JP2018198596A5 - - Google Patents
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- Publication number
- JP2018198596A5 JP2018198596A5 JP2018128111A JP2018128111A JP2018198596A5 JP 2018198596 A5 JP2018198596 A5 JP 2018198596A5 JP 2018128111 A JP2018128111 A JP 2018128111A JP 2018128111 A JP2018128111 A JP 2018128111A JP 2018198596 A5 JP2018198596 A5 JP 2018198596A5
- Authority
- JP
- Japan
- Prior art keywords
- pad4
- antibody according
- antibody
- seq
- pad4 antibody
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 101000735566 Homo sapiens Protein-arginine deiminase type-4 Proteins 0.000 claims 4
- 102100035731 Protein-arginine deiminase type-4 Human genes 0.000 claims 4
- 125000003275 alpha amino acid group Chemical group 0.000 claims 3
- 206010003246 arthritis Diseases 0.000 claims 2
- 239000008194 pharmaceutical composition Substances 0.000 claims 2
- 102000040430 polynucleotide Human genes 0.000 claims 2
- 108091033319 polynucleotide Proteins 0.000 claims 2
- 239000002157 polynucleotide Substances 0.000 claims 2
- 108090000765 processed proteins & peptides Proteins 0.000 claims 2
- QNAYBMKLOCPYGJ-REOHCLBHSA-N L-alanine Chemical compound C[C@H](N)C(O)=O QNAYBMKLOCPYGJ-REOHCLBHSA-N 0.000 claims 1
- 235000004279 alanine Nutrition 0.000 claims 1
- 235000001014 amino acid Nutrition 0.000 claims 1
- 239000000427 antigen Substances 0.000 claims 1
- 102000036639 antigens Human genes 0.000 claims 1
- 108091007433 antigens Proteins 0.000 claims 1
- 239000000969 carrier Substances 0.000 claims 1
- 230000000694 effects Effects 0.000 claims 1
- 239000012634 fragment Substances 0.000 claims 1
- 239000003112 inhibitor Substances 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 239000000203 mixture Substances 0.000 claims 1
- 238000006467 substitution reaction Methods 0.000 claims 1
- 230000001225 therapeutic effect Effects 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2015044518 | 2015-03-06 | ||
| JP2015044518 | 2015-03-06 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017505334A Division JP6369922B2 (ja) | 2015-03-06 | 2016-03-07 | 新規抗ｐａｄ４抗体 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2018198596A JP2018198596A (ja) | 2018-12-20 |
| JP2018198596A5 true JP2018198596A5 (OSRAM) | 2019-04-18 |
| JP6675739B2 JP6675739B2 (ja) | 2020-04-01 |
Family
ID=56880525
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017505334A Active JP6369922B2 (ja) | 2015-03-06 | 2016-03-07 | 新規抗ｐａｄ４抗体 |
| JP2018128111A Active JP6675739B2 (ja) | 2015-03-06 | 2018-07-05 | 新規抗ｐａｄ４抗体 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017505334A Active JP6369922B2 (ja) | 2015-03-06 | 2016-03-07 | 新規抗ｐａｄ４抗体 |
Country Status (5)
| Country | Link |
|---|---|
| US (2) | US11447569B2 (OSRAM) |
| EP (2) | EP4223786A3 (OSRAM) |
| JP (2) | JP6369922B2 (OSRAM) |
| ES (1) | ES2952132T3 (OSRAM) |
| WO (1) | WO2016143753A1 (OSRAM) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2016143753A1 (ja) | 2015-03-06 | 2016-09-15 | 公立大学法人横浜市立大学 | 新規抗ｐａｄ４抗体 |
| WO2019058255A1 (en) | 2017-09-19 | 2019-03-28 | Tropic Biosciences UK Limited | MODIFICATION OF THE SPECIFICITY OF VEGETABLE NON-CODANT RNA MOLECULES FOR THE SILENCING OF GENE EXPRESSION |
| JPWO2019131769A1 (ja) * | 2017-12-26 | 2021-02-12 | 公立大学法人名古屋市立大学 | 新規抗ｐａｄ４抗体 |
