JP2017537070A5 - - Google Patents
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- JP2017537070A5 JP2017537070A5 JP2017522084A JP2017522084A JP2017537070A5 JP 2017537070 A5 JP2017537070 A5 JP 2017537070A5 JP 2017522084 A JP2017522084 A JP 2017522084A JP 2017522084 A JP2017522084 A JP 2017522084A JP 2017537070 A5 JP2017537070 A5 JP 2017537070A5
- Authority
- JP
- Japan
- Prior art keywords
- immune checkpoint
- stranded antisense
- cancer
- antisense oligonucleotide
- patient
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 108020000948 Antisense Oligonucleotides Proteins 0.000 claims 9
- 229920000272 Oligonucleotide Polymers 0.000 claims 9
- 102100019667 STAT3 Human genes 0.000 claims 9
- 108010017324 STAT3 Transcription Factor Proteins 0.000 claims 9
- 239000000074 antisense oligonucleotide Substances 0.000 claims 9
- 239000012274 immune-checkpoint protein inhibitor Substances 0.000 claims 8
- 229940121650 immune-checkpoint protein inhibitors Drugs 0.000 claims 8
- 201000011510 cancer Diseases 0.000 claims 5
- 108090001123 antibodies Proteins 0.000 claims 4
- 102000004965 antibodies Human genes 0.000 claims 4
- 239000000427 antigen Substances 0.000 claims 3
- 108091007172 antigens Proteins 0.000 claims 3
- 102000038129 antigens Human genes 0.000 claims 3
- 102100007290 CD274 Human genes 0.000 claims 2
- 101710012053 CD274 Proteins 0.000 claims 2
- 108009000344 Head and Neck Squamous Cell Carcinoma Proteins 0.000 claims 2
- 206010073071 Hepatocellular carcinoma Diseases 0.000 claims 2
- 208000002154 Non-Small-Cell Lung Carcinoma Diseases 0.000 claims 2
- 108009000071 Non-small cell lung cancer Proteins 0.000 claims 2
- 208000000102 Squamous Cell Carcinoma of Head and Neck Diseases 0.000 claims 2
- 229950007217 Tremelimumab Drugs 0.000 claims 2
- 201000000459 head and neck squamous cell carcinoma Diseases 0.000 claims 2
- 231100000844 hepatocellular carcinoma Toxicity 0.000 claims 2
- 108010072993 tremelimumab Proteins 0.000 claims 2
- 210000003719 B-Lymphocytes Anatomy 0.000 claims 1
- 108010090685 BMS-936559 Proteins 0.000 claims 1
- 206010008342 Cervix carcinoma Diseases 0.000 claims 1
- 108010089187 Ipilimumab Proteins 0.000 claims 1
- 206010058467 Lung neoplasm malignant Diseases 0.000 claims 1
- 206010025323 Lymphomas Diseases 0.000 claims 1
- -1 MPDL3280A Proteins 0.000 claims 1
- 108010019706 Nivolumab Proteins 0.000 claims 1
- 108010042215 OX40 Ligand Proteins 0.000 claims 1
- 102000004473 OX40 Ligand Human genes 0.000 claims 1
- 208000008443 Pancreatic Carcinoma Diseases 0.000 claims 1
- 229950010773 Pidilizumab Drugs 0.000 claims 1
- 206010060862 Prostate cancer Diseases 0.000 claims 1
- 102000006381 STAT1 Transcription Factor Human genes 0.000 claims 1
- 108010044012 STAT1 Transcription Factor Proteins 0.000 claims 1
- 102000005886 STAT4 Transcription Factor Human genes 0.000 claims 1
- 108010019992 STAT4 Transcription Factor Proteins 0.000 claims 1
