JP2017536366A - Ｌｎａキラルホスホロチオエート - Google Patents

Ｌｎａキラルホスホロチオエート Download PDF

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JP2017536366A
JP2017536366A JP2017526905A JP2017526905A JP2017536366A JP 2017536366 A JP2017536366 A JP 2017536366A JP 2017526905 A JP2017526905 A JP 2017526905A JP 2017526905 A JP2017526905 A JP 2017526905A JP 2017536366 A JP2017536366 A JP 2017536366A
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lna
phosphorothioate
oligonucleotide
nucleotide
nucleoside
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JP2017536366A5 (cg-RX-API-DMAC7.html
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ナンナ アルベク
ナンナ アルベク
ヘンリック フリデンランド ハンセン
ヘンリック フリデンランド ハンセン
コッホ　トロールス
トロールス コッホ
ジェイコブ ラバン
ジェイコブ ラバン
クリストフ ローゼンバーム
クリストフ ローゼンバーム
ピーター ヘッジドーン
ピーター ヘッジドーン
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ロシュ イノベーション センター コペンハーゲン エーエス
ロシュ イノベーション センター コペンハーゲン エーエス
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Publication of JP2017536366A publication Critical patent/JP2017536366A/ja
Publication of JP2017536366A5 publication Critical patent/JP2017536366A5/ja
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    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
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    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
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    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/31—Chemical structure of the backbone
    • C12N2310/315—Phosphorothioates
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    • C12N2310/30—Chemical structure
    • C12N2310/32—Chemical structure of the sugar
    • C12N2310/323—Chemical structure of the sugar modified ring structure
    • C12N2310/3231—Chemical structure of the sugar modified ring structure having an additional ring, e.g. LNA, ENA
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/34—Spatial arrangement of the modifications
    • C12N2310/341—Gapmers, i.e. of the type ===---===
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    • C12N2310/00—Structure or type of the nucleic acid
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    • C12N2330/00—Production
    • C12N2330/30—Production chemically synthesised

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  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Saccharide Compounds (AREA)
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  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
JP2017526905A 2014-11-19 2015-11-18 Ｌｎａキラルホスホロチオエート Pending JP2017536366A (ja)

Applications Claiming Priority (13)

Application Number Priority Date Filing Date Title
EP14193887.8 2014-11-19
EP14193887 2014-11-19
EP14198167.0 2014-12-16
EP14198167 2014-12-16
EP15182401 2015-08-25
EP15182401.8 2015-08-25
EP15191076 2015-10-22
EP15191075 2015-10-22
EP15191075.9 2015-10-22
EP15191076.7 2015-10-22
EP15191074.2 2015-10-22
EP15191074 2015-10-22
PCT/EP2015/076971 WO2016079183A1 (en) 2014-11-19 2015-11-18 Lna chiral phosphorothioates

Publications (2)

Publication Number Publication Date
JP2017536366A true JP2017536366A (ja) 2017-12-07
JP2017536366A5 JP2017536366A5 (cg-RX-API-DMAC7.html) 2018-11-15

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JP2017526905A Pending JP2017536366A (ja) 2014-11-19 2015-11-18 Ｌｎａキラルホスホロチオエート
JP2017526918A Pending JP2017536119A (ja) 2014-11-19 2015-11-18 キラルホスホロチオエート連結を含むｌｎａギャップマーオリゴヌクレオチド

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US (2) US20180112217A1 (cg-RX-API-DMAC7.html)
EP (2) EP3220921A1 (cg-RX-API-DMAC7.html)
JP (2) JP2017536366A (cg-RX-API-DMAC7.html)
WO (2) WO2016079183A1 (cg-RX-API-DMAC7.html)

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KR20250069923A (ko) 2022-09-19 2025-05-20 브리스톨-마이어스 스큅 컴퍼니 신규한 인(v)-기반 시약, 이의 제조 방법, 및 입체-규정 유기인(v) 화합물의 제조에 있어서의 그의 용도

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JP2021508689A (ja) * 2017-12-22 2021-03-11 ロシュ イノベーション センター コペンハーゲン エーエス ホスホロジチオアートヌクレオシド間結合を含むギャップマーオリゴヌクレオチド
JP2024041845A (ja) * 2017-12-22 2024-03-27 ロシュ イノベーション センター コペンハーゲン エーエス ホスホロジチオアートヌクレオシド間結合を含むギャップマーオリゴヌクレオチド
JP7476101B2 (ja) 2017-12-22 2024-04-30 ロシュ イノベーション センター コペンハーゲン エーエス ホスホロジチオアートヌクレオシド間結合を含むギャップマーオリゴヌクレオチド

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