JP2018500276A5 - - Google Patents
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- JP2018500276A5 JP2018500276A5 JP2017518533A JP2017518533A JP2018500276A5 JP 2018500276 A5 JP2018500276 A5 JP 2018500276A5 JP 2017518533 A JP2017518533 A JP 2017518533A JP 2017518533 A JP2017518533 A JP 2017518533A JP 2018500276 A5 JP2018500276 A5 JP 2018500276A5
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- 238000000034 method Methods 0.000 claims description 66
- 108010002350 Interleukin-2 Proteins 0.000 claims description 62
- 102000000588 Interleukin-2 Human genes 0.000 claims description 62
- 239000000203 mixture Substances 0.000 claims description 47
- 230000006698 induction Effects 0.000 claims description 22
- 238000011282 treatment Methods 0.000 claims description 21
- 238000012423 maintenance Methods 0.000 claims description 19
- 208000026278 immune system disease Diseases 0.000 claims description 18
- 210000001744 T-lymphocyte Anatomy 0.000 claims description 14
- 210000004027 cell Anatomy 0.000 claims description 8
- 210000003289 regulatory T cell Anatomy 0.000 claims description 7
- 208000009329 Graft vs Host Disease Diseases 0.000 claims description 6
- 241000124008 Mammalia Species 0.000 claims description 6
- 208000024908 graft versus host disease Diseases 0.000 claims description 6
- 101001057504 Homo sapiens Interferon-stimulated gene 20 kDa protein Proteins 0.000 claims description 4
- 101001055144 Homo sapiens Interleukin-2 receptor subunit alpha Proteins 0.000 claims description 4
- 208000022559 Inflammatory bowel disease Diseases 0.000 claims description 4
- 102100026878 Interleukin-2 receptor subunit alpha Human genes 0.000 claims description 4
- 206010067584 Type 1 diabetes mellitus Diseases 0.000 claims description 4
- 230000037396 body weight Effects 0.000 claims description 4
- 230000001684 chronic effect Effects 0.000 claims description 4
- 210000003958 hematopoietic stem cell Anatomy 0.000 claims description 4
- 201000006417 multiple sclerosis Diseases 0.000 claims description 4
- 150000003431 steroids Chemical class 0.000 claims description 4
- 238000013517 stratification Methods 0.000 claims description 4
- 201000000596 systemic lupus erythematosus Diseases 0.000 claims description 4
- 238000002560 therapeutic procedure Methods 0.000 claims description 3
- 238000011269 treatment regimen Methods 0.000 claims description 3
- 102100024222 B-lymphocyte antigen CD19 Human genes 0.000 claims description 2
- 102100027581 Forkhead box protein P3 Human genes 0.000 claims description 2
- 238000003794 Gram staining Methods 0.000 claims description 2
- 101000980825 Homo sapiens B-lymphocyte antigen CD19 Proteins 0.000 claims description 2
- 101000861452 Homo sapiens Forkhead box protein P3 Proteins 0.000 claims description 2
- 201000004681 Psoriasis Diseases 0.000 claims description 2
- 102000001712 STAT5 Transcription Factor Human genes 0.000 claims description 2
- 108010029477 STAT5 Transcription Factor Proteins 0.000 claims description 2
- 206010047115 Vasculitis Diseases 0.000 claims description 2
- 201000009961 allergic asthma Diseases 0.000 claims description 2
- 238000010171 animal model Methods 0.000 claims description 2
- 230000006907 apoptotic process Effects 0.000 claims description 2
- 208000006673 asthma Diseases 0.000 claims description 2
- 239000012620 biological material Substances 0.000 claims description 2
- 230000003833 cell viability Effects 0.000 claims description 2
- 230000000694 effects Effects 0.000 claims description 2
- 238000009472 formulation Methods 0.000 claims description 2
- 238000001802 infusion Methods 0.000 claims description 2
- 238000007918 intramuscular administration Methods 0.000 claims description 2
- 238000007912 intraperitoneal administration Methods 0.000 claims description 2
- 238000001990 intravenous administration Methods 0.000 claims description 2
- 108020004707 nucleic acids Proteins 0.000 claims description 2
- 102000039446 nucleic acids Human genes 0.000 claims description 2
- 150000007523 nucleic acids Chemical class 0.000 claims description 2
- 210000000056 organ Anatomy 0.000 claims description 2
- 230000035755 proliferation Effects 0.000 claims description 2
- 230000004952 protein activity Effects 0.000 claims description 2
