JP2019528082A5 - - Google Patents
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- JP2019528082A5 JP2019528082A5 JP2019517135A JP2019517135A JP2019528082A5 JP 2019528082 A5 JP2019528082 A5 JP 2019528082A5 JP 2019517135 A JP2019517135 A JP 2019517135A JP 2019517135 A JP2019517135 A JP 2019517135A JP 2019528082 A5 JP2019528082 A5 JP 2019528082A5
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- JP
- Japan
- Prior art keywords
- domain
- antibody
- fusion protein
- antigen
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- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2021088589A JP2021143186A (ja) | 2016-06-08 | 2021-05-26 | アゴニスト抗体の活性を増強する抗体重鎖定常領域配列 |
| JP2024087108A JP7809372B2 (ja) | 2016-06-08 | 2024-05-29 | アゴニスト抗体の活性を増強する抗体重鎖定常領域配列 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610404956 | 2016-06-08 | ||
| CN201610404956.7 | 2016-06-08 | ||
| PCT/CN2017/087620 WO2017211321A1 (zh) | 2016-06-08 | 2017-06-08 | 增强激动型抗体活性的抗体重链恒定区序列 |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021088589A Division JP2021143186A (ja) | 2016-06-08 | 2021-05-26 | アゴニスト抗体の活性を増強する抗体重鎖定常領域配列 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2019528082A JP2019528082A (ja) | 2019-10-10 |
| JP2019528082A5 true JP2019528082A5 (enExample) | 2019-11-21 |
Family
ID=60578403
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019517135A Pending JP2019528082A (ja) | 2016-06-08 | 2017-06-08 | アゴニスト抗体の活性を増強する抗体重鎖定常領域配列 |
| JP2021088589A Pending JP2021143186A (ja) | 2016-06-08 | 2021-05-26 | アゴニスト抗体の活性を増強する抗体重鎖定常領域配列 |
| JP2024087108A Active JP7809372B2 (ja) | 2016-06-08 | 2024-05-29 | アゴニスト抗体の活性を増強する抗体重鎖定常領域配列 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021088589A Pending JP2021143186A (ja) | 2016-06-08 | 2021-05-26 | アゴニスト抗体の活性を増強する抗体重鎖定常領域配列 |
| JP2024087108A Active JP7809372B2 (ja) | 2016-06-08 | 2024-05-29 | アゴニスト抗体の活性を増強する抗体重鎖定常領域配列 |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US12145993B2 (enExample) |
| EP (1) | EP3470424B1 (enExample) |
| JP (3) | JP2019528082A (enExample) |
| CN (2) | CN107474136B (enExample) |
| WO (1) | WO2017211321A1 (enExample) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3317297A4 (en) | 2015-06-30 | 2019-03-20 | Sanford-Burnham Medical Research Institute | BTLA FUSION PROTEIN AGONISTS AND USES THEREOF |
| WO2017211321A1 (zh) * | 2016-06-08 | 2017-12-14 | 上海交通大学医学院 | 增强激动型抗体活性的抗体重链恒定区序列 |
| PE20201339A1 (es) * | 2017-12-19 | 2020-11-25 | Univ Rockefeller | Variantes de dominio de fc de igg humana con funcion efectora mejorada |
| CN109970856B (zh) | 2017-12-27 | 2022-08-23 | 信达生物制药(苏州)有限公司 | 抗lag-3抗体及其用途 |
| JP7284759B2 (ja) * | 2017-12-27 | 2023-05-31 | ブリストル-マイヤーズ スクイブ カンパニー | 抗cd40抗体およびその使用 |
