JP2017535249A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2017535249A5 JP2017535249A5 JP2017516315A JP2017516315A JP2017535249A5 JP 2017535249 A5 JP2017535249 A5 JP 2017535249A5 JP 2017516315 A JP2017516315 A JP 2017516315A JP 2017516315 A JP2017516315 A JP 2017516315A JP 2017535249 A5 JP2017535249 A5 JP 2017535249A5
- Authority
- JP
- Japan
- Prior art keywords
- acrylonitrile
- weight
- acrylamide
- mass
- less
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- NLHHRLWOUZZQLW-UHFFFAOYSA-N Acrylonitrile Chemical compound C=CC#N NLHHRLWOUZZQLW-UHFFFAOYSA-N 0.000 claims description 186
- HRPVXLWXLXDGHG-UHFFFAOYSA-N Acrylamide Chemical compound NC(=O)C=C HRPVXLWXLXDGHG-UHFFFAOYSA-N 0.000 claims description 134
- 238000000034 method Methods 0.000 claims description 134
- 108090000790 Enzymes Proteins 0.000 claims description 121
- 102000004190 Enzymes Human genes 0.000 claims description 121
- 239000011942 biocatalyst Substances 0.000 claims description 108
- 239000000203 mixture Substances 0.000 claims description 61
- 239000000243 solution Substances 0.000 claims description 53
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 52
- SMZOUWXMTYCWNB-UHFFFAOYSA-N 2-(2-methoxy-5-methylphenyl)ethanamine Chemical compound COC1=CC=C(C)C=C1CCN SMZOUWXMTYCWNB-UHFFFAOYSA-N 0.000 claims description 46
- NIXOWILDQLNWCW-UHFFFAOYSA-N 2-Propenoic acid Natural products OC(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 claims description 46
- 108010024026 Nitrile hydratase Proteins 0.000 claims description 46
- 230000036983 biotransformation Effects 0.000 claims description 36
- 238000006243 chemical reaction Methods 0.000 claims description 30
- 229920002401 polyacrylamide Polymers 0.000 claims description 27
- 239000007864 aqueous solution Substances 0.000 claims description 26
- 230000008569 process Effects 0.000 claims description 26
- 238000005033 Fourier transform infrared spectroscopy Methods 0.000 claims description 17
- 229920006322 acrylamide copolymer Polymers 0.000 claims description 16
- 238000004128 high performance liquid chromatography Methods 0.000 claims description 15
- 241000187693 Rhodococcus rhodochrous Species 0.000 claims description 13
- 238000001035 drying Methods 0.000 claims description 11
- 241000316848 Rhodococcus <scale insect> Species 0.000 claims description 9
- 125000002091 cationic group Chemical group 0.000 claims description 8
- 238000004519 manufacturing process Methods 0.000 claims description 8
- 241000187654 Nocardia Species 0.000 claims description 7
- 229910052751 metal Inorganic materials 0.000 claims description 7
- 239000002184 metal Substances 0.000 claims description 7
- 241000222120 Candida <Saccharomycetales> Species 0.000 claims description 6
- 241000186146 Brevibacterium Species 0.000 claims description 5
- 238000004108 freeze drying Methods 0.000 claims description 5
- 230000000379 polymerizing effect Effects 0.000 claims description 5
- 241000193830 Bacillus <bacterium> Species 0.000 claims description 4
- 241000186216 Corynebacterium Species 0.000 claims description 4
- 241000588724 Escherichia coli Species 0.000 claims description 4
- 241000626621 Geobacillus Species 0.000 claims description 4
- 241000223259 Trichoderma Species 0.000 claims description 4
- 238000010923 batch production Methods 0.000 claims description 4
- 239000003054 catalyst Substances 0.000 claims description 4
- 238000001694 spray drying Methods 0.000 claims description 4
- 241000589519 Comamonas Species 0.000 claims description 3
- 241000588749 Klebsiella oxytoca Species 0.000 claims description 3
- 241000588747 Klebsiella pneumoniae Species 0.000 claims description 3
