JP2017538927A5 - - Google Patents
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- Publication number
- JP2017538927A5 JP2017538927A5 JP2017526906A JP2017526906A JP2017538927A5 JP 2017538927 A5 JP2017538927 A5 JP 2017538927A5 JP 2017526906 A JP2017526906 A JP 2017526906A JP 2017526906 A JP2017526906 A JP 2017526906A JP 2017538927 A5 JP2017538927 A5 JP 2017538927A5
- Authority
- JP
- Japan
- Prior art keywords
- subject
- biomarker
- pick disease
- group
- level
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Ceased
Links
- 239000000090 biomarker Substances 0.000 claims 35
- 201000011240 Frontotemporal dementia Diseases 0.000 claims 21
- 208000000609 Pick Disease of the Brain Diseases 0.000 claims 21
- 208000024571 Pick disease Diseases 0.000 claims 21
- 150000001875 compounds Chemical class 0.000 claims 17
- 210000004369 blood Anatomy 0.000 claims 15
- 239000008280 blood Substances 0.000 claims 15
- 238000000034 method Methods 0.000 claims 13
- 208000014060 Niemann-Pick disease Diseases 0.000 claims 9
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 8
- 125000000896 monocarboxylic acid group Chemical group 0.000 claims 8
- 238000002560 therapeutic procedure Methods 0.000 claims 8
- 239000010836 blood and blood product Substances 0.000 claims 6
- 229940125691 blood product Drugs 0.000 claims 6
- OKTWQKXBJUBAKS-WQADZSDSSA-N 2-[[(e,2r,3s)-2-amino-3-hydroxyoctadec-4-enoxy]-hydroxyphosphoryl]oxyethyl-trimethylazanium;chloride Chemical compound [Cl-].CCCCCCCCCCCCC\C=C\[C@H](O)[C@H](N)COP(O)(=O)OCC[N+](C)(C)C OKTWQKXBJUBAKS-WQADZSDSSA-N 0.000 claims 4
- 210000001175 cerebrospinal fluid Anatomy 0.000 claims 3
- 238000004949 mass spectrometry Methods 0.000 claims 3
- 210000003296 saliva Anatomy 0.000 claims 3
- 210000002966 serum Anatomy 0.000 claims 3
- 210000001519 tissue Anatomy 0.000 claims 3
- 210000002700 urine Anatomy 0.000 claims 3
- 208000035374 Chronic visceral acid sphingomyelinase deficiency Diseases 0.000 claims 2
- 208000035343 Infantile neurovisceral acid sphingomyelinase deficiency Diseases 0.000 claims 2
- 108010006519 Molecular Chaperones Proteins 0.000 claims 2
- 201000000794 Niemann-Pick disease type A Diseases 0.000 claims 2
- 201000000791 Niemann-Pick disease type B Diseases 0.000 claims 2
- 208000010577 Niemann-Pick disease type C Diseases 0.000 claims 2
- 208000007824 Type A Niemann-Pick Disease Diseases 0.000 claims 2
- 208000008291 Type B Niemann-Pick Disease Diseases 0.000 claims 2
- 208000007930 Type C Niemann-Pick Disease Diseases 0.000 claims 2
- 239000003153 chemical reaction reagent Substances 0.000 claims 2
- 238000002641 enzyme replacement therapy Methods 0.000 claims 2
- 238000001415 gene therapy Methods 0.000 claims 2
- 210000004880 lymph fluid Anatomy 0.000 claims 2
- 239000007787 solid Substances 0.000 claims 2
- 238000011476 stem cell transplantation Methods 0.000 claims 2
- 239000000758 substrate Substances 0.000 claims 2
- 230000001629 suppression Effects 0.000 claims 2
- 238000000018 DNA microarray Methods 0.000 claims 1
- 238000001514 detection method Methods 0.000 claims 1
- 238000003745 diagnosis Methods 0.000 claims 1
- 210000003608 fece Anatomy 0.000 claims 1
- 238000003018 immunoassay Methods 0.000 claims 1
- 230000003993 interaction Effects 0.000 claims 1
- 210000002751 lymph Anatomy 0.000 claims 1
- 238000000816 matrix-assisted laser desorption--ionisation Methods 0.000 claims 1
- 108020004707 nucleic acids Proteins 0.000 claims 1
- 150000007523 nucleic acids Chemical class 0.000 claims 1
- 102000039446 nucleic acids Human genes 0.000 claims 1
- 238000000672 surface-enhanced laser desorption--ionisation Methods 0.000 claims 1
- WDHFPFPKCLQJOH-BMRADRMJSA-N C[N](C)(C)CCOP(O)(OCC(C(/C=C/CCCCCCCCCCCCCC(O)=O)O)N)=O Chemical compound C[N](C)(C)CCOP(O)(OCC(C(/C=C/CCCCCCCCCCCCCC(O)=O)O)N)=O WDHFPFPKCLQJOH-BMRADRMJSA-N 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP14003888.6 | 2014-11-19 | ||
| EP14003888 | 2014-11-19 | ||
| PCT/EP2015/002313 WO2016078762A1 (en) | 2014-11-19 | 2015-11-19 | Method for the diagnosis of niemann-pick disease using a biomarker |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2017538927A JP2017538927A (ja) | 2017-12-28 |
| JP2017538927A5 true JP2017538927A5 (https=) | 2019-09-05 |
Family
ID=51945677
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017526906A Ceased JP2017538927A (ja) | 2014-11-19 | 2015-11-19 | バイオマーカーを用いたニーマン・ピック病の診断のための方法 |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US20180348239A1 (https=) |
| EP (1) | EP3221705A1 (https=) |
| JP (1) | JP2017538927A (https=) |
| AU (1) | AU2015349030A1 (https=) |
| BR (1) | BR112017009605A2 (https=) |
| CA (1) | CA2967504A1 (https=) |
| IL (1) | IL251879A0 (https=) |
| WO (1) | WO2016078762A1 (https=) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2021036201A (ja) * | 2017-12-18 | 2021-03-04 | 国立研究開発法人国立成育医療研究センター | ニーマンピック病ｃ型の診断のための検査方法 |
| EP3894864A2 (en) * | 2018-12-10 | 2021-10-20 | Denali Therapeutics Inc. | Lysosomal storage disorder biomarkers and methods of use thereof |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8497122B2 (en) * | 2008-04-11 | 2013-07-30 | Washington University | Biomarkers for Niemann-pick C disease and related disorders |
| CA2854668A1 (en) * | 2011-11-15 | 2013-05-23 | Centogene Ag | Method for the diagnosis of niemann-pick disease |
| ES2731920T3 (es) * | 2013-05-14 | 2019-11-19 | Centogene Ag | Método para el diagnóstico de la enfermedad de Niemann-Pick |
-
2015
- 2015-11-19 CA CA2967504A patent/CA2967504A1/en not_active Abandoned
- 2015-11-19 BR BR112017009605A patent/BR112017009605A2/pt not_active IP Right Cessation
- 2015-11-19 JP JP2017526906A patent/JP2017538927A/ja not_active Ceased
- 2015-11-19 EP EP15797853.7A patent/EP3221705A1/en not_active Withdrawn
- 2015-11-19 US US15/528,018 patent/US20180348239A1/en not_active Abandoned
- 2015-11-19 AU AU2015349030A patent/AU2015349030A1/en not_active Abandoned
- 2015-11-19 WO PCT/EP2015/002313 patent/WO2016078762A1/en not_active Ceased
-
2017
- 2017-04-24 IL IL251879A patent/IL251879A0/en unknown
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