JP2017533207A5 - - Google Patents
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- JP2017533207A5 JP2017533207A5 JP2017522170A JP2017522170A JP2017533207A5 JP 2017533207 A5 JP2017533207 A5 JP 2017533207A5 JP 2017522170 A JP2017522170 A JP 2017522170A JP 2017522170 A JP2017522170 A JP 2017522170A JP 2017533207 A5 JP2017533207 A5 JP 2017533207A5
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- JP
- Japan
- Prior art keywords
- slamf1
- antibody
- activated
- cells
- antagonist
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 108010074687 Signaling Lymphocytic Activation Molecule Family Member 1 Proteins 0.000 claims 45
- 102100029215 Signaling lymphocytic activation molecule Human genes 0.000 claims 45
- 210000001744 T-lymphocyte Anatomy 0.000 claims 25
- 239000003814 drug Substances 0.000 claims 21
- 239000005557 antagonist Substances 0.000 claims 20
- 238000000034 method Methods 0.000 claims 11
- 102100022203 Tumor necrosis factor receptor superfamily member 25 Human genes 0.000 claims 6
- 230000004927 fusion Effects 0.000 claims 6
- -1 CEACAM-1 Proteins 0.000 claims 5
- 108010002350 Interleukin-2 Proteins 0.000 claims 5
- 102000000588 Interleukin-2 Human genes 0.000 claims 5
- 230000035755 proliferation Effects 0.000 claims 5
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- 230000003308 immunostimulating effect Effects 0.000 claims 4
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- 101000666896 Homo sapiens V-type immunoglobulin domain-containing suppressor of T-cell activation Proteins 0.000 claims 3
- 102100034980 ICOS ligand Human genes 0.000 claims 3
- 108010021625 Immunoglobulin Fragments Proteins 0.000 claims 3
- 102000008394 Immunoglobulin Fragments Human genes 0.000 claims 3
- 102100038282 V-type immunoglobulin domain-containing suppressor of T-cell activation Human genes 0.000 claims 3
- 239000000556 agonist Substances 0.000 claims 3
- 239000003795 chemical substances by application Substances 0.000 claims 3
- 108090000765 processed proteins & peptides Proteins 0.000 claims 3
- 150000003384 small molecules Chemical group 0.000 claims 3
- 108010082808 4-1BB Ligand Proteins 0.000 claims 2
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- 101710185679 CD276 antigen Proteins 0.000 claims 2
- 108010029697 CD40 Ligand Proteins 0.000 claims 2
- 101150013553 CD40 gene Proteins 0.000 claims 2
- 102100032937 CD40 ligand Human genes 0.000 claims 2
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- 102000004127 Cytokines Human genes 0.000 claims 2
- 108090000695 Cytokines Proteins 0.000 claims 2
- 102100037354 Ectodysplasin-A Human genes 0.000 claims 2
- 101000880080 Homo sapiens Ectodysplasin-A Proteins 0.000 claims 2
- 101001019455 Homo sapiens ICOS ligand Proteins 0.000 claims 2
- 101000610605 Homo sapiens Tumor necrosis factor receptor superfamily member 10A Proteins 0.000 claims 2
- 101000610604 Homo sapiens Tumor necrosis factor receptor superfamily member 10B Proteins 0.000 claims 2
- 101000801234 Homo sapiens Tumor necrosis factor receptor superfamily member 18 Proteins 0.000 claims 2
- 102000003814 Interleukin-10 Human genes 0.000 claims 2
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- 102100021592 Interleukin-7 Human genes 0.000 claims 2
- 108010002586 Interleukin-7 Proteins 0.000 claims 2
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- 206010028980 Neoplasm Diseases 0.000 claims 2
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- 108010042215 OX40 Ligand Proteins 0.000 claims 2
- 230000006044 T cell activation Effects 0.000 claims 2
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- 102100040113 Tumor necrosis factor receptor superfamily member 10A Human genes 0.000 claims 2
- 102100040112 Tumor necrosis factor receptor superfamily member 10B Human genes 0.000 claims 2