- 241001014264 Klebsiella variicola Species 0.000 claims description 3
- 241000970829 Mesorhizobium Species 0.000 claims description 3
- 241001532588 Mesorhizobium ciceri Species 0.000 claims description 3
- 241001467578 Microbacterium Species 0.000 claims description 3
- 241001467565 Microbacterium imperiale Species 0.000 claims description 3
- 241000191938 Micrococcus luteus Species 0.000 claims description 3
- 241000187602 Pseudonocardia thermophila Species 0.000 claims description 3
- 241000187561 Rhodococcus erythropolis Species 0.000 claims description 3
- 241000187563 Rhodococcus ruber Species 0.000 claims description 3
- 239000007787 solid Substances 0.000 claims description 3
- 241001103808 Albifimbria verrucaria Species 0.000 claims description 2
- 241000223678 Aureobasidium pullulans Species 0.000 claims description 2
- 241000845990 Bradyrhizobium diazoefficiens Species 0.000 claims description 2
- 241000589174 Bradyrhizobium japonicum Species 0.000 claims description 2
- 241000178956 Bradyrhizobium oligotrophicum Species 0.000 claims description 2
- 241000371430 Burkholderia cenocepacia Species 0.000 claims description 2
- 241001135516 Burkholderia gladioli Species 0.000 claims description 2
- 241000186226 Corynebacterium glutamicum Species 0.000 claims description 2
- 241001522132 Corynebacterium pseudodiphtheriticum Species 0.000 claims description 2
- 241000588722 Escherichia Species 0.000 claims description 2
- 241000159512 Geotrichum Species 0.000 claims description 2
- 241001149669 Hanseniaspora Species 0.000 claims description 2
- 201000008225 Klebsiella pneumonia Diseases 0.000 claims description 2
- 241000235649 Kluyveromyces Species 0.000 claims description 2
- 241000292853 Mesorhizobium opportunistum Species 0.000 claims description 2
- 241000588621 Moraxella Species 0.000 claims description 2
- 241000223251 Myrothecium Species 0.000 claims description 2
- 238000005481 NMR spectroscopy Methods 0.000 claims description 2
- 241000187653 Nocardia globerula Species 0.000 claims description 2
- 241000588912 Pantoea agglomerans Species 0.000 claims description 2
- 241000317987 Pantoea endophytica Species 0.000 claims description 2
- 241000235648 Pichia Species 0.000 claims description 2
- 206010035717 Pneumonia klebsiella Diseases 0.000 claims description 2
- 241000589516 Pseudomonas Species 0.000 claims description 2
- 241001646398 Pseudomonas chlororaphis Species 0.000 claims description 2
- 241000589776 Pseudomonas putida Species 0.000 claims description 2
- 241000205160 Pyrococcus Species 0.000 claims description 2
- 241000589180 Rhizobium Species 0.000 claims description 2
- 241000158504 Rhodococcus hoagii Species 0.000 claims description 2
- 241000190950 Rhodopseudomonas palustris Species 0.000 claims description 2
- 241000223252 Rhodotorula Species 0.000 claims description 2
- 241000607717 Serratia liquefaciens Species 0.000 claims description 2
- 150000003926 acrylamides Chemical class 0.000 claims description 2
- 239000012530 fluid Substances 0.000 claims description 2
- 238000005469 granulation Methods 0.000 claims description 2
- 230000003179 granulation Effects 0.000 claims description 2
- 239000013535 sea water Substances 0.000 claims description 2
- 239000007921 spray Substances 0.000 claims description 2
- 238000001291 vacuum drying Methods 0.000 claims description 2
- 241000187643 Amycolatopsis Species 0.000 claims 1
- 241000186063 Arthrobacter Species 0.000 claims 1
- 241000223651 Aureobasidium Species 0.000 claims 1
- 241001467572 Brevibacterium casei Species 0.000 claims 1
- 241001337994 Cryptococcus <scale insect> Species 0.000 claims 1
