JP2018183141A5 - - Google Patents
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- JP2018183141A5 JP2018183141A5 JP2018111416A JP2018111416A JP2018183141A5 JP 2018183141 A5 JP2018183141 A5 JP 2018183141A5 JP 2018111416 A JP2018111416 A JP 2018111416A JP 2018111416 A JP2018111416 A JP 2018111416A JP 2018183141 A5 JP2018183141 A5 JP 2018183141A5
- Authority
- JP
- Japan
- Prior art keywords
- population
- culture medium
- chondrocytes
- polypeptide
- pluripotent stem
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- NIJJYAXOARWZEE-UHFFFAOYSA-N Valproic acid Chemical compound CCCC(C(O)=O)CCC NIJJYAXOARWZEE-UHFFFAOYSA-N 0.000 claims description 4
- 229960000604 valproic acid Drugs 0.000 claims description 2
- 238000000034 method Methods 0.000 claims 20
- 229920001184 polypeptide Polymers 0.000 claims 10
- 102000004196 processed proteins & peptides Human genes 0.000 claims 10
- 108090000765 processed proteins & peptides Proteins 0.000 claims 10
- 210000001612 chondrocyte Anatomy 0.000 claims 9
- 210000001778 pluripotent stem cell Anatomy 0.000 claims 8
- 239000013604 expression vector Substances 0.000 claims 7
- 239000001963 growth medium Substances 0.000 claims 7
- 102000005789 Vascular Endothelial Growth Factors Human genes 0.000 claims 6
- 108010019530 Vascular Endothelial Growth Factors Proteins 0.000 claims 6
- 238000012258 culturing Methods 0.000 claims 6
- 210000002242 embryoid body Anatomy 0.000 claims 5
- 102100024785 Fibroblast growth factor 2 Human genes 0.000 claims 4
- 108090000379 Fibroblast growth factor 2 Proteins 0.000 claims 4
- 102100024505 Bone morphogenetic protein 4 Human genes 0.000 claims 3
- 101000762379 Homo sapiens Bone morphogenetic protein 4 Proteins 0.000 claims 3
- 108700021430 Kruppel-Like Factor 4 Proteins 0.000 claims 3
- 101100247004 Rattus norvegicus Qsox1 gene Proteins 0.000 claims 3
- 101150086694 SLC22A3 gene Proteins 0.000 claims 3
- 239000006143 cell culture medium Substances 0.000 claims 3
- 108010023082 activin A Proteins 0.000 claims 2
- 210000003038 endothelium Anatomy 0.000 claims 2
- 230000001939 inductive effect Effects 0.000 claims 2
- 239000000049 pigment Substances 0.000 claims 2
- 102100038895 Myc proto-oncogene protein Human genes 0.000 claims 1
- 101710135898 Myc proto-oncogene protein Proteins 0.000 claims 1
- 101710150336 Protein Rex Proteins 0.000 claims 1
- 101710150448 Transcriptional regulator Myc Proteins 0.000 claims 1
- 210000004413 cardiac myocyte Anatomy 0.000 claims 1
- 239000003550 marker Substances 0.000 claims 1
- 108090000623 proteins and genes Proteins 0.000 claims 1
- 230000001177 retroviral effect Effects 0.000 claims 1
- 230000003612 virological effect Effects 0.000 claims 1
- 108010010803 Gelatin Proteins 0.000 description 1
- 102100035846 Pigment epithelium-derived factor Human genes 0.000 description 1
- 229920000159 gelatin Polymers 0.000 description 1
- 239000008273 gelatin Substances 0.000 description 1
