JP2017538722A5 - - Google Patents
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- Publication number
- JP2017538722A5 JP2017538722A5 JP2017532656A JP2017532656A JP2017538722A5 JP 2017538722 A5 JP2017538722 A5 JP 2017538722A5 JP 2017532656 A JP2017532656 A JP 2017532656A JP 2017532656 A JP2017532656 A JP 2017532656A JP 2017538722 A5 JP2017538722 A5 JP 2017538722A5
- Authority
- JP
- Japan
- Prior art keywords
- optionally substituted
- alkyl
- hydrogen
- group
- aryl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- 125000000217 alkyl group Chemical group 0.000 claims 50
- 229910052739 hydrogen Inorganic materials 0.000 claims 44
- 239000001257 hydrogen Substances 0.000 claims 44
- 150000001875 compounds Chemical class 0.000 claims 43
- 150000002431 hydrogen Chemical class 0.000 claims 28
- 125000003107 substituted aryl group Chemical group 0.000 claims 19
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 16
- 125000003118 aryl group Chemical group 0.000 claims 13
- 125000003342 alkenyl group Chemical group 0.000 claims 12
- 239000008194 pharmaceutical composition Substances 0.000 claims 10
- 125000005913 (C3-C6) cycloalkyl group Chemical group 0.000 claims 9
- 125000000304 alkynyl group Chemical group 0.000 claims 9
- 150000001413 amino acids Chemical class 0.000 claims 8
- 125000000753 cycloalkyl group Chemical group 0.000 claims 8
- -1 amino acid ester Chemical class 0.000 claims 7
- 125000000392 cycloalkenyl group Chemical group 0.000 claims 7
- 125000000882 C2-C6 alkenyl group Chemical group 0.000 claims 6
- YZCKVEUIGOORGS-OUBTZVSYSA-N Deuterium Chemical compound [2H] YZCKVEUIGOORGS-OUBTZVSYSA-N 0.000 claims 6
- 229910052805 deuterium Inorganic materials 0.000 claims 6
- 229910052736 halogen Inorganic materials 0.000 claims 6
- 150000002367 halogens Chemical class 0.000 claims 6
- 150000003839 salts Chemical class 0.000 claims 6
- 125000000171 (C1-C6) haloalkyl group Chemical group 0.000 claims 5
- 125000003601 C2-C6 alkynyl group Chemical group 0.000 claims 5
- 241000709661 Enterovirus Species 0.000 claims 5
- 241000700605 Viruses Species 0.000 claims 5
- 241000709664 Picornaviridae Species 0.000 claims 4
- 125000000623 heterocyclic group Chemical group 0.000 claims 4
- 229910052799 carbon Inorganic materials 0.000 claims 3
- 125000001072 heteroaryl group Chemical group 0.000 claims 3
- 229910052760 oxygen Inorganic materials 0.000 claims 3
- 125000006552 (C3-C8) cycloalkyl group Chemical group 0.000 claims 2
- 241000709715 Hepatovirus Species 0.000 claims 2
- OAICVXFJPJFONN-UHFFFAOYSA-N Phosphorus Chemical compound [P] OAICVXFJPJFONN-UHFFFAOYSA-N 0.000 claims 2
- 125000002252 acyl group Chemical group 0.000 claims 2
- 125000004103 aminoalkyl group Chemical group 0.000 claims 2
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims 2
- 125000005335 azido alkyl group Chemical group 0.000 claims 2
- 125000004122 cyclic group Chemical group 0.000 claims 2
- 125000001188 haloalkyl group Chemical group 0.000 claims 2
- 125000005843 halogen group Chemical group 0.000 claims 2
- 239000001301 oxygen Substances 0.000 claims 2
- 229910052698 phosphorus Inorganic materials 0.000 claims 2
- 239000011574 phosphorus Substances 0.000 claims 2
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 claims 1
- 241000031976 Aquamavirus Species 0.000 claims 1
- 241000710190 Cardiovirus Species 0.000 claims 1
- 241001632249 Cosavirus Species 0.000 claims 1
- 241000146303 Coxsackievirus A1 Species 0.000 claims 1
- 241000146367 Coxsackievirus A10 Species 0.000 claims 1
- 241000146297 Coxsackievirus A11 Species 0.000 claims 1
- 241000146296 Coxsackievirus A12 Species 0.000 claims 1
- 241000146307 Coxsackievirus A13 Species 0.000 claims 1
- 241000146306 Coxsackievirus A14 Species 0.000 claims 1
- 241001429382 Coxsackievirus A16 Species 0.000 claims 1
