|
US4603203A
(en)
|
1983-12-14 |
1986-07-29 |
Takeda Chemical Industries, Ltd. |
3-aminopyrazolo[3,4-d]pyrimidine derivatives and production thereof
|
|
CA1251448A
(en)
|
1985-03-27 |
1989-03-21 |
William J. Coates |
Pyridazinone derivatives
|
|
US4666908A
(en)
|
1985-04-05 |
1987-05-19 |
Warner-Lambert Company |
5-Substituted pyrazolo[4,3-d]pyrimidine-7-ones and methods of use
|
|
EP0379917B1
(de)
|
1989-01-26 |
1995-08-09 |
Bayer Ag |
Optisch aktive (Meth)Acrylsäure-Derivate, ihre Herstellung, ihre Polymerisation zu optisch aktiven Polymeren und deren Verwendung
|
|
NZ238609A
(en)
|
1990-06-21 |
1993-12-23 |
Schering Corp |
Polycyclic guanine derivatives; preparation, pharmaceutical compositions,
|
|
US5294612A
(en)
|
1992-03-30 |
1994-03-15 |
Sterling Winthrop Inc. |
6-heterocyclyl pyrazolo [3,4-d]pyrimidin-4-ones and compositions and method of use thereof
|
|
AU681875B2
(en)
|
1993-02-26 |
1997-09-11 |
Schering Corporation |
2-benzyl-polycyclic guanine derivatives and process for preparing them
|
|
DE19541264A1
(de)
|
1995-11-06 |
1997-05-07 |
Bayer Ag |
Purin-6-on-derivate
|
|
US5824683A
(en)
|
1995-11-28 |
1998-10-20 |
Schering Corporation |
2'- 4'-halo- 1,1'-biphenyl!-4-yl!methyl!-5'-methyl-spiro cyclopentane-1,7' (8'H)- 3H! imidazo 2,1-b!purin!-4' (5'H)-ones
|
|
DE19702785A1
(de)
|
1997-01-27 |
1998-07-30 |
Bayer Ag |
Neue cyclische Harnstoffderivate
|
|
SE9701398D0
(sv)
|
1997-04-15 |
1997-04-15 |
Astra Pharma Prod |
Novel compounds
|
|
IT1291372B1
(it)
|
1997-05-21 |
1999-01-07 |
Schering Plough S P A |
Uso di analoghi eterociclici di 1,2,4-triazolo (1,5-c) pirimidine per la preparazione di medicamenti utili per il trattamento delle malattie
|
|
US6013621A
(en)
|
1997-10-17 |
2000-01-11 |
The Rockfeller University |
Method of treating psychosis and/or hyperactivity
|
|
GB9722520D0
(en)
|
1997-10-24 |
1997-12-24 |
Pfizer Ltd |
Compounds
|
|
DE19931206A1
(de)
|
1999-07-07 |
2001-01-11 |
Stief Christian |
Arzneimittel zur Erhöhung des cAMP-Spiegels und deren Verwendung
|
|
CZ20021151A3
(cs)
|
1999-10-11 |
2003-03-12 |
Pfizer Inc. |
5-(2-substituovaný-5-heterocyklylsulfonylpyrid-3-yl)-dihydropyrazolo[4,3-d]-pyrimidin-7-ony jako inhibitory fosfodiesterasy
|
|
IL152925A
(en)
|
1999-10-21 |
2010-04-15 |
Pfizer |
Pharmaceutical preparations for the treatment of neurological disease containing an inhibitor of ring guanizine '3', 5 '- monophosphate phosphodiesterase 5 and one of gabapentin or pregabalin
|
|
CA2407031A1
(en)
|
2000-04-19 |
2001-10-25 |
Lilly Icos Llc |
Use of cyclic gmp-specific phosphodiesterase inhibitors for treatment of parkinson's disease
|
|
WO2002009713A2
(de)
|
2000-08-01 |
2002-02-07 |
Bayer Aktiengesellschaft |
