JP2017538412A - ヒトc−mafに対する結合メンバー - Google Patents
ヒトc−mafに対する結合メンバー Download PDFInfo
- Publication number
- JP2017538412A JP2017538412A JP2017530686A JP2017530686A JP2017538412A JP 2017538412 A JP2017538412 A JP 2017538412A JP 2017530686 A JP2017530686 A JP 2017530686A JP 2017530686 A JP2017530686 A JP 2017530686A JP 2017538412 A JP2017538412 A JP 2017538412A
- Authority
- JP
- Japan
- Prior art keywords
- seq
- sequence
- maf
- binding member
- antibody
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/32—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against translation products of oncogenes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
- G01N33/5748—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving oncogenic proteins
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/82—Translation products from oncogenes
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Immunology (AREA)
- Molecular Biology (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Oncology (AREA)
- Biochemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Engineering & Computer Science (AREA)
- Urology & Nephrology (AREA)
- Biomedical Technology (AREA)
- Hematology (AREA)
- Analytical Chemistry (AREA)
- Microbiology (AREA)
- Pathology (AREA)
- General Physics & Mathematics (AREA)
- Physics & Mathematics (AREA)
- Food Science & Technology (AREA)
- Biotechnology (AREA)
- Cell Biology (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Hospice & Palliative Care (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201462090599P | 2014-12-11 | 2014-12-11 | |
| US62/090,599 | 2014-12-11 | ||
| PCT/IB2015/059562 WO2016092524A1 (en) | 2014-12-11 | 2015-12-11 | Binding members for human c-maf |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2017538412A true JP2017538412A (ja) | 2017-12-28 |
| JP2017538412A5 JP2017538412A5 (enExample) | 2019-01-24 |
Family
ID=55024191
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017530686A Pending JP2017538412A (ja) | 2014-12-11 | 2015-12-11 | ヒトc−mafに対する結合メンバー |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US10793642B2 (enExample) |
| EP (1) | EP3229909B1 (enExample) |
| JP (1) | JP2017538412A (enExample) |
| KR (1) | KR20170093182A (enExample) |
| CN (1) | CN107001480B (enExample) |
| AU (1) | AU2015358868A1 (enExample) |
| BR (1) | BR112017012515A2 (enExample) |
| CA (1) | CA2967224C (enExample) |
| MX (1) | MX2017007381A (enExample) |
| WO (1) | WO2016092524A1 (enExample) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2562274T3 (es) | 2010-10-06 | 2016-03-03 | Fundació Institut De Recerca Biomèdica (Irb Barcelona) | Procedimiento para el diagnóstico, pronóstico y tratamiento de metástasis de cáncer de mama |
| EP2650682A1 (en) | 2012-04-09 | 2013-10-16 | Fundació Privada Institut de Recerca Biomèdica | Method for the prognosis and treatment of cancer metastasis |
| BR112014030750A2 (pt) | 2012-06-06 | 2017-08-22 | Inst Catalana Recerca Estudis Avancats | Método para diagnóstico, prognóstico e tratamento da metástase do câncer pulmonar |
| HK1213946A1 (zh) | 2012-10-12 | 2016-07-15 | Inbiomotion S.L. | 用於使用c-maf对前列腺癌转移进行诊断、预後和治疗的方法 |
| US10119171B2 (en) | 2012-10-12 | 2018-11-06 | Inbiomotion S.L. | Method for the diagnosis, prognosis and treatment of prostate cancer metastasis |
| AU2014229563B2 (en) | 2013-03-15 | 2020-04-09 | Fundacio Institut De Recerca Biomedica (Irb Barcelona) | Method for the diagnosis, prognosis and treatment of cancer metastasis |
