JP2017538680A5 - - Google Patents
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- JP2017538680A5 JP2017538680A5 JP2017525120A JP2017525120A JP2017538680A5 JP 2017538680 A5 JP2017538680 A5 JP 2017538680A5 JP 2017525120 A JP2017525120 A JP 2017525120A JP 2017525120 A JP2017525120 A JP 2017525120A JP 2017538680 A5 JP2017538680 A5 JP 2017538680A5
- Authority
- JP
- Japan
- Prior art keywords
- inhibitor
- cancer
- recurrence
- therapeutic agent
- treating
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Links
- 206010028980 Neoplasm Diseases 0.000 claims 29
- 239000003814 drug Substances 0.000 claims 19
- 229940124597 therapeutic agent Drugs 0.000 claims 19
- 201000011510 cancer Diseases 0.000 claims 13
- 102000040430 polynucleotide Human genes 0.000 claims 13
- 108091033319 polynucleotide Proteins 0.000 claims 13
- 239000002157 polynucleotide Substances 0.000 claims 13
- 229940076838 Immune checkpoint inhibitor Drugs 0.000 claims 10
- 210000004027 cell Anatomy 0.000 claims 10
- 239000012274 immune-checkpoint protein inhibitor Substances 0.000 claims 10
- 108091008026 Inhibitory immune checkpoint proteins Proteins 0.000 claims 9
- 102000037984 Inhibitory immune checkpoint proteins Human genes 0.000 claims 9
- 239000003112 inhibitor Substances 0.000 claims 7
- 210000000612 antigen-presenting cell Anatomy 0.000 claims 4
- 229940045513 CTLA4 antagonist Drugs 0.000 claims 3
- 239000012275 CTLA-4 inhibitor Substances 0.000 claims 2
- 239000012270 PD-1 inhibitor Substances 0.000 claims 2
- 239000012668 PD-1-inhibitor Substances 0.000 claims 2
- 208000002154 non-small cell lung carcinoma Diseases 0.000 claims 2
- 229940121655 pd-1 inhibitor Drugs 0.000 claims 2
- 238000011282 treatment Methods 0.000 claims 2
- 208000029729 tumor suppressor gene on chromosome 11 Diseases 0.000 claims 2
- 241000701161 unidentified adenovirus Species 0.000 claims 2
- 108010021064 CTLA-4 Antigen Proteins 0.000 claims 1
- 102000008203 CTLA-4 Antigen Human genes 0.000 claims 1
- 108060003951 Immunoglobulin Proteins 0.000 claims 1
- 102000017578 LAG3 Human genes 0.000 claims 1
- 101150030213 Lag3 gene Proteins 0.000 claims 1
- 241000710960 Sindbis virus Species 0.000 claims 1
- 210000001744 T-lymphocyte Anatomy 0.000 claims 1
- 101710165473 Tumor necrosis factor receptor superfamily member 4 Proteins 0.000 claims 1
- 102100022153 Tumor necrosis factor receptor superfamily member 4 Human genes 0.000 claims 1
- 241000700618 Vaccinia virus Species 0.000 claims 1
- 230000003213 activating effect Effects 0.000 claims 1
- 125000003275 alpha amino acid group Chemical group 0.000 claims 1
- 229960003852 atezolizumab Drugs 0.000 claims 1
- 239000003795 chemical substances by application Substances 0.000 claims 1
- 230000002950 deficient Effects 0.000 claims 1
- 210000004443 dendritic cell Anatomy 0.000 claims 1
- 229950009791 durvalumab Drugs 0.000 claims 1
- 238000002649 immunization Methods 0.000 claims 1
- 230000003053 immunization Effects 0.000 claims 1
- 102000018358 immunoglobulin Human genes 0.000 claims 1
- 230000002601 intratumoral effect Effects 0.000 claims 1
- 229960005386 ipilimumab Drugs 0.000 claims 1
- 210000002751 lymph Anatomy 0.000 claims 1
- 229960003301 nivolumab Drugs 0.000 claims 1
- 229960002621 pembrolizumab Drugs 0.000 claims 1
- 230000002265 prevention Effects 0.000 claims 1
- 108090000623 proteins and genes Proteins 0.000 claims 1
- 108091006082 receptor inhibitors Proteins 0.000 claims 1
- 230000010076 replication Effects 0.000 claims 1
- 229950007213 spartalizumab Drugs 0.000 claims 1
- 241001529453 unidentified herpesvirus Species 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201462075532P | 2014-11-05 | 2014-11-05 | |
| US62/075,532 | 2014-11-05 | ||
