JP6399558B2 - 軟骨細胞から多能性幹細胞を製造する方法 - Google Patents
軟骨細胞から多能性幹細胞を製造する方法 Download PDFInfo
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- JP6399558B2 JP6399558B2 JP2015539924A JP2015539924A JP6399558B2 JP 6399558 B2 JP6399558 B2 JP 6399558B2 JP 2015539924 A JP2015539924 A JP 2015539924A JP 2015539924 A JP2015539924 A JP 2015539924A JP 6399558 B2 JP6399558 B2 JP 6399558B2
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- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0696—Artificially induced pluripotent stem cells, e.g. iPS
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/32—Bones; Osteocytes; Osteoblasts; Tendons; Tenocytes; Teeth; Odontoblasts; Cartilage; Chondrocytes; Synovial membrane
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/48—Reproductive organs
- A61K35/54—Ovaries; Ova; Ovules; Embryos; Foetal cells; Germ cells
- A61K35/545—Embryonic stem cells; Pluripotent stem cells; Induced pluripotent stem cells; Uncharacterised stem cells
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- A61P19/04—Drugs for skeletal disorders for non-specific disorders of the connective tissue
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- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
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- C12N2501/30—Hormones
- C12N2501/38—Hormones with nuclear receptors
- C12N2501/385—Hormones with nuclear receptors of the family of the retinoic acid recptor, e.g. RAR, RXR; Peroxisome proliferator-activated receptor [PPAR]
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- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
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- C12N2501/602—Sox-2
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- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
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- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/60—Transcription factors
- C12N2501/606—Transcription factors c-Myc
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- C12N2506/00—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells
- C12N2506/13—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from connective tissue cells, from mesenchymal cells
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- C12N2510/00—Genetically modified cells
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- C12N2513/00—3D culture
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- C12N2533/00—Supports or coatings for cell culture, characterised by material
- C12N2533/50—Proteins
- C12N2533/54—Collagen; Gelatin
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- General Health & Medical Sciences (AREA)
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- Physical Education & Sports Medicine (AREA)
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- General Chemical & Material Sciences (AREA)
- Rheumatology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Wood Science & Technology (AREA)
- Genetics & Genomics (AREA)
- Gynecology & Obstetrics (AREA)
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- Transplantation (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Materials For Medical Uses (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
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- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2018111416A JP6898657B2 (ja) | 2012-10-29 | 2018-06-11 | 軟骨細胞から多能性幹細胞を製造する方法 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261719901P | 2012-10-29 | 2012-10-29 | |
| US61/719,901 | 2012-10-29 | ||
| PCT/US2013/067350 WO2014070797A1 (en) | 2012-10-29 | 2013-10-29 | Methods of producing pluripotent stem cells from chondrocytes |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018111416A Division JP6898657B2 (ja) | 2012-10-29 | 2018-06-11 | 軟骨細胞から多能性幹細胞を製造する方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2016502401A JP2016502401A (ja) | 2016-01-28 |
| JP2016502401A5 JP2016502401A5 (enExample) | 2016-11-10 |
| JP6399558B2 true JP6399558B2 (ja) | 2018-10-03 |
Family
ID=50628010
