JP2017533888A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2017533888A5 JP2017533888A5 JP2017515768A JP2017515768A JP2017533888A5 JP 2017533888 A5 JP2017533888 A5 JP 2017533888A5 JP 2017515768 A JP2017515768 A JP 2017515768A JP 2017515768 A JP2017515768 A JP 2017515768A JP 2017533888 A5 JP2017533888 A5 JP 2017533888A5
- Authority
- JP
- Japan
- Prior art keywords
- antigen
- amino acid
- seq
- binding fragment
- acid sequence
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 125000003275 alpha amino acid group Chemical group 0.000 claims description 78
- 150000001413 amino acids Chemical class 0.000 claims description 61
- 239000000203 mixture Substances 0.000 claims description 13
- 210000004027 cell Anatomy 0.000 claims description 9
- 230000000694 effects Effects 0.000 claims description 9
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical group C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims description 7
- 239000003112 inhibitor Substances 0.000 claims description 4
- 239000008194 pharmaceutical composition Substances 0.000 claims description 3
- 239000000137 peptide hydrolase inhibitor Substances 0.000 claims description 2
- 206010039073 rheumatoid arthritis Diseases 0.000 claims description 2
- 239000000427 antigen Substances 0.000 claims 40
- 102000036639 antigens Human genes 0.000 claims 40
- 108091007433 antigens Proteins 0.000 claims 40
- 239000012634 fragment Substances 0.000 claims 40
- 101000853002 Homo sapiens Interleukin-25 Proteins 0.000 claims 24
- 102000055377 human IL25 Human genes 0.000 claims 24
- 239000005557 antagonist Substances 0.000 claims 16
- 102000013691 Interleukin-17 Human genes 0.000 claims 14
- 108050003558 Interleukin-17 Proteins 0.000 claims 14
- 208000006673 asthma Diseases 0.000 claims 11
- 238000002198 surface plasmon resonance spectroscopy Methods 0.000 claims 10
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 9
- 230000011664 signaling Effects 0.000 claims 8
- 206010020751 Hypersensitivity Diseases 0.000 claims 6
- 208000026935 allergic disease Diseases 0.000 claims 5
- 208000035475 disorder Diseases 0.000 claims 5
- 210000003819 peripheral blood mononuclear cell Anatomy 0.000 claims 5
- 102100035018 Interleukin-17 receptor A Human genes 0.000 claims 4
- 101710186083 Interleukin-17 receptor A Proteins 0.000 claims 4
- 102100035014 Interleukin-17 receptor B Human genes 0.000 claims 4
- 101710186071 Interleukin-17 receptor B Proteins 0.000 claims 4
- 230000007815 allergy Effects 0.000 claims 4
- 201000010099 disease Diseases 0.000 claims 4
- 206010012438 Dermatitis atopic Diseases 0.000 claims 3
- 208000022559 Inflammatory bowel disease Diseases 0.000 claims 3
- 201000008937 atopic dermatitis Diseases 0.000 claims 3
- 230000000903 blocking effect Effects 0.000 claims 3
- 150000003431 steroids Chemical class 0.000 claims 3
- 208000006545 Chronic Obstructive Pulmonary Disease Diseases 0.000 claims 2
- 108010047041 Complementarity Determining Regions Proteins 0.000 claims 2
