JP2017538412A - ヒトc−mafに対する結合メンバー - Google Patents

ヒトc−mafに対する結合メンバー Download PDF

Info

Publication number
JP2017538412A
JP2017538412A JP2017530686A JP2017530686A JP2017538412A JP 2017538412 A JP2017538412 A JP 2017538412A JP 2017530686 A JP2017530686 A JP 2017530686A JP 2017530686 A JP2017530686 A JP 2017530686A JP 2017538412 A JP2017538412 A JP 2017538412A
Authority
JP
Japan
Prior art keywords
seq
sequence
maf
binding member
antibody
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2017530686A
Other languages
English (en)
Japanese (ja)
Other versions
JP2017538412A5 (enExample
Inventor
ロジェル ゴミス,
ロジェル ゴミス,
フアン カルロス テルセロ,
フアン カルロス テルセロ,
Original Assignee
インバイオモーション エセ.エレ.
インバイオモーション エセ.エレ.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by インバイオモーション エセ.エレ., インバイオモーション エセ.エレ. filed Critical インバイオモーション エセ.エレ.
Publication of JP2017538412A publication Critical patent/JP2017538412A/ja
Publication of JP2017538412A5 publication Critical patent/JP2017538412A5/ja
Pending legal-status Critical Current

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/32Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against translation products of oncogenes
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/574Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/5748Immunoassay; Biospecific binding assay; Materials therefor for cancer involving oncogenic proteins
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/30Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/90Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/82Translation products from oncogenes
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6893Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Oncology (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Engineering & Computer Science (AREA)
  • Urology & Nephrology (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Analytical Chemistry (AREA)
  • Microbiology (AREA)
  • Pathology (AREA)
  • General Physics & Mathematics (AREA)
  • Physics & Mathematics (AREA)
  • Food Science & Technology (AREA)
  • Biotechnology (AREA)
  • Cell Biology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Hospice & Palliative Care (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
JP2017530686A 2014-12-11 2015-12-11 ヒトc−mafに対する結合メンバー Pending JP2017538412A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201462090599P 2014-12-11 2014-12-11
US62/090,599 2014-12-11
PCT/IB2015/059562 WO2016092524A1 (en) 2014-12-11 2015-12-11 Binding members for human c-maf

Publications (2)

Publication Number Publication Date
JP2017538412A true JP2017538412A (ja) 2017-12-28
JP2017538412A5 JP2017538412A5 (enExample) 2019-01-24

Family

ID=55024191

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2017530686A Pending JP2017538412A (ja) 2014-12-11 2015-12-11 ヒトc−mafに対する結合メンバー

Country Status (10)

Country Link
US (1) US10793642B2 (enExample)
EP (1) EP3229909B1 (enExample)
JP (1) JP2017538412A (enExample)
KR (1) KR20170093182A (enExample)
CN (1) CN107001480B (enExample)
AU (1) AU2015358868A1 (enExample)
BR (1) BR112017012515A2 (enExample)
CA (1) CA2967224C (enExample)
MX (1) MX2017007381A (enExample)
WO (1) WO2016092524A1 (enExample)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2562274T3 (es) 2010-10-06 2016-03-03 Fundació Institut De Recerca Biomèdica (Irb Barcelona) Procedimiento para el diagnóstico, pronóstico y tratamiento de metástasis de cáncer de mama
EP2650682A1 (en) 2012-04-09 2013-10-16 Fundació Privada Institut de Recerca Biomèdica Method for the prognosis and treatment of cancer metastasis
BR112014030750A2 (pt) 2012-06-06 2017-08-22 Inst Catalana Recerca Estudis Avancats Método para diagnóstico, prognóstico e tratamento da metástase do câncer pulmonar
HK1213946A1 (zh) 2012-10-12 2016-07-15 Inbiomotion S.L. 用於使用c-maf对前列腺癌转移进行诊断、预後和治疗的方法
US10119171B2 (en) 2012-10-12 2018-11-06 Inbiomotion S.L. Method for the diagnosis, prognosis and treatment of prostate cancer metastasis
AU2014229563B2 (en) 2013-03-15 2020-04-09 Fundacio Institut De Recerca Biomedica (Irb Barcelona) Method for the diagnosis, prognosis and treatment of cancer metastasis
CA2967224C (en) 2014-12-11 2023-08-22 Inbiomotion S.L. Binding members for human c-maf
PL3458610T3 (pl) 2016-05-25 2021-11-22 Inbiomotion S.L. Leczenie raka piersi w oparciu o status c-MAF
JP2021504339A (ja) 2017-11-22 2021-02-15 インバイオモーション エセ.エレ. c−MAFの状態に基づく乳がんの治療的処置