- 235000019322 gelatine Nutrition 0.000 description 1
- 235000011852 gelatine desserts Nutrition 0.000 description 1
- 108090000102 pigment epithelium-derived factor Proteins 0.000 description 1
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2021093070A JP2021153591A (ja) | 2012-10-29 | 2021-06-02 | 軟骨細胞から多能性幹細胞を製造する方法 |
| JP2022196593A JP2023068668A (ja) | 2012-10-29 | 2022-12-08 | 軟骨細胞から多能性幹細胞を製造する方法 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261719901P | 2012-10-29 | 2012-10-29 | |
| US61/719,901 | 2012-10-29 | ||
| JP2015539924A JP6399558B2 (ja) | 2012-10-29 | 2013-10-29 | 軟骨細胞から多能性幹細胞を製造する方法 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015539924A Division JP6399558B2 (ja) | 2012-10-29 | 2013-10-29 | 軟骨細胞から多能性幹細胞を製造する方法 |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021093070A Division JP2021153591A (ja) | 2012-10-29 | 2021-06-02 | 軟骨細胞から多能性幹細胞を製造する方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2018183141A JP2018183141A (ja) | 2018-11-22 |
| JP2018183141A5 true JP2018183141A5 (enExample) | 2019-09-19 |
| JP6898657B2 JP6898657B2 (ja) | 2021-07-07 |
Family
ID=50628010
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015539924A Active JP6399558B2 (ja) | 2012-10-29 | 2013-10-29 | 軟骨細胞から多能性幹細胞を製造する方法 |
| JP2018111416A Active JP6898657B2 (ja) | 2012-10-29 | 2018-06-11 | 軟骨細胞から多能性幹細胞を製造する方法 |
| JP2021093070A Pending JP2021153591A (ja) | 2012-10-29 | 2021-06-02 | 軟骨細胞から多能性幹細胞を製造する方法 |
| JP2022196593A Pending JP2023068668A (ja) | 2012-10-29 | 2022-12-08 | 軟骨細胞から多能性幹細胞を製造する方法 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015539924A Active JP6399558B2 (ja) | 2012-10-29 | 2013-10-29 | 軟骨細胞から多能性幹細胞を製造する方法 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021093070A Pending JP2021153591A (ja) | 2012-10-29 | 2021-06-02 | 軟骨細胞から多能性幹細胞を製造する方法 |
| JP2022196593A Pending JP2023068668A (ja) | 2012-10-29 | 2022-12-08 | 軟骨細胞から多能性幹細胞を製造する方法 |
Country Status (4)
| Country | Link |
|---|---|
| US (2) | US9914911B2 (enExample) |
| EP (1) | EP2912166B1 (enExample) |
| JP (4) | JP6399558B2 (enExample) |
| WO (1) | WO2014070797A1 (enExample) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US10724005B2 (en) | 2012-09-28 | 2020-07-28 | Scripps Health | Methods of differentiating stem cells into chondrocytes |
| WO2014070797A1 (en) * | 2012-10-29 | 2014-05-08 | Scripps Health | Methods of producing pluripotent stem cells from chondrocytes |
| JP6324395B2 (ja) | 2012-10-29 | 2018-05-16 | スクリップス ヘルス | 軟骨細胞を移植する方法 |
| CN105208969B (zh) | 2013-03-11 | 2017-10-20 | 恩多斯潘有限公司 | 用于主动脉夹层的多组件支架移植物系统 |
| CN105833275B (zh) * | 2016-04-28 | 2019-12-27 | 中国医学科学院血液病医院(中国医学科学院血液学研究所) | 一种利用重编程效应治疗白血病的方法 |
| US10758574B2 (en) * | 2016-04-28 | 2020-09-01 | The Board Of Trustees Of The Leland Stanford Junior University | Cartilage cells with a high regenerative potential and low immune response for use in cellular therapy |
| CN106267363B (zh) * | 2016-09-18 | 2019-06-14 | 辽宁聚高智造科技有限公司 | 一种人造骨 |