Selektive pde 2-inhibitoren als arzneimittel zur verbesserung der wahrnehmung
|
|
DE10064105A1
(de)
|
2000-12-21 |
2002-06-27 |
Bayer Ag |
Neue Substituierte Imidazotriazinone
|
|
DE10108752A1
(de)
|
2001-02-23 |
2002-09-05 |
Bayer Ag |
Neue Substituierte Imidazotriazinone
|
|
SE0102315D0
(sv)
|
2001-06-28 |
2001-06-28 |
Astrazeneca Ab |
Compounds
|
|
DE60226615D1
(cg-RX-API-DMAC7.html)
|
2001-08-28 |
2008-06-26 |
Schering Corp |
|
|
IL160307A0
(en)
|
2001-08-31 |
2004-07-25 |
Univ Rockefeller |
Phosphodiesterase activity and regulation of phosphodiesterase 1-b-mediated signaling in brain
|
|
CA2465893A1
(en)
|
2001-11-09 |
2003-05-22 |
Schering Corporation |
Polycyclic guanine derivative phosphodiesterase v inhibitors
|
|
EP1476200A4
(en)
|
2002-02-21 |
2008-08-13 |
Univ Rockefeller |
COMPOSITION AND METHOD FOR REGULATING CALCIUM DEPENDENT SIGNALING IN THE BRAIN
|
|
WO2004041258A2
(fr)
|
2002-10-30 |
2004-05-21 |
Neuro3D |
Utilisation d’inhibiteurs des phosphodiesterases des nucleotides cycliques, ayant une structure benzodiazepinique en therapie
|
|
CA2504820C
(en)
|
2002-11-06 |
2011-08-23 |
Grelan Pharmaceutical Co., Ltd. |
Pyrazolonaphthyridine derivatives
|
|
EP1601675A1
(en)
|
2003-03-04 |
2005-12-07 |
ALTANA Pharma AG |
Purin-6-one-derivatives
|
|
EP1613747A1
(en)
|
2003-03-31 |
2006-01-11 |
Pfizer Products Inc. |
Crystal structure of 3 ,5 -cyclic nucleotide phosphodiesterase 1b (pde1b) and uses thereof
|
|
AU2004226353A1
(en)
|
2003-04-01 |
2004-10-14 |
Laboratoires Serono Sa |
Inhibitors of phosphodiesterases in infertility
|
|
US7268133B2
(en)
*
|
2003-04-23 |
2007-09-11 |
Pfizer, Inc. Patent Department |
Cannabinoid receptor ligands and uses thereof
|
|
WO2005041957A1
(en)
|
2003-10-29 |
2005-05-12 |
Pfizer Products Inc. |
Oxindole derivatives and their use as phosphodiesterase type 2 inhibitors
|
|
AU2004303609A1
(en)
|
2003-12-16 |
2005-07-07 |
Pfizer Products Inc. |
Pyrido[2,3-d]pyrimidine-2,4-diamines as PDE 2 inhibitors
|
|
EP1548011A1
(en)
|
2003-12-23 |
2005-06-29 |
Neuro3D |
Benzo[1,4]diazepin-2-one derivatives as phosphodiesterase PDE2 inhibitors, preparation and therapeutic use thereof
|
|
WO2005083069A1
(en)
*
|
2004-01-30 |
2005-09-09 |
Pfizer Products Inc. |
Pde2 crystal structures for structure based drug design
|
|
EP1791543B1
(en)
|
2004-09-02 |
2010-06-16 |
Nycomed GmbH |
Triazolophthalazines
|
|
JP5130053B2
(ja)
|
2005-01-05 |
2013-01-30 |
ニコメッド ゲゼルシャフト ミット ベシュレンクテル ハフツング |
トリアゾロフタラジン
|
|
CA2592007C
(en)
|
2005-01-05 |
2013-12-10 |
Altana Pharma Ag |
Triazolophthalazines
|
|
DOP2006000009A
(es)
*
|
2005-01-13 |
2006-08-15 |
Arena Pharm Inc |
Procedimiento para preparar eteres de pirazolo [3,4-d] pirimidina