- 241000235035 Debaryomyces Species 0.000 claims 1
- 241000235036 Debaryomyces hansenii Species 0.000 claims 1
- 241000827781 Geobacillus sp. Species 0.000 claims 1
- 241000187603 Pseudonocardia Species 0.000 claims 1
- 241000607715 Serratia marcescens Species 0.000 claims 1
- 241000894006 Bacteria Species 0.000 description 28
- 244000005700 microbiome Species 0.000 description 21
- 150000007523 nucleic acids Chemical group 0.000 description 21
- 206010003246 arthritis Diseases 0.000 description 20
- 230000000694 effects Effects 0.000 description 16
- 102000039446 nucleic acids Human genes 0.000 description 16
- 108020004707 nucleic acids Proteins 0.000 description 16
- 108091033319 polynucleotide Proteins 0.000 description 13
- 102000040430 polynucleotide Human genes 0.000 description 13
- 239000002157 polynucleotide Substances 0.000 description 13
- 238000007792 addition Methods 0.000 description 12
- 238000000855 fermentation Methods 0.000 description 8
- 230000004151 fermentation Effects 0.000 description 8
- 229920001577 copolymer Polymers 0.000 description 7
- 239000003921 oil Substances 0.000 description 7
- 238000003786 synthesis reaction Methods 0.000 description 7
- 150000001413 amino acids Chemical group 0.000 description 6
- 238000002474 experimental method Methods 0.000 description 6
- 230000035484 reaction time Effects 0.000 description 6
- 241000894007 species Species 0.000 description 6
- 230000015572 biosynthetic process Effects 0.000 description 5
- 125000003729 nucleotide group Chemical group 0.000 description 5
- 239000000843 powder Substances 0.000 description 5
- 238000002360 preparation method Methods 0.000 description 5
- 108020004414 DNA Proteins 0.000 description 4
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 4
- 101710143259 Nitrile hydratase subunit alpha Proteins 0.000 description 4
- 101710139480 Nitrile hydratase subunit beta Proteins 0.000 description 4
- 238000004458 analytical method Methods 0.000 description 4
- 238000007334 copolymerization reaction Methods 0.000 description 4
- 230000007423 decrease Effects 0.000 description 4
- 239000012634 fragment Substances 0.000 description 4
- 230000036571 hydration Effects 0.000 description 4
- 238000006703 hydration reaction Methods 0.000 description 4
- 239000000463 material Substances 0.000 description 4
- 229920000642 polymer Polymers 0.000 description 4
- 238000006116 polymerization reaction Methods 0.000 description 4
- 108091032973 (ribonucleotides)n+m Proteins 0.000 description 3
- WEVYAHXRMPXWCK-UHFFFAOYSA-N Acetonitrile Chemical compound CC#N WEVYAHXRMPXWCK-UHFFFAOYSA-N 0.000 description 3
- 125000003275 alpha amino acid group Chemical group 0.000 description 3
- 239000000872 buffer Substances 0.000 description 3
- 238000005119 centrifugation Methods 0.000 description 3
- 238000012217 deletion Methods 0.000 description 3
- 230000037430 deletion Effects 0.000 description 3
- 230000014509 gene expression Effects 0.000 description 3
- 238000005259 measurement Methods 0.000 description 3
- 230000000704 physical effect Effects 0.000 description 3
- 239000013612 plasmid Substances 0.000 description 3
- 229920001184 polypeptide Polymers 0.000 description 3
- 108090000765 processed proteins & peptides Proteins 0.000 description 3
- 102000004196 processed proteins & peptides Human genes 0.000 description 3
- 239000000047 product Substances 0.000 description 3
- 238000011084 recovery Methods 0.000 description 3
- 238000000926 separation method Methods 0.000 description 3
- 238000006467 substitution reaction Methods 0.000 description 3
- 238000002411 thermogravimetry Methods 0.000 description 3