| CN110144009B (zh) * | 2018-02-14 | 2020-01-21 | 上海洛启生物医药技术有限公司 | Cd47单域抗体及其用途 |
| JP2022513653A (ja) * | 2018-11-28 | 2022-02-09 | ブリストル-マイヤーズ スクイブ カンパニー | 修飾された重鎖定常領域を含む抗体 |
| TWI756621B (zh) * | 2019-01-25 | 2022-03-01 | 大陸商信達生物製藥(蘇州)有限公司 | 新型雙特異性抗體分子以及同時結合pd-l1和lag-3的雙特異性抗體 |
| CN113728008B (zh) * | 2019-04-10 | 2024-04-09 | 南开大学 | 抗cd40抗体及其用途 |
| CN110981958B (zh) * | 2019-08-23 | 2020-10-20 | 四川大学华西医院 | 一种pd-l1抗体 |
| CN112592404B (zh) * | 2019-09-20 | 2023-07-25 | 上海交通大学医学院 | 抗体活性改造及其筛选方法 |
| EP4069291A1 (en) | 2019-12-03 | 2022-10-12 | Evotec International GmbH | Interferon-associated antigen binding proteins and uses thereof |
| CN110862455B (zh) * | 2019-12-03 | 2021-12-21 | 源道隆(苏州)医学科技有限公司 | 可结合cd47的多肽及其应用 |
| EP4071167A4 (en) * | 2019-12-03 | 2024-03-06 | Shanghai Jiao Tong University School of Medicine | ANTIBODIES FC REGION WITH INCREASED FCGRIB AFFINITY |
| MA59827B1 (fr) | 2020-05-26 | 2024-10-31 | Boehringer Ingelheim International Gmbh | Anticorps anti-pd-1 |
| CN114591428B (zh) * | 2020-12-04 | 2024-05-28 | 上海交通大学医学院 | 抗Dsg1抗体及其应用 |
| KR102671409B1 (ko) * | 2021-03-02 | 2024-05-31 | 진화섭 | Cd30을 발현하는 세포에 독성을 나타내는 재조합 단백질 및 이를 유효성분으로 포함하는 암의 치료용 약학적 조성물 |
| CN118339300A (zh) * | 2024-01-02 | 2024-07-12 | 江苏集萃药康生物科技股份有限公司 | 产生人源化抗体的动物模型及其构建方法 |
Family Cites Families (30)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AR039067A1 (es) * | 2001-11-09 | 2005-02-09 | Pfizer Prod Inc | Anticuerpos para cd40 |
| US7388079B2 (en) * | 2002-11-27 | 2008-06-17 | The Regents Of The University Of California | Delivery of pharmaceutical agents via the human insulin receptor |
| EP3342782B1 (en) | 2004-07-15 | 2022-08-17 | Xencor, Inc. | Optimized fc variants |
| CN1993378A (zh) * | 2004-08-03 | 2007-07-04 | 转化技术制药公司 | Rage融合蛋白及使用方法 |
| US20070128193A1 (en) * | 2004-12-22 | 2007-06-07 | O'neil Karyn T | GLP-1 agonists, compositions, methods and uses |
| JP2009514508A (ja) * | 2005-10-24 | 2009-04-09 | セントカー・インコーポレーテツド | Glp−2ミメティボディ、ポリペプチド、組成物、方法および用途 |
| EP2993188B1 (en) * | 2009-04-20 | 2020-08-19 | Kyowa Kirin Co., Ltd. | Anti cd40 antibody containing igg2 having three amino acid mutations introduced therein |
| CA2822366A1 (en) | 2010-12-23 | 2012-06-28 | Janssen Biotech, Inc. | Active protease-resistant antibody fc mutants |
| CA2827923C (en) * | 2011-02-25 | 2021-11-23 | Chugai Seiyaku Kabushiki Kaisha | Fc.gamma.riib-specific fc antibody |
| EP2537864B1 (en) * | 2011-06-24 | 2019-08-07 | Laboratoire Français du Fractionnement et des Biotechnologies | Fc variants with reduced effector functions |
| US20150050269A1 (en) * | 2011-09-30 | 2015-02-19 | Chugai Seiyaku Kabushiki Kaisha | Antigen-binding molecule promoting disappearance of antigens having plurality of biological activities |