| PCT/US2015/059297 WO2016073759A1 (en) | 2014-11-05 | 2015-11-05 | Combination immunotherapy |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2017538680A JP2017538680A (ja) | 2017-12-28 |
| JP2017538680A5 true JP2017538680A5 (enExample) | 2018-12-13 |
| JP7305300B2 JP7305300B2 (ja) | 2023-07-10 |
Family
ID=55909820
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017525120A Active JP7305300B2 (ja) | 2014-11-05 | 2015-11-05 | 併用免疫療法 |
Country Status (4)
| Country | Link |
|---|---|
| US (2) | US11236139B2 (enExample) |
| EP (1) | EP3215182B1 (enExample) |
| JP (1) | JP7305300B2 (enExample) |
| WO (1) | WO2016073759A1 (enExample) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2856839C (en) | 2011-12-01 | 2019-07-30 | Chemocentryx, Inc. | Substituted anilines as ccr(4) antagonists |
| US10441654B2 (en) | 2014-01-24 | 2019-10-15 | Children's Hospital Of Eastern Ontario Research Institute Inc. | SMC combination therapy for the treatment of cancer |
| US11236139B2 (en) | 2014-11-05 | 2022-02-01 | The Regents Of The University Of California | Combination immunotherapy |
| CN115109158A (zh) | 2015-05-07 | 2022-09-27 | 阿吉纳斯公司 | 抗ox40抗体及其使用方法 |
| PT3303396T (pt) | 2015-05-29 | 2023-01-30 | Bristol Myers Squibb Co | Anticorpos contra ox40 e utilizações dos mesmos |
| CA3007233A1 (en) | 2015-12-02 | 2017-06-08 | Agenus Inc. | Antibodies and methods of use thereof |
| TWI794171B (zh) * | 2016-05-11 | 2023-03-01 | 美商滬亞生物國際有限公司 | Ｈｄａｃ抑制劑與ｐｄ-ｌ１抑制劑之組合治療 |
| TWI808055B (zh) | 2016-05-11 | 2023-07-11 | 美商滬亞生物國際有限公司 | Hdac 抑制劑與 pd-1 抑制劑之組合治療 |
| WO2017201502A1 (en) * | 2016-05-20 | 2017-11-23 | Biohaven Pharmaceutical Holding Company Ltd. | Use of glutamate modulating agents with immunotherapies to treat cancer |
| LT3463436T (lt) | 2016-06-02 | 2024-01-25 | Ultimovacs Asa | Vakcina derinyje su imuninės patikros taško slopikliu, skirta vėžiui gydyti |
| WO2018029124A1 (en) * | 2016-08-08 | 2018-02-15 | F. Hoffmann-La Roche Ag | Therapeutic and diagnostic methods for cancer |
| EP3538152A4 (en) | 2016-11-09 | 2020-09-30 | Agenus Inc. | ANTI-OX40 ANTIBODIES, ANTI-GITR ANTIBODIES, AND PROCESSES FOR USE |
| EP3684792A1 (en) | 2017-09-21 | 2020-07-29 | The University of Copenhagen | Chemotaxis-potentiating peptides and uses thereof |
| WO2019217898A1 (en) * | 2018-05-10 | 2019-11-14 | The Regents Of The University Of California | Ccl21 and checkpoint inhibitors for the treatment of cancer |
| KR102817790B1 (ko) * | 2018-08-29 | 2025-06-05 | 케모센트릭스, 인크. | C-c 케모카인 수용체 4(ccr4) 길항제 및 하나 이상의 면역 체크포인트 억제제를 사용한 병용 요법 |
| CA3131630A1 (en) * | 2019-03-26 | 2020-10-01 | Translational Drug Development, Llc | Method of treating malignant rhabdoid tumor of the ovary and small cell cancer of the ovary of the hypercalcemic type |
Family Cites Families (29)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4179337A (en) | 1973-07-20 | 1979-12-18 | Davis Frank F | Non-immunogenic polypeptides |
| US4797368A (en) | 1985-03-15 | 1989-01-10 | The United States Of America As Represented By The Department Of Health And Human Services | Adeno-associated virus as eukaryotic expression vector |
| US5139941A (en) | 1985-10-31 | 1992-08-18 | University Of Florida Research Foundation, Inc. | AAV transduction vectors |
| US5328470A (en) | 1989-03-31 | 1994-07-12 | The Regents Of The University Of Michigan | Treatment of diseases by site-specific instillation of cells or site-specific transformation of cells and kits therefor |
| DE69019727T2 (de) | 1989-09-21 | 1995-10-19 | Idemitsu Kosan Co | Arylstyrolpolymer und -copolymer und verfahren zu ihrer herstellung. |
| AU2147192A (en) | 1991-06-28 | 1993-01-25 | Genentech Inc. | Method of stimulating immune response using growth hormone |
| DK1210428T3 (en) | 1999-08-23 | 2015-06-15 | Dana Farber Cancer Inst Inc | PD-1, a receptor for B7-4 AND USE THEREOF |
