JP2018501322A - トール様受容体４アンタゴニストの炎症促進性およびアジュバント機能 - Google Patents

トール様受容体４アンタゴニストの炎症促進性およびアジュバント機能 Download PDF

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JP2018501322A
JP2018501322A JP2017555445A JP2017555445A JP2018501322A JP 2018501322 A JP2018501322 A JP 2018501322A JP 2017555445 A JP2017555445 A JP 2017555445A JP 2017555445 A JP2017555445 A JP 2017555445A JP 2018501322 A JP2018501322 A JP 2018501322A
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oxpapc
lps
caspase
inflammasome
antigen
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JP2018501322A5 (https=
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ジョナサン シー． カガン，
ジョナサン シー． カガン，
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Boston Childrens Hospital
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Boston Childrens Hospital
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Priority to JP2020213210A priority Critical patent/JP7410845B2/ja
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    • A—HUMAN NECESSITIES
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    • A61K39/00—Medicinal preparations containing antigens or antibodies
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    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
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    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
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    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
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    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
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    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
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    • A61K2039/55511—Organic adjuvants
    • A61K2039/55516—Proteins; Peptides
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A61K2039/55561—CpG containing adjuvants; Oligonucleotide containing adjuvants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A61K2039/55566—Emulsions, e.g. Freund's adjuvant, MF59
    • A—HUMAN NECESSITIES
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    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A61K2039/55572—Lipopolysaccharides; Lipid A; Monophosphoryl lipid A
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/57—Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2
    • A61K2039/575—Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2 humoral response
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

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  • AIDS & HIV (AREA)
  • Pulmonology (AREA)
  • Toxicology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
JP2017555445A 2015-01-12 2016-01-12 トール様受容体４アンタゴニストの炎症促進性およびアジュバント機能 Pending JP2018501322A (ja)

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JP2020213210A JP7410845B2 (ja) 2015-01-12 2020-12-23 トール様受容体４アンタゴニストの炎症促進性およびアジュバント機能
JP2020213211A JP7410846B2 (ja) 2015-01-12 2020-12-23 トール様受容体４アンタゴニストの炎症促進性およびアジュバント機能

Applications Claiming Priority (3)

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US201562102245P 2015-01-12 2015-01-12
US62/102,245 2015-01-12
PCT/US2016/012994 WO2016115097A2 (en) 2015-01-12 2016-01-12 Pro-inflammatory and adjuvant functions of toll-like receptor 4 antagonists

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JP2020213210A Division JP7410845B2 (ja) 2015-01-12 2020-12-23 トール様受容体４アンタゴニストの炎症促進性およびアジュバント機能
JP2020213211A Division JP7410846B2 (ja) 2015-01-12 2020-12-23 トール様受容体４アンタゴニストの炎症促進性およびアジュバント機能

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JP2018501322A true JP2018501322A (ja) 2018-01-18
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JP2017555445A Pending JP2018501322A (ja) 2015-01-12 2016-01-12 トール様受容体４アンタゴニストの炎症促進性およびアジュバント機能
JP2020213210A Active JP7410845B2 (ja) 2015-01-12 2020-12-23 トール様受容体４アンタゴニストの炎症促進性およびアジュバント機能
JP2020213211A Active JP7410846B2 (ja) 2015-01-12 2020-12-23 トール様受容体４アンタゴニストの炎症促進性およびアジュバント機能
JP2023015047A Active JP7719816B2 (ja) 2015-01-12 2023-02-03 トール様受容体４アンタゴニストの炎症促進性およびアジュバント機能
JP2023015026A Active JP7719815B2 (ja) 2015-01-12 2023-02-03 トール様受容体４アンタゴニストの炎症促進性およびアジュバント機能
JP2025041934A Pending JP2025090801A (ja) 2015-01-12 2025-03-14 トール様受容体４アンタゴニストの炎症促進性およびアジュバント機能
JP2025041931A Pending JP2025094038A (ja) 2015-01-12 2025-03-14 トール様受容体４アンタゴニストの炎症促進性およびアジュバント機能