- 241000146309 Coxsackievirus A17 Species 0.000 claims 1
- 241000146305 Coxsackievirus A19 Species 0.000 claims 1
- 241001466951 Coxsackievirus A2 Species 0.000 claims 1
- 241000146316 Coxsackievirus A20 Species 0.000 claims 1
- 241000709698 Coxsackievirus A21 Species 0.000 claims 1
- 241000146325 Coxsackievirus A3 Species 0.000 claims 1
- 241000146328 Coxsackievirus A4 Species 0.000 claims 1
- 241000146327 Coxsackievirus A5 Species 0.000 claims 1
- 241001669084 Coxsackievirus A6 Species 0.000 claims 1
- 241000146321 Coxsackievirus A7 Species 0.000 claims 1
- 241000146319 Coxsackievirus A8 Species 0.000 claims 1
- 241001466953 Echovirus Species 0.000 claims 1
- 241000204855 Echovirus E1 Species 0.000 claims 1
- 241000709714 Echovirus E11 Species 0.000 claims 1
- 241001492221 Echovirus E12 Species 0.000 claims 1
- 241000217429 Echovirus E13 Species 0.000 claims 1
- 241000217415 Echovirus E15 Species 0.000 claims 1
- 241000217417 Echovirus E16 Species 0.000 claims 1
- 241000217419 Echovirus E17 Species 0.000 claims 1
- 241000217421 Echovirus E18 Species 0.000 claims 1
- 241000217423 Echovirus E19 Species 0.000 claims 1
- 241001492220 Echovirus E2 Species 0.000 claims 1
- 241000217425 Echovirus E20 Species 0.000 claims 1
- 241000217427 Echovirus E21 Species 0.000 claims 1
- 241000217448 Echovirus E24 Species 0.000 claims 1
- 241000190163 Echovirus E25 Species 0.000 claims 1
- 241000217449 Echovirus E26 Species 0.000 claims 1
- 241000193778 Echovirus E27 Species 0.000 claims 1
- 241000217450 Echovirus E29 Species 0.000 claims 1
- 241000217440 Echovirus E3 Species 0.000 claims 1
- 241000134257 Echovirus E30 Species 0.000 claims 1
- 241000217434 Echovirus E31 Species 0.000 claims 1
- 241000217436 Echovirus E32 Species 0.000 claims 1
- 241000217438 Echovirus E33 Species 0.000 claims 1
- 241001492209 Echovirus E4 Species 0.000 claims 1
- 241000122140 Echovirus E5 Species 0.000 claims 1
- 241000709638 Echovirus E6 Species 0.000 claims 1
- 241000201383 Echovirus E7 Species 0.000 claims 1
- 241000709643 Echovirus E9 Species 0.000 claims 1
- 241000988559 Enterovirus A Species 0.000 claims 1
- 241001529459 Enterovirus A71 Species 0.000 claims 1
- 241000988556 Enterovirus B Species 0.000 claims 1
- 241000693328 Enterovirus B69 Species 0.000 claims 1
- 241000991587 Enterovirus C Species 0.000 claims 1
- 241000991586 Enterovirus D Species 0.000 claims 1
- 241000146324 Enterovirus D68 Species 0.000 claims 1
- 241000709691 Enterovirus E Species 0.000 claims 1
- 241000033076 Enterovirus F Species 0.000 claims 1
- 241001523584 Enterovirus G Species 0.000 claims 1
- 241001219115 Enterovirus H Species 0.000 claims 1
- 241000033074 Enterovirus J Species 0.000 claims 1
- 241000709716 Human enterovirus 70 Species 0.000 claims 1
- 241000709694 Human parechovirus 1 Species 0.000 claims 1
- 241001529465 Human parechovirus 2 Species 0.000 claims 1
- 241001474317 Human parechovirus 3 Species 0.000 claims 1
- 241001426759 Human parechovirus 4 Species 0.000 claims 1
- 241000172466 Human parechovirus 5 Species 0.000 claims 1
- 241000709701 Human poliovirus 1 Species 0.000 claims 1
- 241000709704 Human poliovirus 2 Species 0.000 claims 1
- 241000709727 Human poliovirus 3 Species 0.000 claims 1
- 241000991583 Parechovirus Species 0.000 claims 1
- 241000365416 Recovirus Species 0.000 claims 1
- 241001325464 Rhinovirus A Species 0.000 claims 1
- 241001325459 Rhinovirus B Species 0.000 claims 1
- 241001139982 Rhinovirus C Species 0.000 claims 1
- 241001333897 Sapelovirus Species 0.000 claims 1
- 241001632234 Senecavirus Species 0.000 claims 1
- 208000036142 Viral infection Diseases 0.000 claims 1
- 125000003545 alkoxy group Chemical group 0.000 claims 1
- 125000004453 alkoxycarbonyl group Chemical group 0.000 claims 1
- 125000003277 amino group Chemical group 0.000 claims 1
