PT2978764T - Derivados de pirazolonaftiridinona como inibidores de metap2 (aminopeptidase de metionina tipo-2) - Google Patents
Derivados de pirazolonaftiridinona como inibidores de metap2 (aminopeptidase de metionina tipo-2)Info
- Publication number
- PT2978764T PT2978764T PT147115240T PT14711524T PT2978764T PT 2978764 T PT2978764 T PT 2978764T PT 147115240 T PT147115240 T PT 147115240T PT 14711524 T PT14711524 T PT 14711524T PT 2978764 T PT2978764 T PT 2978764T
- Authority
- PT
- Portugal
- Prior art keywords
- pyrazolonaphthyridinone
- derivatives
- methionine aminopeptidase
- metap2 inhibitors
- aminopeptidase type
- Prior art date
Links
- 101710181812 Methionine aminopeptidase Proteins 0.000 title 1
- 239000003112 inhibitor Substances 0.000 title 1
- YJTVMKYUFDOGJU-UHFFFAOYSA-N pyrazolo[4,3-b][1,8]naphthyridin-3-one Chemical class N1=NC(C=2C1=CC=1C=CC=NC1N2)=O YJTVMKYUFDOGJU-UHFFFAOYSA-N 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
- C07D471/14—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic Table
- C07F5/02—Boron compounds
- C07F5/04—Esters of boric acids
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Rheumatology (AREA)
- Physical Education & Sports Medicine (AREA)
- Tropical Medicine & Parasitology (AREA)
- Pain & Pain Management (AREA)
- Child & Adolescent Psychology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Gastroenterology & Hepatology (AREA)
- Endocrinology (AREA)
- Reproductive Health (AREA)
- Pulmonology (AREA)
- Dermatology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Ophthalmology & Optometry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Epidemiology (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP13305365 | 2013-03-25 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PT2978764T true PT2978764T (pt) | 2017-07-17 |
Family
ID=48040135
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PT147115240T PT2978764T (pt) | 2013-03-25 | 2014-03-21 | Derivados de pirazolonaftiridinona como inibidores de metap2 (aminopeptidase de metionina tipo-2) |
Country Status (17)
| Country | Link |
|---|---|
| US (1) | US9856257B2 (pt) |
| EP (1) | EP2978764B1 (pt) |
| JP (1) | JP2016515541A (pt) |
| KR (1) | KR20150135406A (pt) |
| CN (1) | CN105246893B (pt) |
| AU (1) | AU2014243257A1 (pt) |
| BR (1) | BR112015024189A2 (pt) |
| CA (1) | CA2907532A1 (pt) |
| DK (1) | DK2978764T3 (pt) |
| ES (1) | ES2633440T3 (pt) |
| IL (1) | IL241447A0 (pt) |
| MX (1) | MX2015013740A (pt) |
| PL (1) | PL2978764T3 (pt) |
| PT (1) | PT2978764T (pt) |
| RU (1) | RU2015145479A (pt) |
| SG (1) | SG11201507519RA (pt) |
| WO (1) | WO2014154586A1 (pt) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB201406486D0 (en) * | 2014-04-10 | 2014-05-28 | Redx Pharma Ltd | Antibacterial compounds |
| KR102562576B1 (ko) * | 2014-12-06 | 2023-08-01 | 인트라-셀룰라 써래피스, 인코퍼레이티드. | 유기 화합물 |
| JP6608934B2 (ja) | 2014-12-06 | 2019-11-20 | イントラ−セルラー・セラピーズ・インコーポレイテッド | 有機化合物 |
| WO2017046606A1 (en) * | 2015-09-18 | 2017-03-23 | Redx Pharma Plc | Antibacterial compounds |
