JP2018501266A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2018501266A5 JP2018501266A5 JP2017533569A JP2017533569A JP2018501266A5 JP 2018501266 A5 JP2018501266 A5 JP 2018501266A5 JP 2017533569 A JP2017533569 A JP 2017533569A JP 2017533569 A JP2017533569 A JP 2017533569A JP 2018501266 A5 JP2018501266 A5 JP 2018501266A5
- Authority
- JP
- Japan
- Prior art keywords
- group
- carbon atoms
- independently
- optionally substituted
- alkyl group
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 125000004432 carbon atom Chemical group C* 0.000 description 11
- 125000000217 alkyl group Chemical group 0.000 description 4
- 125000001188 haloalkyl group Chemical group 0.000 description 3
- 150000001875 compounds Chemical class 0.000 description 2
- 125000005842 heteroatom Chemical group 0.000 description 2
- 125000004433 nitrogen atom Chemical group N* 0.000 description 2
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 description 2
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 1
- 125000001931 aliphatic group Chemical group 0.000 description 1
- 125000003342 alkenyl group Chemical group 0.000 description 1
- 125000003118 aryl group Chemical group 0.000 description 1
- 229910052799 carbon Inorganic materials 0.000 description 1
- 125000005843 halogen group Chemical group 0.000 description 1
- 229910052757 nitrogen Inorganic materials 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FI20146150 | 2014-12-23 | ||
| FI20146150 | 2014-12-23 | ||
| PCT/FI2015/050930 WO2016102776A1 (en) | 2014-12-23 | 2015-12-22 | Prodrugs of 17.beta.-hsd1 -inhibitors |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2018501266A JP2018501266A (ja) | 2018-01-18 |
| JP2018501266A5 true JP2018501266A5 (cg-RX-API-DMAC7.html) | 2019-01-17 |
| JP6523461B2 JP6523461B2 (ja) | 2019-06-05 |
Family
ID=55221442
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017533569A Active JP6523461B2 (ja) | 2014-12-23 | 2015-12-22 | １７β−ＨＳＤ１−阻害剤のプロドラッグ |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US10413557B2 (cg-RX-API-DMAC7.html) |
| EP (1) | EP3237431B1 (cg-RX-API-DMAC7.html) |
| JP (1) | JP6523461B2 (cg-RX-API-DMAC7.html) |
| CN (1) | CN107207561B (cg-RX-API-DMAC7.html) |
| WO (1) | WO2016102776A1 (cg-RX-API-DMAC7.html) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US10626140B2 (en) * | 2014-12-23 | 2020-04-21 | Forendo Pharma Ltd | Prodrugs of 17β-HSD1-inhibitors |
| UA126342C2 (uk) * | 2017-06-08 | 2022-09-21 | Форендо Фарма Лтд | 15-бета-[3-пропанамідо]-заміщені естра-1,3,5(10)-трієн-17-он-сполуки і їх 17-оксими для використання в інгібуванні 17-бета-гідроксистероїддегідрогеназ |
| WO2023122075A1 (en) * | 2021-12-20 | 2023-06-29 | Ohio State Innovation Foundation | Compositions comprising sterol-amino-phosphate compounds and methods of making and use thereof |
| CN120607578A (zh) * | 2024-03-08 | 2025-09-09 | 长春金赛药业有限责任公司 | 17β-HSD1抑制剂化合物、药物组合物及其应用 |