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JP2020213210A Active JP7410845B2 (ja) 2015-01-12 2020-12-23 トール様受容体４アンタゴニストの炎症促進性およびアジュバント機能
JP2020213211A Active JP7410846B2 (ja) 2015-01-12 2020-12-23 トール様受容体４アンタゴニストの炎症促進性およびアジュバント機能
JP2023015047A Active JP7719816B2 (ja) 2015-01-12 2023-02-03 トール様受容体４アンタゴニストの炎症促進性およびアジュバント機能
JP2023015026A Active JP7719815B2 (ja) 2015-01-12 2023-02-03 トール様受容体４アンタゴニストの炎症促進性およびアジュバント機能
JP2025041934A Pending JP2025090801A (ja) 2015-01-12 2025-03-14 トール様受容体４アンタゴニストの炎症促進性およびアジュバント機能
JP2025041931A Pending JP2025094038A (ja) 2015-01-12 2025-03-14 トール様受容体４アンタゴニストの炎症促進性およびアジュバント機能

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US (7) US20180318414A1 (https=)
EP (2) EP4681782A3 (https=)
JP (7) JP2018501322A (https=)
AU (2) AU2021200638B2 (https=)
CA (1) CA2973585A1 (https=)
ES (1) ES3057334T3 (https=)
WO (1) WO2016115097A2 (https=)

Cited By (4)

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JP2022521831A (ja) * 2019-03-29 2022-04-12 ザ ブリガム アンド ウィメンズ ホスピタル インコーポレイテッド 標的指向性協働的がん免疫療法
JP2022552200A (ja) * 2019-10-07 2022-12-15 ノースウエスト バイオセラピューティクス，インコーポレイティド 樹状細胞およびＴ細胞の活性化を増強するためのならびにＴＨ－１免疫応答を誘導するためのｉｎ ｖｉｔｒｏの方法および組成物
JP2023502400A (ja) * 2019-11-18 2023-01-24 ザ・チルドレンズ・メデイカル・センター・コーポレーシヨン がん免疫療法のために常在型樹状細胞を超活性化する刺激
JP2023503427A (ja) * 2019-11-18 2023-01-30 ザ・チルドレンズ・メデイカル・センター・コーポレーシヨン 超活性樹状細胞は養子細胞移植に基づく持続性抗腫瘍免疫を可能にする

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AU2017356295A1 (en) * 2016-11-14 2019-05-23 Beth Israel Deaconess Medical Center Compositions and methods of treating cancer
CN114894910B (zh) * 2022-03-18 2023-10-20 重庆医科大学附属第一医院 1-棕榈酰-2-花生四烯酰-sn-甘油-3-磷酸胆碱检测试剂的新用途

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Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2022521831A (ja) * 2019-03-29 2022-04-12 ザ ブリガム アンド ウィメンズ ホスピタル インコーポレイテッド 標的指向性協働的がん免疫療法
JP2022552200A (ja) * 2019-10-07 2022-12-15 ノースウエスト バイオセラピューティクス，インコーポレイティド 樹状細胞およびＴ細胞の活性化を増強するためのならびにＴＨ－１免疫応答を誘導するためのｉｎ ｖｉｔｒｏの方法および組成物
JP2023502400A (ja) * 2019-11-18 2023-01-24 ザ・チルドレンズ・メデイカル・センター・コーポレーシヨン がん免疫療法のために常在型樹状細胞を超活性化する刺激
JP2023503427A (ja) * 2019-11-18 2023-01-30 ザ・チルドレンズ・メデイカル・センター・コーポレーシヨン 超活性樹状細胞は養子細胞移植に基づく持続性抗腫瘍免疫を可能にする
JP7753205B2 (ja) 2019-11-18 2025-10-14 ザ・チルドレンズ・メデイカル・センター・コーポレーシヨン 超活性樹状細胞は養子細胞移植に基づく持続性抗腫瘍免疫を可能にする
JP7813226B2 (ja) 2019-11-18 2026-02-12 ザ・チルドレンズ・メデイカル・センター・コーポレーシヨン がん免疫療法のために常在型樹状細胞を超活性化する刺激

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JP2023055883A (ja) 2023-04-18
AU2021200638B2 (en) 2024-06-06
ES3057334T3 (en) 2026-02-27
US20200405848A1 (en) 2020-12-31
WO2016115097A2 (en) 2016-07-21
US11400153B2 (en) 2022-08-02
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