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- 101710165473 Tumor necrosis factor receptor superfamily member 4 Proteins 0.000 claims 2
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- 108010079206 V-Set Domain-Containing T-Cell Activation Inhibitor 1 Proteins 0.000 claims 2
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- 102000005789 Vascular Endothelial Growth Factors Human genes 0.000 claims 2
- 108010019530 Vascular Endothelial Growth Factors Proteins 0.000 claims 2
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- 230000000139 costimulatory effect Effects 0.000 claims 2
- 239000000539 dimer Substances 0.000 claims 2
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- IJJVMEJXYNJXOJ-UHFFFAOYSA-N fluquinconazole Chemical compound C=1C=C(Cl)C=C(Cl)C=1N1C(=O)C2=CC(F)=CC=C2N=C1N1C=NC=N1 IJJVMEJXYNJXOJ-UHFFFAOYSA-N 0.000 claims 2
- 229960001438 immunostimulant agent Drugs 0.000 claims 2
- 239000003022 immunostimulating agent Substances 0.000 claims 2
- 230000005764 inhibitory process Effects 0.000 claims 2
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- 239000000178 monomer Substances 0.000 claims 2
- 210000000822 natural killer cell Anatomy 0.000 claims 2
- 230000004510 negative regulation of activated T cell proliferation Effects 0.000 claims 2
- BGFTWECWAICPDG-UHFFFAOYSA-N 2-[bis(4-chlorophenyl)methyl]-4-n-[3-[bis(4-chlorophenyl)methyl]-4-(dimethylamino)phenyl]-1-n,1-n-dimethylbenzene-1,4-diamine Chemical compound C1=C(C(C=2C=CC(Cl)=CC=2)C=2C=CC(Cl)=CC=2)C(N(C)C)=CC=C1NC(C=1)=CC=C(N(C)C)C=1C(C=1C=CC(Cl)=CC=1)C1=CC=C(Cl)C=C1 BGFTWECWAICPDG-UHFFFAOYSA-N 0.000 claims 1
- 102100023990 60S ribosomal protein L17 Human genes 0.000 claims 1
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- 108010085277 Adenosine A2A receptor Proteins 0.000 claims 1
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- 108010008014 B-Cell Maturation Antigen Proteins 0.000 claims 1
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- 101000840545 Bacillus thuringiensis L-isoleucine-4-hydroxylase Proteins 0.000 claims 1
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- 108010046080 CD27 Ligand Proteins 0.000 claims 1
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- 102100036008 CD48 antigen Human genes 0.000 claims 1
- 102000019034 Chemokines Human genes 0.000 claims 1
- 108010012236 Chemokines Proteins 0.000 claims 1
- 101710093674 Cyclic nucleotide-gated cation channel beta-1 Proteins 0.000 claims 1
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- 102100025137 Early activation antigen CD69 Human genes 0.000 claims 1
- 101150089023 FASLG gene Proteins 0.000 claims 1
- 108010001498 Galectin 1 Proteins 0.000 claims 1
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- 102100031351 Galectin-9 Human genes 0.000 claims 1
- 101710121810 Galectin-9 Proteins 0.000 claims 1
- 102100034459 Hepatitis A virus cellular receptor 1 Human genes 0.000 claims 1
- 102100034458 Hepatitis A virus cellular receptor 2 Human genes 0.000 claims 1
- 101000824278 Homo sapiens Acyl-[acyl-carrier-protein] hydrolase Proteins 0.000 claims 1
- 101000775042 Homo sapiens Adhesion G-protein coupled receptor G1 Proteins 0.000 claims 1
- 101000864344 Homo sapiens B- and T-lymphocyte attenuator Proteins 0.000 claims 1
- 101000922348 Homo sapiens C-X-C chemokine receptor type 4 Proteins 0.000 claims 1
- 101000914511 Homo sapiens CD27 antigen Proteins 0.000 claims 1
- 101000716130 Homo sapiens CD48 antigen Proteins 0.000 claims 1
- 101000934356 Homo sapiens CD70 antigen Proteins 0.000 claims 1
- 101000889276 Homo sapiens Cytotoxic T-lymphocyte protein 4 Proteins 0.000 claims 1
- 101000934374 Homo sapiens Early activation antigen CD69 Proteins 0.000 claims 1
