090000765 processed proteins & peptides Proteins 0.000 claims 9
• 101800001415 Bri23 peptide Proteins 0.000 claims 7
• 101800000655 C-terminal peptide Proteins 0.000 claims 7
• 102400000107 C-terminal peptide Human genes 0.000 claims 7
• 125000003275 alpha amino acid group Chemical group 0.000 claims 7
• 125000000539 amino acid group Chemical group 0.000 claims 6
• 108010040721 Flagellin Proteins 0.000 claims 3
• 101800000597 N-terminal peptide Proteins 0.000 claims 3
• 102400000108 N-terminal peptide Human genes 0.000 claims 3
• 230000003115 biocidal effect Effects 0.000 claims 3
• 229920001184 polypeptide Polymers 0.000 claims 3
• 102000004196 processed proteins & peptides Human genes 0.000 claims 3
• 206010042566 Superinfection Diseases 0.000 claims 2
• 229940024606 amino acid Drugs 0.000 claims 2
• 235000001014 amino acid Nutrition 0.000 claims 2
• 150000001413 amino acids Chemical class 0.000 claims 2
• 239000003242 anti bacterial agent Substances 0.000 claims 2
• 229940088710 antibiotic agent Drugs 0.000 claims 2
• 230000001580 bacterial effect Effects 0.000 claims 2
• 206010022000 influenza Diseases 0.000 claims 2
• 230000007774 longterm Effects 0.000 claims 2
• 125000006850 spacer group Chemical group 0.000 claims 2
• IZXIZTKNFFYFOF-UHFFFAOYSA-N 2-Oxazolidone Chemical class O=C1NCCO1 IZXIZTKNFFYFOF-UHFFFAOYSA-N 0.000 claims 1
• FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 1
• WZRJTRPJURQBRM-UHFFFAOYSA-N 4-amino-n-(5-methyl-1,2-oxazol-3-yl)benzenesulfonamide;5-[(3,4,5-trimethoxyphenyl)methyl]pyrimidine-2,4-diamine Chemical compound O1C(C)=CC(NS(=O)(=O)C=2C=CC(N)=CC=2)=N1.COC1=C(OC)C(OC)=CC(CC=2C(=NC(N)=NC=2)N)=C1 WZRJTRPJURQBRM-UHFFFAOYSA-N 0.000 claims 1
• 108010044267 Abnormal Hemoglobins Proteins 0.000 claims 1
• DCXYFEDJOCDNAF-UHFFFAOYSA-N Asparagine Natural products OC(=O)C(N)CC(N)=O DCXYFEDJOCDNAF-UHFFFAOYSA-N 0.000 claims 1
• BSYNRYMUTXBXSQ-UHFFFAOYSA-N Aspirin Chemical compound CC(=O)OC1=CC=CC=C1C(O)=O BSYNRYMUTXBXSQ-UHFFFAOYSA-N 0.000 claims 1
• 208000024172 Cardiovascular disease Diseases 0.000 claims 1
• 208000017667 Chronic Disease Diseases 0.000 claims 1
• 108010015899 Glycopeptides Proteins 0.000 claims 1
• 102000002068 Glycopeptides Human genes 0.000 claims 1
• 241000606768 Haemophilus influenzae Species 0.000 claims 1
• 206010062016 Immunosuppression Diseases 0.000 claims 1
• 108010028921 Lipopeptides Proteins 0.000 claims 1
• 241000588655 Moraxella catarrhalis Species 0.000 claims 1
• 108010040201 Polymyxins Proteins 0.000 claims 1
• 229930189077 Rifamycin Natural products 0.000 claims 1
• MTCFGRXMJLQNBG-UHFFFAOYSA-N Serine Natural products OCC(N)C(O)=O MTCFGRXMJLQNBG-UHFFFAOYSA-N 0.000 claims 1
• 241000191967 Staphylococcus aureus Species 0.000 claims 1
• 241000193998 Streptococcus pneumoniae Species 0.000 claims 1
• 108010034396 Streptogramins Proteins 0.000 claims 1
• 239000004098 Tetracycline Substances 0.000 claims 1
• 229960001138 acetylsalicylic acid Drugs 0.000 claims 1
• 229940126575 aminoglycoside Drugs 0.000 claims 1
• LSQZJLSUYDQPKJ-NJBDSQKTSA-N amoxicillin Chemical compound C1([C@@H](N)C(=O)N[C@H]2[C@H]3SC([C@@H](N3C2=O)C(O)=O)(C)C)=CC=C(O)C=C1 LSQZJLSUYDQPKJ-NJBDSQKTSA-N 0.000 claims 1
• 229960003022 amoxicillin Drugs 0.000 claims 1
• 229960001230 asparagine Drugs 0.000 claims 1
• 235000009582 asparagine Nutrition 0.000 claims 1
• 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims 1
• 210000000748 cardiovascular system Anatomy 0.000 claims 1
• 230000001684 chronic effect Effects 0.000 claims 1
• 208000016097 disease of metabolism Diseases 0.000 claims 1
• 229940124307 fluoroquinolone Drugs 0.000 claims 1
• 230000001506 immunosuppresive effect Effects 0.000 claims 1
• 210000004072 lung Anatomy 0.000 claims 1
• 239000003120 macrolide antibiotic agent Substances 0.000 claims 1
• 229940041033 macrolides Drugs 0.000 claims 1
• 230000001404 mediated effect Effects 0.000 claims 1
• 208000030159 metabolic disease Diseases 0.000 claims 1
• LSQZJLSUYDQPKJ-UHFFFAOYSA-N p-Hydroxyampicillin Natural products O=C1N2C(C(O)=O)C(C)(C)SC2C1NC(=O)C(N)C1=CC=C(O)C=C1 LSQZJLSUYDQPKJ-UHFFFAOYSA-N 0.000 claims 1
• 229940041153 polymyxins Drugs 0.000 claims 1
• 230000035935 pregnancy Effects 0.000 claims 1
• 150000007660 quinolones Chemical class 0.000 claims 1
• 230000008085 renal dysfunction Effects 0.000 claims 1
• BTVYFIMKUHNOBZ-QXMMDKDBSA-N rifamycin s Chemical class O=C1C(C(O)=C2C)=C3C(=O)C=C1NC(=O)\C(C)=C/C=C\C(C)C(O)C(C)C(O)C(C)C(OC(C)=O)C(C)C(OC)\C=C/OC1(C)OC2=C3C1=O BTVYFIMKUHNOBZ-QXMMDKDBSA-N 0.000 claims 1
• 229940081192 rifamycins Drugs 0.000 claims 1
• 125000003607 serino group Chemical group [H]N([H])[C@]([H])(C(=O)[*])C(O[H])([H])[H] 0.000 claims 1
• 241000894007 species Species 0.000 claims 1
• 229940031000 streptococcus pneumoniae Drugs 0.000 claims 1
• 229940041030 streptogramins Drugs 0.000 claims 1
• 229940006995 sulfamethoxazole and trimethoprim Drugs 0.000 claims 1
• -1 sulfamethoxazoles Substances 0.000 claims 1
• 229940124530 sulfonamide Drugs 0.000 claims 1
• 150000003456 sulfonamides Chemical class 0.000 claims 1
• 235000019364 tetracycline Nutrition 0.000 claims 1
• 150000003522 tetracyclines Chemical class 0.000 claims 1
• 229940040944 tetracyclines Drugs 0.000 claims 1
• 150000003952 β-lactams Chemical class 0.000 claims 1