JP2017536548A5 - - Google Patents

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Publication number
JP2017536548A5
JP2017536548A5 JP2017527719A JP2017527719A JP2017536548A5 JP 2017536548 A5 JP2017536548 A5 JP 2017536548A5 JP 2017527719 A JP2017527719 A JP 2017527719A JP 2017527719 A JP2017527719 A JP 2017527719A JP 2017536548 A5 JP2017536548 A5 JP 2017536548A5
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JP
Japan
Prior art keywords
group
binding molecule
modified binding
chemical ligation
antibody
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JP2017527719A
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English (en)
Japanese (ja)
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JP2017536548A (ja
JP6909156B2 (ja
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Priority claimed from PCT/EP2015/077484 external-priority patent/WO2016083364A1/en
Publication of JP2017536548A publication Critical patent/JP2017536548A/ja
Publication of JP2017536548A5 publication Critical patent/JP2017536548A5/ja
Application granted granted Critical
Publication of JP6909156B2 publication Critical patent/JP6909156B2/ja
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JP2017527719A 2014-11-25 2015-11-24 化学ライゲーション及びハプテン移行を用いた近接アッセイ Active JP6909156B2 (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201462084452P 2014-11-25 2014-11-25
US62/084,452 2014-11-25
US201562116962P 2015-02-17 2015-02-17
US62/116,962 2015-02-17
PCT/EP2015/077484 WO2016083364A1 (en) 2014-11-25 2015-11-24 Proximity assays using chemical ligation and hapten transfer

Publications (3)

Publication Number Publication Date
JP2017536548A JP2017536548A (ja) 2017-12-07
JP2017536548A5 true JP2017536548A5 (https=) 2020-01-16
JP6909156B2 JP6909156B2 (ja) 2021-07-28

Family

ID=54697581

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2017527719A Active JP6909156B2 (ja) 2014-11-25 2015-11-24 化学ライゲーション及びハプテン移行を用いた近接アッセイ

Country Status (8)

Country Link
US (3) US10620217B2 (https=)
EP (1) EP3224621B1 (https=)
JP (1) JP6909156B2 (https=)
CN (1) CN107003323B (https=)
AU (1) AU2015352625B2 (https=)
CA (1) CA2965872C (https=)
DK (1) DK3224621T3 (https=)
WO (1) WO2016083364A1 (https=)

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CN107923915B (zh) 2015-08-28 2021-05-04 文塔纳医疗系统公司 使用经掩蔽的半抗原在福尔马林固定石蜡包埋的组织中的蛋白质邻近测定
EP4220164B1 (en) * 2016-12-19 2024-08-21 Ventana Medical Systems, Inc. Methods and systems for quantitative immunohistochemistry
GB2562721A (en) * 2017-05-16 2018-11-28 Fastbase Solutions Ltd Kits, methods and their uses for detecting cell-cell interactions in a sample
US10871485B2 (en) 2018-04-13 2020-12-22 Rarecyte, Inc. Kits for labeling of biomarkers and methods of using the same
US12068058B2 (en) 2018-06-11 2024-08-20 Merck Sharp & Dohme Llc Cut vertex method for identifying complex molecule substructures
WO2020102094A1 (en) * 2018-11-15 2020-05-22 Arizona Board Of Regents On Behalf Ofarizona State University Cleavable fluorescent tyramide for sensitive and multiplexed analysis of biological samples
EP4281779A1 (en) * 2021-01-25 2023-11-29 Ventana Medical Systems, Inc. Stained biological specimens including one or more biomarkers labeled with one or more detectable moieties
CN113552362B (zh) * 2021-07-23 2024-08-09 湖北百奥斯生物科技有限公司 一种新型信号放大的免疫荧光试剂盒
WO2023058624A1 (ja) * 2021-10-08 2023-04-13 コニカミノルタ株式会社 染色方法、評価方法および標本
WO2025265126A1 (en) * 2024-06-21 2025-12-26 Arizona Board Of Regents On Behalf Of Arizona State University Systems and methods for detecting biomolecular interactions

Family Cites Families (21)

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Publication number Priority date Publication date Assignee Title
US4711955A (en) 1981-04-17 1987-12-08 Yale University Modified nucleotides and methods of preparing and using same
US5266684A (en) 1988-05-02 1993-11-30 The Reagents Of The University Of California Peptide mixtures
CH683667A5 (fr) 1992-02-26 1994-04-29 Nestle Sa Matière première aromatique.
US5654419A (en) 1994-02-01 1997-08-05 The Regents Of The University Of California Fluorescent labels and their use in separations
DK0839152T3 (da) 1995-06-21 2002-07-08 Martek Biosciences Corp Kombinatoriske biblioteker af mærkede, biokemiske forbindelser og fremgangsmåde til fremstilling af disse
US5661028A (en) 1995-09-29 1997-08-26 Lockheed Martin Energy Systems, Inc. Large scale DNA microsequencing device
US6444421B1 (en) * 1997-11-19 2002-09-03 The United States Of America As Represented By The Department Of Health And Human Services Methods for detecting intermolecular interactions in vivo and in vitro
EP1681983A4 (en) * 2003-10-14 2008-12-10 Monogram Biosciences Inc RECEPTOR TYROSINE KINASE SIGNAL PATH ANALYSIS FOR DIAGNOSIS AND THERAPY
CA2606018A1 (en) 2005-04-28 2006-11-02 Ventana Medical Systems, Inc. Nanoparticle conjugates
US20060246523A1 (en) 2005-04-28 2006-11-02 Christopher Bieniarz Antibody conjugates
DK2963011T3 (en) 2005-11-23 2018-08-06 Ventana Med Syst Inc MOLECULAR CONJUGATE
WO2008063378A2 (en) 2006-11-01 2008-05-29 Ventana Medical Systems, Inc. Haptens, hapten conjugates, compositions thereof and method for their preparation and use
WO2008098100A2 (en) * 2007-02-07 2008-08-14 Perscitus Biosciences, Llc Detection of molecule proximity
WO2009032716A1 (en) * 2007-09-04 2009-03-12 Sanofi-Aventis Identifying molecules that modulate protein- protein interactions using protease activated reporters
SG172984A1 (en) * 2009-01-15 2011-08-29 Lab Corp America Holdings Methods of determining patient response by measurement of her-2 expression
CN101620233B (zh) * 2009-05-27 2012-10-31 华中科技大学 一种蛋白质相互作用的检测方法
US20120129248A1 (en) * 2009-07-31 2012-05-24 Prognosys Biosciences, Inc. Assay tools and methods of use
GB0918712D0 (en) 2009-10-26 2009-12-09 Axis Shield Diagnostics Ltd An assay
EP2831587B1 (en) 2012-03-27 2018-05-16 Ventana Medical Systems, Inc. Signaling conjugates and methods of use
DK2971064T3 (da) * 2013-03-12 2019-12-16 Ventana Med Syst Inc Nærhedsassay til in situ-påvisning af mål
CN103245789B (zh) * 2013-04-27 2014-10-29 深圳先进技术研究院 用于肿瘤病理诊断的试剂盒及对组织切片进行染色的方法

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