- 230000000306 recurrent effect Effects 0.000 claims description 2
- 206010039073 rheumatoid arthritis Diseases 0.000 claims description 2
- 239000007787 solid Substances 0.000 claims description 2
- 238000007920 subcutaneous administration Methods 0.000 claims description 2
- 230000002459 sustained effect Effects 0.000 claims description 2
- 230000009885 systemic effect Effects 0.000 claims description 2
- 238000009121 systemic therapy Methods 0.000 claims description 2
- 238000002054 transplantation Methods 0.000 claims description 2
- 238000011374 additional therapy Methods 0.000 claims 1
- 230000026731 phosphorylation Effects 0.000 claims 1
- 238000006366 phosphorylation reaction Methods 0.000 claims 1
- 239000012472 biological sample Substances 0.000 description 2
- 239000000523 sample Substances 0.000 description 2
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201462061952P | 2014-10-09 | 2014-10-09 | |
| US62/061,952 | 2014-10-09 | ||
| PCT/US2015/054466 WO2016057651A1 (en) | 2014-10-09 | 2015-10-07 | Multiple-variable il-2 dose regimen for treating immune disorders |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2018500276A JP2018500276A (ja) | 2018-01-11 |
| JP2018500276A5 true JP2018500276A5 (https=) | 2018-11-15 |
| JP6941561B2 JP6941561B2 (ja) | 2021-09-29 |
Family
ID=55653714
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017518533A Active JP6941561B2 (ja) | 2014-10-09 | 2015-10-07 | 免疫障害を処置するための複数の可変ｉｌ−２用量レジメン |
Country Status (7)
| Country | Link |
|---|---|
| US (2) | US10806773B2 (https=) |
| EP (1) | EP3204119B1 (https=) |
| JP (1) | JP6941561B2 (https=) |
| CN (2) | CN107106876B (https=) |
| AU (1) | AU2015328163B2 (https=) |
| CA (1) | CA2963602A1 (https=) |
| WO (1) | WO2016057651A1 (https=) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2016025385A1 (en) | 2014-08-11 | 2016-02-18 | Delinia, Inc. | Modified il-2 variants that selectively activate regulatory t cells for the treatment of autoimmune diseases |
| US20170204154A1 (en) | 2016-01-20 | 2017-07-20 | Delinia, Inc. | Molecules that selectively activate regulatory t cells for the treatment of autoimmune diseases |
| US11077172B2 (en) | 2016-11-08 | 2021-08-03 | Delinia, Inc. | IL-2 variants for the treatment of psoriasis |
| SG11201908271WA (en) * | 2017-03-14 | 2019-10-30 | Juno Therapeutics Inc | Methods for cryogenic storage |
| JP2020028278A (ja) * | 2018-08-24 | 2020-02-27 | 国立大学法人九州大学 | 被検体に生じるイベントを予測するための判別器の生成方法、及び前記判別器を用いた被検体の層別化方法 |
| US12331320B2 (en) | 2018-10-10 | 2025-06-17 | The Research Foundation For The State University Of New York | Genome edited cancer cell vaccines |
| JP2022553370A (ja) * | 2019-10-25 | 2022-12-22 | ネオルーキン セラピューティクス，インコーポレイティド | Ｉｌ－２受容体作動薬の投与方法 |
| US20230414720A1 (en) * | 2020-11-23 | 2023-12-28 | University Of Florida Research Foundation, Incorporated | Use of insulin-like growth factors with gamma-chain cytokines to induce homeostatic proliferation of lymphocytes |
| EP4016078A1 (en) * | 2020-12-18 | 2022-06-22 | Rheinische Friedrich-Wilhelms-Universität Bonn | Method useful in tolerance induction therapy and kits therefore |
| EP4422668A1 (en) * | 2021-10-25 | 2024-09-04 | Ellennbe GmbH | Pharmaceutical composition and kit comprising an immunomodulatory substance for treating diseases |
| EP4169524A1 (en) * | 2021-10-25 | 2023-04-26 | Ellennbe GmbH | Immunomodulatory substance for use in a method for treatment and/or prevention of a disease |
| EP4426318A4 (en) * | 2021-11-04 | 2025-11-19 | Orca Biosystems Inc | THERAPEUTIC COMPOSITIONS AND TRANSPLANTATION PROCESSES OF ALLOGENEIC HEMATOPOIETIC CELLS |
| WO2024084038A1 (en) * | 2022-10-20 | 2024-04-25 | Ellennbe Gmbh | Platform technology for treatment of inflammatory, immunological and/or autoimmunological diseases |
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| US33653A (en) | 1861-11-05 | Improvement in swivel hooks and rings | ||
| US548257A (en) | 1895-10-22 | Hay rake and loader | ||
| US4405712A (en) | 1981-07-01 | 1983-09-20 | The United States Of America As Represented By The Department Of Health And Human Services | LTR-Vectors |
| US4853332A (en) | 1982-10-19 | 1989-08-01 | Cetus Corporation | Structural genes, plasmids and transformed cells for producing cysteine depleted muteins of biologically active proteins |
