JP2017536385A5 - - Google Patents
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- Publication number
- JP2017536385A5 JP2017536385A5 JP2017528789A JP2017528789A JP2017536385A5 JP 2017536385 A5 JP2017536385 A5 JP 2017536385A5 JP 2017528789 A JP2017528789 A JP 2017528789A JP 2017528789 A JP2017528789 A JP 2017528789A JP 2017536385 A5 JP2017536385 A5 JP 2017536385A5
- Authority
- JP
- Japan
- Prior art keywords
- difluorophenyl
- piperazin
- triazol
- tetrahydrofuran
- methoxy
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP14196662.2 | 2014-12-05 | ||
| EP14196662 | 2014-12-05 | ||
| PCT/GB2015/053733 WO2016087880A1 (en) | 2014-12-05 | 2015-12-04 | Antimycotic compound |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2017536385A JP2017536385A (ja) | 2017-12-07 |
| JP2017536385A5 true JP2017536385A5 (https=) | 2019-01-31 |
| JP6666345B2 JP6666345B2 (ja) | 2020-03-13 |
Family
ID=52006914
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017528775A Active JP6669751B2 (ja) | 2014-12-05 | 2015-12-04 | 抗真菌化合物 |
| JP2017528789A Active JP6666345B2 (ja) | 2014-12-05 | 2015-12-04 | 抗真菌化合物 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017528775A Active JP6669751B2 (ja) | 2014-12-05 | 2015-12-04 | 抗真菌化合物 |
Country Status (18)
| Country | Link |
|---|---|
| US (12) | US10106531B2 (https=) |
| EP (2) | EP3227277B1 (https=) |
| JP (2) | JP6669751B2 (https=) |
| KR (1) | KR102579848B1 (https=) |
| CN (2) | CN107001343B (https=) |
| AU (1) | AU2015356795B2 (https=) |
| BR (1) | BR112017008481B1 (https=) |
| CA (1) | CA2963625C (https=) |
| DK (2) | DK3227278T3 (https=) |
| EA (1) | EA033736B1 (https=) |
| ES (2) | ES2786374T3 (https=) |
| HU (2) | HUE048905T2 (https=) |
| IL (1) | IL251631B (https=) |
| MX (1) | MX370412B (https=) |
| PL (1) | PL3227277T3 (https=) |
| PT (1) | PT3227277T (https=) |
| SG (1) | SG11201702835RA (https=) |
| WO (2) | WO2016087880A1 (https=) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3227277B1 (en) | 2014-12-05 | 2020-02-05 | Pulmocide Limited | Antimycotic compound |
| JP6694886B2 (ja) | 2014-12-18 | 2020-05-20 | プルモシデ リミテド | ４，５−ジヒドロ−６Ｈ−チエノ［３，２−ｄ］ベンゾアゼピン誘導体及び呼吸器合胞体ウイルス（ＲＳＶ）感染を治療するためのその使用 |
| KR102653821B1 (ko) | 2015-05-21 | 2024-04-02 | 풀모사이드 리미티드 | 항진균성 4-(4-(4-(((3r,5r)-5-((1h-1,2,4-트리아졸-1-일)메틸)-5-(2,4-디플루오로페닐)테트라하이드로푸란-3-일)메톡시)-3-메틸페닐)피페라진-1-일)-n-(2-하이드록시사이클로헥실)벤즈아미드 또는 이의 약학적으로 허용가능한 염. |
| WO2017093491A1 (en) * | 2015-12-04 | 2017-06-08 | Pulmocide Limited | Antimycotic triazole compound |
| WO2018096405A1 (en) * | 2016-11-28 | 2018-05-31 | Cellix Bio Private Limited | Compositions and methods for the treatment of oral infectious diseases |
| US11185548B2 (en) | 2016-12-23 | 2021-11-30 | Helmholtz Zentrum Munchen—Deutsches Forschungszentrum Für Gesundheit Und Umwelt (Gmbh) | Inhibitors of cytochrome P450 family 7 subfamily B member 1 (CYP7B1) for use in treating diseases |
| GB201917867D0 (en) * | 2019-12-06 | 2020-01-22 | Pulmocide Ltd | Polymorphs |