- RNIHAPSVIGPAFF-UHFFFAOYSA-N Acrylamide-acrylic acid resin Chemical compound NC(=O)C=C.OC(=O)C=C RNIHAPSVIGPAFF-UHFFFAOYSA-N 0.000 description 2
- 241000589155 Agrobacterium tumefaciens Species 0.000 description 2
- 241000194110 Bacillus sp. (in: Bacteria) Species 0.000 description 2
- RYGMFSIKBFXOCR-UHFFFAOYSA-N Copper Chemical compound [Cu] RYGMFSIKBFXOCR-UHFFFAOYSA-N 0.000 description 2
- 240000004808 Saccharomyces cerevisiae Species 0.000 description 2
- 235000014680 Saccharomyces cerevisiae Nutrition 0.000 description 2
- 230000002210 biocatalytic effect Effects 0.000 description 2
- 238000004364 calculation method Methods 0.000 description 2
- 239000013592 cell lysate Substances 0.000 description 2
- 239000006285 cell suspension Substances 0.000 description 2
- 239000003153 chemical reaction reagent Substances 0.000 description 2
- GUTLYIVDDKVIGB-UHFFFAOYSA-N cobalt atom Chemical compound [Co] GUTLYIVDDKVIGB-UHFFFAOYSA-N 0.000 description 2
- 238000010924 continuous production Methods 0.000 description 2
- 229910052802 copper Inorganic materials 0.000 description 2
- 239000010949 copper Substances 0.000 description 2
- 239000008367 deionised water Substances 0.000 description 2
- 229910021641 deionized water Inorganic materials 0.000 description 2
- 238000010790 dilution Methods 0.000 description 2
- 239000012895 dilution Substances 0.000 description 2
- 239000003480 eluent Substances 0.000 description 2
- 229920001519 homopolymer Polymers 0.000 description 2
- 238000003780 insertion Methods 0.000 description 2
- 230000037431 insertion Effects 0.000 description 2
- XEEYBQQBJWHFJM-UHFFFAOYSA-N iron Substances [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 description 2
- 239000011159 matrix material Substances 0.000 description 2
- 108020004999 messenger RNA Proteins 0.000 description 2
- 238000005065 mining Methods 0.000 description 2
- 238000002156 mixing Methods 0.000 description 2
- 238000012986 modification Methods 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
- 239000002773 nucleotide Substances 0.000 description 2
- 239000008057 potassium phosphate buffer Substances 0.000 description 2
- 108090000623 proteins and genes Proteins 0.000 description 2
- 239000002994 raw material Substances 0.000 description 2
- 239000011541 reaction mixture Substances 0.000 description 2
- 230000009467 reduction Effects 0.000 description 2
- 150000003839 salts Chemical class 0.000 description 2
- 239000006228 supernatant Substances 0.000 description 2
- 238000001308 synthesis method Methods 0.000 description 2
- 239000008399 tap water Substances 0.000 description 2
- 235000020679 tap water Nutrition 0.000 description 2
- 102000040650 (ribonucleotides)n+m Human genes 0.000 description 1
- 241000726119 Acidovorax Species 0.000 description 1
- 241001600124 Acidovorax avenae Species 0.000 description 1
- 241000726118 Acidovorax facilis Species 0.000 description 1
- 241000589158 Agrobacterium Species 0.000 description 1
- 108020005544 Antisense RNA Proteins 0.000 description 1
- 241000228212 Aspergillus Species 0.000 description 1
- 241000228245 Aspergillus niger Species 0.000 description 1
- 241000193399 Bacillus smithii Species 0.000 description 1
- 244000063299 Bacillus subtilis Species 0.000 description 1
- 235000014469 Bacillus subtilis Nutrition 0.000 description 1
- 241000589173 Bradyrhizobium Species 0.000 description 1
- 241001453380 Burkholderia Species 0.000 description 1
- 241000206602 Eukaryota Species 0.000 description 1
- 241000579497 Falsibacillus pallidus Species 0.000 description 1
- 241000481961 Lachancea thermotolerans Species 0.000 description 1
- 108020005196 Mitochondrial DNA Proteins 0.000 description 1