Family Cites Families (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1094798A2 (en) | 1998-03-11 | 2001-05-02 | Endorecherche Inc. | INHIBITORS OF TYPE 5 AND TYPE 3 17beta-HYDROXYSTEROID DEHYDROGENASE AND METHODS FOR THEIR USE |
| ATE355279T1 (de) | 1998-08-07 | 2006-03-15 | Novartis Vaccines & Diagnostic | Pyrazole als modulatoren des östrogenrezeptors |
| GB9929302D0 (en) | 1999-12-11 | 2000-02-02 | Univ Cardiff | Benzyl tetralins compositions and uses thereof |
| ATE350375T1 (de) | 2001-09-06 | 2007-01-15 | Schering Corp | 17beta-hydroxysteroid dehydrogenase type 3 inhibitoren zur behandlung von androgen- abhängigen erkrankungen |
| CN1571782A (zh) | 2001-10-17 | 2005-01-26 | 先灵公司 | 作为3型17β－羟基类固醇脱氢酶抑制剂用于治疗雄激素依赖疾病的哌啶乙酰胺类化合物和哌嗪乙酰胺类化合物 |
| US6750248B2 (en) | 2001-11-09 | 2004-06-15 | National University Of Singapore | Methods for preparing an estrogenic preparation and isolated estrogenic compounds from a plant and uses thereof |
| PE20040750A1 (es) | 2002-11-18 | 2004-11-06 | Schering Corp | Derivados de n-(1-acetilpiperidin-4-il)-4-benzidril-2-isopropilpiperazin-1-carboxamida como inhibidores de 17beta-hidroxiesteroide deshidrogenasa de tipo 3 |
| CN1744930A (zh) | 2002-12-17 | 2006-03-08 | 先灵公司 | 治疗雄激素依赖性疾病的3型17β－羟基类固醇脱氢酶抑制剂 |
| WO2004085345A2 (en) | 2003-03-21 | 2004-10-07 | Yale University | 15α-SUBSTITUTED ESTRADIOL CARBOXYLIC ACID ESTERS AS LOCALLY ACTIVE ESTROGENS |
| GB0306718D0 (en) | 2003-03-24 | 2003-04-30 | Sterix Ltd | Compound |
| US7465739B2 (en) | 2003-06-10 | 2008-12-16 | Solvay Pharmaceuticals B.V. | Compounds and their use in therapy |
| US7754709B2 (en) | 2003-06-10 | 2010-07-13 | Solvay Pharmaceuticals Bv | Tetracyclic thiophenepyrimidinone compounds as inhibitors of 17β hydroxysteroid dehydrogenase compounds |
| TWI331154B (en) | 2003-11-12 | 2010-10-01 | Solvay Pharm Gmbh | Novel 17-hydroxysteroid dehydrogenase type i inhibitors |
| US8088758B2 (en) | 2003-11-12 | 2012-01-03 | Abbott Products Gmbh | 17β-hydroxysteroid dehydrogenase type I inhibitors |
| US7378426B2 (en) | 2004-03-01 | 2008-05-27 | Bristol-Myers Squibb Company | Fused heterotricyclic compounds as inhibitors of 17β-hydroxysteroid dehydrogenase 3 |
| DE102004032673A1 (de) | 2004-07-02 | 2006-01-26 | Schering Ag | Neue 2-substituierte D-Homo-estra-1,3,5(10)-triene als Inhibitoren der 17ß-Hydroxysteroiddehydrogenase Typ 1 |
| DE102004032674A1 (de) | 2004-07-02 | 2006-01-26 | Schering Ag | Neue 2-substituierte Estra-1,3,5(10)-trien-17-one als Inhibitoren der 17β-Hydroxysteroiddehydrogenase Typ 1 |
| UA89964C2 (ru) | 2004-09-08 | 2010-03-25 | Н.В. Органон | 15β-ЗАМЕЩЕННЫЕ СТЕРОИДЫ, КОТОРЫЕ ИМЕЮТ СЕЛЕКТИВНУЮ ЭСТРОГЕННУЮ АКТИВНОСТЬ |
| US8030298B2 (en) * | 2005-05-26 | 2011-10-04 | Abbott Products Gmbh | 17β-HSD1 and STS inhibitors |
