JP2018502851A5 - - Google Patents
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- JP2018502851A5 JP2018502851A5 JP2017534309A JP2017534309A JP2018502851A5 JP 2018502851 A5 JP2018502851 A5 JP 2018502851A5 JP 2017534309 A JP2017534309 A JP 2017534309A JP 2017534309 A JP2017534309 A JP 2017534309A JP 2018502851 A5 JP2018502851 A5 JP 2018502851A5
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- JP
- Japan
- Prior art keywords
- och
- alkyl
- compound
- formula
- aralkyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 0 C[C@@](*C([C@@](C)C=CC=CC=CC=CC=CC=CC=C[C@@](C[C@@](C([C@](C1)O)NC(NCCC(OCC=C)=O)=O)O[C@]1(CC(CC(C(CCC(C*(C1)O)O)O)O)O)O)O[C@](C(C(C2O)N)O)OC2N)O)*C1=O Chemical compound C[C@@](*C([C@@](C)C=CC=CC=CC=CC=CC=CC=C[C@@](C[C@@](C([C@](C1)O)NC(NCCC(OCC=C)=O)=O)O[C@]1(CC(CC(C(CCC(C*(C1)O)O)O)O)O)O)O[C@](C(C(C2O)N)O)OC2N)O)*C1=O 0.000 description 4
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562100988P | 2015-01-08 | 2015-01-08 | |
| US62/100,988 | 2015-01-08 | ||
| PCT/US2016/012602 WO2016112260A1 (en) | 2015-01-08 | 2016-01-08 | Concise synthesis of urea derivatives of amphotericin b |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2018502851A JP2018502851A (ja) | 2018-02-01 |
| JP2018502851A5 true JP2018502851A5 (enExample) | 2019-01-31 |
| JP6726192B2 JP6726192B2 (ja) | 2020-07-22 |
Family
ID=56356457
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017534309A Active JP6726192B2 (ja) | 2015-01-08 | 2016-01-08 | アムホテリシンｂの尿素誘導体の簡便な合成法 |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US20180273571A1 (enExample) |
| EP (1) | EP3242554A4 (enExample) |
| JP (1) | JP6726192B2 (enExample) |
| AU (1) | AU2016205187B2 (enExample) |
| WO (1) | WO2016112260A1 (enExample) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PT3283171T (pt) | 2015-04-15 | 2021-07-14 | Sfunga Therapeutics Inc | Derivados de anfotericina b |
| RU2688658C1 (ru) * | 2018-04-10 | 2019-05-22 | Федеральное государственное бюджетное научное учреждение "Научно-исследовательский институт по изысканию новых антибиотиков имени Г.Ф. Гаузе" | Противогрибковый полусинтетический полиеновый антибиотик, его водорастворимые соли и фармацевтические композиции на их основе |
| EP4009984A4 (en) * | 2019-08-08 | 2023-09-06 | The Board Of Trustees Of The University Of Illinois | HYBRID AMPHOTERICIN B DERIVATIVES WITH REDUCED TOXICITY |
| AU2020325163B2 (en) * | 2019-08-08 | 2026-04-23 | The Board Of Trustees Of The University Of Illinois | Hybrid amide derivatives of amphotericin B |
| RU2751333C1 (ru) * | 2020-12-16 | 2021-07-13 | Федеральное государственное бюджетное научное учреждение "Научно-исследовательский институт по изысканию новых антибиотиков имени Г.Ф. Гаузе" | Способ получения противогрибкового полусинтетического полиенового антибиотика |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0431870A1 (en) * | 1989-12-08 | 1991-06-12 | Beecham Group p.l.c. | Amphotericin B derivatives |
| EP0431874A1 (en) * | 1989-12-08 | 1991-06-12 | Beecham Group p.l.c. | Novel compounds |
| JP3507486B2 (ja) | 1991-03-15 | 2004-03-15 | アムジエン・インコーポレーテツド | 顆粒球コロニー刺激因子の肺内投与 |
| WO1993016090A1 (en) * | 1992-02-12 | 1993-08-19 | Smithkline Beecham Plc | Amphotericin b derivative |
| US5451569A (en) | 1994-04-19 | 1995-09-19 | Hong Kong University Of Science And Technology R & D Corporation Limited | Pulmonary drug delivery system |
| MX365184B (es) * | 2010-12-21 | 2019-05-21 | Centro De Investig Y De Estudios Avanzados Del I P N | Nuevos compuestos analogos de la anfotericina y composiciones farmaceuticas que los contienen. |
| WO2014165676A1 (en) * | 2013-04-03 | 2014-10-09 | The Board Of Trustees Of The University Of Illinois | Amphotericin b derivative with reduced toxicity |
| KR102548341B1 (ko) | 2013-10-07 | 2023-06-26 | 더 보오드 오브 트러스티스 오브 더 유니버시티 오브 일리노이즈 | 개선된 치료 지수를 갖는 암포테리신 b 유도체 |
| MX378786B (es) * | 2014-06-12 | 2025-03-11 | Shionogi & Co | Derivado de macrólido de polieno. |
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2016
- 2016-01-08 JP JP2017534309A patent/JP6726192B2/ja active Active
- 2016-01-08 WO PCT/US2016/012602 patent/WO2016112260A1/en not_active Ceased
- 2016-01-08 AU AU2016205187A patent/AU2016205187B2/en active Active
- 2016-01-08 EP EP16735456.2A patent/EP3242554A4/en active Pending
- 2016-01-08 US US15/541,747 patent/US20180273571A1/en not_active Abandoned