- 108090000978 Interleukin-4 Proteins 0.000 claims 2
- 241000124008 Mammalia Species 0.000 claims 2
- 241001465754 Metazoa Species 0.000 claims 2
- 206010047115 Vasculitis Diseases 0.000 claims 2
- 241000700605 Viruses Species 0.000 claims 2
- 206010003246 arthritis Diseases 0.000 claims 2
- 210000001072 colon Anatomy 0.000 claims 2
- 239000003814 drug Substances 0.000 claims 2
- 230000009610 hypersensitivity Effects 0.000 claims 2
- 239000000041 non-steroidal anti-inflammatory agent Substances 0.000 claims 2
- 229940021182 non-steroidal anti-inflammatory drug Drugs 0.000 claims 2
- ZFXYFBGIUFBOJW-UHFFFAOYSA-N theophylline Chemical compound O=C1N(C)C(=O)N(C)C2=C1NC=N2 ZFXYFBGIUFBOJW-UHFFFAOYSA-N 0.000 claims 2
- 229940124597 therapeutic agent Drugs 0.000 claims 2
- UCTWMZQNUQWSLP-VIFPVBQESA-N (R)-adrenaline Chemical compound CNC[C@H](O)C1=CC=C(O)C(O)=C1 UCTWMZQNUQWSLP-VIFPVBQESA-N 0.000 claims 1
- 229930182837 (R)-adrenaline Natural products 0.000 claims 1
- 241000238876 Acari Species 0.000 claims 1
- 208000027496 Behcet disease Diseases 0.000 claims 1
- 208000009137 Behcet syndrome Diseases 0.000 claims 1
- 208000024172 Cardiovascular disease Diseases 0.000 claims 1
- 206010009895 Colitis ischaemic Diseases 0.000 claims 1
- 206010056979 Colitis microscopic Diseases 0.000 claims 1
- 206010009900 Colitis ulcerative Diseases 0.000 claims 1
- 102000008186 Collagen Human genes 0.000 claims 1
- 108010035532 Collagen Proteins 0.000 claims 1
- 208000011231 Crohn disease Diseases 0.000 claims 1
- CMSMOCZEIVJLDB-UHFFFAOYSA-N Cyclophosphamide Chemical compound ClCCN(CCCl)P1(=O)NCCCO1 CMSMOCZEIVJLDB-UHFFFAOYSA-N 0.000 claims 1
- PMATZTZNYRCHOR-CGLBZJNRSA-N Cyclosporin A Chemical compound CC[C@@H]1NC(=O)[C@H]([C@H](O)[C@H](C)C\C=C\C)N(C)C(=O)[C@H](C(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](C(C)C)NC(=O)[C@H](CC(C)C)N(C)C(=O)CN(C)C1=O PMATZTZNYRCHOR-CGLBZJNRSA-N 0.000 claims 1
- 108010036949 Cyclosporine Proteins 0.000 claims 1
- 206010058838 Enterocolitis infectious Diseases 0.000 claims 1
- 206010064212 Eosinophilic oesophagitis Diseases 0.000 claims 1
- 206010048643 Hypereosinophilic syndrome Diseases 0.000 claims 1
- 206010061218 Inflammation Diseases 0.000 claims 1
- 108010002352 Interleukin-1 Proteins 0.000 claims 1
- 102100020793 Interleukin-13 receptor subunit alpha-2 Human genes 0.000 claims 1
- 108010002616 Interleukin-5 Proteins 0.000 claims 1
- 108090001005 Interleukin-6 Proteins 0.000 claims 1
- 102100037792 Interleukin-6 receptor subunit alpha Human genes 0.000 claims 1
- 108090001007 Interleukin-8 Proteins 0.000 claims 1
- 108010002335 Interleukin-9 Proteins 0.000 claims 1
- FBOZXECLQNJBKD-ZDUSSCGKSA-N L-methotrexate Chemical compound C=1N=C2N=C(N)N=C(N)C2=NC=1CN(C)C1=CC=C(C(=O)N[C@@H](CCC(O)=O)C(O)=O)C=C1 FBOZXECLQNJBKD-ZDUSSCGKSA-N 0.000 claims 1
- 206010054949 Metaplasia Diseases 0.000 claims 1
- 229940121948 Muscarinic receptor antagonist Drugs 0.000 claims 1
- 241000208125 Nicotiana Species 0.000 claims 1