- 101001068136 Homo sapiens Hepatitis A virus cellular receptor 1 Proteins 0.000 claims 1
- 101001068133 Homo sapiens Hepatitis A virus cellular receptor 2 Proteins 0.000 claims 1
- 101001037256 Homo sapiens Indoleamine 2,3-dioxygenase 1 Proteins 0.000 claims 1
- 101001057504 Homo sapiens Interferon-stimulated gene 20 kDa protein Proteins 0.000 claims 1
- 101001055144 Homo sapiens Interleukin-2 receptor subunit alpha Proteins 0.000 claims 1
- 101000984189 Homo sapiens Leukocyte immunoglobulin-like receptor subfamily B member 2 Proteins 0.000 claims 1
- 101001138062 Homo sapiens Leukocyte-associated immunoglobulin-like receptor 1 Proteins 0.000 claims 1
- 101001023712 Homo sapiens Nectin-3 Proteins 0.000 claims 1
- 101001117317 Homo sapiens Programmed cell death 1 ligand 1 Proteins 0.000 claims 1
- 101001117312 Homo sapiens Programmed cell death 1 ligand 2 Proteins 0.000 claims 1
- 101000831286 Homo sapiens Protein timeless homolog Proteins 0.000 claims 1
- 101000752245 Homo sapiens Rho guanine nucleotide exchange factor 5 Proteins 0.000 claims 1
- 101000669511 Homo sapiens T-cell immunoglobulin and mucin domain-containing protein 4 Proteins 0.000 claims 1
- 101000831007 Homo sapiens T-cell immunoreceptor with Ig and ITIM domains Proteins 0.000 claims 1
- 101000914514 Homo sapiens T-cell-specific surface glycoprotein CD28 Proteins 0.000 claims 1
- 101100207070 Homo sapiens TNFSF8 gene Proteins 0.000 claims 1
- 101000831567 Homo sapiens Toll-like receptor 2 Proteins 0.000 claims 1
- 101000764622 Homo sapiens Transmembrane and immunoglobulin domain-containing protein 2 Proteins 0.000 claims 1
- 101000610602 Homo sapiens Tumor necrosis factor receptor superfamily member 10C Proteins 0.000 claims 1
- 101000610609 Homo sapiens Tumor necrosis factor receptor superfamily member 10D Proteins 0.000 claims 1
- 101000798130 Homo sapiens Tumor necrosis factor receptor superfamily member 11B Proteins 0.000 claims 1
- 101000795167 Homo sapiens Tumor necrosis factor receptor superfamily member 13B Proteins 0.000 claims 1
- 101000795169 Homo sapiens Tumor necrosis factor receptor superfamily member 13C Proteins 0.000 claims 1
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- 101000679921 Homo sapiens Tumor necrosis factor receptor superfamily member 21 Proteins 0.000 claims 1
- 101000679907 Homo sapiens Tumor necrosis factor receptor superfamily member 27 Proteins 0.000 claims 1
- 101000611023 Homo sapiens Tumor necrosis factor receptor superfamily member 6 Proteins 0.000 claims 1
- 101000851376 Homo sapiens Tumor necrosis factor receptor superfamily member 8 Proteins 0.000 claims 1
- 101000920026 Homo sapiens Tumor necrosis factor receptor superfamily member EDAR Proteins 0.000 claims 1
- 101710093458 ICOS ligand Proteins 0.000 claims 1
- 102000017727 Immunoglobulin Variable Region Human genes 0.000 claims 1
- 108010067060 Immunoglobulin Variable Region Proteins 0.000 claims 1
- 102100040061 Indoleamine 2,3-dioxygenase 1 Human genes 0.000 claims 1
- 102100026878 Interleukin-2 receptor subunit alpha Human genes 0.000 claims 1
- 102100030703 Interleukin-22 Human genes 0.000 claims 1
- 108010018951 Interleukin-8B Receptors Proteins 0.000 claims 1
- 102000002698 KIR Receptors Human genes 0.000 claims 1
- 108010043610 KIR Receptors Proteins 0.000 claims 1
- 102000017578 LAG3 Human genes 0.000 claims 1
- 101150030213 Lag3 gene Proteins 0.000 claims 1
- 102100025583 Leukocyte immunoglobulin-like receptor subfamily B member 2 Human genes 0.000 claims 1
- 102100020943 Leukocyte-associated immunoglobulin-like receptor 1 Human genes 0.000 claims 1
- 108010061593 Member 14 Tumor Necrosis Factor Receptors Proteins 0.000 claims 1
- 101100046559 Mus musculus Tnfrsf12a gene Proteins 0.000 claims 1