| EP3900787A4 (en) * | 2018-12-21 | 2022-02-23 | Kyoto University | LUBRICIN-LOCALIZED CARTILE-LIKE TISSUE, METHOD OF MANUFACTURE THEREOF AND COMPOSITION THEREOF FOR TREATMENT OF ARTICULATE-CARTILAGE DEFECTS |
| WO2021100796A1 (ja) * | 2019-11-20 | 2021-05-27 | 一丸ファルコス株式会社 | 軟骨を作製するための剤及び軟骨の作製方法 |
| JP7774794B2 (ja) * | 2021-06-17 | 2025-11-25 | 学校法人近畿大学 | 人工耳介および人工軟骨組織の骨格構造 |
Family Cites Families (38)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5399347A (en) | 1987-06-24 | 1995-03-21 | Autoimmune, Inc. | Method of treating rheumatoid arthritis with type II collagen |
| US5645851A (en) | 1994-02-28 | 1997-07-08 | Moore; Eugene R. | Product for alleviating the symptons of arthritis in mammals |
| US5843780A (en) | 1995-01-20 | 1998-12-01 | Wisconsin Alumni Research Foundation | Primate embryonic stem cells |
| GB9503492D0 (en) | 1995-02-22 | 1995-04-12 | Ed Geistlich S Hne A G F R Che | Chemical product |
| US6025327A (en) | 1997-08-08 | 2000-02-15 | Biocell Technology, Llc | Hydrolyzed collagen type II and use thereof |
| US6511958B1 (en) | 1997-08-14 | 2003-01-28 | Sulzer Biologics, Inc. | Compositions for regeneration and repair of cartilage lesions |
| US20030026786A1 (en) | 1999-06-04 | 2003-02-06 | Mark F. Pittenger | Chondrogenic differentiation of human mesenchymal stem cells |
| EP1254670A1 (en) | 2001-05-03 | 2002-11-06 | Stichting Katholieke Universiteit | Type II collagen matrices for use in cartilage engineering |
| US6780841B2 (en) | 2001-11-13 | 2004-08-24 | Biocell Technology, Llc | Hyaluronic acid and chondroitin sulfate based hydrolyzed collagen type II and method of making same |
| CA2412012C (en) | 2001-11-20 | 2011-08-02 | Ed. Geistlich Soehne Ag Fuer Chemische Industrie | Resorbable extracellular matrix containing collagen i and collagen ii for reconstruction of cartilage |
| US6852331B2 (en) | 2002-02-11 | 2005-02-08 | Taipei Biotechnology Ltd., Inc. | Fabrication of a cartilage implant |
| ES2265199B1 (es) | 2003-06-12 | 2008-02-01 | Cellerix, S.L. | Celulas madre adultas multipotentes procedentes de condrocitos desdiferenciados y sus aplicaciones. |
| WO2006015209A2 (en) | 2004-07-29 | 2006-02-09 | Stem Cell Innovations, Inc. | Differentiation of stem cells |
| AU2005287855B2 (en) | 2004-09-24 | 2011-06-16 | Mesoblast, Inc. | Method of enhancing proliferation and/or survival of mesenchymal precursor cells (MPC) |
| US20080260694A1 (en) | 2004-09-24 | 2008-10-23 | Angioblast Systems, Inc. | Multipotential Expanded Mesenchymal Precursor Cell Progeny (Memp) and Uses Thereof |
| US20060189840A1 (en) | 2005-02-18 | 2006-08-24 | Acorn Cardiovascular, Inc. | Transmyocardial delivery of cardiac wall tension relief |
| ES2329636B2 (es) * | 2006-02-17 | 2010-07-26 | Universitat De Valencia, Estudi General (Participa Con El 70%) | Uso del factor pedf para inducir la auto-renovacion de celulas madre. |