- 235000002637 Nicotiana tabacum Nutrition 0.000 claims 1
- 208000002193 Pain Diseases 0.000 claims 1
- 229940123932 Phosphodiesterase 4 inhibitor Drugs 0.000 claims 1
- 201000004681 Psoriasis Diseases 0.000 claims 1
- 201000001263 Psoriatic Arthritis Diseases 0.000 claims 1
- 208000036824 Psoriatic arthropathy Diseases 0.000 claims 1
- 206010039085 Rhinitis allergic Diseases 0.000 claims 1
- QJJXYPPXXYFBGM-LFZNUXCKSA-N Tacrolimus Chemical compound C1C[C@@H](O)[C@H](OC)C[C@@H]1\C=C(/C)[C@@H]1[C@H](C)[C@@H](O)CC(=O)[C@H](CC=C)/C=C(C)/C[C@H](C)C[C@H](OC)[C@H]([C@H](C[C@H]2C)OC)O[C@@]2(O)C(=O)C(=O)N2CCCC[C@H]2C(=O)O1 QJJXYPPXXYFBGM-LFZNUXCKSA-N 0.000 claims 1
- GUGOEEXESWIERI-UHFFFAOYSA-N Terfenadine Chemical compound C1=CC(C(C)(C)C)=CC=C1C(O)CCCN1CCC(C(O)(C=2C=CC=CC=2)C=2C=CC=CC=2)CC1 GUGOEEXESWIERI-UHFFFAOYSA-N 0.000 claims 1
- 201000006704 Ulcerative Colitis Diseases 0.000 claims 1
- 206010046851 Uveitis Diseases 0.000 claims 1
- ANGKOCUUWGHLCE-HKUYNNGSSA-N [(3s)-1,1-dimethylpyrrolidin-1-ium-3-yl] (2r)-2-cyclopentyl-2-hydroxy-2-phenylacetate Chemical compound C1[N+](C)(C)CC[C@@H]1OC(=O)[C@](O)(C=1C=CC=CC=1)C1CCCC1 ANGKOCUUWGHLCE-HKUYNNGSSA-N 0.000 claims 1
- 238000003915 air pollution Methods 0.000 claims 1
- 208000037883 airway inflammation Diseases 0.000 claims 1
- 208000037884 allergic airway inflammation Diseases 0.000 claims 1
- 201000009961 allergic asthma Diseases 0.000 claims 1
- 201000010105 allergic rhinitis Diseases 0.000 claims 1
- 230000001387 anti-histamine Effects 0.000 claims 1
- 239000000739 antihistaminic agent Substances 0.000 claims 1
- LMEKQMALGUDUQG-UHFFFAOYSA-N azathioprine Chemical compound CN1C=NC([N+]([O-])=O)=C1SC1=NC=NC2=C1NC=N2 LMEKQMALGUDUQG-UHFFFAOYSA-N 0.000 claims 1
- 229960002170 azathioprine Drugs 0.000 claims 1
- 230000037365 barrier function of the epidermis Effects 0.000 claims 1
- 229940124748 beta 2 agonist Drugs 0.000 claims 1
- 239000002876 beta blocker Substances 0.000 claims 1
- 229940097320 beta blocking agent Drugs 0.000 claims 1
- 229940124630 bronchodilator Drugs 0.000 claims 1
- 229940082638 cardiac stimulant phosphodiesterase inhibitors Drugs 0.000 claims 1
- 239000000812 cholinergic antagonist Substances 0.000 claims 1
- 208000030949 chronic idiopathic urticaria Diseases 0.000 claims 1
- 206010072757 chronic spontaneous urticaria Diseases 0.000 claims 1
- 208000024376 chronic urticaria Diseases 0.000 claims 1
- 229960001265 ciclosporin Drugs 0.000 claims 1
- 206010009887 colitis Diseases 0.000 claims 1
- 229920001436 collagen Polymers 0.000 claims 1
- 230000000295 complement effect Effects 0.000 claims 1
- 239000003246 corticosteroid Substances 0.000 claims 1
- 229960000265 cromoglicic acid Drugs 0.000 claims 1
- IMZMKUWMOSJXDT-UHFFFAOYSA-N cromoglycic acid Chemical compound O1C(C(O)=O)=CC(=O)C2=C1C=CC=C2OCC(O)COC1=CC=CC2=C1C(=O)C=C(C(O)=O)O2 IMZMKUWMOSJXDT-UHFFFAOYSA-N 0.000 claims 1
- 229960004397 cyclophosphamide Drugs 0.000 claims 1
- 229930182912 cyclosporin Natural products 0.000 claims 1
