AU2015356795B2 - Antimycotic compound - Google Patents
Antimycotic compound Download PDFInfo
- Publication number
- AU2015356795B2 AU2015356795B2 AU2015356795A AU2015356795A AU2015356795B2 AU 2015356795 B2 AU2015356795 B2 AU 2015356795B2 AU 2015356795 A AU2015356795 A AU 2015356795A AU 2015356795 A AU2015356795 A AU 2015356795A AU 2015356795 B2 AU2015356795 B2 AU 2015356795B2
- Authority
- AU
- Australia
- Prior art keywords
- compound
- salt
- formula
- treatment
- mmol
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Links
- 0 CC(*)Cc(c(F)c1)ccc1F Chemical compound CC(*)Cc(c(F)c1)ccc1F 0.000 description 7
- OFCKPSLERZREGN-UHFFFAOYSA-N CC(C)(C)OC(N(CC1)CCN1c(cc1)ccc1C(Nc(cc1)ccc1F)=O)=O Chemical compound CC(C)(C)OC(N(CC1)CCN1c(cc1)ccc1C(Nc(cc1)ccc1F)=O)=O OFCKPSLERZREGN-UHFFFAOYSA-N 0.000 description 1
- IWJGMJHAIUBWKT-UHFFFAOYSA-N Cc(cc(cc1)Br)c1O Chemical compound Cc(cc(cc1)Br)c1O IWJGMJHAIUBWKT-UHFFFAOYSA-N 0.000 description 1
- SFQAWTDVQDGTPV-VFNWGFHPSA-N Cc(cc(cc1)Br)c1OC[C@@H](C1)CO[C@@]1(C[n]1ncnc1)c(c(F)c1)ccc1F Chemical compound Cc(cc(cc1)Br)c1OC[C@@H](C1)CO[C@@]1(C[n]1ncnc1)c(c(F)c1)ccc1F SFQAWTDVQDGTPV-VFNWGFHPSA-N 0.000 description 1
- MZBLEEOPYOLKPD-KRWDZBQOSA-N Cc(cc(cc1)Br)c1OC[C@@H](CCc(c(F)c1)ccc1F)COCC[n]1ncnc1 Chemical compound Cc(cc(cc1)Br)c1OC[C@@H](CCc(c(F)c1)ccc1F)COCC[n]1ncnc1 MZBLEEOPYOLKPD-KRWDZBQOSA-N 0.000 description 1
- ITKPHVYYHCMODU-UHFFFAOYSA-N Cc(cc(cc1)N(CC2)CCN2P)c1O Chemical compound Cc(cc(cc1)N(CC2)CCN2P)c1O ITKPHVYYHCMODU-UHFFFAOYSA-N 0.000 description 1
- OVDRQGWNRFUGKH-IANOAQMISA-N Cc(cc(cc1)N(CC2)CCN2c(cc2)ccc2C(OC)=O)c1OC[C@@H](C1)CO[C@@]1(C[n]1ncnc1)c(c(F)c1)ccc1F Chemical compound Cc(cc(cc1)N(CC2)CCN2c(cc2)ccc2C(OC)=O)c1OC[C@@H](C1)CO[C@@]1(C[n]1ncnc1)c(c(F)c1)ccc1F OVDRQGWNRFUGKH-IANOAQMISA-N 0.000 description 1
- QEBCBVBUQNDEQN-UHFFFAOYSA-N Cc(cc(cc1)NCCNc(cc2)ccc2C(Nc(cc2)ccc2F)=O)c1O Chemical compound Cc(cc(cc1)NCCNc(cc2)ccc2C(Nc(cc2)ccc2F)=O)c1O QEBCBVBUQNDEQN-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/14—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D295/155—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- G—PHYSICS
- G06—COMPUTING OR CALCULATING; COUNTING
- G06F—ELECTRIC DIGITAL DATA PROCESSING
- G06F1/00—Details not covered by groups G06F3/00 - G06F13/00 and G06F21/00
- G06F1/26—Power supply means, e.g. regulation thereof
- G06F1/32—Means for saving power
- G06F1/3203—Power management, i.e. event-based initiation of a power-saving mode
- G06F1/3234—Power saving characterised by the action undertaken
- G06F1/325—Power saving in peripheral device
- G06F1/3268—Power saving in hard disk drive
-
- G—PHYSICS
- G11—INFORMATION STORAGE
- G11C—STATIC STORES
- G11C11/00—Digital stores characterised by the use of particular electric or magnetic storage elements; Storage elements therefor
- G11C11/21—Digital stores characterised by the use of particular electric or magnetic storage elements; Storage elements therefor using electric elements
- G11C11/34—Digital stores characterised by the use of particular electric or magnetic storage elements; Storage elements therefor using electric elements using semiconductor devices
- G11C11/40—Digital stores characterised by the use of particular electric or magnetic storage elements; Storage elements therefor using electric elements using semiconductor devices using transistors