| KR20210128443A (ko) | 2019-02-15 | 2021-10-26 | 인테그럴 몰큘러 인코포레이티드 | 클라우딘 6 항체 및 이의 용도 |
| CA3129317A1 (en) | 2019-02-15 | 2020-08-20 | Integral Molecular, Inc. | Antibodies comprising a common light chain and uses thereof |
| CN111733151B (zh) * | 2020-07-13 | 2021-11-12 | 山东新创生物科技有限公司 | 一种基于padi4作为肿瘤标志物制得的抗原、抗体及应用 |
| CN116323673A (zh) * | 2020-08-10 | 2023-06-23 | 整体分子公司 | 用于制备抗体文库和从其分离的抗体的方法和组合物 |
| AR124914A1 (es) * | 2021-02-18 | 2023-05-17 | Mitsubishi Tanabe Pharma Corp | Nuevo anticuerpo anti-pad4 |
| CA3215997A1 (en) * | 2021-04-21 | 2022-10-27 | Connor SWEENEY | Method and composition |
| EP4558529A1 (en) * | 2022-07-22 | 2025-05-28 | Bristol-Myers Squibb Company | Antibodies binding to human pad4 and uses thereof |
| CN120282987A (zh) | 2022-11-30 | 2025-07-08 | 因特格尔莫来库乐有限公司 | 包括双特异性型式的针对紧密连接蛋白6的抗体 |
| CN120476150A (zh) | 2022-12-19 | 2025-08-12 | 阿斯利康(瑞典)有限公司 | 自身免疫性疾病的治疗 |
| WO2024233254A2 (en) * | 2023-05-05 | 2024-11-14 | The Johns Hopkins University | Human monoclonal antibodies for treating subjects suffering from pulmonary fibrosis |
| WO2025024265A1 (en) | 2023-07-21 | 2025-01-30 | Bristol-Myers Squibb Company | Methods of assessing citrullination and activity of pad4 modulators |
| WO2025122927A1 (en) * | 2023-12-06 | 2025-06-12 | Integral Molecular, Inc. | Antibodies directed to claudin 18.2, including bispecific formats thereof |
| US20250230251A1 (en) | 2023-12-20 | 2025-07-17 | Bristol-Myers Squibb Company | Antibodies targeting il-18 receptor beta (il-18rb) and related methods |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4816567A (en) | 1983-04-08 | 1989-03-28 | Genentech, Inc. | Recombinant immunoglobin preparations |
| JP4304274B2 (ja) | 2004-03-04 | 2009-07-29 | 国立大学法人広島大学 | ニワトリ−ヒトキメラ抗体発現用ベクターおよびこれを用いたニワトリ−ヒトキメラ抗体生産方法、並びにその利用 |
| JP4857450B2 (ja) | 2004-03-09 | 2012-01-18 | 財団法人名古屋産業科学研究所 | ヒト関節リウマチの病態を再現するトランスジェニック非ヒト哺乳動物 |
| JP5252339B2 (ja) | 2007-12-25 | 2013-07-31 | 地方独立行政法人東京都健康長寿医療センター | Ｐａｄ４及び抗ｐａｄ４抗体の測定方法並びに関節リウマチの検出方法 |
| WO2011066372A2 (en) * | 2009-11-25 | 2011-06-03 | The Johns Hopkins University | Citrullination of human peptidylarginine deiminase 4 (pad-4) regulates its function and immunogenicity |
| JPWO2012026309A1 (ja) * | 2010-08-23 | 2013-10-28 | 公立大学法人横浜市立大学 | 抗ｐａｄ４抗体医薬の創成 |
| WO2013143026A1 (en) | 2012-03-31 | 2013-10-03 | Abmart (Shanghai) Co., Ltd | Peptide and antibody libraries and uses thereof |
| WO2016143753A1 (ja) | 2015-03-06 | 2016-09-15 | 公立大学法人横浜市立大学 | 新規抗ｐａｄ４抗体 |
| WO2016155745A1 (en) * | 2015-03-27 | 2016-10-06 | Rigshospitalet | Cross-reactive anti-pad antibodies |
-
2016
- 2016-03-07 WO PCT/JP2016/057030 patent/WO2016143753A1/ja not_active Ceased
- 2016-03-07 ES ES16761721T patent/ES2952132T3/es active Active
- 2016-03-07 JP JP2017505334A patent/JP6369922B2/ja active Active
- 2016-03-07 EP EP23165932.7A patent/EP4223786A3/en active Pending
- 2016-03-07 EP EP16761721.6A patent/EP3266872B1/en active Active
- 2016-03-07 US US15/555,808 patent/US11447569B2/en active Active
-
2018
- 2018-07-05 JP JP2018128111A patent/JP6675739B2/ja active Active
-
2022
- 2022-09-19 US US17/933,229 patent/US12448464B2/en active Active
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