- 239000000850 decongestant Substances 0.000 claims 1
- 239000003085 diluting agent Substances 0.000 claims 1
- 238000010494 dissociation reaction Methods 0.000 claims 1
- 230000005593 dissociations Effects 0.000 claims 1
- 230000009977 dual effect Effects 0.000 claims 1
- 239000000428 dust Substances 0.000 claims 1
- 230000004064 dysfunction Effects 0.000 claims 1
- 230000002327 eosinophilic effect Effects 0.000 claims 1
- 201000000708 eosinophilic esophagitis Diseases 0.000 claims 1
- 201000009580 eosinophilic pneumonia Diseases 0.000 claims 1
- 229960005139 epinephrine Drugs 0.000 claims 1
- 230000005713 exacerbation Effects 0.000 claims 1
- 235000013305 food Nutrition 0.000 claims 1
- 229960002462 glycopyrronium bromide Drugs 0.000 claims 1
- 210000002175 goblet cell Anatomy 0.000 claims 1
- 210000003630 histaminocyte Anatomy 0.000 claims 1
- 229960003444 immunosuppressant agent Drugs 0.000 claims 1
- 230000001861 immunosuppressant effect Effects 0.000 claims 1
- 239000003018 immunosuppressive agent Substances 0.000 claims 1
- 208000027138 indeterminate colitis Diseases 0.000 claims 1
- 208000027139 infectious colitis Diseases 0.000 claims 1
- 230000004054 inflammatory process Effects 0.000 claims 1
- 108040003607 interleukin-13 receptor activity proteins Proteins 0.000 claims 1
- 108040006852 interleukin-4 receptor activity proteins Proteins 0.000 claims 1
- 108040006858 interleukin-6 receptor activity proteins Proteins 0.000 claims 1
- 201000010659 intrinsic asthma Diseases 0.000 claims 1
- 201000008222 ischemic colitis Diseases 0.000 claims 1
- 239000003199 leukotriene receptor blocking agent Substances 0.000 claims 1
- 206010025135 lupus erythematosus Diseases 0.000 claims 1
- 208000004341 lymphocytic colitis Diseases 0.000 claims 1
- 230000002912 lymphogenic effect Effects 0.000 claims 1
- 230000015689 metaplastic ossification Effects 0.000 claims 1
- 229960000485 methotrexate Drugs 0.000 claims 1
- 201000006417 multiple sclerosis Diseases 0.000 claims 1
- 239000000472 muscarinic agonist Substances 0.000 claims 1
- 201000008482 osteoarthritis Diseases 0.000 claims 1
- 239000002587 phosphodiesterase IV inhibitor Substances 0.000 claims 1
- 239000002571 phosphodiesterase inhibitor Substances 0.000 claims 1
- KASDHRXLYQOAKZ-ZPSXYTITSA-N pimecrolimus Chemical compound C/C([C@H]1OC(=O)[C@@H]2CCCCN2C(=O)C(=O)[C@]2(O)O[C@@H]([C@H](C[C@H]2C)OC)[C@@H](OC)C[C@@H](C)C/C(C)=C/[C@H](C(C[C@H](O)[C@H]1C)=O)CC)=C\[C@@H]1CC[C@@H](Cl)[C@H](OC)C1 KASDHRXLYQOAKZ-ZPSXYTITSA-N 0.000 claims 1
- 229960005330 pimecrolimus Drugs 0.000 claims 1
- 230000002685 pulmonary effect Effects 0.000 claims 1
- 201000009732 pulmonary eosinophilia Diseases 0.000 claims 1
- 229960002586 roflumilast Drugs 0.000 claims 1
- MNDBXUUTURYVHR-UHFFFAOYSA-N roflumilast Chemical compound FC(F)OC1=CC=C(C(=O)NC=2C(=CN=CC=2Cl)Cl)C=C1OCC1CC1 MNDBXUUTURYVHR-UHFFFAOYSA-N 0.000 claims 1
- 239000000779 smoke Substances 0.000 claims 1
- 239000000126 substance Substances 0.000 claims 1