| EP3858357A1 (en) * | 2020-01-28 | 2021-08-04 | Diaccurate | Use of azole compounds to stimulate the immune system and as inhibitors for s-pla2gib |
| RU2770598C1 (ru) * | 2021-06-29 | 2022-04-18 | Федеральное государственное автономное образовательное учреждение высшего образования "Пермский государственный национальный исследовательский университет" (ПГНИУ) | ПРИМЕНЕНИЕ ПРОТИВОГРИБКОВОГО СРЕДСТВА НА ОСНОВЕ 2-((4-R1-5-R2-3-(ЭТОКСИКАРБОНИЛ)ТИОФЕН-2-ИЛ)АМИНО)-4-ОКСО-4-R3-БУТ-2-ЕНОВЫХ КИСЛОТ ПО ОТНОШЕНИЮ К Candida aldicans |
| TW202541814A (zh) | 2023-11-30 | 2025-11-01 | 瑞士商巴塞利亞阿爾斯維爾藥業國際股份有限公司 | 用於治療真菌感染的藥物組合 |
Family Cites Families (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5533466A (en) * | 1978-07-14 | 1980-03-08 | Janssen Pharmaceutica Nv | Novel azole derivatives and their manufacture |
| CH655103A5 (de) * | 1983-03-11 | 1986-03-27 | Sandoz Ag | Azolderivate, verfahren zu ihrer herstellung und ihre verwendung. |
| CA1292472C (en) | 1985-12-03 | 1991-11-26 | Alfonsus Guilielmus Knaeps | Derivatives of ¬¬4-¬4-(4-phenyl-1-piperazinyl)- phenoxymethyl|-1,3-dioxolan-2-yl|methyl|-1h-imidazoles and 1h-1,2,4-triazoles |
| DE3609598A1 (de) * | 1986-03-21 | 1987-10-01 | Hoechst Ag | 2-azolylmethyl-2-aryl-1,3-dioxolane und deren salze, verfahren zu ihrer herstellung, sie enthaltende mittel und ihre verwendung |
| DE3852477T2 (de) | 1987-11-20 | 1995-05-04 | Schering Corp | Tri- und tetrasubstituierte Oxetane und Tetrahydrofurane und deren Zwischenprodukte. |
| US5039678A (en) | 1989-03-23 | 1991-08-13 | Wake Forest University | Method of increasing cranial vessel proliferation by administering nimodipine |
| US5039676A (en) | 1990-05-11 | 1991-08-13 | Schering Corporation | Tri- and tetra-substituted-oxetanes and tetrahydrofurans and intermediates thereof |
| US5403937A (en) * | 1993-04-30 | 1995-04-04 | Schering Corporation | Process for preparing intermediates for the synthesis of antifungal agents |
| US5714490A (en) | 1993-12-21 | 1998-02-03 | Schering Corporation | Tetrahydrofuran antifungals |
| PL181193B1 (pl) | 1993-12-21 | 2001-06-29 | Schering Corp | Nowe pochodne tetrahydrofuranowe o działaniu przeciwgrzybicznym, kompozycja farmaceutyczna do leczenia infekcji grzybiczych oraz sposób wytwarzania tych związków |
| US5486625A (en) | 1994-07-08 | 1996-01-23 | Schering Corporation | Process for the preparation of chiral intermediates useful for the synthesis of antifungal agents |
| HUP9701690A3 (en) | 1995-06-02 | 1998-04-28 | Schering Corp Kenilwort | Tetrahydrofuran derivatives as antifungals and pharmaceutical compositions containing the same |
| EP0957101A1 (en) | 1998-05-14 | 1999-11-17 | Janssen Pharmaceutica N.V. | Water soluble azoles as broad-spectrum antifungals |
| EP1372394A1 (en) | 2001-04-03 | 2004-01-02 | Schering Corporation | Antifungal composition with enhanced bioavailability |
| CA2709784A1 (en) * | 2007-12-21 | 2009-07-09 | University Of Rochester | Method for altering the lifespan of eukaryotic organisms |
