JP2018058822A5 - - Google Patents
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- Publication number
- JP2018058822A5 JP2018058822A5 JP2017147506A JP2017147506A JP2018058822A5 JP 2018058822 A5 JP2018058822 A5 JP 2018058822A5 JP 2017147506 A JP2017147506 A JP 2017147506A JP 2017147506 A JP2017147506 A JP 2017147506A JP 2018058822 A5 JP2018058822 A5 JP 2018058822A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- nrc
- cancer
- pharmaceutically acceptable
- solvate
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- 0 CC*(C1C*CC(CC)CC1)C(C(C)(C)N**C)=O Chemical compound CC*(C1C*CC(CC)CC1)C(C(C)(C)N**C)=O 0.000 description 5
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2022102984A JP7555998B2 (ja) | 2016-08-03 | 2022-06-27 | ヘテロアリールスルホンをベースとするコンジュゲーションハンドル、これらの調製のための方法、および抗体薬物コンジュゲートの合成におけるこれらの使用 |
| JP2024157625A JP2024174998A (ja) | 2016-08-03 | 2024-09-11 | ヘテロアリールスルホンをベースとするコンジュゲーションハンドル、これらの調製のための方法、および抗体薬物コンジュゲートの合成におけるこれらの使用 |
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662370270P | 2016-08-03 | 2016-08-03 | |
| US62/370,270 | 2016-08-03 | ||
| US201762530554P | 2017-07-10 | 2017-07-10 | |
| US62/530,554 | 2017-07-10 |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022102984A Division JP7555998B2 (ja) | 2016-08-03 | 2022-06-27 | ヘテロアリールスルホンをベースとするコンジュゲーションハンドル、これらの調製のための方法、および抗体薬物コンジュゲートの合成におけるこれらの使用 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2018058822A JP2018058822A (ja) | 2018-04-12 |
| JP2018058822A5 true JP2018058822A5 (OSRAM) | 2020-08-13 |
Family
ID=59677272
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017147506A Withdrawn JP2018058822A (ja) | 2016-08-03 | 2017-07-31 | ヘテロアリールスルホンをベースとするコンジュゲーションハンドル、これらの調製のための方法、および抗体薬物コンジュゲートの合成におけるこれらの使用 |
| JP2022102984A Active JP7555998B2 (ja) | 2016-08-03 | 2022-06-27 | ヘテロアリールスルホンをベースとするコンジュゲーションハンドル、これらの調製のための方法、および抗体薬物コンジュゲートの合成におけるこれらの使用 |
| JP2024157625A Withdrawn JP2024174998A (ja) | 2016-08-03 | 2024-09-11 | ヘテロアリールスルホンをベースとするコンジュゲーションハンドル、これらの調製のための方法、および抗体薬物コンジュゲートの合成におけるこれらの使用 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022102984A Active JP7555998B2 (ja) | 2016-08-03 | 2022-06-27 | ヘテロアリールスルホンをベースとするコンジュゲーションハンドル、これらの調製のための方法、および抗体薬物コンジュゲートの合成におけるこれらの使用 |
| JP2024157625A Withdrawn JP2024174998A (ja) | 2016-08-03 | 2024-09-11 | ヘテロアリールスルホンをベースとするコンジュゲーションハンドル、これらの調製のための方法、および抗体薬物コンジュゲートの合成におけるこれらの使用 |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US11712480B2 (OSRAM) |
| EP (1) | EP3493853A1 (OSRAM) |
| JP (3) | JP2018058822A (OSRAM) |
| CA (1) | CA3032559C (OSRAM) |
| WO (1) | WO2018025168A1 (OSRAM) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2859755C (en) | 2011-12-23 | 2021-04-20 | Pfizer Inc. | Engineered antibody constant regions for site-specific conjugation and methods and uses therefor |
| US11364303B2 (en) | 2017-09-29 | 2022-06-21 | Pfizer Inc. | Cysteine engineered antibody drug conjugates |
| EP4667495A2 (en) | 2017-12-15 | 2025-12-24 | Sichuan Kelun-Biotech Biopharmaceutical Co., Ltd. | Bioactive molecule conjugate, preparation method and use thereof |
| WO2023278592A1 (en) * | 2021-06-29 | 2023-01-05 | Duke University | Radiolabeled parp inhibitor conjugates for cancer treatment |