- 208000011580 syndromic disease Diseases 0.000 claims 1
- 229960001967 tacrolimus Drugs 0.000 claims 1
- QJJXYPPXXYFBGM-SHYZHZOCSA-N tacrolimus Natural products CO[C@H]1C[C@H](CC[C@@H]1O)C=C(C)[C@H]2OC(=O)[C@H]3CCCCN3C(=O)C(=O)[C@@]4(O)O[C@@H]([C@H](C[C@H]4C)OC)[C@@H](C[C@H](C)CC(=C[C@@H](CC=C)C(=O)C[C@H](O)[C@H]2C)C)OC QJJXYPPXXYFBGM-SHYZHZOCSA-N 0.000 claims 1
- 229960000278 theophylline Drugs 0.000 claims 1
- 230000002992 thymic effect Effects 0.000 claims 1
- LERNTVKEWCAPOY-DZZGSBJMSA-N tiotropium Chemical compound O([C@H]1C[C@@H]2[N+]([C@H](C1)[C@@H]1[C@H]2O1)(C)C)C(=O)C(O)(C=1SC=CC=1)C1=CC=CS1 LERNTVKEWCAPOY-DZZGSBJMSA-N 0.000 claims 1
- 229940110309 tiotropium Drugs 0.000 claims 1
- 230000000699 topical effect Effects 0.000 claims 1
- 238000002054 transplantation Methods 0.000 claims 1
- 229920001184 polypeptide Polymers 0.000 description 106
- 102000004196 processed proteins & peptides Human genes 0.000 description 106
- 108090000765 processed proteins & peptides Proteins 0.000 description 106
- 235000001014 amino acid Nutrition 0.000 description 79
- 229940012957 plasmin Drugs 0.000 description 66
- 108010088842 Fibrinolysin Proteins 0.000 description 65
- 230000002401 inhibitory effect Effects 0.000 description 57
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 description 28
- 238000000034 method Methods 0.000 description 15
- PYUSHNKNPOHWEZ-YFKPBYRVSA-N N-formyl-L-methionine Chemical compound CSCC[C@@H](C(O)=O)NC=O PYUSHNKNPOHWEZ-YFKPBYRVSA-N 0.000 description 14
- 229930182817 methionine Natural products 0.000 description 14
- 125000001360 methionine group Chemical group N[C@@H](CCSC)C(=O)* 0.000 description 14
- 238000001356 surgical procedure Methods 0.000 description 11
- 108091005804 Peptidases Proteins 0.000 description 6
- 102000035195 Peptidases Human genes 0.000 description 6
- 235000019833 protease Nutrition 0.000 description 6
- 210000004899 c-terminal region Anatomy 0.000 description 4
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 description 4
- 101710181812 Methionine aminopeptidase Proteins 0.000 description 3
- 125000000151 cysteine group Chemical group N[C@@H](CS)C(=O)* 0.000 description 3
- 108091033319 polynucleotide Proteins 0.000 description 3
- 102000040430 polynucleotide Human genes 0.000 description 3
- 239000002157 polynucleotide Substances 0.000 description 3
- 235000018102 proteins Nutrition 0.000 description 3
- 108090000623 proteins and genes Proteins 0.000 description 3
- 102000004169 proteins and genes Human genes 0.000 description 3
- 239000007790 solid phase Substances 0.000 description 3
- 206010051379 Systemic Inflammatory Response Syndrome Diseases 0.000 description 2
- 239000012472 biological sample Substances 0.000 description 2
- 239000013604 expression vector Substances 0.000 description 2
- 108020001507 fusion proteins Proteins 0.000 description 2
- 102000037865 fusion proteins Human genes 0.000 description 2
- 239000012535 impurity Substances 0.000 description 2
