JP2017538786A5 - - Google Patents
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- Publication number
- JP2017538786A5 JP2017538786A5 JP2017548368A JP2017548368A JP2017538786A5 JP 2017538786 A5 JP2017538786 A5 JP 2017538786A5 JP 2017548368 A JP2017548368 A JP 2017548368A JP 2017548368 A JP2017548368 A JP 2017548368A JP 2017538786 A5 JP2017538786 A5 JP 2017538786A5
- Authority
- JP
- Japan
- Prior art keywords
- acetaminophen
- amino acid
- seq
- acid sequence
- protein
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- RZVAJINKPMORJF-UHFFFAOYSA-N Acetaminophen Chemical compound CC(=O)NC1=CC=C(O)C=C1 RZVAJINKPMORJF-UHFFFAOYSA-N 0.000 claims 96
- 229960005489 paracetamol Drugs 0.000 claims 48
- 238000000034 method Methods 0.000 claims 34
- 102000004169 proteins and genes Human genes 0.000 claims 26
- 108090000623 proteins and genes Proteins 0.000 claims 26
- 125000003275 alpha amino acid group Chemical group 0.000 claims 20
- 230000001988 toxicity Effects 0.000 claims 12
- 231100000419 toxicity Toxicity 0.000 claims 12
- 239000012472 biological sample Substances 0.000 claims 11
- 231100000304 hepatotoxicity Toxicity 0.000 claims 8
- 239000000523 sample Substances 0.000 claims 8
- 206010019851 Hepatotoxicity Diseases 0.000 claims 7
- 230000007686 hepatotoxicity Effects 0.000 claims 7
- 238000003018 immunoassay Methods 0.000 claims 5
- 150000001413 amino acids Chemical class 0.000 claims 4
- 238000006467 substitution reaction Methods 0.000 claims 4
- 108091028043 Nucleic acid sequence Proteins 0.000 claims 2
- YNPNZTXNASCQKK-UHFFFAOYSA-N Phenanthrene Natural products C1=CC=C2C3=CC=CC=C3C=CC2=C1 YNPNZTXNASCQKK-UHFFFAOYSA-N 0.000 claims 2
- DGEZNRSVGBDHLK-UHFFFAOYSA-N [1,10]phenanthroline Chemical compound C1=CN=C2C3=NC=CC=C3C=CC2=C1 DGEZNRSVGBDHLK-UHFFFAOYSA-N 0.000 claims 2
- -1 acetamino Chemical group 0.000 claims 2
- 210000004369 blood Anatomy 0.000 claims 2
- 239000008280 blood Substances 0.000 claims 2
- 230000002209 hydrophobic effect Effects 0.000 claims 2
- 238000010324 immunological assay Methods 0.000 claims 2
- 239000007788 liquid Substances 0.000 claims 2
- 150000007523 nucleic acids Chemical group 0.000 claims 2
- 210000002381 plasma Anatomy 0.000 claims 2
- 210000003296 saliva Anatomy 0.000 claims 2
- 210000002966 serum Anatomy 0.000 claims 2
- 210000002700 urine Anatomy 0.000 claims 2
- 102000008394 Immunoglobulin Fragments Human genes 0.000 claims 1
- 108010021625 Immunoglobulin Fragments Proteins 0.000 claims 1
- 208000029618 autoimmune pulmonary alveolar proteinosis Diseases 0.000 claims 1
- 230000002163 immunogen Effects 0.000 claims 1
- 230000007056 liver toxicity Effects 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201462086923P | 2014-12-03 | 2014-12-03 | |
| US62/086,923 | 2014-12-03 | ||
| PCT/US2015/063786 WO2016090163A2 (en) | 2014-12-03 | 2015-12-03 | Anti-acetaminophen antibodies and acetaminophen protein adducts |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020123616A Division JP7072022B2 (ja) | 2014-12-03 | 2020-07-20 | 抗アセトアミノフェン抗体及びアセトアミノフェンタンパク質付加物 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2017538786A JP2017538786A (ja) | 2017-12-28 |
| JP2017538786A5 true JP2017538786A5 (enExample) | 2019-11-21 |
| JP6785239B2 JP6785239B2 (ja) | 2020-11-18 |
Family
ID=56092671
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017548368A Active JP6785239B2 (ja) | 2014-12-03 | 2015-12-03 | 抗アセトアミノフェン抗体及びアセトアミノフェンタンパク質付加物 |
| JP2020123616A Active JP7072022B2 (ja) | 2014-12-03 | 2020-07-20 | 抗アセトアミノフェン抗体及びアセトアミノフェンタンパク質付加物 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020123616A Active JP7072022B2 (ja) | 2014-12-03 | 2020-07-20 | 抗アセトアミノフェン抗体及びアセトアミノフェンタンパク質付加物 |
Country Status (6)
| Country | Link |
|---|---|
| US (2) | US10570216B2 (enExample) |
| EP (1) | EP3227681B1 (enExample) |
| JP (2) | JP6785239B2 (enExample) |
| AU (2) | AU2015358373B2 (enExample) |
| ES (1) | ES2841904T3 (enExample) |
| WO (1) | WO2016090163A2 (enExample) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2754282T3 (es) | 2014-02-14 | 2020-04-16 | Bioventures Llc | Aductos acetaminofén proteína y procedimientos de uso de los mismos |