| CA2967224C (en) | 2014-12-11 | 2023-08-22 | Inbiomotion S.L. | Binding members for human c-maf |
| PL3458610T3 (pl) | 2016-05-25 | 2021-11-22 | Inbiomotion S.L. | Leczenie raka piersi w oparciu o status c-MAF |
| JP2021504339A (ja) | 2017-11-22 | 2021-02-15 | インバイオモーション エセ.エレ. | c−MAFの状態に基づく乳がんの治療的処置 |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2013182912A2 (en) * | 2012-06-06 | 2013-12-12 | Fundacio Privada Institut De Recerca Biomedica | Method for the diagnosis, prognosis and treatment of lung cancer metastasis |
| WO2014057357A2 (en) * | 2012-10-12 | 2014-04-17 | Inbiomotion S.L. | Method for the diagnosis, prognosis and treatment of prostate cancer metastasis |
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| US4275149A (en) | 1978-11-24 | 1981-06-23 | Syva Company | Macromolecular environment control in specific receptor assays |
| US4318980A (en) | 1978-04-10 | 1982-03-09 | Miles Laboratories, Inc. | Heterogenous specific binding assay employing a cycling reactant as label |
| US4424200A (en) | 1979-05-14 | 1984-01-03 | Nuc Med Inc. | Method for radiolabeling proteins with technetium-99m |
| US4479930A (en) | 1982-07-26 | 1984-10-30 | Trustees Of The University Of Massachusetts | Amines coupled wth dicyclic dianhydrides capable of being radiolabeled product |
| GB8308235D0 (en) | 1983-03-25 | 1983-05-05 | Celltech Ltd | Polypeptides |
| US4816567A (en) | 1983-04-08 | 1989-03-28 | Genentech, Inc. | Recombinant immunoglobin preparations |
| JPS61134325A (ja) | 1984-12-04 | 1986-06-21 | Teijin Ltd | ハイブリツド抗体遺伝子の発現方法 |
| GB8607679D0 (en) | 1986-03-27 | 1986-04-30 | Winter G P | Recombinant dna product |
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| GB8928874D0 (en) | 1989-12-21 | 1990-02-28 | Celltech Ltd | Humanised antibodies |
| GB9015198D0 (en) | 1990-07-10 | 1990-08-29 | Brien Caroline J O | Binding substance |
| DK0617706T3 (da) | 1991-11-25 | 2001-11-12 | Enzon Inc | Multivalente antigenbindende proteiner |
| CA2150262C (en) | 1992-12-04 | 2008-07-08 | Kaspar-Philipp Holliger | Multivalent and multispecific binding proteins, their manufacture and use |
| US6121022A (en) | 1995-04-14 | 2000-09-19 | Genentech, Inc. | Altered polypeptides with increased half-life |
| GB9509957D0 (en) | 1995-05-17 | 1995-07-12 | Khalil Nasreen | Post-translational activation of tgf-1 involving the tsp-1 receptor cd36 |
| US5814468A (en) | 1996-03-27 | 1998-09-29 | Coulter International Corp. | Methods of enumerating receptor molecules for specific binding partners on formed bodies and in solution |
| US5958671A (en) | 1996-04-23 | 1999-09-28 | Presidents And Fellows Of Harvard College | Methods and compositions for regulating T cell subsets by modulating transcription factor activity |
| JP2002509431A (ja) | 1996-12-23 | 2002-03-26 | イミュネックス・コーポレーション | NF−κBのレセプター活性化因子−レセプターはTNFレセプタースーパーファミリーの一員である− |
| US6316408B1 (en) | 1997-04-16 | 2001-11-13 | Amgen Inc. | Methods of use for osetoprotegerin binding protein receptors |
| US6274338B1 (en) * | 1998-02-24 | 2001-08-14 | President And Fellows Of Harvard College | Human c-Maf compositions and methods of use thereof |
| ATE439592T1 (de) | 1998-12-10 | 2009-08-15 | Bristol Myers Squibb Co | Proteingerüste für antikörper-nachahmer und andere bindende proteine |
| ES2215626T3 (es) | 1999-03-15 | 2004-10-16 | Axys Pharmaceuticals, Inc. | N-cianomethil amidas como inhibidores de proteasas. |