- 229920001515 polyalkylene glycol Polymers 0.000 description 2
- 239000000523 sample Substances 0.000 description 2
- 102000055046 tissue-factor-pathway inhibitor 2 Human genes 0.000 description 2
- 108010016054 tissue-factor-pathway inhibitor 2 Proteins 0.000 description 2
- 208000031220 Hemophilia Diseases 0.000 description 1
- 208000009292 Hemophilia A Diseases 0.000 description 1
- 206010028980 Neoplasm Diseases 0.000 description 1
- 108091028043 Nucleic acid sequence Proteins 0.000 description 1
- 239000002202 Polyethylene glycol Substances 0.000 description 1
- 238000012084 abdominal surgery Methods 0.000 description 1
- 230000002491 angiogenic effect Effects 0.000 description 1
- 230000010072 bone remodeling Effects 0.000 description 1
- 201000011510 cancer Diseases 0.000 description 1
- 238000013130 cardiovascular surgery Methods 0.000 description 1
- 210000004351 coronary vessel Anatomy 0.000 description 1
- 238000002316 cosmetic surgery Methods 0.000 description 1
- 238000012258 culturing Methods 0.000 description 1
- 230000004927 fusion Effects 0.000 description 1
- 238000000338 in vitro Methods 0.000 description 1
- 230000005764 inhibitory process Effects 0.000 description 1
- 208000014674 injury Diseases 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 230000014508 negative regulation of coagulation Effects 0.000 description 1
- 230000000926 neurological effect Effects 0.000 description 1
- 150000007523 nucleic acids Chemical group 0.000 description 1
- 230000000771 oncological effect Effects 0.000 description 1
- 230000000399 orthopedic effect Effects 0.000 description 1
- 229920001223 polyethylene glycol Polymers 0.000 description 1
- 230000017854 proteolysis Effects 0.000 description 1
- 210000000115 thoracic cavity Anatomy 0.000 description 1
- 230000008733 trauma Effects 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2020002597A JP6916319B2 (ja) | 2014-09-23 | 2020-01-10 | 抗ｉｌ−２５抗体およびその使用 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201462054167P | 2014-09-23 | 2014-09-23 | |
| US62/054,167 | 2014-09-23 | ||
| PCT/US2015/051407 WO2016049000A2 (en) | 2014-09-23 | 2015-09-22 | Anti-il-25 antibodies and uses thereof |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020002597A Division JP6916319B2 (ja) | 2014-09-23 | 2020-01-10 | 抗ｉｌ−２５抗体およびその使用 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2017533888A JP2017533888A (ja) | 2017-11-16 |
| JP2017533888A5 true JP2017533888A5 (OSRAM) | 2018-10-25 |
| JP6694877B2 JP6694877B2 (ja) | 2020-05-20 |
Family
ID=54207847
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017515768A Active JP6694877B2 (ja) | 2014-09-23 | 2015-09-22 | 抗ｉｌ−２５抗体およびその使用 |
| JP2020002597A Active JP6916319B2 (ja) | 2014-09-23 | 2020-01-10 | 抗ｉｌ−２５抗体およびその使用 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020002597A Active JP6916319B2 (ja) | 2014-09-23 | 2020-01-10 | 抗ｉｌ−２５抗体およびその使用 |
Country Status (18)
| Country | Link |
|---|---|
| US (3) | US9840557B2 (OSRAM) |