| GB8308235D0 (en) | 1983-03-25 | 1983-05-05 | Celltech Ltd | Polypeptides |
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| JPS60115528A (ja) | 1983-11-28 | 1985-06-22 | Takeda Chem Ind Ltd | ヒトインタ―ロイキン―２蛋白質を含有する抗腫瘍用または免疫機能低下疾患治療用組成物 |
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| GB8607679D0 (en) | 1986-03-27 | 1986-04-30 | Winter G P | Recombinant dna product |
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| US5322770A (en) | 1989-12-22 | 1994-06-21 | Hoffman-Laroche Inc. | Reverse transcription with thermostable DNA polymerases - high temperature reverse transcription |
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| EP0378576B1 (en) | 1987-09-11 | 1995-01-18 | Whitehead Institute For Biomedical Research | Transduced fibroblasts and uses therefor |
| WO1989005349A1 (en) | 1987-12-09 | 1989-06-15 | The Australian National University | Method of combating viral infections |
| AP129A (en) | 1988-06-03 | 1991-04-17 | Smithkline Biologicals S A | Expression of retrovirus gag protein eukaryotic cells |
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| IL162181A (en) | 1988-12-28 | 2006-04-10 | Pdl Biopharma Inc | A method of producing humanized immunoglubulin, and polynucleotides encoding the same |
| JP2752788B2 (ja) | 1989-01-23 | 1998-05-18 | カイロン コーポレイション | 感染および過剰増殖障害の為の組換え療法 |
| US5703055A (en) | 1989-03-21 | 1997-12-30 | Wisconsin Alumni Research Foundation | Generation of antibodies through lipid mediated DNA delivery |
| ES2116269T3 (es) | 1989-03-21 | 1998-07-16 | Vical Inc | Expresion de secuencias exogenas de polinucleotidos en un vertebrado. |
| US5328470A (en) | 1989-03-31 | 1994-07-12 | The Regents Of The University Of Michigan | Treatment of diseases by site-specific instillation of cells or site-specific transformation of cells and kits therefor |
| US5459039A (en) | 1989-05-12 | 1995-10-17 | Duke University | Methods for mapping genetic mutations |
| JP4041535B2 (ja) | 1989-08-18 | 2008-01-30 | オックスフォード バイオメディカ（ユーケー）リミテッド | 標的細胞にベクター構造体を運搬する組換レトロウィルス |
| GB8919607D0 (en) | 1989-08-30 | 1989-10-11 | Wellcome Found | Novel entities for cancer therapy |
| AU647741B2 (en) | 1989-12-01 | 1994-03-31 | Regents Of The University Of California, The | Methods and compositions for chromosome-specific staining |
| DE69132905T2 (de) | 1990-12-06 | 2002-08-01 | Affymetrix, Inc. (N.D.Ges.D.Staates Delaware) | Detektion von Nukleinsäuresequenzen |
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| US7651855B2 (en) * | 2003-04-17 | 2010-01-26 | The Trustees Of The University Of Pennsylvania | Regulatory T cells and their use in immunotherapy and suppression of autoimmune responses |
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| WO2010101870A1 (en) | 2009-03-03 | 2010-09-10 | St. Jude Children's Research Hospital | Compositions and methods for generating interleukin-35-induced regulatory t cells |
| WO2011106558A1 (en) * | 2010-02-24 | 2011-09-01 | The Board Of Trustees Of The Leland Stanford Junior University | Methods for autoimmune disease diagnosis, prognosis, and treatment |
| WO2011139738A2 (en) | 2010-04-28 | 2011-11-10 | Tenx Biopharma, Inc. | Therapies using zanolimumab to enhance the immune response |
| KR102220006B1 (ko) * | 2011-03-11 | 2021-02-24 | 아시스땅스 퍼블리끄-오삐또 드 빠리 | 자가면역 - 관련 또는 염증성 장애를 치료하기 위한 저용량 ｉｌ２ 의 용도 |
| WO2012177624A2 (en) | 2011-06-21 | 2012-12-27 | The Johns Hopkins University | Focused radiation for augmenting immune-based therapies against neoplasms |
-
2015
- 2015-10-07 AU AU2015328163A patent/AU2015328163B2/en not_active Ceased
- 2015-10-07 JP JP2017518533A patent/JP6941561B2/ja active Active
- 2015-10-07 WO PCT/US2015/054466 patent/WO2016057651A1/en not_active Ceased
- 2015-10-07 CA CA2963602A patent/CA2963602A1/en active Pending
- 2015-10-07 CN CN201580067147.5A patent/CN107106876B/zh active Active
- 2015-10-07 US US15/516,775 patent/US10806773B2/en active Active
- 2015-10-07 EP EP15849237.1A patent/EP3204119B1/en active Active
- 2015-10-07 CN CN202110564807.8A patent/CN113230384A/zh active Pending
-
2020
- 2020-08-25 US US17/002,072 patent/US20210077580A1/en not_active Abandoned
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