JP2018504919A5 - - Google Patents
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- Publication number
- JP2018504919A5 JP2018504919A5 JP2017548375A JP2017548375A JP2018504919A5 JP 2018504919 A5 JP2018504919 A5 JP 2018504919A5 JP 2017548375 A JP2017548375 A JP 2017548375A JP 2017548375 A JP2017548375 A JP 2017548375A JP 2018504919 A5 JP2018504919 A5 JP 2018504919A5
- Authority
- JP
- Japan
- Prior art keywords
- bacterium
- gene
- bacterium according
- arginine
- wild
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 241000894006 Bacteria Species 0.000 claims 31
- 239000004475 Arginine Substances 0.000 claims 10
- ODKSFYDXXFIFQN-UHFFFAOYSA-N arginine Natural products OC(=O)C(N)CCCNC(N)=N ODKSFYDXXFIFQN-UHFFFAOYSA-N 0.000 claims 10
- 108090000623 proteins and genes Proteins 0.000 claims 9
- 108010032178 Amino-acid N-acetyltransferase Proteins 0.000 claims 7
- 102000007610 Amino-acid N-acetyltransferase Human genes 0.000 claims 6
- 206010021143 Hypoxia Diseases 0.000 claims 6
- 239000008194 pharmaceutical composition Substances 0.000 claims 6
- 230000007954 hypoxia Effects 0.000 claims 5
- 206010020575 Hyperammonaemia Diseases 0.000 claims 4
- 201000010099 disease Diseases 0.000 claims 4
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 4
- 210000001035 gastrointestinal tract Anatomy 0.000 claims 3
- 239000000203 mixture Substances 0.000 claims 3
- 101150118463 argG gene Proteins 0.000 claims 2
- 230000001580 bacterial effect Effects 0.000 claims 2
- 230000005764 inhibitory process Effects 0.000 claims 2
- 239000013612 plasmid Substances 0.000 claims 2
- 208000024891 symptom Diseases 0.000 claims 2
- 208000019932 Aciduria Diseases 0.000 claims 1
- 208000007788 Acute Liver Failure Diseases 0.000 claims 1
- 206010000804 Acute hepatic failure Diseases 0.000 claims 1
- 206010062695 Arginase deficiency Diseases 0.000 claims 1
- 208000034318 Argininemia Diseases 0.000 claims 1
- 206010058298 Argininosuccinate synthetase deficiency Diseases 0.000 claims 1
- 206010003591 Ataxia Diseases 0.000 claims 1
- 101100427060 Bacillus spizizenii (strain ATCC 23059 / NRRL B-14472 / W23) thyA1 gene Proteins 0.000 claims 1
- 241000606125 Bacteroides Species 0.000 claims 1
- 241000186000 Bifidobacterium Species 0.000 claims 1
- 201000004569 Blindness Diseases 0.000 claims 1
- 208000014644 Brain disease Diseases 0.000 claims 1
- 206010048962 Brain oedema Diseases 0.000 claims 1
- 206010058297 Carbamoyl phosphate synthetase deficiency Diseases 0.000 claims 1
- 208000033910 Carbamoyl-phosphate synthetase 1 deficiency Diseases 0.000 claims 1
- 201000011297 Citrullinemia Diseases 0.000 claims 1
- 241000193403 Clostridium Species 0.000 claims 1
- 206010010071 Coma Diseases 0.000 claims 1
- 208000032274 Encephalopathy Diseases 0.000 claims 1
- 208000010334 End Stage Liver Disease Diseases 0.000 claims 1
- 102000004190 Enzymes Human genes 0.000 claims 1
- 108090000790 Enzymes Proteins 0.000 claims 1
- 241000588722 Escherichia Species 0.000 claims 1
- 241000588724 Escherichia coli Species 0.000 claims 1
- 101100153154 Escherichia phage T5 thy gene Proteins 0.000 claims 1
- 101000986595 Homo sapiens Ornithine transcarbamylase, mitochondrial Proteins 0.000 claims 1
