JP2016502401A5 - - Google Patents

Info

Publication number

JP2016502401A5

JP2016502401A5 JP2015539924A JP2015539924A JP2016502401A5 JP 2016502401 A5 JP2016502401 A5 JP 2016502401A5 JP 2015539924 A JP2015539924 A JP 2015539924A JP 2015539924 A JP2015539924 A JP 2015539924A JP 2016502401 A5 JP2016502401 A5 JP 2016502401A5

Authority

JP

Japan

Prior art keywords

population

pluripotent stem

cells

polypeptide

chondrocytes

Prior art date

2013-10-29

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Granted

Links

• Espacenet
• Global Dossier
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• 238000000034 method Methods 0.000 claims 20
• 210000001778 pluripotent stem cell Anatomy 0.000 claims 10
• 210000001612 chondrocyte Anatomy 0.000 claims 8
• 229920001184 polypeptide Polymers 0.000 claims 8
• 108090000765 processed proteins & peptides Proteins 0.000 claims 8
• 102000004196 processed proteins & peptides Human genes 0.000 claims 8
• 210000000845 cartilage Anatomy 0.000 claims 6
• 210000004027 cell Anatomy 0.000 claims 5
• 210000000130 stem cell Anatomy 0.000 claims 5
• 108010035532 Collagen Proteins 0.000 claims 4
• 102000008186 Collagen Human genes 0.000 claims 4
• 229920001436 collagen Polymers 0.000 claims 4
• 210000003494 hepatocyte Anatomy 0.000 claims 4
• 108010073385 Fibrin Proteins 0.000 claims 2
• 102000009123 Fibrin Human genes 0.000 claims 2
• BWGVNKXGVNDBDI-UHFFFAOYSA-N Fibrin monomer Chemical compound CNC(=O)CNC(=O)CN BWGVNKXGVNDBDI-UHFFFAOYSA-N 0.000 claims 2
• 108700021430 Kruppel-Like Factor 4 Proteins 0.000 claims 2
• 102100038895 Myc proto-oncogene protein Human genes 0.000 claims 2
• 101710135898 Myc proto-oncogene protein Proteins 0.000 claims 2
• 101100247004 Rattus norvegicus Qsox1 gene Proteins 0.000 claims 2
• 101150086694 SLC22A3 gene Proteins 0.000 claims 2
• 101710150448 Transcriptional regulator Myc Proteins 0.000 claims 2
• 238000012258 culturing Methods 0.000 claims 2
• 229950003499 fibrin Drugs 0.000 claims 2
• KIUKXJAPPMFGSW-DNGZLQJQSA-N (2S,3S,4S,5R,6R)-6-[(2S,3R,4R,5S,6R)-3-Acetamido-2-[(2S,3S,4R,5R,6R)-6-[(2R,3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-DNGZLQJQSA-N 0.000 claims 1
• FHVDTGUDJYJELY-UHFFFAOYSA-N 6-{[2-carboxy-4,5-dihydroxy-6-(phosphanyloxy)oxan-3-yl]oxy}-4,5-dihydroxy-3-phosphanyloxane-2-carboxylic acid Chemical compound O1C(C(O)=O)C(P)C(O)C(O)C1OC1C(C(O)=O)OC(OP)C(O)C1O FHVDTGUDJYJELY-UHFFFAOYSA-N 0.000 claims 1
• 229920001817 Agar Polymers 0.000 claims 1
• 108010049931 Bone Morphogenetic Protein 2 Proteins 0.000 claims 1
• 102100024506 Bone morphogenetic protein 2 Human genes 0.000 claims 1
• 108010010803 Gelatin Proteins 0.000 claims 1
• 229920001244 Poly(D,L-lactide) Polymers 0.000 claims 1
• 229920000954 Polyglycolide Polymers 0.000 claims 1
• 101710150336 Protein Rex Proteins 0.000 claims 1
• 102000016611 Proteoglycans Human genes 0.000 claims 1
• 108010067787 Proteoglycans Proteins 0.000 claims 1
• 102000056172 Transforming growth factor beta-3 Human genes 0.000 claims 1
• 108090000097 Transforming growth factor beta-3 Proteins 0.000 claims 1
• 239000008272 agar Substances 0.000 claims 1
• 229940072056 alginate Drugs 0.000 claims 1
• 235000010443 alginic acid Nutrition 0.000 claims 1
• 229920000615 alginic acid Polymers 0.000 claims 1
• 108010045569 atelocollagen Proteins 0.000 claims 1
• 230000015572 biosynthetic process Effects 0.000 claims 1
• 210000000988 bone and bone Anatomy 0.000 claims 1
• 239000001506 calcium phosphate Substances 0.000 claims 1
• 229910000389 calcium phosphate Inorganic materials 0.000 claims 1
• 235000011010 calcium phosphates Nutrition 0.000 claims 1
• 230000007547 defect Effects 0.000 claims 1
• 230000004069 differentiation Effects 0.000 claims 1
• 210000002242 embryoid body Anatomy 0.000 claims 1
• 210000003038 endothelium Anatomy 0.000 claims 1
• 239000013604 expression vector Substances 0.000 claims 1
• 239000008273 gelatin Substances 0.000 claims 1
• 229920000159 gelatin Polymers 0.000 claims 1
• 235000019322 gelatine Nutrition 0.000 claims 1
• 235000011852 gelatine desserts Nutrition 0.000 claims 1
• 229920002674 hyaluronan Polymers 0.000 claims 1
• 229960003160 hyaluronic acid Drugs 0.000 claims 1
• 229910052588 hydroxylapatite Inorganic materials 0.000 claims 1
• 230000001939 inductive effect Effects 0.000 claims 1
• XYJRXVWERLGGKC-UHFFFAOYSA-D pentacalcium;hydroxide;triphosphate Chemical compound [OH-].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O XYJRXVWERLGGKC-UHFFFAOYSA-D 0.000 claims 1
• 239000000049 pigment Substances 0.000 claims 1
• 229920001432 poly(L-lactide) Polymers 0.000 claims 1
• 229920000747 poly(lactic acid) Polymers 0.000 claims 1
• -1 poly-D-lactide Polymers 0.000 claims 1
• 239000004633 polyglycolic acid Substances 0.000 claims 1
• 239000004626 polylactic acid Substances 0.000 claims 1
• 108090000623 proteins and genes Proteins 0.000 claims 1
• 210000001519 tissue Anatomy 0.000 claims 1
• QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 claims 1