- 101100207071 Mus musculus Tnfsf8 gene Proteins 0.000 claims 1
- 102100035487 Nectin-3 Human genes 0.000 claims 1
- 102100036056 Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform Human genes 0.000 claims 1
- 101710204747 Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform Proteins 0.000 claims 1
- 102100024216 Programmed cell death 1 ligand 1 Human genes 0.000 claims 1
- 102100024213 Programmed cell death 1 ligand 2 Human genes 0.000 claims 1
- 101710089372 Programmed cell death protein 1 Proteins 0.000 claims 1
- 102000014128 RANK Ligand Human genes 0.000 claims 1
- 108010025832 RANK Ligand Proteins 0.000 claims 1
- 108010052562 RELT Proteins 0.000 claims 1
- 102000018795 RELT Human genes 0.000 claims 1
- 229940044665 STING agonist Drugs 0.000 claims 1
- 101001037255 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) Indoleamine 2,3-dioxygenase Proteins 0.000 claims 1
- 102100039367 T-cell immunoglobulin and mucin domain-containing protein 4 Human genes 0.000 claims 1
- 102100024834 T-cell immunoreceptor with Ig and ITIM domains Human genes 0.000 claims 1
- 102100027213 T-cell-specific surface glycoprotein CD28 Human genes 0.000 claims 1
- 108010014401 TWEAK Receptor Proteins 0.000 claims 1
- 102000016946 TWEAK Receptor Human genes 0.000 claims 1
- 102100024333 Toll-like receptor 2 Human genes 0.000 claims 1
- 102100025946 Transforming growth factor beta activator LRRC32 Human genes 0.000 claims 1
- 101710169732 Transforming growth factor beta activator LRRC32 Proteins 0.000 claims 1
- 102100026224 Transmembrane and immunoglobulin domain-containing protein 2 Human genes 0.000 claims 1
- 108060008682 Tumor Necrosis Factor Proteins 0.000 claims 1
- 108060008683 Tumor Necrosis Factor Receptor Proteins 0.000 claims 1
- 102000000852 Tumor Necrosis Factor-alpha Human genes 0.000 claims 1
- 102100024584 Tumor necrosis factor ligand superfamily member 12 Human genes 0.000 claims 1
- 101710097155 Tumor necrosis factor ligand superfamily member 12 Proteins 0.000 claims 1
- 102100024587 Tumor necrosis factor ligand superfamily member 15 Human genes 0.000 claims 1
- 108090000138 Tumor necrosis factor ligand superfamily member 15 Proteins 0.000 claims 1
- 102100031988 Tumor necrosis factor ligand superfamily member 6 Human genes 0.000 claims 1
- 102100032100 Tumor necrosis factor ligand superfamily member 8 Human genes 0.000 claims 1
- 102100040115 Tumor necrosis factor receptor superfamily member 10C Human genes 0.000 claims 1
- 102100040110 Tumor necrosis factor receptor superfamily member 10D Human genes 0.000 claims 1
- 102100032236 Tumor necrosis factor receptor superfamily member 11B Human genes 0.000 claims 1
- 102100029675 Tumor necrosis factor receptor superfamily member 13B Human genes 0.000 claims 1
- 102100029690 Tumor necrosis factor receptor superfamily member 13C Human genes 0.000 claims 1
- 102100028785 Tumor necrosis factor receptor superfamily member 14 Human genes 0.000 claims 1
- 102100033760 Tumor necrosis factor receptor superfamily member 19 Human genes 0.000 claims 1
- 102100022205 Tumor necrosis factor receptor superfamily member 21 Human genes 0.000 claims 1
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- 102100030810 Tumor necrosis factor receptor superfamily member EDAR Human genes 0.000 claims 1
- 230000004913 activation Effects 0.000 claims 1
- 239000004037 angiogenesis inhibitor Substances 0.000 claims 1
- 239000012829 chemotherapy agent Substances 0.000 claims 1
- 238000003881 globally optimized alternating phase rectangular pulse Methods 0.000 claims 1
- 230000003259 immunoinhibitory effect Effects 0.000 claims 1
- 238000000338 in vitro Methods 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 239000012528 membrane Substances 0.000 claims 1