- 206010021113 Hypothermia Diseases 0.000 claims 1
- 208000028547 Inborn Urea Cycle disease Diseases 0.000 claims 1
- 241000186660 Lactobacillus Species 0.000 claims 1
- 241000194036 Lactococcus Species 0.000 claims 1
- 108700043217 N-acetyl glutamate synthetase deficiency Proteins 0.000 claims 1
- 108091028043 Nucleic acid sequence Proteins 0.000 claims 1
- 208000000599 Ornithine Carbamoyltransferase Deficiency Disease Diseases 0.000 claims 1
- 206010052450 Ornithine transcarbamoylase deficiency Diseases 0.000 claims 1
- 208000035903 Ornithine transcarbamylase deficiency Diseases 0.000 claims 1
- 102100028200 Ornithine transcarbamylase, mitochondrial Human genes 0.000 claims 1
- 208000028017 Psychotic disease Diseases 0.000 claims 1
- 206010038664 Respiratory alkalosis Diseases 0.000 claims 1
- 101100313751 Rickettsia conorii (strain ATCC VR-613 / Malish 7) thyX gene Proteins 0.000 claims 1
- 206010047700 Vomiting Diseases 0.000 claims 1
- 230000005856 abnormality Effects 0.000 claims 1
- 230000001154 acute effect Effects 0.000 claims 1
- 231100000836 acute liver failure Toxicity 0.000 claims 1
- 239000003242 anti bacterial agent Substances 0.000 claims 1
- 101150089004 argR gene Proteins 0.000 claims 1
- KDZOASGQNOPSCU-UHFFFAOYSA-N argininosuccinate Chemical compound OC(=O)C(N)CCCN=C(N)NC(C(O)=O)CC(O)=O KDZOASGQNOPSCU-UHFFFAOYSA-N 0.000 claims 1
- 210000003578 bacterial chromosome Anatomy 0.000 claims 1
- 244000052616 bacterial pathogen Species 0.000 claims 1
- 230000003115 biocidal effect Effects 0.000 claims 1
- 230000001851 biosynthetic effect Effects 0.000 claims 1
- 208000006752 brain edema Diseases 0.000 claims 1
- 208000022843 carbamoyl phosphate synthetase I deficiency disease Diseases 0.000 claims 1
- 210000000349 chromosome Anatomy 0.000 claims 1
- 208000011444 chronic liver failure Diseases 0.000 claims 1
- 101150073654 dapB gene Proteins 0.000 claims 1
- 238000012217 deletion Methods 0.000 claims 1
- 230000037430 deletion Effects 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 230000002068 genetic effect Effects 0.000 claims 1
- 208000007386 hepatic encephalopathy Diseases 0.000 claims 1
- 201000011286 hyperargininemia Diseases 0.000 claims 1
- 230000002631 hypothermal effect Effects 0.000 claims 1
- 230000001146 hypoxic effect Effects 0.000 claims 1
- 238000003780 insertion Methods 0.000 claims 1
- 230000037431 insertion Effects 0.000 claims 1
- 229940039696 lactobacillus Drugs 0.000 claims 1
- 230000003902 lesion Effects 0.000 claims 1
- 208000019423 liver disease Diseases 0.000 claims 1
- 239000002773 nucleotide Substances 0.000 claims 1
- 125000003729 nucleotide group Chemical group 0.000 claims 1
- 201000011278 ornithine carbamoyltransferase deficiency Diseases 0.000 claims 1
- 229920001184 polypeptide Polymers 0.000 claims 1
- 239000006041 probiotic Substances 0.000 claims 1
- 230000000529 probiotic effect Effects 0.000 claims 1
- 235000018291 probiotics Nutrition 0.000 claims 1
- 108090000765 processed proteins & peptides Proteins 0.000 claims 1
- 102000004196 processed proteins & peptides Human genes 0.000 claims 1
- 238000006467 substitution reaction Methods 0.000 claims 1
- 101150072314 thyA gene Proteins 0.000 claims 1