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015539924A Active JP6399558B2 (ja) | 2012-10-29 | 2013-10-29 | 軟骨細胞から多能性幹細胞を製造する方法 |
| JP2018111416A Active JP6898657B2 (ja) | 2012-10-29 | 2018-06-11 | 軟骨細胞から多能性幹細胞を製造する方法 |
| JP2021093070A Pending JP2021153591A (ja) | 2012-10-29 | 2021-06-02 | 軟骨細胞から多能性幹細胞を製造する方法 |
| JP2022196593A Pending JP2023068668A (ja) | 2012-10-29 | 2022-12-08 | 軟骨細胞から多能性幹細胞を製造する方法 |
Family Applications After (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018111416A Active JP6898657B2 (ja) | 2012-10-29 | 2018-06-11 | 軟骨細胞から多能性幹細胞を製造する方法 |
| JP2021093070A Pending JP2021153591A (ja) | 2012-10-29 | 2021-06-02 | 軟骨細胞から多能性幹細胞を製造する方法 |
| JP2022196593A Pending JP2023068668A (ja) | 2012-10-29 | 2022-12-08 | 軟骨細胞から多能性幹細胞を製造する方法 |
Country Status (4)
| Country | Link |
|---|---|
| US (2) | US9914911B2 (enExample) |
| EP (1) | EP2912166B1 (enExample) |
| JP (4) | JP6399558B2 (enExample) |
| WO (1) | WO2014070797A1 (enExample) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US10724005B2 (en) | 2012-09-28 | 2020-07-28 | Scripps Health | Methods of differentiating stem cells into chondrocytes |
| WO2014070797A1 (en) * | 2012-10-29 | 2014-05-08 | Scripps Health | Methods of producing pluripotent stem cells from chondrocytes |
| JP6324395B2 (ja) | 2012-10-29 | 2018-05-16 | スクリップス ヘルス | 軟骨細胞を移植する方法 |
| CN105208969B (zh) | 2013-03-11 | 2017-10-20 | 恩多斯潘有限公司 | 用于主动脉夹层的多组件支架移植物系统 |
| CN105833275B (zh) * | 2016-04-28 | 2019-12-27 | 中国医学科学院血液病医院(中国医学科学院血液学研究所) | 一种利用重编程效应治疗白血病的方法 |
| US10758574B2 (en) * | 2016-04-28 | 2020-09-01 | The Board Of Trustees Of The Leland Stanford Junior University | Cartilage cells with a high regenerative potential and low immune response for use in cellular therapy |
| CN106267363B (zh) * | 2016-09-18 | 2019-06-14 | 辽宁聚高智造科技有限公司 | 一种人造骨 |
| EP3900787A4 (en) * | 2018-12-21 | 2022-02-23 | Kyoto University | LUBRICIN-LOCALIZED CARTILE-LIKE TISSUE, METHOD OF MANUFACTURE THEREOF AND COMPOSITION THEREOF FOR TREATMENT OF ARTICULATE-CARTILAGE DEFECTS |
| WO2021100796A1 (ja) * | 2019-11-20 | 2021-05-27 | 一丸ファルコス株式会社 | 軟骨を作製するための剤及び軟骨の作製方法 |
| JP7774794B2 (ja) * | 2021-06-17 | 2025-11-25 | 学校法人近畿大学 | 人工耳介および人工軟骨組織の骨格構造 |
Family Cites Families (38)
| Publication number | Priority date | Publication date | Assignee | Title |
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| US5399347A (en) | 1987-06-24 | 1995-03-21 | Autoimmune, Inc. | Method of treating rheumatoid arthritis with type II collagen |
| US5645851A (en) | 1994-02-28 | 1997-07-08 | Moore; Eugene R. | Product for alleviating the symptons of arthritis in mammals |
| US5843780A (en) | 1995-01-20 | 1998-12-01 | Wisconsin Alumni Research Foundation | Primate embryonic stem cells |
| GB9503492D0 (en) | 1995-02-22 | 1995-04-12 | Ed Geistlich S Hne A G F R Che | Chemical product |
| US6025327A (en) | 1997-08-08 | 2000-02-15 | Biocell Technology, Llc | Hydrolyzed collagen type II and use thereof |
| US6511958B1 (en) | 1997-08-14 | 2003-01-28 | Sulzer Biologics, Inc. | Compositions for regeneration and repair of cartilage lesions |
| US20030026786A1 (en) | 1999-06-04 | 2003-02-06 | Mark F. Pittenger | Chondrogenic differentiation of human mesenchymal stem cells |
| EP1254670A1 (en) | 2001-05-03 | 2002-11-06 | Stichting Katholieke Universiteit | Type II collagen matrices for use in cartilage engineering |
| US6780841B2 (en) | 2001-11-13 | 2004-08-24 | Biocell Technology, Llc | Hyaluronic acid and chondroitin sulfate based hydrolyzed collagen type II and method of making same |
| CA2412012C (en) | 2001-11-20 | 2011-08-02 | Ed. Geistlich Soehne Ag Fuer Chemische Industrie | Resorbable extracellular matrix containing collagen i and collagen ii for reconstruction of cartilage |
| US6852331B2 (en) | 2002-02-11 | 2005-02-08 | Taipei Biotechnology Ltd., Inc. | Fabrication of a cartilage implant |
| ES2265199B1 (es) | 2003-06-12 | 2008-02-01 | Cellerix, S.L. | Celulas madre adultas multipotentes procedentes de condrocitos desdiferenciados y sus aplicaciones. |
| WO2006015209A2 (en) | 2004-07-29 | 2006-02-09 | Stem Cell Innovations, Inc. | Differentiation of stem cells |