- 102000013968 STAT6 Transcription Factor Human genes 0.000 claims 1
- 108010011005 STAT6 Transcription Factor Proteins 0.000 claims 1
- 239000000556 agonist Substances 0.000 claims 1
- 201000009030 carcinoma Diseases 0.000 claims 1
- 210000004027 cells Anatomy 0.000 claims 1
- 201000010881 cervical cancer Diseases 0.000 claims 1
- 239000003795 chemical substances by application Substances 0.000 claims 1
- 201000011231 colorectal cancer Diseases 0.000 claims 1
- 230000002401 inhibitory effect Effects 0.000 claims 1
- 229960005386 ipilimumab Drugs 0.000 claims 1
- 201000005202 lung cancer Diseases 0.000 claims 1
- 229960003301 nivolumab Drugs 0.000 claims 1
- 201000002528 pancreatic cancer Diseases 0.000 claims 1
- 108010026276 pembrolizumab Proteins 0.000 claims 1
- 229960002621 pembrolizumab Drugs 0.000 claims 1
- 108010051812 pidilizumab Proteins 0.000 claims 1
Claims (16)
- （ｉ）少なくとも１つの免疫チェックポイント阻害剤と（ｉｉ）ＳＴＡＴ３を標的とする一本鎖アンチセンスオリゴヌクレオチドとを、その治療を必要とする患者に投与することを含むがんの治療方法。
- 前記少なくとも１つの免疫チェックポイント阻害剤が、抗ＰＤ−Ｌ１抗体またはその抗原結合断片、抗ＰＤ１抗体またはその抗原結合断片、抗ＣＴＬＡ−４抗体またはその抗原結合断片およびＯＸ−４０アゴニストから選択される、請求項１に記載の方法。
- 前記少なくとも１つの免疫チェックポイント阻害剤が、ＭＥＤＩ４７３６、ＭＰＤＬ３２８０Ａ、２．７Ａ４、ＡＭＰ−７１４、ＭＤＸ−１１０５、ニボルマブ、ペンブロリズマブ、ピディリズマブ、ＢＭＳ９３６５５９、ＭＰＤＬ３２８０Ａ、トレメリムマブ、イピリムマブおよびＯＸ４０Ｌ ＦＰから選択される、請求項１に記載の方法。
- 前記少なくとも１つの免疫チェックポイント阻害剤がＭＥＤＩ４７３６である、請求項３に記載の方法。
- ＳＴＡＴ３を標的とする一本鎖アンチセンスオリゴヌクレオチドがＳＴＡＴ１、ＳＴＡＴ４またはＳＴＡＴ６を阻害しない、請求項１に記載の方法。
- ＳＴＡＴ３を標的とする一本鎖アンチセンスオリゴヌクレオチドがＡＺＤ９１５０である、請求項１〜５のいずれか一項に記載の方法。
- がんが、非小細胞肺がん（ＮＳＣＬＣ）をはじめとする肺がん、膵がん、前立腺がん、結腸直腸がん、肝細胞癌（ＨＣＣ）、頭頸部扁平上皮癌（ＨＮＳＣＣ）をはじめとする頭頸部がん、およびびまん性大細胞型Ｂ細胞癌（ＤＬＢＣＬ）をはじめとするリンパ腫から選択される、請求項１に記載の方法。
- がん細胞がＰＤ−Ｌ１を発現する、請求項７に記載の方法。
- 前記治療を必要とする患者が、ＰＤ−Ｌ１陽性であるがんを有すると同定された、請求項１に記載の方法。
- 抗ＰＤ−Ｌ１抗体がＭＥＤＩ４７３６であり、ＳＴＡＴ３を標的とする一本鎖アンチセンスオリゴヌクレオチドがＡＺＤ９１５０である、請求項２に記載の方法。
- 約１ｍｇ／ｋｇ〜２０ｍｇ／ｋｇのＭＥＤＩ４７３６と約１ｍｇ／ｋｇ〜１０ｍｇ／ｋｇのＡＺＤ９１５０とを、その治療を必要とする患者に投与する、請求項１０に記載の方法。
- その治療を１週毎に、２週毎に、３週毎にまたは４週毎に投与する、請求項１１に記載の方法。
- ＳＴＡＴ３を標的とする一本鎖アンチセンスオリゴヌクレオチドを前記少なくとも１つの免疫チェックポイント阻害剤の前に患者に投与する、請求項１に記載の方法。
- ＳＴＡＴ３を標的とする一本鎖アンチセンスオリゴヌクレオチドを、前記少なくとも１つの免疫チェックポイント阻害剤を患者に投与する少なくとも１日前に前記患者に投与する、請求項１３に記載の方法。
- ＳＴＡＴ３を標的とする一本鎖アンチセンスオリゴヌクレオチドがＡＺＤ９１５０であり、前記少なくとも１つの免疫チェックポイント阻害剤がＭＥＤＩ４７３６であり、ＡＺＤ９１５０とＭＥＤＩ４７３６を同時にまたは異なる時間で投与する、請求項１に記載の方法。
- （ｉ）２つの免疫チェックポイント阻害剤と（ｉｉ）ＳＴＡＴ３を標的とする一本鎖アンチセンスオリゴヌクレオチドとを、その治療を必要とする患者に投与することを含み、前記２つの免疫チェックポイント阻害剤がＭＥＤＩ４７３６およびトレメリムマブであり、ＳＴＡＴ３を標的とする一本鎖アンチセンスオリゴヌクレオチドがＡＺＤ９１５０である、請求項１に記載の方法。
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201462068141P | 2014-10-24 | 2014-10-24 | |
| US62/068141 | 2014-10-24 | ||
| PCT/EP2015/074271 WO2016062722A1 (en) | 2014-10-24 | 2015-10-20 | Combination |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2017537070A JP2017537070A (ja) | 2017-12-14 |
| JP2017537070A5 true JP2017537070A5 (ja) | 2018-11-29 |
| JP6687612B2 JP6687612B2 (ja) | 2020-04-22 |
Family
ID=54347516
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017522084A Active JP6687612B2 (ja) | 2014-10-24 | 2015-10-20 | 組合せ |