| WO2016090163A2 (en) | 2014-12-03 | 2016-06-09 | Board Of Trustees Of The University Of Arkansas | Anti-acetaminophen antibodies and acetaminophen protein adducts |
| CN112980808B (zh) * | 2019-12-12 | 2024-10-29 | 深圳迈瑞生物医疗电子股份有限公司 | 尿酸酶、及其制备方法和用途 |
| CN113248596B (zh) * | 2021-04-15 | 2022-12-16 | 华南农业大学 | 一种可同时检测对乙酰氨基酚和非那西丁的人工抗原、抗体及其制备方法和应用 |
Family Cites Families (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4424150A (en) | 1982-04-02 | 1984-01-03 | Syva Company | Acetaminophen analogs, antigens, and antibodies |
| US5103021A (en) | 1982-04-02 | 1992-04-07 | Syntex (U.S.A.) Inc. | Acetaminophen analogs, antigens, and antibodies |
| ATE195022T1 (de) | 1987-04-27 | 2000-08-15 | Unilever Nv | Spezifische bindungstestverfahren |
| US6352862B1 (en) | 1989-02-17 | 2002-03-05 | Unilever Patent Holdings B.V. | Analytical test device for imuno assays and methods of using same |
| DE69121844T2 (de) | 1990-11-20 | 1997-01-23 | Behringwerke Ag | Immunotest für Cyclosporin |
| US6905882B2 (en) | 1992-05-21 | 2005-06-14 | Biosite, Inc. | Diagnostic devices and apparatus for the controlled movement of reagents without membranes |
| US5747352A (en) | 1994-05-23 | 1998-05-05 | Beckman Instruments, Inc. | Reagents and methods for the rapid and quantitative assay of pharmacological agents |
| US5620890A (en) | 1995-03-14 | 1997-04-15 | The United States Of America As Represented By The Secretary Of Agriculture | Monoclonal antibodies to hygromycin B and the method of making the same |
| US20040185040A1 (en) * | 2001-11-21 | 2004-09-23 | Celltech R & D Limited | Modulating immune responses |
| WO2009097133A2 (en) * | 2008-01-30 | 2009-08-06 | Monsanto Technology, Llc | Transgenic plants with enhanced agronomic traits |
| US9029636B2 (en) * | 2008-02-05 | 2015-05-12 | Monsanto Technology Llc | Isolated novel nucleic acid and protein molecules from soy and methods of using those molecules to generate transgenic plants with enhanced agronomic traits |
| EP2277040A4 (en) * | 2008-04-21 | 2011-06-08 | Univ Arkansas | DEVICE AND METHOD FOR PARACETAMOL PROTEIN ADDUCT TEST |
| US9012723B2 (en) | 2009-01-16 | 2015-04-21 | Monsanto Technology Llc | Isolated novel acid and protein molecules from soy and methods of using those molecules to generate transgene plants with enhanced agronomic traits |
| KR101606236B1 (ko) | 2009-08-19 | 2016-03-24 | 메르크 파텐트 게엠베하 | Ｆｆｐｅ 물질 내의 인테그린 복합체의 검출용 항체 |
| ES2712892T3 (es) * | 2010-02-16 | 2019-05-16 | Oesterreichische Akademie Der Wss | Anticuerpos anti-E7 del HPV |
| US20110214205A1 (en) * | 2010-02-26 | 2011-09-01 | Monsanto Technology Llc. | Isolated Novel Nucleic Acid and Protein Molecules from Foxtail Millet and Methods of Using Those Molecules to Generate Transgenic Plants with Enhanced Agronomic Traits |
| JP6016892B2 (ja) * | 2011-04-29 | 2016-10-26 | セルジーン コーポレイション | セレブロンを予測因子として使用する癌及び炎症性疾患の治療方法 |
| CA2871614C (en) * | 2012-04-27 | 2021-08-31 | Millennium Pharmaceuticals, Inc. | Anti-gcc antibody molecules and use of same to test for susceptibility to gcc-targeted therapy |
| ES2754282T3 (es) | 2014-02-14 | 2020-04-16 | Bioventures Llc | Aductos acetaminofén proteína y procedimientos de uso de los mismos |
| WO2016090163A2 (en) | 2014-12-03 | 2016-06-09 | Board Of Trustees Of The University Of Arkansas | Anti-acetaminophen antibodies and acetaminophen protein adducts |
-
2015
- 2015-12-03 WO PCT/US2015/063786 patent/WO2016090163A2/en not_active Ceased
- 2015-12-03 ES ES15865732T patent/ES2841904T3/es active Active
- 2015-12-03 EP EP15865732.0A patent/EP3227681B1/en active Active
- 2015-12-03 JP JP2017548368A patent/JP6785239B2/ja active Active
- 2015-12-03 US US15/532,418 patent/US10570216B2/en active Active
- 2015-12-03 AU AU2015358373A patent/AU2015358373B2/en active Active
-
2020
- 2020-01-10 US US16/740,030 patent/US11566081B2/en active Active
- 2020-07-20 JP JP2020123616A patent/JP7072022B2/ja active Active
-
2021
- 2021-08-11 AU AU2021215156A patent/AU2021215156A1/en not_active Abandoned
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