| EP (1) | EP3197914B1 (OSRAM) |
| JP (2) | JP6694877B2 (OSRAM) |
| KR (1) | KR102576368B1 (OSRAM) |
| CN (1) | CN107207589B (OSRAM) |
| AU (1) | AU2015321517B2 (OSRAM) |
| CA (1) | CA2961517C (OSRAM) |
| CL (2) | CL2017000703A1 (OSRAM) |
| CO (1) | CO2017003072A2 (OSRAM) |
| EA (1) | EA036658B1 (OSRAM) |
| IL (1) | IL251001B (OSRAM) |
| MA (1) | MA40106A1 (OSRAM) |
| MX (1) | MX2017003841A (OSRAM) |
| MY (1) | MY185832A (OSRAM) |
| PH (1) | PH12017500403A1 (OSRAM) |
| SG (2) | SG10201913084PA (OSRAM) |
| WO (1) | WO2016049000A2 (OSRAM) |
| ZA (1) | ZA201701663B (OSRAM) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SG10201913084PA (en) | 2014-09-23 | 2020-03-30 | Regeneron Pharma | Anti-il-25 antibodies and uses thereof |
| KR20240052871A (ko) | 2016-04-27 | 2024-04-23 | 애브비 인코포레이티드 | 항-il-13 항체를 이용한 il-13 활성이 유해한 질환의 치료 방법 |
| US11285191B2 (en) | 2016-07-26 | 2022-03-29 | The Board Of Supervisors Of Louisiana State University And Agricultural And Mechanical College | Immunostimulatory compositions and uses therefor |
| CN107213463A (zh) * | 2017-05-24 | 2017-09-29 | 清华大学 | 白介素25在银屑病的发育中的作用 |
| DE102017215154A1 (de) | 2017-08-30 | 2019-02-28 | Markus Bläss | Zusammensetzung zur topischen Behandlung von nicht-Mikroorganismus-verursachten entzündlichen Haut- und Schleimhauterkrankungen |
| CN112638940B (zh) * | 2018-11-19 | 2022-09-30 | 苏州鑫康合生物医药科技有限公司 | 抗-il-25抗体及其用途 |
| BR112022012093A2 (pt) | 2019-12-20 | 2022-08-30 | Momenta Pharmaceuticals Inc | Anticorpos contra integrina alfa 11 beta 1 |
| KR20210095781A (ko) | 2020-01-24 | 2021-08-03 | 주식회사 에이프릴바이오 | 항원결합 단편 및 생리활성 이펙터 모이어티로 구성된 융합 컨스트럭트를 포함하는 다중결합항체 및 이를 포함하는 약학조성물 |
| US11365239B2 (en) | 2020-03-20 | 2022-06-21 | Tsb Therapeutics (Beijing) Co., Ltd. | Anti-SARS-COV-2 antibodies and uses thereof |
| WO2022150660A1 (en) * | 2021-01-08 | 2022-07-14 | 10X Genomics, Inc. | Antigen-binding polypeptides specific for coronaviruses and uses thereof |
| WO2023060144A1 (en) * | 2021-10-05 | 2023-04-13 | Lanier Biotherapeutics | Monoclonal antibodies to il-25 and uses thereof |
| CN119183384A (zh) * | 2022-02-24 | 2024-12-24 | 中国抗体制药有限公司 | 针对警报素的双特异性结合蛋白及其用途 |
| KR20250162899A (ko) * | 2023-03-31 | 2025-11-19 | 노바록 바이오테라퓨틱스 리미티드 | 항-il-25 항체 및 이의 사용 방법 |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB8308236D0 (en) * | 1983-03-25 | 1983-05-05 | Celltech Ltd | Dna vectors |
| IL85035A0 (en) | 1987-01-08 | 1988-06-30 | Int Genetic Eng | Polynucleotide molecule,a chimeric antibody with specificity for human b cell surface antigen,a process for the preparation and methods utilizing the same |
| DE122004000008I1 (de) | 1991-06-14 | 2005-06-09 | Genentech Inc | Humanisierter Heregulin Antikörper. |
| US7060802B1 (en) * | 2000-09-18 | 2006-06-13 | The Trustees Of Columbia University In The City Of New York | Tumor-associated marker |
| US6596541B2 (en) | 2000-10-31 | 2003-07-22 | Regeneron Pharmaceuticals, Inc. | Methods of modifying eukaryotic cells |