- 238000013518 transcription Methods 0.000 claims 1
- 230000035897 transcription Effects 0.000 claims 1
- 230000004143 urea cycle Effects 0.000 claims 1
- 208000030954 urea cycle disease Diseases 0.000 claims 1
- 230000004393 visual impairment Effects 0.000 claims 1
- 230000008673 vomiting Effects 0.000 claims 1
Applications Claiming Priority (21)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201462087854P | 2014-12-05 | 2014-12-05 | |
| US62/087,854 | 2014-12-05 | ||
| US201562103513P | 2015-01-14 | 2015-01-14 | |
| US62/103,513 | 2015-01-14 | ||
| US201562150508P | 2015-04-21 | 2015-04-21 | |
| US62/150,508 | 2015-04-21 | ||
| US201562173706P | 2015-06-10 | 2015-06-10 | |
| US201562173710P | 2015-06-10 | 2015-06-10 | |
| US62/173,710 | 2015-06-10 | ||
| US62/173,706 | 2015-06-10 | ||
| US201562183935P | 2015-06-24 | 2015-06-24 | |
| US62/183,935 | 2015-06-24 | ||
| US201562184811P | 2015-06-25 | 2015-06-25 | |
| US62/184,811 | 2015-06-25 | ||
| US201562256039P | 2015-11-16 | 2015-11-16 | |
| US201562256041P | 2015-11-16 | 2015-11-16 | |
| US62/256,041 | 2015-11-16 | ||
| US62/256,039 | 2015-11-16 | ||
| US201562263329P | 2015-12-04 | 2015-12-04 | |
| PCT/US2015/064140 WO2016090343A1 (en) | 2014-12-05 | 2015-12-04 | Bacteria engineered to treat diseases associated with hyperammonemia |
| US62/263,329 | 2015-12-04 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2018504919A JP2018504919A (ja) | 2018-02-22 |
| JP2018504919A5 true JP2018504919A5 (enExample) | 2019-01-24 |
| JP6768689B2 JP6768689B2 (ja) | 2020-10-14 |
Family
ID=55022714
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017548375A Expired - Fee Related JP6768689B2 (ja) | 2014-12-05 | 2015-12-04 | 高アンモニア血症に関連する病気を処置するために操作された細菌 |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US9487764B2 (enExample) |
| JP (1) | JP6768689B2 (enExample) |
| KR (1) | KR102493174B1 (enExample) |
| AU (1) | AU2015357549B2 (enExample) |
| BR (1) | BR112017011923A2 (enExample) |
| CA (1) | CA2969724A1 (enExample) |
| IL (2) | IL252627B (enExample) |
| MX (2) | MX383245B (enExample) |
| SG (2) | SG11201704543XA (enExample) |
| WO (1) | WO2016090343A1 (enExample) |
Families Citing this family (34)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9688967B2 (en) | 2014-12-05 | 2017-06-27 | Synlogic, Inc. | Bacteria engineered to treat diseases associated with hyperammonemia |
| US10610546B2 (en) | 2015-05-13 | 2020-04-07 | Synlogic Operating Company Inc. | Bacteria engineered to reduce hyperphenylalaninemia |
| BR112017011923A2 (pt) * | 2014-12-05 | 2018-02-27 | Synlogic Inc | bactéria modificada para tratar doenças associadas com hiperamonemia |
| US20160206666A1 (en) | 2014-12-22 | 2016-07-21 | Synlogic, Inc. | Bacteria engineered to treat diseases that benefit from reduced gut inflammation and/or tighten gut mucosal barrier |
| US11883439B2 (en) | 2015-05-13 | 2024-01-30 | Synlogic Operating Company, Inc. | Bacteria engineered to treat a disease or disorder |
| WO2016210384A2 (en) | 2015-06-25 | 2016-12-29 | Synlogic, Inc. | Bacteria engineered to treat metabolic diseases |
| US11685925B2 (en) | 2015-10-30 | 2023-06-27 | Synlogic Operating Company, Inc. | Bacteria engineered to treat diseases that benefit from reduced gut inflammation and/or tightened gut mucosal barrier |