- 108091028043 Nucleic acid sequence Proteins 0.000 description 1
- 108091034117 Oligonucleotide Proteins 0.000 description 1
- 241001489192 Pichia kluyveri Species 0.000 description 1
- 241001148023 Pyrococcus abyssi Species 0.000 description 1
- 241000205156 Pyrococcus furiosus Species 0.000 description 1
- 241000522615 Pyrococcus horikoshii Species 0.000 description 1
- 108020004511 Recombinant DNA Proteins 0.000 description 1
- 241001524101 Rhodococcus opacus Species 0.000 description 1
- 241001478124 Rhodococcus pyridinivorans Species 0.000 description 1
- 241000223253 Rhodotorula glutinis Species 0.000 description 1
- 241000220317 Rosa Species 0.000 description 1
- 241000607720 Serratia Species 0.000 description 1
- 108020005202 Viral DNA Proteins 0.000 description 1
- 108020000999 Viral RNA Proteins 0.000 description 1
- JLCPHMBAVCMARE-UHFFFAOYSA-N [3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-hydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methyl [5-(6-aminopurin-9-yl)-2-(hydroxymethyl)oxolan-3-yl] hydrogen phosphate Polymers Cc1cn(C2CC(OP(O)(=O)OCC3OC(CC3OP(O)(=O)OCC3OC(CC3O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c3nc(N)[nH]c4=O)C(COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3CO)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cc(C)c(=O)[nH]c3=O)n3cc(C)c(=O)[nH]c3=O)n3ccc(N)nc3=O)n3cc(C)c(=O)[nH]c3=O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)O2)c(=O)[nH]c1=O JLCPHMBAVCMARE-UHFFFAOYSA-N 0.000 description 1
- 239000000654 additive Substances 0.000 description 1
- 238000004220 aggregation Methods 0.000 description 1
- 230000002776 aggregation Effects 0.000 description 1
- 125000000129 anionic group Chemical group 0.000 description 1
- 230000000721 bacterilogical effect Effects 0.000 description 1
- 230000008827 biological function Effects 0.000 description 1
- 239000006227 byproduct Substances 0.000 description 1
- 229920003118 cationic copolymer Polymers 0.000 description 1
- 229910017052 cobalt Inorganic materials 0.000 description 1
- 239000010941 cobalt Substances 0.000 description 1
- 230000000295 complement effect Effects 0.000 description 1
- 239000002299 complementary DNA Substances 0.000 description 1
- 239000003184 complementary RNA Substances 0.000 description 1
- 239000012141 concentrate Substances 0.000 description 1
- 230000021615 conjugation Effects 0.000 description 1
- 239000010779 crude oil Substances 0.000 description 1
- 230000003247 decreasing effect Effects 0.000 description 1
- 238000001514 detection method Methods 0.000 description 1
- 238000007865 diluting Methods 0.000 description 1
- 238000006073 displacement reaction Methods 0.000 description 1
- 238000004090 dissolution Methods 0.000 description 1
- 238000004821 distillation Methods 0.000 description 1
- 238000011143 downstream manufacturing Methods 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 238000001914 filtration Methods 0.000 description 1
- 239000008394 flocculating agent Substances 0.000 description 1
- 230000006870 function Effects 0.000 description 1
- 239000011521 glass Substances 0.000 description 1
- 239000008187 granular material Substances 0.000 description 1
- 229910052736 halogen Inorganic materials 0.000 description 1
- 150000002367 halogens Chemical class 0.000 description 1
- 238000010438 heat treatment Methods 0.000 description 1
- 230000002440 hepatic effect Effects 0.000 description 1
- 230000000887 hydrating effect Effects 0.000 description 1
- 229910052738 indium Inorganic materials 0.000 description 1
- 230000006698 induction Effects 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 230000000977 initiatory effect Effects 0.000 description 1