| NZ573557A (en) | 2006-06-02 | 2010-08-27 | Regeneron Pharma | High affinity antibodies to human il-6 receptor |
| GB0707505D0 (en) | 2007-04-18 | 2007-05-30 | Medical Res Council | Antibodies against il-25 |
| GB0817891D0 (en) | 2008-09-30 | 2008-11-05 | Medical Res Council | Antibodies against il-25 |
| HRP20180340T1 (hr) | 2010-03-30 | 2018-03-23 | Janssen Biotech, Inc. | Humanizirana il-25 protutijela |
| WO2012097126A2 (en) * | 2011-01-13 | 2012-07-19 | The University Of Maryland, Baltimore | Il-25 treatment of obesity and metabolic disorders |
| JP2015521591A (ja) * | 2012-06-12 | 2015-07-30 | オレガ・バイオテック | Ｉｌ−１７アイソフォームのアンタゴニストおよびその使用 |
| SG10201913084PA (en) | 2014-09-23 | 2020-03-30 | Regeneron Pharma | Anti-il-25 antibodies and uses thereof |
-
2015
- 2015-09-22 SG SG10201913084PA patent/SG10201913084PA/en unknown
- 2015-09-22 WO PCT/US2015/051407 patent/WO2016049000A2/en not_active Ceased
- 2015-09-22 CA CA2961517A patent/CA2961517C/en active Active
- 2015-09-22 MY MYPI2017700743A patent/MY185832A/en unknown
- 2015-09-22 JP JP2017515768A patent/JP6694877B2/ja active Active
- 2015-09-22 CN CN201580063385.9A patent/CN107207589B/zh active Active
- 2015-09-22 US US14/861,320 patent/US9840557B2/en active Active
- 2015-09-22 MX MX2017003841A patent/MX2017003841A/es unknown
- 2015-09-22 AU AU2015321517A patent/AU2015321517B2/en active Active
- 2015-09-22 MA MA40106A patent/MA40106A1/fr unknown
- 2015-09-22 EA EA201790441A patent/EA036658B1/ru unknown
- 2015-09-22 KR KR1020177009048A patent/KR102576368B1/ko active Active
- 2015-09-22 EP EP15771489.0A patent/EP3197914B1/en active Active
- 2015-09-22 SG SG11201701712WA patent/SG11201701712WA/en unknown
-
2017
- 2017-03-03 PH PH12017500403A patent/PH12017500403A1/en unknown
- 2017-03-07 IL IL251001A patent/IL251001B/en active IP Right Grant
- 2017-03-08 ZA ZA2017/01663A patent/ZA201701663B/en unknown
- 2017-03-23 CL CL2017000703A patent/CL2017000703A1/es unknown
- 2017-03-29 CO CONC2017/0003072A patent/CO2017003072A2/es unknown
- 2017-11-07 US US15/805,584 patent/US10640558B2/en active Active
-
2018
- 2018-12-14 CL CL2018003608A patent/CL2018003608A1/es unknown
-
2020
- 2020-01-10 JP JP2020002597A patent/JP6916319B2/ja active Active
- 2020-02-27 US US16/803,582 patent/US11542326B2/en active Active
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2017533888A5 (OSRAM) | ||
| RU2650767C2 (ru) | Интерлейкин-13-связывающие белки | |
| JP6216772B2 (ja) | 抗ｂａｆｆ−抗ｉｌ−１７二重特異性抗体 | |
| KR101773505B1 (ko) | 인간 ｉｌ-１３에 대한 결합 특이성을 갖는 항체 분자 | |
| JP6876156B2 (ja) | Ｉｌ−１７ａ及びｉｌ−１７ｆに反応するモノクローナル抗体、及びその使用 | |
| CN102307899A (zh) | 炎症、自身免疫疾病和心血管疾病的嗜酸细胞活化趋化因子-2(ccl24)抑制剂 | |
| JP2017528466A (ja) | Ｃｄ４０ｌに対するドメイン抗体を用いて自己免疫疾患を処置する方法 | |
| US20240182556A1 (en) | Stem cell factor antibodies and methods of use thereof | |
| NZ730105B2 (en) | Anti-il-25 antibodies and uses thereof | |
| NZ730105A (en) | Anti-il-25 antibodies and uses thereof | |
| HK1256740B (en) | Interleukin -13 binding proteins | |
| HK1128495B (en) | Interleukin -13 binding proteins |