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2013182912A2 (en) * 2012-06-06 2013-12-12 Fundacio Privada Institut De Recerca Biomedica Method for the diagnosis, prognosis and treatment of lung cancer metastasis
WO2014057357A2 (en) * 2012-10-12 2014-04-17 Inbiomotion S.L. Method for the diagnosis, prognosis and treatment of prostate cancer metastasis

Family Cites Families (56)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4275149A (en) 1978-11-24 1981-06-23 Syva Company Macromolecular environment control in specific receptor assays
US4318980A (en) 1978-04-10 1982-03-09 Miles Laboratories, Inc. Heterogenous specific binding assay employing a cycling reactant as label
US4424200A (en) 1979-05-14 1984-01-03 Nuc Med Inc. Method for radiolabeling proteins with technetium-99m
US4479930A (en) 1982-07-26 1984-10-30 Trustees Of The University Of Massachusetts Amines coupled wth dicyclic dianhydrides capable of being radiolabeled product
GB8308235D0 (en) 1983-03-25 1983-05-05 Celltech Ltd Polypeptides
US4816567A (en) 1983-04-08 1989-03-28 Genentech, Inc. Recombinant immunoglobin preparations
JPS61134325A (ja) 1984-12-04 1986-06-21 Teijin Ltd ハイブリツド抗体遺伝子の発現方法
GB8607679D0 (en) 1986-03-27 1986-04-30 Winter G P Recombinant dna product
US4987071A (en) 1986-12-03 1991-01-22 University Patents, Inc. RNA ribozyme polymerases, dephosphorylases, restriction endoribonucleases and methods
US5185243A (en) 1988-08-25 1993-02-09 Syntex (U.S.A.) Inc. Method for detection of specific nucleic acid sequences
GB8928874D0 (en) 1989-12-21 1990-02-28 Celltech Ltd Humanised antibodies
GB9015198D0 (en) 1990-07-10 1990-08-29 Brien Caroline J O Binding substance
DK0617706T3 (da) 1991-11-25 2001-11-12 Enzon Inc Multivalente antigenbindende proteiner
CA2150262C (en) 1992-12-04 2008-07-08 Kaspar-Philipp Holliger Multivalent and multispecific binding proteins, their manufacture and use
US6121022A (en) 1995-04-14 2000-09-19 Genentech, Inc. Altered polypeptides with increased half-life
GB9509957D0 (en) 1995-05-17 1995-07-12 Khalil Nasreen Post-translational activation of tgf-›1 involving the tsp-1 receptor cd36
US5814468A (en) 1996-03-27 1998-09-29 Coulter International Corp. Methods of enumerating receptor molecules for specific binding partners on formed bodies and in solution
US5958671A (en) 1996-04-23 1999-09-28 Presidents And Fellows Of Harvard College Methods and compositions for regulating T cell subsets by modulating transcription factor activity
JP2002509431A (ja) 1996-12-23 2002-03-26 イミュネックス・コーポレーション NF−κBのレセプター活性化因子−レセプターはTNFレセプタースーパーファミリーの一員である−
US6316408B1 (en) 1997-04-16 2001-11-13 Amgen Inc. Methods of use for osetoprotegerin binding protein receptors
US6274338B1 (en) * 1998-02-24 2001-08-14 President And Fellows Of Harvard College Human c-Maf compositions and methods of use thereof
ATE439592T1 (de) 1998-12-10 2009-08-15 Bristol Myers Squibb Co Proteingerüste für antikörper-nachahmer und andere bindende proteine
ES2215626T3 (es) 1999-03-15 2004-10-16 Axys Pharmaceuticals, Inc. N-cianomethil amidas como inhibidores de proteasas.
CA2396257A1 (en) 2000-01-06 2001-07-12 Merck Frosst Canada & Co./Merck Frosst Canada & Cie Novel compounds and compositions as protease inhibitors
DE60126592T2 (de) 2000-04-03 2007-11-22 Corixa Corp., Hamilton Verfahren, zusammensetzungen und kits zur identifizierung und überwachung von brustkrebs
US7700359B2 (en) 2000-06-02 2010-04-20 Novartis Vaccines And Diagnostics, Inc. Gene products differentially expressed in cancerous cells
MY143582A (en) 2001-06-26 2011-05-31 Amgent Fremont Inc Antibodies to opgl
WO2004006955A1 (en) 2001-07-12 2004-01-22 Jefferson Foote Super humanized antibodies
AR036375A1 (es) 2001-08-30 2004-09-01 Novartis Ag Compuestos pirrolo [2,3-d] pirimidina -2- carbonitrilo, un proceso para su preparacion, una composicion farmaceutica y el uso de dichos compuestos para la preparacion de medicamentos