- 238000002347 injection Methods 0.000 description 1
- 239000007924 injection Substances 0.000 description 1
- 238000005342 ion exchange Methods 0.000 description 1
- 229910052742 iron Inorganic materials 0.000 description 1
- 239000012528 membrane Substances 0.000 description 1
- 230000000813 microbial effect Effects 0.000 description 1
- 238000009629 microbiological culture Methods 0.000 description 1
- 238000010369 molecular cloning Methods 0.000 description 1
- 239000000178 monomer Substances 0.000 description 1
- 230000035772 mutation Effects 0.000 description 1
- 150000002825 nitriles Chemical class 0.000 description 1
- 238000004391 petroleum recovery Methods 0.000 description 1
- 239000002861 polymer material Substances 0.000 description 1
- 125000001453 quaternary ammonium group Chemical group 0.000 description 1
- 239000000376 reactant Substances 0.000 description 1
- 230000006798 recombination Effects 0.000 description 1
- 238000005215 recombination Methods 0.000 description 1
- 238000007430 reference method Methods 0.000 description 1
- 230000010076 replication Effects 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 108091092562 ribozyme Proteins 0.000 description 1
- 239000011435 rock Substances 0.000 description 1
- 238000004062 sedimentation Methods 0.000 description 1
- 239000007858 starting material Substances 0.000 description 1
- 238000003860 storage Methods 0.000 description 1
- 238000010189 synthetic method Methods 0.000 description 1
- 239000002562 thickening agent Substances 0.000 description 1
- RYYWUUFWQRZTIU-UHFFFAOYSA-K thiophosphate Chemical compound [O-]P([O-])([O-])=S RYYWUUFWQRZTIU-UHFFFAOYSA-K 0.000 description 1
- 238000013518 transcription Methods 0.000 description 1
- 230000035897 transcription Effects 0.000 description 1
- 230000026683 transduction Effects 0.000 description 1
- 238000010361 transduction Methods 0.000 description 1
- 238000001890 transfection Methods 0.000 description 1
- 230000009466 transformation Effects 0.000 description 1
- 238000013519 translation Methods 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP14003377.0 | 2014-09-30 | ||
| EP14003377 | 2014-09-30 | ||
| PCT/EP2015/072508 WO2016050818A1 (en) | 2014-09-30 | 2015-09-30 | Method for preparing an aqueous acrylamide solution having a low acrylic acid concentration |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2017535249A JP2017535249A (ja) | 2017-11-30 |
| JP2017535249A5 true JP2017535249A5 (cg-RX-API-DMAC7.html) | 2018-11-15 |
| JP6716547B2 JP6716547B2 (ja) | 2020-07-01 |
Family
ID=51661845
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017516315A Expired - Fee Related JP6716547B2 (ja) | 2014-09-30 | 2015-09-30 | 低いアクリル酸濃度を有するアクリルアミド水溶液の製造方法 |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US10227621B2 (cg-RX-API-DMAC7.html) |
| EP (1) | EP3201348B2 (cg-RX-API-DMAC7.html) |
| JP (1) | JP6716547B2 (cg-RX-API-DMAC7.html) |
| KR (1) | KR20170066471A (cg-RX-API-DMAC7.html) |
| CN (1) | CN106715702B (cg-RX-API-DMAC7.html) |
| AU (1) | AU2015326907B2 (cg-RX-API-DMAC7.html) |
| BR (1) | BR112017005840A2 (cg-RX-API-DMAC7.html) |
| CA (1) | CA2962510A1 (cg-RX-API-DMAC7.html) |
| CO (1) | CO2017004030A2 (cg-RX-API-DMAC7.html) |
| MY (1) | MY187158A (cg-RX-API-DMAC7.html) |
| RU (1) | RU2706533C2 (cg-RX-API-DMAC7.html) |
| WO (1) | WO2016050818A1 (cg-RX-API-DMAC7.html) |
Families Citing this family (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US10428361B2 (en) | 2015-03-26 | 2019-10-01 | Basf Se | Biocatalytic production of l-fucose |
| WO2017186685A1 (en) * | 2016-04-26 | 2017-11-02 | Basf Se | Method for preparing an aqueous polyacrylamide solution |