| US11723932B2 (en) | 2016-01-11 | 2023-08-15 | Synlogic Operating Company, Inc. | Microorganisms programmed to produce immune modulators and anti-cancer therapeutics in tumor cells |
| WO2017139708A1 (en) | 2016-02-10 | 2017-08-17 | Synlogic, Inc. | Bacteria engineered to treat nonalcoholic steatohepatitis (nash) |
| EP3445857B1 (en) | 2016-04-20 | 2023-07-05 | The Board of Trustees of the Leland Stanford Junior University | Compositions and methods for nucleic acid expression and protein secretion in bacteroides |
| WO2018112194A1 (en) | 2016-12-15 | 2018-06-21 | The Board Of Trustees Of The Leland Stanford Junior University | Compositions and methods for modulating growth of a genetically modified gut bacterial cell |
| AU2018205276A1 (en) | 2017-01-06 | 2019-07-18 | Synlogic Operating Company, Inc. | Microorganisms programmed to produce immune modulators and anti-cancer therapeutics in tumor cells |
| EP3612198A4 (en) * | 2017-04-17 | 2021-01-13 | The Regents of the University of California | MODIFIED COMMENSAL BACTERIA AND METHODS OF USE |
| AU2018290278B2 (en) | 2017-06-21 | 2022-12-15 | Synlogic Operating Company, Inc. | Bacteria for the treatment of disorders |
| WO2019006246A1 (en) * | 2017-06-30 | 2019-01-03 | The Rockefeller University | N-ACYL AMIDES DERIVED FROM THE HUMAN MICROBIOTE FOR THE TREATMENT OF A HUMAN DISEASE |
| EP3651782A1 (en) * | 2017-07-12 | 2020-05-20 | Synlogic Operating Company, Inc. | Microorganisms programmed to produce immune modulators and anti-cancer therapeutics in tumor cells |
| EP3703705B1 (en) | 2017-11-03 | 2024-05-15 | DSM Nutritional Products, LLC | Glucose-containing glycan preparations for use in the treatment of hyperammonaemia |
| EP3720458A4 (en) * | 2017-12-05 | 2021-12-08 | BioPlx, Inc. | METHODS AND COMPOSITIONS FOR PREVENTING MICROBIAL INFECTION |
| WO2019118984A2 (en) | 2017-12-15 | 2019-06-20 | Solarea Bio, Inc. | Microbial compositions and methods for treating type 2 diabetes, obesity, and metabolic syndrome |
| WO2019232415A1 (en) | 2018-06-02 | 2019-12-05 | Synlogic Operating Company, Inc. | Bacteria engineered to treat liver disease |
| US12410206B2 (en) | 2018-08-21 | 2025-09-09 | Dsm Nutritional Products, Llc | Oligosaccharide compositions and methods of use thereof for reducing ammonia levels |
| US11980647B2 (en) | 2018-09-05 | 2024-05-14 | Solarea Bio, Inc. | Methods and compositions for treating musculoskeletal diseases, treating inflammation, and managing symptoms of menopause |
| CA3111795A1 (en) | 2018-09-05 | 2020-03-12 | Solarea Bio, Inc. | Methods and compositions for treating musculoskeletal diseases |
| CN113260635B (zh) | 2018-11-08 | 2023-10-31 | Dsm营养产品有限责任公司 | 寡糖组合物及其使用方法 |
| KR20220003030A (ko) | 2019-04-29 | 2022-01-07 | 신로직 오퍼레이팅 컴퍼니, 인코포레이티드 | 살아 있는 세포 계수 기술에 의한 유전적으로 조작된 미생물의 계수 |
| WO2020237246A1 (en) * | 2019-05-23 | 2020-11-26 | University Of Maryland, Baltimore | Live attenuated non-transmissible vaccines |
| AU2020288624B2 (en) | 2019-06-04 | 2025-09-25 | Cocoon Biotech Inc. | Silk-based products, formulations, and methods of use |