Country Status (16)
| Country | Link |
|---|---|
| US (2) | US20190194654A1 (ja) |
| EP (2) | EP3550019A1 (ja) |
| JP (1) | JP6687612B2 (ja) |
| KR (2) | KR20230128139A (ja) |
| CN (2) | CN115920007A (ja) |
| AU (1) | AU2015335029B2 (ja) |
| CA (1) | CA2965034C (ja) |
| DK (1) | DK3209778T3 (ja) |
| ES (1) | ES2727154T3 (ja) |
| HU (1) | HUE043227T2 (ja) |
| IL (2) | IL251813A0 (ja) |
| PL (1) | PL3209778T3 (ja) |
| RU (1) | RU2744841C2 (ja) |
| SG (2) | SG10202105879XA (ja) |
| TR (1) | TR201906415T4 (ja) |
| WO (1) | WO2016062722A1 (ja) |
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| KR20170078843A (ko) | 2014-11-21 | 2017-07-07 | 노오쓰웨스턴 유니버시티 | 구형 핵산 나노입자 접합체의 서열 특이적 세포 흡수 |
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| EP2819693A4 (en) | 2012-03-02 | 2015-10-28 | Providence Health & Services Oregon | ANTICANCER BITHERAPY BASED ON OX40 / IL-2 AGONIST |
| AU2013230881A1 (en) * | 2012-03-07 | 2014-10-30 | Board Of Trustees Of The University Of Illinois | Selective histone deactylase 6 inhibitors |
| EP2920308B1 (en) | 2012-10-31 | 2018-12-12 | Ionis Pharmaceuticals, Inc. | Cancer treatment |
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2015
- 2015-10-20 US US15/521,185 patent/US20190194654A1/en not_active Abandoned
- 2015-10-20 KR KR1020237028459A patent/KR20230128139A/ko not_active Application Discontinuation
- 2015-10-20 EP EP19166017.4A patent/EP3550019A1/en active Pending
- 2015-10-20 WO PCT/EP2015/074271 patent/WO2016062722A1/en active Application Filing
- 2015-10-20 CN CN202211353077.8A patent/CN115920007A/zh active Pending
- 2015-10-20 AU AU2015335029A patent/AU2015335029B2/en active Active
- 2015-10-20 CA CA2965034A patent/CA2965034C/en active Active
- 2015-10-20 JP JP2017522084A patent/JP6687612B2/ja active Active
- 2015-10-20 SG SG10202105879XA patent/SG10202105879XA/en unknown
- 2015-10-20 ES ES15784628T patent/ES2727154T3/es active Active
- 2015-10-20 RU RU2017117664A patent/RU2744841C2/ru active
- 2015-10-20 PL PL15784628T patent/PL3209778T3/pl unknown
- 2015-10-20 CN CN201580057882.8A patent/CN107106590B/zh active Active
- 2015-10-20 HU HUE15784628A patent/HUE043227T2/hu unknown
- 2015-10-20 KR KR1020177013607A patent/KR20170072928A/ko active Application Filing
- 2015-10-20 TR TR2019/06415T patent/TR201906415T4/tr unknown
- 2015-10-20 SG SG11201703219WA patent/SG11201703219WA/en unknown
- 2015-10-20 EP EP15784628.8A patent/EP3209778B1/en active Active
- 2015-10-20 DK DK15784628.8T patent/DK3209778T3/da active
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2017
- 2017-04-20 IL IL251813A patent/IL251813A0/en unknown
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2022
- 2022-10-13 US US18/046,173 patent/US20230374503A1/en active Pending
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2023
- 2023-07-23 IL IL304663A patent/IL304663A/en unknown
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