| TWI782056B (zh) * | 2017-07-14 | 2022-11-01 | 日商鹽野義製藥股份有限公司 | 具有ｍｇａｔ２抑制活性的縮合環衍生物 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1925617B1 (en) | 2005-09-15 | 2012-11-14 | ASKA Pharmaceutical Co., Ltd. | Heterocyclic compound, and production process and use thereof |
| BRPI0816132B1 (pt) * | 2007-08-27 | 2019-06-18 | Basf Se | Métodos para controlar pestes invertebradas, e para proteger material de propagação de planta e/ou plantas que crescem a partir dos mesmos, material de propagação de planta, método para tratar ou proteger um animal contra infestação ou infecção por parasitas, composto de pirazol, e, composição agrícola |
| CN103748094B (zh) * | 2011-05-06 | 2016-06-29 | 扎夫根股份有限公司 | 三环磺酰胺化合物及其制备和使用方法 |
| DK2573073T3 (en) | 2011-09-26 | 2015-01-19 | Sanofi Sa | Pyrazolquinolinonderivater, their preparation and therapeutic use thereof |
| US20140235616A1 (en) | 2011-09-26 | 2014-08-21 | Sanofi | Pyrazoloquinolinone derivatives, preparation thereof and therapeutic use thereof |
| US9169246B2 (en) | 2011-09-26 | 2015-10-27 | Sanofi | Pyrazoloquinolinone derivatives, preparation thereof and therapeutic use thereof |
-
2014
- 2014-03-21 PT PT147115240T patent/PT2978764T/pt unknown
- 2014-03-21 ES ES14711524.0T patent/ES2633440T3/es active Active
- 2014-03-21 WO PCT/EP2014/055719 patent/WO2014154586A1/en active Application Filing
- 2014-03-21 MX MX2015013740A patent/MX2015013740A/es unknown
- 2014-03-21 US US14/778,948 patent/US9856257B2/en not_active Expired - Fee Related
- 2014-03-21 PL PL14711524T patent/PL2978764T3/pl unknown
- 2014-03-21 DK DK14711524.0T patent/DK2978764T3/en active
- 2014-03-21 CN CN201480029260.XA patent/CN105246893B/zh not_active Expired - Fee Related
- 2014-03-21 JP JP2016503675A patent/JP2016515541A/ja active Pending
- 2014-03-21 EP EP14711524.0A patent/EP2978764B1/en not_active Not-in-force
- 2014-03-21 AU AU2014243257A patent/AU2014243257A1/en not_active Abandoned
- 2014-03-21 RU RU2015145479A patent/RU2015145479A/ru not_active Application Discontinuation
- 2014-03-21 KR KR1020157030319A patent/KR20150135406A/ko not_active Application Discontinuation
- 2014-03-21 SG SG11201507519RA patent/SG11201507519RA/en unknown
- 2014-03-21 BR BR112015024189A patent/BR112015024189A2/pt not_active Application Discontinuation
- 2014-03-21 CA CA2907532A patent/CA2907532A1/en not_active Abandoned
-
2015
- 2015-09-10 IL IL241447A patent/IL241447A0/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CA2907532A1 (en) | 2014-10-02 |
| WO2014154586A1 (en) | 2014-10-02 |
| IL241447A0 (en) | 2015-11-30 |
| MX2015013740A (es) | 2016-02-29 |
| RU2015145479A (ru) | 2017-05-02 |
| EP2978764B1 (en) | 2017-04-19 |
| SG11201507519RA (en) | 2015-10-29 |
| JP2016515541A (ja) | 2016-05-30 |
| US20160060265A1 (en) | 2016-03-03 |
| PL2978764T3 (pl) | 2017-09-29 |
| KR20150135406A (ko) | 2015-12-02 |
| US9856257B2 (en) | 2018-01-02 |
| BR112015024189A2 (pt) | 2017-07-18 |
| EP2978764A1 (en) | 2016-02-03 |
| CN105246893A (zh) | 2016-01-13 |
| AU2014243257A1 (en) | 2015-10-15 |
| DK2978764T3 (en) | 2017-07-31 |
| ES2633440T3 (es) | 2017-09-21 |
| CN105246893B (zh) | 2017-10-27 |
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