JP2017536548A5 - - Google Patents

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Publication number
JP2017536548A5
JP2017536548A5 JP2017527719A JP2017527719A JP2017536548A5 JP 2017536548 A5 JP2017536548 A5 JP 2017536548A5 JP 2017527719 A JP2017527719 A JP 2017527719A JP 2017527719 A JP2017527719 A JP 2017527719A JP 2017536548 A5 JP2017536548 A5 JP 2017536548A5
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JP
Japan
Prior art keywords
group
binding molecule
modified binding
chemical ligation
antibody
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JP2017527719A
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English (en)
Japanese (ja)
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JP6909156B2 (ja
JP2017536548A (ja
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Priority claimed from PCT/EP2015/077484 external-priority patent/WO2016083364A1/en
Publication of JP2017536548A publication Critical patent/JP2017536548A/ja
Publication of JP2017536548A5 publication Critical patent/JP2017536548A5/ja
Application granted granted Critical
Publication of JP6909156B2 publication Critical patent/JP6909156B2/ja
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JP2017527719A 2014-11-25 2015-11-24 化学ライゲーション及びハプテン移行を用いた近接アッセイ Active JP6909156B2 (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201462084452P 2014-11-25 2014-11-25
US62/084,452 2014-11-25
US201562116962P 2015-02-17 2015-02-17
US62/116,962 2015-02-17
PCT/EP2015/077484 WO2016083364A1 (en) 2014-11-25 2015-11-24 Proximity assays using chemical ligation and hapten transfer

Publications (3)

Publication Number Publication Date
JP2017536548A JP2017536548A (ja) 2017-12-07
JP2017536548A5 true JP2017536548A5 (https=) 2020-01-16
JP6909156B2 JP6909156B2 (ja) 2021-07-28

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ID=54697581

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2017527719A Active JP6909156B2 (ja) 2014-11-25 2015-11-24 化学ライゲーション及びハプテン移行を用いた近接アッセイ

Country Status (8)

Country Link
US (3) US10620217B2 (https=)
EP (1) EP3224621B1 (https=)
JP (1) JP6909156B2 (https=)
CN (1) CN107003323B (https=)
AU (1) AU2015352625B2 (https=)
CA (1) CA2965872C (https=)
DK (1) DK3224621T3 (https=)
WO (1) WO2016083364A1 (https=)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2016316846B2 (en) 2015-08-28 2021-07-08 Ventana Medical Systems, Inc. Protein proximity assay in formalin fixed paffafin embedded tissue using caged haptens
WO2018118786A1 (en) * 2016-12-19 2018-06-28 Ventana Medical Systems, Inc. Methods and systems for quantitative immunohistochemistry
GB2562721A (en) * 2017-05-16 2018-11-28 Fastbase Solutions Ltd Kits, methods and their uses for detecting cell-cell interactions in a sample
WO2019200326A1 (en) 2018-04-13 2019-10-17 Rarecyte, Inc. Kits for labeling of biomarkers and methods of using the same
WO2019241191A1 (en) * 2018-06-11 2019-12-19 Merck Sharp & Dohme Corp. Cut vertex method for identifying complex molecule substructures
WO2020102094A1 (en) * 2018-11-15 2020-05-22 Arizona Board Of Regents On Behalf Ofarizona State University Cleavable fluorescent tyramide for sensitive and multiplexed analysis of biological samples
WO2022156920A1 (en) * 2021-01-25 2022-07-28 Ventana Medical Systems, Inc. Stained biological specimens including one or more biomarkers labeled with one or more detectable moieties
CN113552362B (zh) * 2021-07-23 2024-08-09 湖北百奥斯生物科技有限公司 一种新型信号放大的免疫荧光试剂盒
WO2023058624A1 (ja) * 2021-10-08 2023-04-13 コニカミノルタ株式会社 染色方法、評価方法および標本
WO2025265126A1 (en) * 2024-06-21 2025-12-26 Arizona Board Of Regents On Behalf Of Arizona State University Systems and methods for detecting biomolecular interactions

Family Cites Families (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4711955A (en) 1981-04-17 1987-12-08 Yale University Modified nucleotides and methods of preparing and using same
US5266684A (en) 1988-05-02 1993-11-30 The Reagents Of The University Of California Peptide mixtures
CH683667A5 (fr) 1992-02-26 1994-04-29 Nestle Sa Matière première aromatique.
US5654419A (en) 1994-02-01 1997-08-05 The Regents Of The University Of California Fluorescent labels and their use in separations
WO1997000887A1 (en) 1995-06-21 1997-01-09 Martek Biosciences Corporation Combinatorial libraries of labeled biochemical compounds and methods for producing same
US5661028A (en) 1995-09-29 1997-08-26 Lockheed Martin Energy Systems, Inc. Large scale DNA microsequencing device
US6444421B1 (en) * 1997-11-19 2002-09-03 The United States Of America As Represented By The Department Of Health And Human Services Methods for detecting intermolecular interactions in vivo and in vitro
US7402399B2 (en) * 2003-10-14 2008-07-22 Monogram Biosciences, Inc. Receptor tyrosine kinase signaling pathway analysis for diagnosis and therapy
CA2609702C (en) 2005-04-28 2013-05-28 Ventana Medical Systems, Inc. Antibody conjugates via heterobifunctional peg linkers
CA2606018A1 (en) 2005-04-28 2006-11-02 Ventana Medical Systems, Inc. Nanoparticle conjugates
US20070117153A1 (en) 2005-11-23 2007-05-24 Christopher Bieniarz Molecular conjugate
DK2444807T3 (da) 2006-11-01 2014-08-11 Ventana Med Syst Inc Mono- og dinitropyrazolhaptenkonjugater
WO2008098100A2 (en) * 2007-02-07 2008-08-14 Perscitus Biosciences, Llc Detection of molecule proximity
CA2698362C (en) 2007-09-04 2013-03-26 Sanofi-Aventis Identifying molecules that modulate protein- protein interactions using protease activated reporters
JP2012515353A (ja) 2009-01-15 2012-07-05 ラボラトリー コーポレイション オブ アメリカ ホールディングス Ｈｅｒ−２発現の測定による患者の反応を判定する方法
CN101620233B (zh) * 2009-05-27 2012-10-31 华中科技大学 一种蛋白质相互作用的检测方法
AU2010278710A1 (en) 2009-07-31 2012-03-15 Prognosys Biosciences, Inc. Assay tools and methods of use
GB0918712D0 (en) * 2009-10-26 2009-12-09 Axis Shield Diagnostics Ltd An assay
ES2678211T3 (es) 2012-03-27 2018-08-09 Ventana Medical Systems, Inc. Conjugados de señalización y procedimientos de uso
CA2901513C (en) * 2013-03-12 2020-12-29 Ventana Medical Systems, Inc. Proximity assay for in situ detection of targets
CN103245789B (zh) * 2013-04-27 2014-10-29 深圳先进技术研究院 用于肿瘤病理诊断的试剂盒及对组织切片进行染色的方法

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