- 102000004169 proteins and genes Human genes 0.000 claims 1
- 108090000623 proteins and genes Proteins 0.000 claims 1
- 229940124597 therapeutic agent Drugs 0.000 claims 1
- 239000003970 toll like receptor agonist Substances 0.000 claims 1
- 102000003298 tumor necrosis factor receptor Human genes 0.000 claims 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201462067638P | 2014-10-23 | 2014-10-23 | |
| US62/067,638 | 2014-10-23 | ||
| US201562155810P | 2015-05-01 | 2015-05-01 | |
| US62/155,810 | 2015-05-01 | ||
| PCT/US2015/056714 WO2016065038A1 (en) | 2014-10-23 | 2015-10-21 | Slamf1 antagonists and uses thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2017533207A JP2017533207A (ja) | 2017-11-09 |
| JP2017533207A5 true JP2017533207A5 (enExample) | 2018-11-29 |
Family
ID=54397011
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017522170A Pending JP2017533207A (ja) | 2014-10-23 | 2015-10-21 | Ｓｌａｍｆ１アンタゴニスト及びその使用 |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US20180016555A1 (enExample) |
| EP (1) | EP3209688A1 (enExample) |
| JP (1) | JP2017533207A (enExample) |
| CN (1) | CN108064166A (enExample) |
| WO (1) | WO2016065038A1 (enExample) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MX2017011644A (es) | 2015-03-13 | 2017-12-04 | Cytomx Therapeutics Inc | Anticuerpos anti-pdl1, anticuerpos anti-pdl1 activables y metodos de uso de los mismos. |
| EP3322732A2 (en) | 2015-07-13 | 2018-05-23 | Cytomx Therapeutics Inc. | Anti-pd-1 antibodies, activatable anti-pd-1 antibodies, and methods of use thereof |
| PE20180773A1 (es) | 2015-10-02 | 2018-05-07 | Hoffmann La Roche | Anticuerpos biespecificos para pd1 y tim3 |
| CN116375876A (zh) | 2017-04-05 | 2023-07-04 | 豪夫迈·罗氏有限公司 | 特异性结合pd1和lag3的双特异性抗体 |
| EP3630838A1 (en) | 2017-06-01 | 2020-04-08 | CytomX Therapeutics, Inc. | Activatable anti-pdl1 antibodies, and methods of use thereof |
| CN110305210B (zh) * | 2018-03-27 | 2023-02-28 | 信达生物制药(苏州)有限公司 | 新型抗体分子、其制备方法及其用途 |
| WO2019184909A1 (zh) * | 2018-03-27 | 2019-10-03 | 信达生物制药(苏州)有限公司 | 新型抗体分子、其制备方法及其用途 |
| BR112021024997A2 (pt) * | 2019-07-03 | 2022-01-25 | Oxford Biotherapeutics Ltd | Anticorpos, polinucleotídeo, vetor de expressão, célula hospedeira, composição farmacêutica, métodos e uso |
| TW202216768A (zh) | 2020-06-22 | 2022-05-01 | 美商恩格姆生物製藥公司 | Ｌａｉｒ－１結合劑及其使用方法 |
| CN113899903B (zh) * | 2020-07-06 | 2025-08-29 | 上海市免疫学研究所 | 结直肠癌生物标志物及其在诊断、预防、治疗及预后中的应用 |
| CN116284405B (zh) * | 2023-03-15 | 2024-03-19 | 中国科学技术大学 | 靶向cd150蛋白的纳米抗体及其应用 |
| CN116162653A (zh) * | 2023-03-30 | 2023-05-26 | 湖北省农业科学院畜牧兽医研究所 | 靶向切除猪SlamF1基因编码区DNA的成对编辑位点、使用方法及其应用 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AR002004A1 (es) * | 1994-12-02 | 1998-01-07 | Schering Corp | Proteina slam, anticuerpo o un fragmento del mismo que se fija a dicha proteina, metodo de purificacion, acido nucleico que codifica dicha proteina,vector de expresion, equipo que la contiene, metodo de deteccion, metodo de modulacion y metodo para preparar una composicion farmaceutica. |
| US5576423A (en) * | 1994-12-02 | 1996-11-19 | Schering Corporation | Antibodies to the slam protein expressed on activated T cells |
| JP2006515165A (ja) * | 2002-09-16 | 2006-05-25 | ジェネンテック・インコーポレーテッド | 免疫関連疾患の治療のための新規組成物と方法 |
| WO2012121429A1 (ko) * | 2011-03-07 | 2012-09-13 | 연세대학교 산학협력단 | 암 세포 바이오 마커를 동정하는 방법 및 상기 방법으로 동정한 nmd-무관 암 세포 바이오 마커 |
-
2015
- 2015-10-21 WO PCT/US2015/056714 patent/WO2016065038A1/en not_active Ceased
- 2015-10-21 EP EP15790387.3A patent/EP3209688A1/en not_active Withdrawn
- 2015-10-21 JP JP2017522170A patent/JP2017533207A/ja active Pending
- 2015-10-21 US US15/520,998 patent/US20180016555A1/en not_active Abandoned
- 2015-10-21 CN CN201580070049.7A patent/CN108064166A/zh active Pending
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