| AU2002256268A1 (en) * | 2001-04-18 | 2002-11-05 | The Regents Of The University Of California | Methods of using secondary lymphoid organ chemokine to modulate physiological processes in mammals |
| EP2243493A1 (en) | 2002-07-03 | 2010-10-27 | Ono Pharmaceutical Co., Ltd. | Immunopotentiative composition |
| BR0316880A (pt) | 2002-12-23 | 2005-10-25 | Wyeth Corp | Anticorpos contra pd-1 e usos dos mesmos |
| US7563869B2 (en) | 2003-01-23 | 2009-07-21 | Ono Pharmaceutical Co., Ltd. | Substance specific to human PD-1 |
| CA2970873C (en) | 2005-05-09 | 2022-05-17 | E. R. Squibb & Sons, L.L.C. | Human monoclonal antibodies to programmed death 1 (pd-1) and methods for treating cancer using anti-pd-1 antibodies alone or in combination with other immunotherapeutics |
| EA019344B1 (ru) | 2005-07-01 | 2014-03-31 | МЕДАРЕКС, Эл.Эл.Си. | Человеческие моноклональные антитела против лиганда-1 запрограммированной гибели клеток (pd-l1) и их применения |
| CA2647282A1 (en) | 2006-04-05 | 2007-10-11 | Pfizer Products Inc. | Ctla4 antibody combination therapy |
| SI2170959T1 (sl) | 2007-06-18 | 2014-04-30 | Merck Sharp & Dohme B.V. | Protitelesa proti receptorjem pd-1 za humano programirano smrt |
| WO2009014708A2 (en) | 2007-07-23 | 2009-01-29 | Cell Genesys, Inc. | Pd-1 antibodies in combination with a cytokine-secreting cell and methods of use thereof |
| WO2009117566A1 (en) * | 2008-03-21 | 2009-09-24 | H. Lee Moffitt Cancer Center And Research Institute, Inc. | Chemokine gene-modified cells for cancer immunotherapy |
| US8927697B2 (en) | 2008-09-12 | 2015-01-06 | Isis Innovation Limited | PD-1 specific antibodies and uses thereof |
| BRPI0919377A2 (pt) | 2008-09-26 | 2016-09-27 | Dana Farber Cancer Inst Inc | anticorpo isolado ou um fragmento ligante de antígeno do memso, ácido nucleico isolado, vetor, célula hospedeira, composição farmacêutica, método de produzir o referido anticorpo ou fragmento, uso dos mesmos, e composição compreendendo o referido anticorpo ou fragmento |
| KR101050829B1 (ko) | 2008-10-02 | 2011-07-20 | 서울대학교산학협력단 | 항 ｐｄ-1 항체 또는 항 ｐｄ-ｌ1 항체를 포함하는 항암제 |
| FI4209510T3 (fi) | 2008-12-09 | 2024-03-22 | Hoffmann La Roche | Anti-PD-L1-vasta-aineita ja niiden käyttö T-solutoiminnan tehostamiseksi |
| ES2629337T3 (es) | 2009-02-09 | 2017-08-08 | Inserm - Institut National De La Santé Et De La Recherche Médicale | Anticuerpos contra PD-1 y anticuerpos contra PD-L1 y usos de los mismos |
| SG11201407875UA (en) * | 2012-06-08 | 2014-12-30 | Aduro Biotech | Compostions and methods for cancer immunotherapy |
| ES2927567T3 (es) | 2013-09-13 | 2022-11-08 | Beigene Switzerland Gmbh | Anticuerpos anti-PD1 y su uso como productos terapéuticos y de diagnóstico |
| US11236139B2 (en) | 2014-11-05 | 2022-02-01 | The Regents Of The University Of California | Combination immunotherapy |
| GB201516047D0 (en) | 2015-09-10 | 2015-10-28 | Cancer Rec Tech Ltd | Method |
| WO2017151524A1 (en) | 2016-02-29 | 2017-09-08 | Foundation Medicine, Inc. | Methods and systems for evaluating tumor mutational burden |
| EP4317422A3 (en) * | 2017-04-13 | 2024-05-01 | Senti Biosciences, Inc. | Combinatorial cancer immunotherapy |
| WO2019217898A1 (en) | 2018-05-10 | 2019-11-14 | The Regents Of The University Of California | Ccl21 and checkpoint inhibitors for the treatment of cancer |
-
2015
- 2015-11-05 US US15/524,740 patent/US11236139B2/en active Active
- 2015-11-05 EP EP15856689.3A patent/EP3215182B1/en active Active
- 2015-11-05 JP JP2017525120A patent/JP7305300B2/ja active Active
- 2015-11-05 WO PCT/US2015/059297 patent/WO2016073759A1/en not_active Ceased
-
2022
- 2022-01-18 US US17/577,973 patent/US20220162279A1/en active Pending
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