|
|
EP1888534B1
(en)
|
2005-06-06 |
2017-07-26 |
Intra-Cellular Therapies, Inc. |
Organic compounds
|
|
EP1749824A1
(en)
|
2005-08-03 |
2007-02-07 |
Neuro3D |
Benzodiazepine derivatives, their preparation and the therapeutic use thereof
|
|
WO2007025103A2
(en)
|
2005-08-23 |
2007-03-01 |
Intra-Cellular Therapies, Inc. |
Organic compounds for treating reduced dopamine receptor signalling activity
|
|
WO2007032466A1
(ja)
|
2005-09-15 |
2007-03-22 |
Aska Pharmaceutical Co., Ltd. |
複素環化合物、その製造方法並びに用途
|
|
AU2006304787A1
(en)
|
2005-10-21 |
2007-04-26 |
Braincells, Inc. |
Modulation of neurogenesis by PDE inhibition
|
|
US9255099B2
(en)
|
2006-06-06 |
2016-02-09 |
Intra-Cellular Therapies, Inc. |
Pyrazolo[3,4-D]pyrimidine-4,6(5H,7H)-diones as phosphodiesterase 1 inhibitors
|
|
JP2010509399A
(ja)
|
2006-11-13 |
2010-03-25 |
イントラ−セルラー・セラピーズ・インコーポレイテッド |
有機化合物
|
|
EP2089034A4
(en)
|
2006-12-05 |
2010-07-28 |
Intra Cellular Therapies Inc |
NEW USES
|
|
GEP20125405B
(en)
|
2007-05-11 |
2012-02-27 |
Pfizer |
Amino-heterocyclic compounds
|
|
US7807629B1
(en)
|
2007-06-05 |
2010-10-05 |
Alcon Research, Ltd. |
Use of bradykinin and related B2R agonists to treat ocular hypertension and glaucoma
|
|
DK2240490T3
(da)
|
2007-12-06 |
2013-12-16 |
Takeda Pharmaceutical |
Organiske forbindelser
|
|
AU2008331833A1
(en)
|
2007-12-06 |
2009-06-11 |
Intra-Cellular Therapies, Inc |
Organic compounds
|
|
EP2355657A4
(en)
|
2008-10-31 |
2012-05-09 |
Corridor Pharmaceuticals Inc |
Compositions and methods for treating endothelial dysfunction
|
|
US20100120762A1
(en)
|
2008-11-07 |
2010-05-13 |
Wyeth |
Triazine derivatives as inhibitors of phosphodiesterases
|
|
WO2010054260A1
(en)
|
2008-11-07 |
2010-05-14 |
Biotie Therapies Gmbh |
Imidazo[5,1-c][1,2,4]benzotriazine derivatives as inhibitors of phosphodiesterases
|
|
ES2544976T3
(es)
|
2008-12-06 |
2015-09-07 |
Intra-Cellular Therapies, Inc. |
Compuestos de 4,5,7,8-tetrahidro-2H-imidazo[1,2-a]pirrolo[3,4-e]pirimidina como inhibidores de la PDE1
|
|
BRPI0922131A2
(pt)
|
2008-12-06 |
2015-08-18 |
Intracellular Therapies Inc |
Compostos orgânicos
|
|
PE20110922A1
(es)
|
2008-12-06 |
2012-01-22 |
Intra Cellular Therapies Inc |
DERIVADOS DE PIRAZOLO[4,3-e]PIRIMIDIN COMO INHIBIDORES DE LA FOSFODIESTERASA 1 (PDE1)
|
|
GEP20146029B
(en)
|
2008-12-06 |
2014-02-10 |
Intracellular Therapies Inc |
Organic compounds
|
|
US8927556B2
(en)
|
2008-12-06 |
2015-01-06 |
Intra-Cellular Therapies, Inc. |
1H-pyrrolo[3,4-D]pyrimidin-2(6H)-one compounds
|
|
SG171777A1
(en)
|
2008-12-06 |
2011-07-28 |
Intra Cellular Therapies Inc |
Organic compounds
|
|
JP2012518685A
(ja)
|
2009-02-25 |
2012-08-16 |
イントラ−セルラー・セラピーズ・インコーポレイテッド |