GB0121033D0 (en) 2001-08-30 2001-10-24 Novartis Ag Organic compounds
JP4238138B2 (ja) 2001-12-22 2009-03-11 4−アンチボディ アーゲー 遺伝的に修飾された脊椎動物前駆体リンパ球の生成方法及び異種結合タンパク質の産生を目的としたその使用。
SE0201980D0 (sv) 2002-06-24 2002-06-24 Astrazeneca Ab Novel compounds
WO2005046731A1 (en) 2003-10-17 2005-05-26 The Government Of The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Interference with c-maf function in multiple myeloma
US20090048117A1 (en) 2003-12-18 2009-02-19 President And Fellows Of Harvard College Modulation of immune system function by modulation of polypeptide arginine methyltransferases
JP5457673B2 (ja) 2005-09-20 2014-04-02 ベリデックス・リミテッド・ライアビリティ・カンパニー ユニーク配列のdnaプローブを作製するための方法および組成物、dnaプローブの標識、ならびにこれらプローブの使用
US9134237B2 (en) 2005-09-20 2015-09-15 Janssen Diagnotics, LLC High sensitivity multiparameter method for rare event analysis in a biological sample
EP1777523A1 (en) 2005-10-19 2007-04-25 INSERM (Institut National de la Santé et de la Recherche Médicale) An in vitro method for the prognosis of progression of a cancer and of the outcome in a patient and means for performing said method
US8785150B2 (en) 2006-06-30 2014-07-22 University Of Southern California Quantifiable internal reference standards for immunohistochemistry and uses thereof
WO2008086800A2 (en) 2007-01-15 2008-07-24 Aarhus Universitet Predisposition to, prognosis for and treatment of breast cancer relating to human chromosome 16
WO2008098351A1 (en) 2007-02-14 2008-08-21 University Health Network Treatment of d-cyclin mediated proliferative diseases and hemotological malignancies
AU2008244648A1 (en) 2007-02-16 2008-11-06 Pacific Arrow Limited Blocking the migration or metastasis of cancer cells by affecting adhesion proteins and the uses of new compounds thereof
RU2481355C2 (ru) 2007-05-24 2013-05-10 Аблинкс Н.В. Аминокислотные последовательности, направленные на rank-l, и полипептиды, включающие их, для лечения заболеваний и нарушений костей
WO2010003773A1 (en) 2008-06-16 2010-01-14 Siemens Medical Solutions Diagnostics Gmbh Algorithms for outcome prediction in patients with node-positive chemotherapy-treated breast cancer
JPWO2010110346A1 (ja) 2009-03-24 2012-10-04 独立行政法人理化学研究所 白血病幹細胞マーカー
WO2011039734A2 (en) 2009-10-02 2011-04-07 Enzo Medico Use of genes involved in anchorage independence for the optimization of diagnosis and treatment of human cancer
ES2562274T3 (es) 2010-10-06 2016-03-03 Fundació Institut De Recerca Biomèdica (Irb Barcelona) Procedimiento para el diagnóstico, pronóstico y tratamiento de metástasis de cáncer de mama
WO2012106718A2 (en) 2011-02-04 2012-08-09 Bioarray Therapeutics, Inc. Methods of using gene expression signatures to select a method of treatment, predict prognosis, survival, and/or predict response to treatment
EP2650682A1 (en) 2012-04-09 2013-10-16 Fundació Privada Institut de Recerca Biomèdica Method for the prognosis and treatment of cancer metastasis
US10119171B2 (en) 2012-10-12 2018-11-06 Inbiomotion S.L. Method for the diagnosis, prognosis and treatment of prostate cancer metastasis
CN105324491B (zh) 2013-03-15 2021-10-26 生物医学研究机构基金会 用于癌症转移的诊断和治疗的方法
WO2014184679A2 (en) 2013-03-15 2014-11-20 Inbiomotion S.L. Method for the prognosis and treatment of renal cell carcinoma metastasis
AU2014229563B2 (en) 2013-03-15 2020-04-09 Fundacio Institut De Recerca Biomedica (Irb Barcelona) Method for the diagnosis, prognosis and treatment of cancer metastasis
EP3055429B1 (en) 2013-10-09 2019-03-27 Fundació Institut de Recerca Biomèdica (IRB Barcelona) Method for the prognosis and treatment of metastasizing cancer of the bone originating from breast cancer
CA2967224C (en) 2014-12-11 2023-08-22 Inbiomotion S.L. Binding members for human c-maf
PL3458610T3 (pl) 2016-05-25 2021-11-22 Inbiomotion S.L. Leczenie raka piersi w oparciu o status c-MAF
JP2021504339A (ja) 2017-11-22 2021-02-15 インバイオモーション エセ.エレ. c−MAFの状態に基づく乳がんの治療的処置