| JP7455316B2 (ja) * | 2021-10-20 | 2024-03-26 | 国立研究開発法人産業技術総合研究所 | 抗ガン剤、抗ガン剤のプロドラッグ、体外でガン細胞を死滅させる方法、ガンの治療方法、及びガンの治療装置 |
| EP4426299A4 (en) * | 2021-11-03 | 2025-11-12 | Adcentrx Therapeutics Inc | Drug combinations and their methods of preparation and use |
| AU2023397331A1 (en) | 2022-12-14 | 2025-06-26 | Merck Sharp & Dohme Llc | Auristatin linker-payloads, pharmaceutical compositions, and uses thereof |
| WO2024194851A1 (en) * | 2023-03-23 | 2024-09-26 | Beigene Switzerland Gmbh | Bioactive conjugate, preparation method therefor and use thereof |
| TW202500198A (zh) * | 2023-06-29 | 2025-01-01 | 瑞士商百濟神州瑞士有限責任公司 | 生物活性偶聯物、其製備方法及用途 |
| WO2025002368A1 (en) * | 2023-06-29 | 2025-01-02 | Beigene, Ltd. | Bioactive conjugates, preparation method and use thereof |
Family Cites Families (38)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB2036891B (en) | 1978-12-05 | 1983-05-05 | Windsor Smith C | Change speed gear |
| GB8308235D0 (en) | 1983-03-25 | 1983-05-05 | Celltech Ltd | Polypeptides |
| US4816567A (en) | 1983-04-08 | 1989-03-28 | Genentech, Inc. | Recombinant immunoglobin preparations |
| JPS6147500A (ja) | 1984-08-15 | 1986-03-07 | Res Dev Corp Of Japan | キメラモノクロ−ナル抗体及びその製造法 |
| EP0173494A3 (en) | 1984-08-27 | 1987-11-25 | The Board Of Trustees Of The Leland Stanford Junior University | Chimeric receptors by dna splicing and expression |
| GB8422238D0 (en) | 1984-09-03 | 1984-10-10 | Neuberger M S | Chimeric proteins |
| JPS61134325A (ja) | 1984-12-04 | 1986-06-21 | Teijin Ltd | ハイブリツド抗体遺伝子の発現方法 |
| JPS63501765A (ja) | 1985-11-01 | 1988-07-21 | インタ−ナショナル、ジェネティック、エンジニアリング インコ−ポレ−テッド | 抗体遺伝子のモジュ−ル組立体、それにより産生された抗体及び用途 |
| US5225539A (en) | 1986-03-27 | 1993-07-06 | Medical Research Council | Recombinant altered antibodies and methods of making altered antibodies |
| US5225530A (en) | 1986-07-16 | 1993-07-06 | Eniricerche S.P.A. | Polypeptide useful for the preparation of antimalarial vaccines and of diagnostic kits for the detection of malarial affections |
| US5530101A (en) | 1988-12-28 | 1996-06-25 | Protein Design Labs, Inc. | Humanized immunoglobulins |
| DE3920358A1 (de) | 1989-06-22 | 1991-01-17 | Behringwerke Ag | Bispezifische und oligospezifische, mono- und oligovalente antikoerperkonstrukte, ihre herstellung und verwendung |
| US5661016A (en) | 1990-08-29 | 1997-08-26 | Genpharm International Inc. | Transgenic non-human animals capable of producing heterologous antibodies of various isotypes |
| AU8507191A (en) | 1990-08-29 | 1992-03-30 | Genpharm International, Inc. | Transgenic non-human animals capable of producing heterologous antibodies |
| US5545806A (en) | 1990-08-29 | 1996-08-13 | Genpharm International, Inc. | Ransgenic non-human animals for producing heterologous antibodies |
| US5625126A (en) | 1990-08-29 | 1997-04-29 | Genpharm International, Inc. | Transgenic non-human animals for producing heterologous antibodies |
| US5633425A (en) | 1990-08-29 | 1997-05-27 | Genpharm International, Inc. | Transgenic non-human animals capable of producing heterologous antibodies |
| EP0617706B1 (en) | 1991-11-25 | 2001-10-17 | Enzon, Inc. | Multivalent antigen-binding proteins |