| WO2021107500A1 (ko) | 2019-11-29 | 2021-06-03 | 주식회사 지니스 | 혈중 암모니아 수치 저하능을 갖는 균주 및 이를 포함하는 신경세포 보호용 조성물 |
| CN112924607A (zh) * | 2019-12-05 | 2021-06-08 | 湖北远大生物技术有限公司 | 一种同时检测酶促反应液中α-酮戊二酸和L-谷氨酸的方法 |
| BR112022018571A2 (pt) | 2020-03-20 | 2022-11-01 | Synlogic Operating Co Inc | Microrganismos manipulados para reduzir a hiperfenilalaninemia |
| AU2021393455A1 (en) | 2020-12-02 | 2023-06-29 | Synlogic Operating Company, Inc. | Engineered microorganisms |
| CA3238788A1 (en) | 2021-11-22 | 2023-05-25 | Eric Michael Schott | Methods and compositions for treating musculoskeletal diseases, treating inflammation, and managing symptoms of menopause |
| US20230190834A1 (en) | 2021-12-21 | 2023-06-22 | Solarea Bio, Inc. | Immunomodulatory compositions comprising microbial entities |
| CN115960807A (zh) * | 2022-11-29 | 2023-04-14 | 深圳先进技术研究院 | 一种厌氧高产l-精氨酸工程菌及其制备方法和应用 |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9107305D0 (en) | 1991-04-08 | 1991-05-22 | Unilever Plc | Probiotic |
| US5989463A (en) | 1997-09-24 | 1999-11-23 | Alkermes Controlled Therapeutics, Inc. | Methods for fabricating polymer-based controlled release devices |
| US6203797B1 (en) | 1998-01-06 | 2001-03-20 | Stephen C. Perry | Dietary supplement and method for use as a probiotic, for alleviating the symptons associated with irritable bowel syndrome |
| EP1135461A4 (en) | 1998-12-02 | 2003-03-26 | Univ Boston | GEN NETWORKS FOR CONTROLLING GENE EXPRESSION |
| EP1034787A1 (en) | 1999-03-11 | 2000-09-13 | Société des Produits Nestlé S.A. | Lactobacillus strains preventing diarrhea caused by pathogenic bacteria |
| JP4682454B2 (ja) * | 2000-06-28 | 2011-05-11 | 味の素株式会社 | 新規変異型ｎ−アセチルグルタミン酸合成酵素及びｌ−アルギニンの製造法 |
| DE10101793A1 (de) * | 2001-01-17 | 2002-08-01 | Manfred Nilius | Verwendung von SLPI zur Behandlung chronisch-entzündlicher Darmerkrankungen |
| US7731976B2 (en) | 2003-08-29 | 2010-06-08 | Cobb And Company, Llp | Treatment of irritable bowel syndrome using probiotic composition |
| WO2006035831A1 (ja) * | 2004-09-28 | 2006-04-06 | Kyowa Hakko Kogyo Co., Ltd. | Ｌ－アルギニン、ｌ－オルニチンまたはｌ－シトルリンの製造法 |
| BR112017011923A2 (pt) * | 2014-12-05 | 2018-02-27 | Synlogic Inc | bactéria modificada para tratar doenças associadas com hiperamonemia |
-
2015
- 2015-12-04 BR BR112017011923A patent/BR112017011923A2/pt not_active Application Discontinuation
- 2015-12-04 SG SG11201704543XA patent/SG11201704543XA/en unknown
- 2015-12-04 MX MX2017007148A patent/MX383245B/es unknown
- 2015-12-04 US US14/960,333 patent/US9487764B2/en active Active
- 2015-12-04 SG SG10202010444UA patent/SG10202010444UA/en unknown
- 2015-12-04 KR KR1020177018338A patent/KR102493174B1/ko active Active
- 2015-12-04 AU AU2015357549A patent/AU2015357549B2/en not_active Ceased
- 2015-12-04 CA CA2969724A patent/CA2969724A1/en not_active Abandoned
- 2015-12-04 WO PCT/US2015/064140 patent/WO2016090343A1/en not_active Ceased
- 2015-12-04 JP JP2017548375A patent/JP6768689B2/ja not_active Expired - Fee Related
-
2017
- 2017-06-01 IL IL252627A patent/IL252627B/en active IP Right Grant
- 2017-06-05 MX MX2021006581A patent/MX2021006581A/es unknown
-
2020
- 2020-10-19 IL IL278150A patent/IL278150A/en unknown
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