- G11C11/401—Digital stores characterised by the use of particular electric or magnetic storage elements; Storage elements therefor using electric elements using semiconductor devices using transistors forming cells needing refreshing or charge regeneration, i.e. dynamic cells
- G11C11/4063—Auxiliary circuits, e.g. for addressing, decoding, driving, writing, sensing or timing
- G11C11/407—Auxiliary circuits, e.g. for addressing, decoding, driving, writing, sensing or timing for memory cells of the field-effect type
- G11C11/4074—Power supply or voltage generation circuits, e.g. bias voltage generators, substrate voltage generators, back-up power, power control circuits
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Theoretical Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Microelectronics & Electronic Packaging (AREA)
- Physics & Mathematics (AREA)
- General Engineering & Computer Science (AREA)
- General Physics & Mathematics (AREA)
- Computer Hardware Design (AREA)
- Oncology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Communicable Diseases (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP14196662.2 | 2014-12-05 | ||
| EP14196662 | 2014-12-05 | ||
| PCT/GB2015/053731 WO2016087878A1 (en) | 2014-12-05 | 2015-12-04 | Antimycotic compound |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| AU2015356795A1 AU2015356795A1 (en) | 2017-04-27 |
| AU2015356795B2 true AU2015356795B2 (en) | 2020-01-16 |
Family
ID=52006914
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AU2015356795A Active AU2015356795B2 (en) | 2014-12-05 | 2015-12-04 | Antimycotic compound |
Country Status (18)
| Country | Link |
|---|---|
| US (12) | US10106531B2 (https=) |
| EP (2) | EP3227277B1 (https=) |
| JP (2) | JP6669751B2 (https=) |
| KR (1) | KR102579848B1 (https=) |
| CN (2) | CN107001343B (https=) |
| AU (1) | AU2015356795B2 (https=) |
| BR (1) | BR112017008481B1 (https=) |
| CA (1) | CA2963625C (https=) |
| DK (2) | DK3227278T3 (https=) |
| EA (1) | EA033736B1 (https=) |
| ES (2) | ES2786374T3 (https=) |
| HU (2) | HUE048905T2 (https=) |
| IL (1) | IL251631B (https=) |
| MX (1) | MX370412B (https=) |
| PL (1) | PL3227277T3 (https=) |
| PT (1) | PT3227277T (https=) |
| SG (1) | SG11201702835RA (https=) |
| WO (2) | WO2016087880A1 (https=) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3227277B1 (en) | 2014-12-05 | 2020-02-05 | Pulmocide Limited | Antimycotic compound |
| JP6694886B2 (ja) | 2014-12-18 | 2020-05-20 | プルモシデ リミテド | ４，５−ジヒドロ−６Ｈ−チエノ［３，２−ｄ］ベンゾアゼピン誘導体及び呼吸器合胞体ウイルス（ＲＳＶ）感染を治療するためのその使用 |
| KR102653821B1 (ko) | 2015-05-21 | 2024-04-02 | 풀모사이드 리미티드 | 항진균성 4-(4-(4-(((3r,5r)-5-((1h-1,2,4-트리아졸-1-일)메틸)-5-(2,4-디플루오로페닐)테트라하이드로푸란-3-일)메톡시)-3-메틸페닐)피페라진-1-일)-n-(2-하이드록시사이클로헥실)벤즈아미드 또는 이의 약학적으로 허용가능한 염. |
| WO2017093491A1 (en) * | 2015-12-04 | 2017-06-08 | Pulmocide Limited | Antimycotic triazole compound |
| WO2018096405A1 (en) * | 2016-11-28 | 2018-05-31 | Cellix Bio Private Limited | Compositions and methods for the treatment of oral infectious diseases |
| US11185548B2 (en) | 2016-12-23 | 2021-11-30 | Helmholtz Zentrum Munchen—Deutsches Forschungszentrum Für Gesundheit Und Umwelt (Gmbh) | Inhibitors of cytochrome P450 family 7 subfamily B member 1 (CYP7B1) for use in treating diseases |