| US6214345B1 (en) | 1993-05-14 | 2001-04-10 | Bristol-Myers Squibb Co. | Lysosomal enzyme-cleavable antitumor drug conjugates |
| US5773001A (en) | 1994-06-03 | 1998-06-30 | American Cyanamid Company | Conjugates of methyltrithio antitumor agents and intermediates for their synthesis |
| JP4046354B2 (ja) | 1996-03-18 | 2008-02-13 | ボード オブ リージェンツ，ザ ユニバーシティ オブ テキサス システム | 増大した半減期を有する免疫グロブリン様ドメイン |
| US20050287596A9 (en) * | 1998-06-26 | 2005-12-29 | Braisted Andrew C | Novel ligands and libraries of ligands |
| RU2402548C2 (ru) | 2004-05-19 | 2010-10-27 | Медарекс, Инк. | Химические линкеры и их конъюгаты |
| JP2005330229A (ja) * | 2004-05-20 | 2005-12-02 | Ube Ind Ltd | ４−トリフルオロメトキシフェニル（オキシ）エチルアミン誘導体及び抗菌剤 |
| SI3248613T1 (sl) | 2005-07-18 | 2022-04-29 | Seagen Inc. | Konjugati beta-glukuronidni linker-zdravilo |
| EP3725775A1 (en) | 2009-02-17 | 2020-10-21 | Syntrix Biosystems, Inc. | Pyridine- and pyrimidinecarboxamides as cxcr2 modulators |
| US9676871B2 (en) | 2010-11-05 | 2017-06-13 | Pfizer Inc. | Engineered polypeptide conjugates and methods for making thereof using transglutaminase |
| RS54936B1 (sr) | 2011-10-14 | 2016-11-30 | Ambit Biosciences Corp | Heterociklična jedinjenja i njihova upotreba kao modulatora receptora tirozin kinaza tipa iii |
| US8871908B2 (en) | 2011-11-11 | 2014-10-28 | Rinat Neuroscience Corp. | Antibodies specific for Trop-2 and their uses |
| EP2780039B9 (en) | 2011-11-17 | 2018-04-18 | Pfizer Inc | Cytotoxic peptides and antibody drug conjugates thereof |
| CA2859755C (en) | 2011-12-23 | 2021-04-20 | Pfizer Inc. | Engineered antibody constant regions for site-specific conjugation and methods and uses therefor |
| KR101762047B1 (ko) | 2012-11-05 | 2017-07-27 | 화이자 인코포레이티드 | 스플라이세오스타틴 유사체 |
| WO2014144878A2 (en) * | 2013-03-15 | 2014-09-18 | The Scripps Research Institute | Novel thiol & amino modifying reagents for protein chemistry and methods of use thereof |
| CA3012994C (en) | 2013-07-31 | 2020-10-20 | Rinat Neuroscience Corp. | Engineered polypeptide conjugates |
| BR112016016490B1 (pt) | 2014-01-27 | 2022-11-29 | Pfizer Inc | Compostos de agentes citotóxicos bifuncionais, composição farmacêutica compreendendo os referidos compostos e usos dos mesmos |
| KR102430829B1 (ko) | 2014-04-25 | 2022-08-09 | 리나트 뉴로사이언스 코프. | 약물이 고도로 로딩된 항체-약물 접합체 |
| DK3185908T3 (da) | 2014-08-28 | 2020-06-15 | Rinat Neuroscience Corp | Stabilitets-modulerende linkere til anvendelse med antistof-lægemiddel-konjugater |
| TWI712605B (zh) | 2015-03-20 | 2020-12-11 | 美商輝瑞股份有限公司 | 含有ｃｔｉ藥效基團之雙功能性細胞毒性劑 |
-
2017
- 2017-07-31 WO PCT/IB2017/054675 patent/WO2018025168A1/en not_active Ceased
- 2017-07-31 US US16/321,695 patent/US11712480B2/en active Active
- 2017-07-31 JP JP2017147506A patent/JP2018058822A/ja not_active Withdrawn
- 2017-07-31 CA CA3032559A patent/CA3032559C/en active Active
- 2017-07-31 EP EP17754802.1A patent/EP3493853A1/en active Pending
-
2022
- 2022-06-27 JP JP2022102984A patent/JP7555998B2/ja active Active
-
2024
- 2024-09-11 JP JP2024157625A patent/JP2024174998A/ja not_active Withdrawn
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