| AU2005287855B2 (en) | 2004-09-24 | 2011-06-16 | Mesoblast, Inc. | Method of enhancing proliferation and/or survival of mesenchymal precursor cells (MPC) |
| US20080260694A1 (en) | 2004-09-24 | 2008-10-23 | Angioblast Systems, Inc. | Multipotential Expanded Mesenchymal Precursor Cell Progeny (Memp) and Uses Thereof |
| US20060189840A1 (en) | 2005-02-18 | 2006-08-24 | Acorn Cardiovascular, Inc. | Transmyocardial delivery of cardiac wall tension relief |
| ES2329636B2 (es) * | 2006-02-17 | 2010-07-26 | Universitat De Valencia, Estudi General (Participa Con El 70%) | Uso del factor pedf para inducir la auto-renovacion de celulas madre. |
| FR2900155B1 (fr) | 2006-04-21 | 2008-06-27 | Diana Naturals Sa | Hydrolisat de cartilage aviaire, procede d'obtention et utilisations |
| CN101721349B (zh) | 2008-10-16 | 2011-07-20 | 常州百瑞吉生物医药有限公司 | 可注射原位交联水凝胶及其制备方法和用途 |
| KR101091028B1 (ko) | 2009-07-02 | 2011-12-09 | 아주대학교산학협력단 | 체내 주입형 하이드로젤 및 이의 생의학적 용도 |
| JP5636174B2 (ja) | 2009-07-10 | 2014-12-03 | 学校法人近畿大学 | 間葉系細胞または軟骨細胞の製法ならびに発癌性の抑制方法 |
| ES2638464T3 (es) * | 2009-10-16 | 2017-10-20 | The Scripps Research Institute | Inducción de células pluripotentes |
| JP6263329B2 (ja) | 2009-11-24 | 2018-01-17 | ザ ユニバーシティ オブ コネチカット | ヒト胚性および人工多能性幹細胞の分化 |
| KR100990436B1 (ko) | 2009-11-30 | 2010-10-29 | 동국대학교 산학협력단 | 중간엽 줄기세포를 DKK-1 또는 sFRP-1을 이용하여 연골세포로 분화시키는 방법 |
| EP2529009A4 (en) | 2010-01-28 | 2013-11-13 | Univ Queensland | METHOD OF STEM CELL DIFFERENTIATION |
| AU2011235212B2 (en) | 2010-03-31 | 2014-07-31 | The Scripps Research Institute | Reprogramming cells |
| CN102933704A (zh) | 2010-04-08 | 2013-02-13 | 爱丁堡大学管理处 | 软骨祖细胞、用于细胞衍生的方案和其用途 |
| CN101810855B (zh) | 2010-05-20 | 2012-06-13 | 广州创尔生物技术有限公司 | 一种ⅱ型胶原关节软骨修复液及其制备方法 |
| WO2012013969A1 (en) * | 2010-07-26 | 2012-02-02 | The University Of Manchester | Targeted differentiation of stem cells |
| CN101934092A (zh) | 2010-08-27 | 2011-01-05 | 中国人民解放军第三军医大学第一附属医院 | 用于软骨再生修复的注射型软骨仿生基质材料及使用方法 |
| US20120087868A1 (en) | 2010-10-08 | 2012-04-12 | Gabriele Todd | Nanoparticle-loaded cells |
| KR101340458B1 (ko) | 2010-11-02 | 2013-12-11 | 서울대학교산학협력단 | 하이드로겔을 포함하는 연골 이식용 조성물 |
| US8663675B2 (en) | 2010-11-18 | 2014-03-04 | Jalaledin Ghanavi | Injectable matrix having a polymer and a stem cell niche composed of cup-shaped nanoparticles containing growth factors or physiological agents for organ reconstruction |
| WO2012126824A1 (en) | 2011-03-18 | 2012-09-27 | Inserm (Institut National De La Sante Et De La Recherche Medicale) | Chondrogenic differentiation media and methods for inducing chondrogenic differentiation of cells |
| US10724005B2 (en) | 2012-09-28 | 2020-07-28 | Scripps Health | Methods of differentiating stem cells into chondrocytes |
| WO2014070797A1 (en) | 2012-10-29 | 2014-05-08 | Scripps Health | Methods of producing pluripotent stem cells from chondrocytes |
| JP6324395B2 (ja) | 2012-10-29 | 2018-05-16 | スクリップス ヘルス | 軟骨細胞を移植する方法 |
| WO2014157257A1 (ja) * | 2013-03-25 | 2014-10-02 | 公益財団法人先端医療振興財団 | 細胞の選別方法 |
-
2013
- 2013-10-29 WO PCT/US2013/067350 patent/WO2014070797A1/en not_active Ceased
- 2013-10-29 EP EP13851668.7A patent/EP2912166B1/en active Active
- 2013-10-29 US US14/438,581 patent/US9914911B2/en active Active
- 2013-10-29 JP JP2015539924A patent/JP6399558B2/ja active Active
-
2018
- 2018-01-16 US US15/872,577 patent/US10385318B2/en active Active
- 2018-06-11 JP JP2018111416A patent/JP6898657B2/ja active Active
-
2021
- 2021-06-02 JP JP2021093070A patent/JP2021153591A/ja active Pending
-
2022
- 2022-12-08 JP JP2022196593A patent/JP2023068668A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| EP2912166A1 (en) | 2015-09-02 |
| WO2014070797A1 (en) | 2014-05-08 |
| JP2021153591A (ja) | 2021-10-07 |
| US10385318B2 (en) | 2019-08-20 |
| US20180155694A1 (en) | 2018-06-07 |
| US9914911B2 (en) | 2018-03-13 |
| EP2912166B1 (en) | 2019-05-01 |
| JP2018183141A (ja) | 2018-11-22 |
| EP2912166A4 (en) | 2016-06-01 |
| JP2016502401A (ja) | 2016-01-28 |
| US20150275181A1 (en) | 2015-10-01 |
| JP6898657B2 (ja) | 2021-07-07 |
| JP2023068668A (ja) | 2023-05-17 |
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