| CN107475317B (zh) * | 2016-06-07 | 2021-12-17 | 中国石油化工股份有限公司 | 丙烯酰胺水溶液的制备方法 |
| CN107779481A (zh) * | 2016-08-29 | 2018-03-09 | 中国石油化工股份有限公司 | 丙烯酰胺水溶液的制备方法 |
| AU2018354767B2 (en) | 2017-10-25 | 2024-01-11 | Basf Se | Process for producing aqueous polyacrylamide solutions |
| US11634515B2 (en) | 2017-10-25 | 2023-04-25 | Basf Se | Process for producing aqueous polyacrylamide solutions |
| WO2019081004A1 (en) | 2017-10-25 | 2019-05-02 | Basf Se | PROCESS FOR PRODUCING AQUEOUS POLYACRYLAMIDE SOLUTIONS |
| AR113386A1 (es) | 2017-10-25 | 2020-04-29 | Basf Se | Proceso y planta modular y reubicable para producir soluciones acuosas de poliacrilamida |
| WO2019081327A1 (en) | 2017-10-25 | 2019-05-02 | Basf Se | PROCESS FOR PRODUCING AQUEOUS POLYACRYLAMIDE SOLUTIONS |
| WO2019081003A1 (en) | 2017-10-25 | 2019-05-02 | Basf Se | PROCESS FOR PRODUCING AQUEOUS POLYACRYLAMIDE SOLUTIONS |
| MX2020004310A (es) | 2017-10-25 | 2020-08-13 | Basf Se | Proceso para producir soluciones acuosas de poliacrilamida. |
| WO2019081008A1 (en) | 2017-10-25 | 2019-05-02 | Basf Se | PROCESS FOR PRODUCING AQUEOUS ACRYLAMIDE SOLUTION |
| CN108251330B (zh) * | 2017-12-28 | 2021-03-23 | 江苏世邦生物工程科技有限公司 | 用于治理土壤污染的复合微生物菌剂及其制备方法和应用 |
| WO2020079148A1 (en) | 2018-10-18 | 2020-04-23 | Basf Se | Process of fracturing subterranean formations |
| WO2020079124A1 (en) | 2018-10-18 | 2020-04-23 | Basf Se | Process for producing aqueous polyacrylamide compositions |
| WO2020079119A1 (en) | 2018-10-18 | 2020-04-23 | Basf Se | Method of providing aqueous polyacrylamide concentrates |
| AU2019359988B2 (en) | 2018-10-18 | 2024-12-12 | Basf Se | Process for producing an aqueous polyacrylamide concentrate |
| CN109797164B (zh) * | 2019-01-31 | 2022-09-02 | 大连理工大学 | 一种新型腈水合酶高效催化脂肪二腈水合反应的体系 |
| CN110195026B (zh) * | 2019-03-04 | 2022-10-11 | 暨南大学 | 一种dehp降解菌剂制备及其有效降低蔬菜生产中dehp污染的方法 |
| CA3151818A1 (en) * | 2019-10-03 | 2021-04-08 | Anton Kaiser | Biopolymers for enhanced hydrocarbon recovery |
| WO2021138205A1 (en) * | 2019-12-30 | 2021-07-08 | Kemira Oyj | Ftnir spectroscopy for reaction monitoring of acrylamide synthesis |
| CN111269848B (zh) * | 2019-12-30 | 2022-03-18 | 浙江工业大学 | 赤红球菌jj-3及其在降解丙烯酸中的应用 |
| WO2021204850A1 (en) * | 2020-04-09 | 2021-10-14 | Basf Se | Biocatalytic synthesis of monomer mixtures for polyacrylamide manufacturing |
| JP7771186B2 (ja) | 2020-12-04 | 2025-11-17 | エージーシー ケミカルズ アメリカズ，インコーポレイテッド | 処理された物品、当該処理された物品の製造方法、及び当該処理された物品の製造に用いるための分散剤 |
| WO2023041515A2 (en) | 2021-09-15 | 2023-03-23 | Basf Se | Method for preparing an aqueous (meth) acrylamide solution |
| JPWO2024195728A1 (cg-RX-API-DMAC7.html) | 2023-03-17 | 2024-09-26 |
Family Cites Families (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3597481A (en) | 1969-01-16 | 1971-08-03 | Dow Chemical Co | Heterogeneous catalyst for the liquid phase hydrolysis of nitriles to amides |
| BE795361A (fr) | 1972-02-16 | 1973-08-13 | American Cyanamid Co | Catalyseur au cuivre pour l'hydratation des nitriles en amides |
| US4711955A (en) | 1981-04-17 | 1987-12-08 | Yale University | Modified nucleotides and methods of preparing and using same |
| CA1223831A (en) | 1982-06-23 | 1987-07-07 | Dean Engelhardt | Modified nucleotides, methods of preparing and utilizing and compositions containing the same |
| US5179014A (en) * | 1985-01-08 | 1993-01-12 | Nitto Chemical Industry Co., Ltd. | Process for the preparation of amides using microorganisms |
| JPS61162193A (ja) * | 1985-01-08 | 1986-07-22 | Nitto Chem Ind Co Ltd | 微生物によるアミド類の製造法 |
| US5792608A (en) | 1991-12-12 | 1998-08-11 | Gilead Sciences, Inc. | Nuclease stable and binding competent oligomers and methods for their use |