| CA2396257A1 (en) | 2000-01-06 | 2001-07-12 | Merck Frosst Canada & Co./Merck Frosst Canada & Cie | Novel compounds and compositions as protease inhibitors |
| DE60126592T2 (de) | 2000-04-03 | 2007-11-22 | Corixa Corp., Hamilton | Verfahren, zusammensetzungen und kits zur identifizierung und überwachung von brustkrebs |
| US7700359B2 (en) | 2000-06-02 | 2010-04-20 | Novartis Vaccines And Diagnostics, Inc. | Gene products differentially expressed in cancerous cells |
| MY143582A (en) | 2001-06-26 | 2011-05-31 | Amgent Fremont Inc | Antibodies to opgl |
| WO2004006955A1 (en) | 2001-07-12 | 2004-01-22 | Jefferson Foote | Super humanized antibodies |
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| GB0121033D0 (en) | 2001-08-30 | 2001-10-24 | Novartis Ag | Organic compounds |
| JP4238138B2 (ja) | 2001-12-22 | 2009-03-11 | 4−アンチボディ アーゲー | 遺伝的に修飾された脊椎動物前駆体リンパ球の生成方法及び異種結合タンパク質の産生を目的としたその使用。 |
| SE0201980D0 (sv) | 2002-06-24 | 2002-06-24 | Astrazeneca Ab | Novel compounds |
| WO2005046731A1 (en) | 2003-10-17 | 2005-05-26 | The Government Of The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Interference with c-maf function in multiple myeloma |
| US20090048117A1 (en) | 2003-12-18 | 2009-02-19 | President And Fellows Of Harvard College | Modulation of immune system function by modulation of polypeptide arginine methyltransferases |
| JP5457673B2 (ja) | 2005-09-20 | 2014-04-02 | ベリデックス・リミテッド・ライアビリティ・カンパニー | ユニーク配列のdnaプローブを作製するための方法および組成物、dnaプローブの標識、ならびにこれらプローブの使用 |
| US9134237B2 (en) | 2005-09-20 | 2015-09-15 | Janssen Diagnotics, LLC | High sensitivity multiparameter method for rare event analysis in a biological sample |
| EP1777523A1 (en) | 2005-10-19 | 2007-04-25 | INSERM (Institut National de la Santé et de la Recherche Médicale) | An in vitro method for the prognosis of progression of a cancer and of the outcome in a patient and means for performing said method |
| US8785150B2 (en) | 2006-06-30 | 2014-07-22 | University Of Southern California | Quantifiable internal reference standards for immunohistochemistry and uses thereof |
| WO2008086800A2 (en) | 2007-01-15 | 2008-07-24 | Aarhus Universitet | Predisposition to, prognosis for and treatment of breast cancer relating to human chromosome 16 |
| WO2008098351A1 (en) | 2007-02-14 | 2008-08-21 | University Health Network | Treatment of d-cyclin mediated proliferative diseases and hemotological malignancies |
| AU2008244648A1 (en) | 2007-02-16 | 2008-11-06 | Pacific Arrow Limited | Blocking the migration or metastasis of cancer cells by affecting adhesion proteins and the uses of new compounds thereof |
| RU2481355C2 (ru) | 2007-05-24 | 2013-05-10 | Аблинкс Н.В. | Аминокислотные последовательности, направленные на rank-l, и полипептиды, включающие их, для лечения заболеваний и нарушений костей |
| WO2010003773A1 (en) | 2008-06-16 | 2010-01-14 | Siemens Medical Solutions Diagnostics Gmbh | Algorithms for outcome prediction in patients with node-positive chemotherapy-treated breast cancer |
| JPWO2010110346A1 (ja) | 2009-03-24 | 2012-10-04 | 独立行政法人理化学研究所 | 白血病幹細胞マーカー |
| WO2011039734A2 (en) | 2009-10-02 | 2011-04-07 | Enzo Medico | Use of genes involved in anchorage independence for the optimization of diagnosis and treatment of human cancer |
| ES2562274T3 (es) | 2010-10-06 | 2016-03-03 | Fundació Institut De Recerca Biomèdica (Irb Barcelona) | Procedimiento para el diagnóstico, pronóstico y tratamiento de metástasis de cáncer de mama |