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2013182912A2 (en) * 2012-06-06 2013-12-12 Fundacio Privada Institut De Recerca Biomedica Method for the diagnosis, prognosis and treatment of lung cancer metastasis
WO2014057357A2 (en) * 2012-10-12 2014-04-17 Inbiomotion S.L. Method for the diagnosis, prognosis and treatment of prostate cancer metastasis

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
"PURIFIED ANTI-C-MAF ANTIBODY", BIOLEGEND CATALOG / VERSION 1, JPN5017010215, 15 May 2013 (2013-05-15), pages 1 - 3, ISSN: 0004364565 *
J BIOL CHEM, 2002, VOL.277, NO.51, P.49903-49910, JPN6019042645, ISSN: 0004364563 *
PRODUCT CATALOG[ONLINE], C-MAF(M-153):SC-7866, ,<HTTP://DATASHEETS.SCBT.COM/SC-7866.PDF>, [RETRIEVE, JPN6019042646, ISSN: 0004364564 *

Also Published As

Publication number Publication date
EP3229909A1 (en) 2017-10-18
BR112017012515A2 (pt) 2018-01-02
US20170369589A1 (en) 2017-12-28
CN107001480A (zh) 2017-08-01
EP3229909B1 (en) 2020-10-14
KR20170093182A (ko) 2017-08-14
CA2967224A1 (en) 2016-06-16
WO2016092524A1 (en) 2016-06-16
AU2015358868A1 (en) 2017-06-01
MX2017007381A (es) 2017-11-06
CN107001480B (zh) 2021-12-03
US10793642B2 (en) 2020-10-06
CA2967224C (en) 2023-08-22

Similar Documents

Publication Publication Date Title
US10793642B2 (en) Binding members for human c-MAF
US20230381209A1 (en) Therapeutic treatment of breast cancer based on c-maf status
CN102762227B (zh) 内皮因子抗体
JP6581572B2 (ja) 補体因子h阻害薬
US9683032B2 (en) Anti-S100A4 antibody molecules and their uses
JP2017523776A (ja) 膠芽腫の診断方法及びその治療用組成物
MX2014013931A (es) Metodos para tratar el cancer gastrico.
JP2021531007A (ja) Vistaに対する受容体
CN120754270A (zh) 用特定抗体药物偶联物与帕博利珠单抗组合治疗癌症
WO2024254596A1 (en) Compositions and methods for detection of aberrant cdk5 expression
HK1263074B (en) Therapeutic treatment of breast cancer based on c-maf status
HK1263074A1 (en) Therapeutic treatment of breast cancer based on c-maf status
BR112018074076B1 (pt) Métodos in vitro para projetar uma terapia customizada para um indivíduo que tem câncer de mama e para prever sobrevivência sem doença invasiva

Legal Events

Date Code Title Description
A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20181210

A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20181210

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20191105

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20200105

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20200507

A02 Decision of refusal

Free format text: JAPANESE INTERMEDIATE CODE: A02

Effective date: 20201012