| US5525711A (en) | 1994-05-18 | 1996-06-11 | The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Pteridine nucleotide analogs as fluorescent DNA probes |
| US6153415A (en) * | 1998-04-29 | 2000-11-28 | Board Of Trustees Operating Michigan State University | Method for producing amide compounds using a nitrile hydratase from a thermophilic bacillus |
| DE10120550A1 (de) * | 2001-04-26 | 2002-10-31 | Stockhausen Chem Fab Gmbh | Verfahren zur Herstellung einer wässrigen Acrylamidlösung mit einem Biokatalysator |
| FR2835531B1 (fr) | 2002-02-06 | 2004-12-03 | Snf Sa | Procede pour la fabrication d'amides en presence d'une nitrile hydratase d'origine microbiologique et nouveau microorganisme |
| JP2003277416A (ja) | 2002-03-22 | 2003-10-02 | Daiyanitorikkusu Kk | 糖類を含むアクリルアミド水溶液 |
| GB0327901D0 (en) * | 2003-12-02 | 2004-01-07 | Ciba Spec Chem Water Treat Ltd | Process for producing polymers |
| AU2004295409B2 (en) | 2003-12-02 | 2010-07-29 | Ciba Specialty Chemicals Water Treatments Limited | Strain of Rhodococcus rhodochrous NCIMB 41164 and its use as producer of nitrile hydratase |
| US8518685B2 (en) | 2008-03-24 | 2013-08-27 | Tsinghua University | Engineered nitrile hydratase-producing bacterium with amidase gene knocked-out, the construction and the use thereof |
| JP2013162746A (ja) | 2010-05-24 | 2013-08-22 | Mitsui Chemicals Inc | アミド化合物の製造方法 |
| US8563479B2 (en) * | 2010-11-03 | 2013-10-22 | Saudi Arabian Oil Company | Volcanic ash-based drilling mud to overcome drilling challenges |
| RU2520870C1 (ru) * | 2012-12-27 | 2014-06-27 | Кемира Оюй | Штамм бактерий rhodococcus aetherivorans bkm ac-2610d - продуцент нитрилгидратазы, способ его культивирования и способ получения акриламида |
| KR102775925B1 (ko) * | 2014-09-30 | 2025-03-04 | 바스프 에스이 | 적은 아크릴산을 갖는 아미드 화합물의 제조를 위한 수단 및 방법 |
-
2015
- 2015-09-30 CA CA2962510A patent/CA2962510A1/en active Pending
- 2015-09-30 US US15/514,321 patent/US10227621B2/en active Active
- 2015-09-30 MY MYPI2017000418A patent/MY187158A/en unknown
- 2015-09-30 KR KR1020177011261A patent/KR20170066471A/ko not_active Ceased
- 2015-09-30 WO PCT/EP2015/072508 patent/WO2016050818A1/en not_active Ceased
- 2015-09-30 BR BR112017005840-5A patent/BR112017005840A2/pt not_active Application Discontinuation
- 2015-09-30 EP EP15788335.6A patent/EP3201348B2/en not_active Not-in-force
- 2015-09-30 JP JP2017516315A patent/JP6716547B2/ja not_active Expired - Fee Related
- 2015-09-30 AU AU2015326907A patent/AU2015326907B2/en not_active Ceased
- 2015-09-30 RU RU2017114398A patent/RU2706533C2/ru active
- 2015-09-30 CN CN201580051699.7A patent/CN106715702B/zh not_active Expired - Fee Related
-
2017
- 2017-04-26 CO CONC2017/0004030A patent/CO2017004030A2/es unknown
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP6716547B2 (ja) | 低いアクリル酸濃度を有するアクリルアミド水溶液の製造方法 | |
| JP2017535249A5 (cg-RX-API-DMAC7.html) | ||
| WO2016050819A1 (en) | Method for preparing an acrylamide solution having a low acrylic acid concentration | |
| AU2015326905B2 (en) | Means and methods for producing amide compounds with less acrylic acid | |
| AU2017242461B2 (en) | Process for producing a polyacrylamide solution with increased viscosity | |
| EP3201316B1 (en) | Method of cultivating microorganisms having nitrile hydratase activity | |
| WO2017055518A1 (en) | Means and methods for producing an amide compound | |
| EP3225694A1 (en) | Method for the production of acrylamide by defined addition of the biocatalyst | |
| EP3225693A1 (en) | Method for preparing aqueous acrylamide solutions | |
| US20220403426A1 (en) | Method of storing a biocatalyst |