| FR2900155B1 (fr) | 2006-04-21 | 2008-06-27 | Diana Naturals Sa | Hydrolisat de cartilage aviaire, procede d'obtention et utilisations |
| CN101721349B (zh) | 2008-10-16 | 2011-07-20 | 常州百瑞吉生物医药有限公司 | 可注射原位交联水凝胶及其制备方法和用途 |
| KR101091028B1 (ko) | 2009-07-02 | 2011-12-09 | 아주대학교산학협력단 | 체내 주입형 하이드로젤 및 이의 생의학적 용도 |
| JP5636174B2 (ja) | 2009-07-10 | 2014-12-03 | 学校法人近畿大学 | 間葉系細胞または軟骨細胞の製法ならびに発癌性の抑制方法 |
| ES2638464T3 (es) * | 2009-10-16 | 2017-10-20 | The Scripps Research Institute | Inducción de células pluripotentes |
| JP6263329B2 (ja) | 2009-11-24 | 2018-01-17 | ザ ユニバーシティ オブ コネチカット | ヒト胚性および人工多能性幹細胞の分化 |
| KR100990436B1 (ko) | 2009-11-30 | 2010-10-29 | 동국대학교 산학협력단 | 중간엽 줄기세포를 DKK-1 또는 sFRP-1을 이용하여 연골세포로 분화시키는 방법 |
| EP2529009A4 (en) | 2010-01-28 | 2013-11-13 | Univ Queensland | METHOD OF STEM CELL DIFFERENTIATION |
| AU2011235212B2 (en) | 2010-03-31 | 2014-07-31 | The Scripps Research Institute | Reprogramming cells |
| CN102933704A (zh) | 2010-04-08 | 2013-02-13 | 爱丁堡大学管理处 | 软骨祖细胞、用于细胞衍生的方案和其用途 |
| CN101810855B (zh) | 2010-05-20 | 2012-06-13 | 广州创尔生物技术有限公司 | 一种ⅱ型胶原关节软骨修复液及其制备方法 |
| WO2012013969A1 (en) * | 2010-07-26 | 2012-02-02 | The University Of Manchester | Targeted differentiation of stem cells |
| CN101934092A (zh) | 2010-08-27 | 2011-01-05 | 中国人民解放军第三军医大学第一附属医院 | 用于软骨再生修复的注射型软骨仿生基质材料及使用方法 |
| US20120087868A1 (en) | 2010-10-08 | 2012-04-12 | Gabriele Todd | Nanoparticle-loaded cells |
| KR101340458B1 (ko) | 2010-11-02 | 2013-12-11 | 서울대학교산학협력단 | 하이드로겔을 포함하는 연골 이식용 조성물 |
| US8663675B2 (en) | 2010-11-18 | 2014-03-04 | Jalaledin Ghanavi | Injectable matrix having a polymer and a stem cell niche composed of cup-shaped nanoparticles containing growth factors or physiological agents for organ reconstruction |
| WO2012126824A1 (en) | 2011-03-18 | 2012-09-27 | Inserm (Institut National De La Sante Et De La Recherche Medicale) | Chondrogenic differentiation media and methods for inducing chondrogenic differentiation of cells |
| US10724005B2 (en) | 2012-09-28 | 2020-07-28 | Scripps Health | Methods of differentiating stem cells into chondrocytes |
| WO2014070797A1 (en) | 2012-10-29 | 2014-05-08 | Scripps Health | Methods of producing pluripotent stem cells from chondrocytes |
| JP6324395B2 (ja) | 2012-10-29 | 2018-05-16 | スクリップス ヘルス | 軟骨細胞を移植する方法 |
| WO2014157257A1 (ja) * | 2013-03-25 | 2014-10-02 | 公益財団法人先端医療振興財団 | 細胞の選別方法 |
-
2013
- 2013-10-29 WO PCT/US2013/067350 patent/WO2014070797A1/en not_active Ceased
- 2013-10-29 EP EP13851668.7A patent/EP2912166B1/en active Active
- 2013-10-29 US US14/438,581 patent/US9914911B2/en active Active
- 2013-10-29 JP JP2015539924A patent/JP6399558B2/ja active Active
-
2018
- 2018-01-16 US US15/872,577 patent/US10385318B2/en active Active
- 2018-06-11 JP JP2018111416A patent/JP6898657B2/ja active Active
-
2021
- 2021-06-02 JP JP2021093070A patent/JP2021153591A/ja active Pending
-
2022
- 2022-12-08 JP JP2022196593A patent/JP2023068668A/ja active Pending
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