- 230000001548 androgenic effect Effects 0.000 claims 1
- 230000003796 beauty Effects 0.000 claims 1
- 239000003795 chemical substances by application Substances 0.000 claims 1
- 201000002491 encephalomyelitis Diseases 0.000 claims 1
- 208000006454 hepatitis Diseases 0.000 claims 1
- 231100000283 hepatitis Toxicity 0.000 claims 1
- 125000005842 heteroatom Chemical group 0.000 claims 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 1
- 230000002401 inhibitory effect Effects 0.000 claims 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 1
- 229910052757 nitrogen Inorganic materials 0.000 claims 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 1
- 230000010076 replication Effects 0.000 claims 1
- SNOOUWRIMMFWNE-UHFFFAOYSA-M sodium;6-[(3,4,5-trimethoxybenzoyl)amino]hexanoate Chemical compound [Na+].COC1=CC(C(=O)NCCCCCC([O-])=O)=CC(OC)=C1OC SNOOUWRIMMFWNE-UHFFFAOYSA-M 0.000 claims 1
- 125000001424 substituent group Chemical group 0.000 claims 1
- 229910052717 sulfur Inorganic materials 0.000 claims 1
- 230000009385 viral infection Effects 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201462094418P | 2014-12-19 | 2014-12-19 | |
| US62/094,418 | 2014-12-19 | ||
| PCT/US2015/066193 WO2016100569A1 (en) | 2014-12-19 | 2015-12-16 | Substituted nucleosides, nucleotides and analogs thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2017538722A JP2017538722A (ja) | 2017-12-28 |
| JP2017538722A5 true JP2017538722A5 (https=) | 2019-02-07 |
Family
ID=56127561
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017532656A Withdrawn JP2017538722A (ja) | 2014-12-19 | 2015-12-16 | 置換ヌクレオシド、ヌクレオチド、及びそのアナログ |
Country Status (12)
| Country | Link |
|---|---|
| US (2) | US9890188B2 (https=) |
| EP (1) | EP3233879A4 (https=) |
| JP (1) | JP2017538722A (https=) |
| CN (1) | CN107250145A (https=) |
| AU (1) | AU2015364630A1 (https=) |
| CA (1) | CA2970936A1 (https=) |
| HK (1) | HK1245800A1 (https=) |
| MA (1) | MA41213A (https=) |
| MX (1) | MX2017008184A (https=) |
| TW (1) | TW201625658A (https=) |
| WO (1) | WO2016100569A1 (https=) |
| ZA (1) | ZA201704876B (https=) |
Families Citing this family (37)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| UA117095C2 (uk) | 2011-12-22 | 2018-06-25 | Аліос Біофарма, Інк. | Нуклеозидна сполука або її фармацевтично прийнятна сіль |
| USRE48171E1 (en) | 2012-03-21 | 2020-08-25 | Janssen Biopharma, Inc. | Substituted nucleosides, nucleotides and analogs thereof |
| WO2013142124A1 (en) | 2012-03-21 | 2013-09-26 | Vertex Pharmaceuticals Incorporated | Solid forms of a thiophosphoramidate nucleotide prodrug |
| US9441007B2 (en) | 2012-03-21 | 2016-09-13 | Alios Biopharma, Inc. | Substituted nucleosides, nucleotides and analogs thereof |
| GEP201706757B (en) | 2012-12-21 | 2017-10-25 | Alios Biopharma Inc | Substituted nucleosides, nucleotides and analogs thereof |
| WO2014100498A1 (en) | 2012-12-21 | 2014-06-26 | Alios Biopharma, Inc. | Substituted nucleosides, nucleotides and analogs thereof |
| US9504705B2 (en) | 2013-04-05 | 2016-11-29 | Alios Biopharma, Inc. | Hepatitis C viral infection treatment using a combination of compounds |
| WO2014209983A1 (en) | 2013-06-26 | 2014-12-31 | Alios Biopharma, Inc. | Substituted nucleosides, nucleotides and analogs thereof |
| HK1224229A1 (zh) * | 2013-06-26 | 2017-08-18 | Alios Biopharma, Inc. | 取代的核苷，核苷酸及其类似物 |
| EP3055319A4 (en) | 2013-10-11 | 2018-01-10 | Alios Biopharma, Inc. | Substituted nucleosides, nucleotides and analogs thereof |
| TN2016000566A1 (en) | 2014-06-24 | 2018-04-04 | Alios Biopharma Inc | Substituted nucleosides, nucleotides and analogs thereof |
| LT3160476T (lt) | 2014-06-24 | 2021-04-12 | Janssen Biopharma, Inc. | Pakeistieji nukleozidai, nukleotidai ir jų analogai, skirti naudoti virusinių infekcijų gydyme |