眼障害のためのpde1阻害剤
|
|
WO2010132127A1
(en)
|
2009-05-13 |
2010-11-18 |
Intra-Cellular Therapies, Inc. |
Organic compounds
|
|
EP2456440B1
(en)
|
2009-07-22 |
2015-08-19 |
Merck Sharp & Dohme Corp. |
Quinolinone pde2 inhibitors
|
|
EP2485771A4
(en)
|
2009-10-08 |
2014-11-12 |
Intra Cellular Therapies Inc |
TRACER AND METHODS TAGGED ON PHOSPHODIESTERASE 1
|
|
US20120220624A1
(en)
|
2009-10-19 |
2012-08-30 |
Tony Siu |
Pyrazolo [3,4-b] pyridin-4-one kinase inhibitors
|
|
US9434730B2
(en)
|
2010-05-31 |
2016-09-06 |
Intra-Cellular Therapies, Inc. |
PDE1 inhibitor compounds
|
|
TW201206937A
(en)
|
2010-05-31 |
2012-02-16 |
Intra Cellular Therapies Inc |
Organic compounds
|
|
EP2590657A4
(en)
|
2010-05-31 |
2014-02-12 |
Intra Cellular Therapies Inc |
ORGANIC CONNECTIONS
|
|
US9763948B2
(en)
|
2010-05-31 |
2017-09-19 |
Intra-Cellular Therapies, Inc. |
PDE1 inhibitory compounds and methods
|
|
US9540379B2
(en)
|
2011-01-31 |
2017-01-10 |
Boehringer Ingelheim International Gmbh |
(1,2,4)triazolo[4,3-A]quinoxaline derivatives as inhibitors of phosphodiesterases
|
|
AU2012221828C1
(en)
|
2011-02-23 |
2015-10-01 |
Pfizer Inc. |
Imidazo[5,1-f][1,2,4]triazines for treatment of neurological disorders
|
|
US8829010B2
(en)
|
2011-06-07 |
2014-09-09 |
Pfizer Inc. |
Pyrazolo[3,4-d]pyrimidine compounds and their use as PDE2 inhibitors and/or CYP3A4 inhibitors
|
|
US10561656B2
(en)
|
2011-06-10 |
2020-02-18 |
Intra-Cellular Therapies, Inc. |
Organic compounds
|
|
EA027418B1
(ru)
|
2011-06-27 |
2017-07-31 |
Янссен Фармацевтика Нв |
ПРОИЗВОДНЫЕ 1-АРИЛ-4-МЕТИЛ[1,2,4]ТРИАЗОЛО[4,3-a]ХИНОКСАЛИНА, ФАРМАЦЕВТИЧЕСКАЯ КОМПОЗИЦИЯ НА ИХ ОСНОВЕ, СПОСОБЫ ПОЛУЧЕНИЯ И ПРИМЕНЕНИЯ ИХ, ПРОМЕЖУТОЧНЫЕ СОЕДИНЕНИЯ
|
|
WO2013034758A1
(en)
|
2011-09-09 |
2013-03-14 |
H. Lundbeck A/S |
Substituted triazolopyrazines and uses thereof
|
|
WO2013034755A1
(en)
|
2011-09-09 |
2013-03-14 |
H. Lundbeck A/S |
Triazolopyrazine derivatives and their use for treating neurological and psychiatric disorders
|
|
US9056863B2
(en)
|
2011-09-09 |
2015-06-16 |
H. Lundbeck A/S |
Substituted 2,3,5,9,9B-pentaazacyclopenta[a]naphthalenes and uses thereof
|
|
AR091507A1
(es)
|
2012-06-21 |
2015-02-11 |
Intra Cellular Therapies Inc |
SALES DE (6aR,9aS)-5,6a,7,8,9,9a-HEXAHIDRO-5-METIL-3-(FENILAMINO)-2-((4-(6-FLUOROPIRIDIN-2-IL)FENIL)METIL)-CICLOPENT[4,5]IMIDAZO[1,2-a]PIRAZOLO[4,3-e]PIRIMIDIN-4(2H)-ONA
|
|
TWI659032B
(zh)
|
2013-03-15 |
2019-05-11 |
美商內胞醫療公司 |
有機化合物及其用途
|
|
CA2907532A1
(en)
|
2013-03-25 |
2014-10-02 |
Sanofi |
Pyrazolonaphthyridinone derivatives as metap2 inhibitors (methionine aminopeptidase type-2)
|
|
US9546175B2
(en)
|
2014-08-07 |
2017-01-17 |
Intra-Cellular Therapies, Inc. |
Organic compounds
|