| WO2012106718A2 (en) | 2011-02-04 | 2012-08-09 | Bioarray Therapeutics, Inc. | Methods of using gene expression signatures to select a method of treatment, predict prognosis, survival, and/or predict response to treatment |
| EP2650682A1 (en) | 2012-04-09 | 2013-10-16 | Fundació Privada Institut de Recerca Biomèdica | Method for the prognosis and treatment of cancer metastasis |
| US10119171B2 (en) | 2012-10-12 | 2018-11-06 | Inbiomotion S.L. | Method for the diagnosis, prognosis and treatment of prostate cancer metastasis |
| CN105324491B (zh) | 2013-03-15 | 2021-10-26 | 生物医学研究机构基金会 | 用于癌症转移的诊断和治疗的方法 |
| WO2014184679A2 (en) | 2013-03-15 | 2014-11-20 | Inbiomotion S.L. | Method for the prognosis and treatment of renal cell carcinoma metastasis |
| AU2014229563B2 (en) | 2013-03-15 | 2020-04-09 | Fundacio Institut De Recerca Biomedica (Irb Barcelona) | Method for the diagnosis, prognosis and treatment of cancer metastasis |
| EP3055429B1 (en) | 2013-10-09 | 2019-03-27 | Fundació Institut de Recerca Biomèdica (IRB Barcelona) | Method for the prognosis and treatment of metastasizing cancer of the bone originating from breast cancer |
| CA2967224C (en) | 2014-12-11 | 2023-08-22 | Inbiomotion S.L. | Binding members for human c-maf |
| PL3458610T3 (pl) | 2016-05-25 | 2021-11-22 | Inbiomotion S.L. | Leczenie raka piersi w oparciu o status c-MAF |
| JP2021504339A (ja) | 2017-11-22 | 2021-02-15 | インバイオモーション エセ.エレ. | c−MAFの状態に基づく乳がんの治療的処置 |
-
2015
- 2015-12-11 CA CA2967224A patent/CA2967224C/en active Active
- 2015-12-11 AU AU2015358868A patent/AU2015358868A1/en not_active Abandoned
- 2015-12-11 BR BR112017012515A patent/BR112017012515A2/pt not_active Application Discontinuation
- 2015-12-11 KR KR1020177018132A patent/KR20170093182A/ko not_active Withdrawn
- 2015-12-11 WO PCT/IB2015/059562 patent/WO2016092524A1/en not_active Ceased
- 2015-12-11 CN CN201580067068.4A patent/CN107001480B/zh active Active
- 2015-12-11 JP JP2017530686A patent/JP2017538412A/ja active Pending
- 2015-12-11 MX MX2017007381A patent/MX2017007381A/es unknown
- 2015-12-11 US US15/534,893 patent/US10793642B2/en active Active
- 2015-12-11 EP EP15816535.7A patent/EP3229909B1/en active Active
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2013182912A2 (en) * | 2012-06-06 | 2013-12-12 | Fundacio Privada Institut De Recerca Biomedica | Method for the diagnosis, prognosis and treatment of lung cancer metastasis |
| WO2014057357A2 (en) * | 2012-10-12 | 2014-04-17 | Inbiomotion S.L. | Method for the diagnosis, prognosis and treatment of prostate cancer metastasis |
Non-Patent Citations (3)
| Title |
|---|
| "PURIFIED ANTI-C-MAF ANTIBODY", BIOLEGEND CATALOG / VERSION 1, JPN5017010215, 15 May 2013 (2013-05-15), pages 1 - 3, ISSN: 0004364565 * |
| J BIOL CHEM, 2002, VOL.277, NO.51, P.49903-49910, JPN6019042645, ISSN: 0004364563 * |
| PRODUCT CATALOG[ONLINE], C-MAF(M-153):SC-7866, ,<HTTP://DATASHEETS.SCBT.COM/SC-7866.PDF>, [RETRIEVE, JPN6019042646, ISSN: 0004364564 * |
Also Published As
| Publication number | Publication date |
|---|---|
| EP3229909A1 (en) | 2017-10-18 |
| BR112017012515A2 (pt) | 2018-01-02 |
| US20170369589A1 (en) | 2017-12-28 |
| CN107001480A (zh) | 2017-08-01 |
| EP3229909B1 (en) | 2020-10-14 |
| KR20170093182A (ko) | 2017-08-14 |
| CA2967224A1 (en) | 2016-06-16 |
| WO2016092524A1 (en) | 2016-06-16 |
| AU2015358868A1 (en) | 2017-06-01 |
| MX2017007381A (es) | 2017-11-06 |
| CN107001480B (zh) | 2021-12-03 |
| US10793642B2 (en) | 2020-10-06 |
| CA2967224C (en) | 2023-08-22 |
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