| WO2016069489A1 (en) | 2014-10-28 | 2016-05-06 | Alios Biopharma, Inc. | Methods of preparing substituted nucleoside analogs |
| MA41441A (fr) | 2014-12-19 | 2017-12-12 | Alios Biopharma Inc | Nucléosides substitués, nucléotides et analogues de ceux-ci |
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| CR20200126A (es) * | 2017-09-18 | 2020-07-11 | Janssen Biopharma Inc | Nucleósidos sustituidos, nucleótidos y análogos de estos |
| EP3773753A4 (en) | 2018-04-10 | 2021-12-22 | ATEA Pharmaceuticals, Inc. | TREATMENT OF PATIENTS INFECTED WITH THE HEPATITIS C VIRUS WITH CIRRHOSIS |
| AU2020231934B2 (en) | 2019-03-06 | 2023-04-20 | Glaxosmithkline Intellectual Property (No.2) Limited | Compounds useful in HIV therapy |
| TWI775313B (zh) | 2020-02-18 | 2022-08-21 | 美商基利科學股份有限公司 | 抗病毒化合物 |
| AU2021224588B2 (en) | 2020-02-18 | 2024-07-18 | Gilead Sciences, Inc. | Antiviral compounds |
| TWI794742B (zh) | 2020-02-18 | 2023-03-01 | 美商基利科學股份有限公司 | 抗病毒化合物 |
| US10874687B1 (en) | 2020-02-27 | 2020-12-29 | Atea Pharmaceuticals, Inc. | Highly active compounds against COVID-19 |
| US11718637B2 (en) | 2020-03-20 | 2023-08-08 | Gilead Sciences, Inc. | Prodrugs of 4′-C-substituted-2-halo-2′- deoxyadenosine nucleosides and methods of making and using the same |
| US12274700B1 (en) | 2020-10-30 | 2025-04-15 | Accencio LLC | Methods of treating symptoms of coronavirus infection with RNA polymerase inhibitors |
| EP4323362B1 (en) | 2021-04-16 | 2025-05-07 | Gilead Sciences, Inc. | Methods of preparing carbanucleosides using amides |
| KR20240022574A (ko) | 2021-06-17 | 2024-02-20 | 아테아 파마슈티컬즈, 인크. | 유리한 항-hcv 조합 요법 |
| AU2022328698B2 (en) | 2021-08-18 | 2025-02-20 | Gilead Sciences, Inc. | Phospholipid compounds and methods of making and using the same |
| TW202333706A (zh) | 2021-11-01 | 2023-09-01 | 德商埃慕尼克股份公司 | Ｎ—羥基胞磷膽鹼（ｃｉｔｉｃｏｌｉｎｅ）化合物的醫藥用途 |
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| EP3055319A4 (en) * | 2013-10-11 | 2018-01-10 | Alios Biopharma, Inc. | Substituted nucleosides, nucleotides and analogs thereof |
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| LT3160476T (lt) | 2014-06-24 | 2021-04-12 | Janssen Biopharma, Inc. | Pakeistieji nukleozidai, nukleotidai ir jų analogai, skirti naudoti virusinių infekcijų gydyme |
| TN2016000566A1 (en) | 2014-06-24 | 2018-04-04 | Alios Biopharma Inc | Substituted nucleosides, nucleotides and analogs thereof |
| CA2952812A1 (en) | 2014-06-24 | 2015-12-30 | Alios Biopharma, Inc. | Methods of preparing substituted nucleotide analogs |
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| SG11201700851WA (en) | 2014-08-05 | 2017-03-30 | Alios Biopharma Inc | Combination therapy for treating a paramyxovirus |
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| MA41441A (fr) | 2014-12-19 | 2017-12-12 | Alios Biopharma Inc | Nucléosides substitués, nucléotides et analogues de ceux-ci |
-
2015
- 2015-12-15 MA MA041213A patent/MA41213A/fr unknown
- 2015-12-16 US US14/971,926 patent/US9890188B2/en not_active Expired - Fee Related
- 2015-12-16 EP EP15871022.8A patent/EP3233879A4/en not_active Withdrawn
- 2015-12-16 MX MX2017008184A patent/MX2017008184A/es unknown
- 2015-12-16 JP JP2017532656A patent/JP2017538722A/ja not_active Withdrawn
- 2015-12-16 WO PCT/US2015/066193 patent/WO2016100569A1/en not_active Ceased
- 2015-12-16 HK HK18105072.0A patent/HK1245800A1/zh unknown
- 2015-12-16 AU AU2015364630A patent/AU2015364630A1/en not_active Abandoned
- 2015-12-16 CN CN201580076647.5A patent/CN107250145A/zh active Pending
- 2015-12-16 CA CA2970936A patent/CA2970936A1/en not_active Abandoned
- 2015-12-18 TW TW104142822A patent/TW201625658A/zh unknown
-
2017
- 2017-07-18 ZA ZA2017/04876A patent/ZA201704876B/en unknown
-
2018
- 2018-01-30 US US15/884,052 patent/US20180155384A1/en not_active Abandoned
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