| US8324385B2 (en) * | 2008-10-30 | 2012-12-04 | Madrigal Pharmaceuticals, Inc. | Diacylglycerol acyltransferase inhibitors |
| EP2734517B1 (en) * | 2011-07-18 | 2017-08-30 | Merck Patent GmbH | Benzamides |
| US9346791B2 (en) | 2011-09-07 | 2016-05-24 | The Johns Hopkins University | Itraconazole analogs and use thereof |
| EP3227277B1 (en) | 2014-12-05 | 2020-02-05 | Pulmocide Limited | Antimycotic compound |
| GB201917867D0 (en) | 2019-12-06 | 2020-01-22 | Pulmocide Ltd | Polymorphs |
-
2015
- 2015-12-04 EP EP15808770.0A patent/EP3227277B1/en active Active
- 2015-12-04 CN CN201580066092.6A patent/CN107001343B/zh active Active
- 2015-12-04 DK DK15817507.5T patent/DK3227278T3/da active
- 2015-12-04 KR KR1020177013730A patent/KR102579848B1/ko active Active
- 2015-12-04 CN CN202011308132.2A patent/CN112375073B/zh active Active
- 2015-12-04 MX MX2017007188A patent/MX370412B/es active IP Right Grant
- 2015-12-04 SG SG11201702835RA patent/SG11201702835RA/en unknown
- 2015-12-04 WO PCT/GB2015/053733 patent/WO2016087880A1/en not_active Ceased
- 2015-12-04 JP JP2017528775A patent/JP6669751B2/ja active Active
- 2015-12-04 ES ES15817507T patent/ES2786374T3/es active Active
- 2015-12-04 HU HUE15808770A patent/HUE048905T2/hu unknown
- 2015-12-04 HU HUE15817507A patent/HUE048685T2/hu unknown
- 2015-12-04 BR BR112017008481-3A patent/BR112017008481B1/pt active IP Right Grant
- 2015-12-04 PL PL15808770T patent/PL3227277T3/pl unknown
- 2015-12-04 CA CA2963625A patent/CA2963625C/en active Active
- 2015-12-04 EP EP15817507.5A patent/EP3227278B1/en active Active
- 2015-12-04 DK DK15808770.0T patent/DK3227277T3/da active
- 2015-12-04 EA EA201791174A patent/EA033736B1/ru not_active IP Right Cessation
- 2015-12-04 ES ES15808770T patent/ES2790875T3/es active Active
- 2015-12-04 PT PT158087700T patent/PT3227277T/pt unknown
- 2015-12-04 JP JP2017528789A patent/JP6666345B2/ja active Active
- 2015-12-04 WO PCT/GB2015/053731 patent/WO2016087878A1/en not_active Ceased
- 2015-12-04 US US15/524,505 patent/US10106531B2/en active Active
- 2015-12-04 AU AU2015356795A patent/AU2015356795B2/en active Active
-
2016
- 2016-10-20 US US15/298,431 patent/US10093659B2/en active Active
-
2017
- 2017-04-06 IL IL251631A patent/IL251631B/en active IP Right Grant
-
2018
- 2018-09-12 US US16/129,322 patent/US10487073B2/en active Active
- 2018-09-24 US US16/139,591 patent/US10344022B2/en active Active
-
2019
- 2019-05-24 US US16/422,062 patent/US10450304B2/en active Active
- 2019-09-12 US US16/569,128 patent/US10662179B2/en active Active
- 2019-10-04 US US16/593,444 patent/US10800762B2/en active Active
-
2020
- 2020-04-15 US US16/849,476 patent/US10858345B2/en active Active
- 2020-09-04 US US17/012,685 patent/US11008307B2/en active Active
- 2020-11-04 US US17/089,441 patent/US11661415B2/en active Active
-
2021
- 2021-04-14 US US17/230,009 patent/US20210238169A1/en not_active Abandoned
-
2023
- 2023-04-18 US US18/302,557 patent/US12269814B2/en active Active
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