| WO2013125667A1 (ja) | 2012-02-24 | 2013-08-29 | 中外製薬株式会社 | FcγRIIBを介して抗原の消失を促進する抗原結合分子 |
| US9890378B2 (en) * | 2012-05-11 | 2018-02-13 | Merck Sharp & Dohme Corp. | Surface anchored light chain bait antibody display system |
| SG11201500873XA (en) | 2012-08-24 | 2015-04-29 | Chugai Pharmaceutical Co Ltd | Fcgriib-specific fc region variant |
| CN104918957B (zh) | 2012-10-30 | 2018-11-16 | 埃派斯进有限公司 | 抗-cd40抗体及其使用方法 |
| TWI682941B (zh) | 2013-02-01 | 2020-01-21 | 美商再生元醫藥公司 | 含嵌合恆定區之抗體 |
| MD20180107A2 (ro) * | 2013-03-18 | 2019-06-30 | Biocerox Products B.V. | Anticorpi anti-CD134 (OX40) umanizaţi şi utilizarea acestora |
| EP3068798B1 (en) | 2013-11-12 | 2020-10-07 | OGD2 Pharma | Human igg1 derived antibody with pro-apoptotic activity |
| AU2015210750B2 (en) * | 2014-01-31 | 2020-08-20 | Children's Medical Center Corporation | Antibody molecules to TIM-3 and uses thereof |
| EP3131926A1 (en) * | 2014-04-16 | 2017-02-22 | UCB Biopharma SPRL | Multimeric fc proteins |
| DK3148579T3 (da) * | 2014-05-28 | 2021-03-08 | Agenus Inc | Anti-gitr antistoffer og fremgangsmåder til anvendelse deraf |
| CN106535932A (zh) * | 2014-06-05 | 2017-03-22 | 阿肯色大学评议会 | 抗体引导的疫苗和用于产生快速成熟的免疫应答的方法 |
| PL3221346T3 (pl) * | 2014-11-21 | 2021-03-08 | Bristol-Myers Squibb Company | Przeciwciała ze zmodyfikowanym regionem stałym łańcucha ciężkiego |
| TWI711630B (zh) * | 2014-11-21 | 2020-12-01 | 美商必治妥美雅史谷比公司 | 抗cd73抗體及其用途 |
| CA3005855A1 (en) * | 2015-11-19 | 2017-05-26 | Bristol-Myers Squibb Company | Antibodies against glucocorticoid-induced tumor necrosis factor receptor (gitr) and uses thereof |
| WO2017211321A1 (zh) * | 2016-06-08 | 2017-12-14 | 上海交通大学医学院 | 增强激动型抗体活性的抗体重链恒定区序列 |
| CN108623686A (zh) | 2017-03-25 | 2018-10-09 | 信达生物制药(苏州)有限公司 | 抗ox40抗体及其用途 |
| EP4071167A4 (en) * | 2019-12-03 | 2024-03-06 | Shanghai Jiao Tong University School of Medicine | ANTIBODIES FC REGION WITH INCREASED FCGRIB AFFINITY |
| WO2021222894A1 (en) * | 2020-05-01 | 2021-11-04 | Bolt Biotherapeutics, Inc. | Anti-dectin-2 antibodies |
| CN114106174A (zh) * | 2020-08-27 | 2022-03-01 | 苏州景涞医疗科技有限公司 | 低毒性抗ox40抗体、其药物组合物及应用 |
-
2017
- 2017-06-08 WO PCT/CN2017/087620 patent/WO2017211321A1/zh not_active Ceased
- 2017-06-08 EP EP17809760.6A patent/EP3470424B1/en active Active
- 2017-06-08 CN CN201710429281.6A patent/CN107474136B/zh active Active
- 2017-06-08 CN CN202210729123.3A patent/CN115304669A/zh active Pending
- 2017-06-08 US US16/308,156 patent/US12145993B2/en active Active
- 2017-06-08 JP JP2019517135A patent/JP2019528082A/ja active Pending
-
2021
- 2021-05-26 JP JP2021088589A patent/JP2021143186A/ja active Pending
-
2024
- 2024-05-29 JP JP2024087108A patent/JP7809372B2/ja active Active
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