| GB201917867D0 (en) * | 2019-12-06 | 2020-01-22 | Pulmocide Ltd | Polymorphs |
| EP3858357A1 (en) * | 2020-01-28 | 2021-08-04 | Diaccurate | Use of azole compounds to stimulate the immune system and as inhibitors for s-pla2gib |
| RU2770598C1 (ru) * | 2021-06-29 | 2022-04-18 | Федеральное государственное автономное образовательное учреждение высшего образования "Пермский государственный национальный исследовательский университет" (ПГНИУ) | ПРИМЕНЕНИЕ ПРОТИВОГРИБКОВОГО СРЕДСТВА НА ОСНОВЕ 2-((4-R1-5-R2-3-(ЭТОКСИКАРБОНИЛ)ТИОФЕН-2-ИЛ)АМИНО)-4-ОКСО-4-R3-БУТ-2-ЕНОВЫХ КИСЛОТ ПО ОТНОШЕНИЮ К Candida aldicans |
| TW202541814A (zh) | 2023-11-30 | 2025-11-01 | 瑞士商巴塞利亞阿爾斯維爾藥業國際股份有限公司 | 用於治療真菌感染的藥物組合 |
Family Cites Families (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5533466A (en) * | 1978-07-14 | 1980-03-08 | Janssen Pharmaceutica Nv | Novel azole derivatives and their manufacture |
| CH655103A5 (de) * | 1983-03-11 | 1986-03-27 | Sandoz Ag | Azolderivate, verfahren zu ihrer herstellung und ihre verwendung. |
| CA1292472C (en) | 1985-12-03 | 1991-11-26 | Alfonsus Guilielmus Knaeps | Derivatives of ¬¬4-¬4-(4-phenyl-1-piperazinyl)- phenoxymethyl|-1,3-dioxolan-2-yl|methyl|-1h-imidazoles and 1h-1,2,4-triazoles |
| DE3609598A1 (de) * | 1986-03-21 | 1987-10-01 | Hoechst Ag | 2-azolylmethyl-2-aryl-1,3-dioxolane und deren salze, verfahren zu ihrer herstellung, sie enthaltende mittel und ihre verwendung |
| DE3852477T2 (de) | 1987-11-20 | 1995-05-04 | Schering Corp | Tri- und tetrasubstituierte Oxetane und Tetrahydrofurane und deren Zwischenprodukte. |
| US5039678A (en) | 1989-03-23 | 1991-08-13 | Wake Forest University | Method of increasing cranial vessel proliferation by administering nimodipine |
| US5039676A (en) | 1990-05-11 | 1991-08-13 | Schering Corporation | Tri- and tetra-substituted-oxetanes and tetrahydrofurans and intermediates thereof |
| US5403937A (en) * | 1993-04-30 | 1995-04-04 | Schering Corporation | Process for preparing intermediates for the synthesis of antifungal agents |
| US5714490A (en) | 1993-12-21 | 1998-02-03 | Schering Corporation | Tetrahydrofuran antifungals |
| PL181193B1 (pl) | 1993-12-21 | 2001-06-29 | Schering Corp | Nowe pochodne tetrahydrofuranowe o działaniu przeciwgrzybicznym, kompozycja farmaceutyczna do leczenia infekcji grzybiczych oraz sposób wytwarzania tych związków |
| US5486625A (en) | 1994-07-08 | 1996-01-23 | Schering Corporation | Process for the preparation of chiral intermediates useful for the synthesis of antifungal agents |
| HUP9701690A3 (en) | 1995-06-02 | 1998-04-28 | Schering Corp Kenilwort | Tetrahydrofuran derivatives as antifungals and pharmaceutical compositions containing the same |
| EP0957101A1 (en) | 1998-05-14 | 1999-11-17 | Janssen Pharmaceutica N.V. | Water soluble azoles as broad-spectrum antifungals |
| EP1372394A1 (en) | 2001-04-03 | 2004-01-02 | Schering Corporation | Antifungal composition with enhanced bioavailability |
| CA2709784A1 (en) * | 2007-12-21 | 2009-07-09 | University Of Rochester | Method for altering the lifespan of eukaryotic organisms |
| US8324385B2 (en) * | 2008-10-30 | 2012-12-04 | Madrigal Pharmaceuticals, Inc. | Diacylglycerol acyltransferase inhibitors |
| EP2734517B1 (en) * | 2011-07-18 | 2017-08-30 | Merck Patent GmbH | Benzamides |
| US9346791B2 (en) | 2011-09-07 | 2016-05-24 | The Johns Hopkins University | Itraconazole analogs and use thereof |