| ES2388297T3 (es) | 2005-05-26 | 2012-10-11 | Abbott Products Gmbh | Inhibidores de 17-HSD1 y STS |
| MX2009002579A (es) | 2006-09-19 | 2009-03-20 | Solvay Pharm Gmbh | Derivados de estratrieno y sus usos como inhibidores de 17beta-hidroxiesteroide deshidrogenasa. |
| MX2009005201A (es) * | 2006-11-30 | 2009-05-27 | Solvay Pharm Gmbh | Derivados de estratrieno sustituidos como inhibidores de 17beta hsd. |
| BR112015031846A8 (pt) * | 2013-06-25 | 2018-03-06 | Forendo Pharma Ltd | derivados de estratrientiazol, seus usos, e composição farmacêutica |
| US9850272B2 (en) | 2013-06-25 | 2017-12-26 | Forendo Pharma Ltd. | Therapeutically active estratrienthiazole derivatives as inhibitors of 17.beta-hydroxy-steroid dehydrogenase, type 1 |
| AR096728A1 (es) | 2013-06-25 | 2016-01-27 | Forendo Pharma Ltd | Derivados de estratrieno-tiazol terapéuticamente activos |
| US10626140B2 (en) | 2014-12-23 | 2020-04-21 | Forendo Pharma Ltd | Prodrugs of 17β-HSD1-inhibitors |
-
2015
- 2015-12-22 US US15/539,184 patent/US10413557B2/en active Active
- 2015-12-22 JP JP2017533569A patent/JP6523461B2/ja active Active
- 2015-12-22 CN CN201580074140.6A patent/CN107207561B/zh active Active
- 2015-12-22 EP EP15828340.8A patent/EP3237431B1/en active Active
- 2015-12-22 WO PCT/FI2015/050930 patent/WO2016102776A1/en not_active Ceased
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| EA201170096A1 (ru) | Замещенные производные пиримидона | |
| JP2016506958A5 (cg-RX-API-DMAC7.html) | ||
| JP2017521436A5 (cg-RX-API-DMAC7.html) | ||
| JP2017511357A5 (cg-RX-API-DMAC7.html) | ||
| JP2019104748A5 (cg-RX-API-DMAC7.html) | ||
| RU2020110780A (ru) | Ингибитор fgfr и его медицинское применение | |
| EA201690019A1 (ru) | Производное аминотриазина и содержащая его фармацевтическая композиция | |
| MX2014015501A (es) | Carboxamidas heterociclicas fungicidas. | |
| JP2016503799A5 (cg-RX-API-DMAC7.html) | ||
| PH12016502154A1 (en) | Pyridazonine herbicides | |
| JP2016536364A5 (cg-RX-API-DMAC7.html) | ||
| JP2016505614A5 (cg-RX-API-DMAC7.html) | ||
| EA201591429A1 (ru) | 2,3-дизамещенные производные 1-ацил-4-амино-1,2,3,4-тетрагидрохинолинов и их применение в качестве ингибиторов бромодомена | |
| TR201909694T4 (tr) | Janus kinaz (jak) inhibitörleri. | |
| EA201591703A1 (ru) | Замещенные 2-азабициклы и их применение в качестве модуляторов рецепторов орексина | |
| PH12012501773A1 (en) | Arylethynyl derivatives | |
| JP2014526533A5 (cg-RX-API-DMAC7.html) | ||
| UA117151C2 (uk) | N-ациліміногетероциклічні сполуки | |
| CY1119220T1 (el) | Μονοκυκλικο παραγωγο πυριδινης | |
| RU2021109549A (ru) | ИНГИБИТОРЫ α-АМИНО-β-КАРБОКСИМУКОНАТ ε-СЕМИАЛЬДЕГИД-ДЕКАРБОКСИЛАЗЫ | |
| JP2008505194A5 (cg-RX-API-DMAC7.html) | ||
| JP2015535839A5 (cg-RX-API-DMAC7.html) | ||
| RU2020131276A (ru) | Терапевтические соединения и композиции | |
| JP2014510147A5 (cg-RX-API-DMAC7.html) | ||
| JP2015530408A5 (cg-RX-API-DMAC7.html) |