| EP3227277B1 (en) | 2014-12-05 | 2020-02-05 | Pulmocide Limited | Antimycotic compound |
| GB201917867D0 (en) | 2019-12-06 | 2020-01-22 | Pulmocide Ltd | Polymorphs |
-
2015
- 2015-12-04 EP EP15808770.0A patent/EP3227277B1/en active Active
- 2015-12-04 CN CN201580066092.6A patent/CN107001343B/zh active Active
- 2015-12-04 DK DK15817507.5T patent/DK3227278T3/da active
- 2015-12-04 KR KR1020177013730A patent/KR102579848B1/ko active Active
- 2015-12-04 CN CN202011308132.2A patent/CN112375073B/zh active Active
- 2015-12-04 MX MX2017007188A patent/MX370412B/es active IP Right Grant
- 2015-12-04 SG SG11201702835RA patent/SG11201702835RA/en unknown
- 2015-12-04 WO PCT/GB2015/053733 patent/WO2016087880A1/en not_active Ceased
- 2015-12-04 JP JP2017528775A patent/JP6669751B2/ja active Active
- 2015-12-04 ES ES15817507T patent/ES2786374T3/es active Active
- 2015-12-04 HU HUE15808770A patent/HUE048905T2/hu unknown
- 2015-12-04 HU HUE15817507A patent/HUE048685T2/hu unknown
- 2015-12-04 BR BR112017008481-3A patent/BR112017008481B1/pt active IP Right Grant
- 2015-12-04 PL PL15808770T patent/PL3227277T3/pl unknown
- 2015-12-04 CA CA2963625A patent/CA2963625C/en active Active
- 2015-12-04 EP EP15817507.5A patent/EP3227278B1/en active Active
- 2015-12-04 DK DK15808770.0T patent/DK3227277T3/da active
- 2015-12-04 EA EA201791174A patent/EA033736B1/ru not_active IP Right Cessation
- 2015-12-04 ES ES15808770T patent/ES2790875T3/es active Active
- 2015-12-04 PT PT158087700T patent/PT3227277T/pt unknown
- 2015-12-04 JP JP2017528789A patent/JP6666345B2/ja active Active
- 2015-12-04 WO PCT/GB2015/053731 patent/WO2016087878A1/en not_active Ceased
- 2015-12-04 US US15/524,505 patent/US10106531B2/en active Active
- 2015-12-04 AU AU2015356795A patent/AU2015356795B2/en active Active
-
2016
- 2016-10-20 US US15/298,431 patent/US10093659B2/en active Active
-
2017
- 2017-04-06 IL IL251631A patent/IL251631B/en active IP Right Grant
-
2018
- 2018-09-12 US US16/129,322 patent/US10487073B2/en active Active
- 2018-09-24 US US16/139,591 patent/US10344022B2/en active Active
-
2019
- 2019-05-24 US US16/422,062 patent/US10450304B2/en active Active
- 2019-09-12 US US16/569,128 patent/US10662179B2/en active Active
- 2019-10-04 US US16/593,444 patent/US10800762B2/en active Active
-
2020
- 2020-04-15 US US16/849,476 patent/US10858345B2/en active Active
- 2020-09-04 US US17/012,685 patent/US11008307B2/en active Active
- 2020-11-04 US US17/089,441 patent/US11661415B2/en active Active
-
2021
- 2021-04-14 US US17/230,009 patent/US20210238169A1/en not_active Abandoned
-
2023
- 2023-04-18 US US18/302,557 patent/US12269814B2/en active Active
Non-Patent Citations (2)
| Title |
|---|
| HEPPERLE M ET AL, "Mono N-arylation of piperazine(III): metal-catalyzed N-arylation and its application to the novel preparations of the antifungal posaconazole. . .", TETRAHEDRON LETTERS, (2002-04-29), vol. 43, no. 18, pp 3359 - 3363 * |
| SAKSENA A K ET AL, "Stereoselective Grignard additions to N-formyl hydrazone: a concise synthesis of NoxafilR side chain and a synthesis of NoxafilR ", TETRAHEDRON LETTERS, (2004-10-25), vol. 45, no. 44, pages 8249 - 8251 * |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FGA | Letters patent sealed or granted (standard patent) |